Identification of a protein phosphatase-1/phospholamban complex that is regulated by cAMP-dependent phosphorylation

scientific article published on 14 November 2013

Identification of a protein phosphatase-1/phospholamban complex that is regulated by cAMP-dependent phosphorylation is …
instance of (P31):
scholarly articleQ13442814

External links are
P819ADS bibcode2013PLoSO...880867V
P356DOI10.1371/JOURNAL.PONE.0080867
P932PMC publication ID3828283
P698PubMed publication ID24244723
P5875ResearchGate publication ID258639764

P50authorDimitrios A. ArvanitisQ47862532
Despina SanoudouQ54109040
P2093author name stringElizabeth Vafiadaki
Evangelia G Kranias
P2860cites workHistidine-rich Ca-binding protein interacts with sarcoplasmic reticulum Ca-ATPaseQ24307062
Multiple structural elements define the specificity of recombinant human inhibitor-1 as a protein phosphatase-1 inhibitorQ24324682
Modulation of cardiac contractility by the phospholamban/SERCA2a regulatomeQ24337593
Structural basis for the recognition of regulatory subunits by the catalytic subunit of protein phosphatase 1Q24532150
SMART, a simple modular architecture research tool: identification of signaling domainsQ24597380
The muscle-specific protein phosphatase PP1G/R(GL)(G(M))is essential for activation of glycogen synthase by exerciseQ28214445
Protein phosphatases come of ageQ28255165
A prevalent variant in PPP1R3A impairs glycogen synthesis and reduces muscle glycogen content in humans and miceQ28472075
Heart failure-inducible gene therapy targeting protein phosphatase 1 prevents progressive left ventricular remodelingQ28482901
AKAP complex regulates Ca2+ re-uptake into heart sarcoplasmic reticulumQ28571497
Mutations of the serine phosphorylated in the protein phosphatase-1-binding motif in the skeletal muscle glycogen-targeting subunitQ30304658
Glycogen synthase association with the striated muscle glycogen-targeting subunit of protein phosphatase-1. Synthase activation involves scaffolding regulated by beta-adrenergic signalingQ30305751
Insulin control of glycogen metabolism in knockout mice lacking the muscle-specific protein phosphatase PP1G/RGL.Q30453548
A conserved domain for glycogen binding in protein phosphatase-1 targeting subunitsQ30472922
Phosphoproteome analysis of cardiomyocytes subjected to beta-adrenergic stimulation: identification and characterization of a cardiac heat shock protein p20.Q31024742
Proteomic analysis reveals significant alternations of cardiac small heat shock protein expression in congestive heart failureQ33234723
Phospholamban interacts with HAX-1, a mitochondrial protein with anti-apoptotic functionQ33269972
Human mutation in the anti-apoptotic heat shock protein 20 abrogates its cardioprotective effectsQ33369367
Sites of regulatory interaction between calcium ATPases and phospholambanQ33798495
Regulation of protein phosphatase-1.Q33831359
Phosphorylation of the skeletal muscle glycogen-targetting subunit of protein phosphatase 1 in response to adrenaline in vivoQ33887873
Digenic inheritance of severe insulin resistance in a human pedigreeQ34138875
Type 1 phosphatase, a negative regulator of cardiac functionQ34281889
Regulation of protein phosphatase-1G from rabbit skeletal muscle. 1. Phosphorylation by cAMP-dependent protein kinase at site 2 releases catalytic subunit from the glycogen-bound holoenzymeQ34457676
Biophysical interaction between phospholamban and protein phosphatase 1 regulatory subunit GM.Q34482698
Small heat shock protein 20 (HspB6) in cardiac hypertrophy and failureQ34550912
Targeting protein-protein interactions within the cyclic AMP signaling system as a therapeutic strategy for cardiovascular diseaseQ34621208
Disruption of the striated muscle glycogen targeting subunit PPP1R3A of protein phosphatase 1 leads to increased weight gain, fat deposition, and development of insulin resistanceQ34648339
The large isoforms of A-kinase anchoring protein 18 mediate the phosphorylation of inhibitor-1 by protein kinase A and the inhibition of protein phosphatase 1 activity.Q34700997
The extended PP1 toolkit: designed to create specificityQ35092072
Phospholamban: a crucial regulator of cardiac contractilityQ35167969
The A-kinase-anchoring protein AKAP-Lbc facilitates cardioprotective PKA phosphorylation of Hsp20 on Ser(16).Q36401530
Regulation of protein phosphatase 1 by intrinsically disordered proteinsQ36413937
Phosphodiesterase type 3A regulates basal myocardial contractility through interacting with sarcoplasmic reticulum calcium ATPase type 2a signaling complexes in mouse heartQ36630526
AAV9.I-1c delivered via direct coronary infusion in a porcine model of heart failure improves contractility and mitigates adverse remodelingQ36707489
The anti-apoptotic protein HAX-1 interacts with SERCA2 and regulates its protein levels to promote cell survivalQ37035026
Toward biologically targeted therapy of calcium cycling defects in heart failureQ37082359
Role of PP1 in the regulation of Ca cycling in cardiac physiology and pathophysiologyQ37145537
Role of protein phosphatase-1 inhibitor-1 in cardiac physiology and pathophysiologyQ37276968
A human polymorphism of protein phosphatase-1 inhibitor-1 is associated with attenuated contractile response of cardiomyocytes to beta-adrenergic stimulationQ37357819
Phosphatase-1 inhibitor-1 in physiological and pathological β-adrenoceptor signallingQ37847537
The PP1 binding code: a molecular-lego strategy that governs specificityQ37987596
Disruption of the cyclic AMP phosphodiesterase-4 (PDE4)-HSP20 complex attenuates the β-agonist induced hypertrophic response in cardiac myocytesQ39589356
Transgenic approaches to define the functional role of dual site phospholamban phosphorylationQ42450966
A single site (Ser16) phosphorylation in phospholamban is sufficient in mediating its maximal cardiac responses to beta -agonistsQ42493338
Small heat shock protein 20 interacts with protein phosphatase-1 and enhances sarcoplasmic reticulum calcium cyclingQ42778625
Blockade of Hsp20 phosphorylation exacerbates cardiac ischemia/reperfusion injury by suppressed autophagy and increased cell deathQ42946286
A common variant in PPP1R3 associated with insulin resistance and type 2 diabetesQ43506039
The protein phosphatases involved in cellular regulation. Purification and characterisation of the glycogen-bound form of protein phosphatase-1 from rabbit skeletal muscleQ43553490
Ser 16 -, but not Thr 17 -phosphorylation of phospholamban influences frequency-dependent force generation in human myocardiumQ44609266
Phosphatase inhibitor-1-deficient mice are protected from catecholamine-induced arrhythmias and myocardial hypertrophyQ46438826
Ser16 prevails over Thr17 phospholamban phosphorylation in the beta-adrenergic regulation of cardiac relaxation.Q52979010
Enhancement of cardiac function and suppression of heart failure progression by inhibition of protein phosphatase 1Q64378890
Targetting of protein phosphatase 1 to the sarcoplasmic reticulum of rabbit skeletal muscle by a protein that is very similar or identical to the G subunit that directs the enzyme to glycogenQ68459342
Maximal inhibition of SERCA2 Ca(2+) affinity by phospholamban in transgenic hearts overexpressing a non-phosphorylatable form of phospholambanQ73680642
Combinatorial control of protein phosphatase-1Q74147400
Decreased protein and phosphorylation level of the protein phosphatase inhibitor-1 in failing human heartsQ75294807
Reduced Ca(2+)-sensitivity of SERCA 2a in failing human myocardium due to reduced serin-16 phospholamban phosphorylationQ77306347
P275copyright licenseCreative Commons CC0 LicenseQ6938433
P6216copyright statuscopyrighted, dedicated to the public domain by copyright holderQ88088423
P433issue11
P407language of work or nameEnglishQ1860
P921main subjectphosphorylationQ242736
P304page(s)e80867
P577publication date2013-11-14
P1433published inPLOS OneQ564954
P1476titleIdentification of a protein phosphatase-1/phospholamban complex that is regulated by cAMP-dependent phosphorylation
P478volume8

Reverse relations

cites work (P2860)
Q36399731Human G109E-inhibitor-1 impairs cardiac function and promotes arrhythmias
Q35032742Phospholamban interactome in cardiac contractility and survival: A new vision of an old friend

Search more.