Site-specific phosphorylation and point mutations of telokin modulate its Ca2+-desensitizing effect in smooth muscle

scientific article

Site-specific phosphorylation and point mutations of telokin modulate its Ca2+-desensitizing effect in smooth muscle is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M103560200
P698PubMed publication ID11346659

P50authorJustin A. MacDonaldQ42413506
P2093author name stringX Liu
A P Somlyo
A V Somlyo
R K Nakamoto
T A Haystead
L A Walker
P2860cites workKinase-related protein (telokin) is phosphorylated by smooth-muscle myosin light-chain kinase and modulates the kinase activityQ24530594
Kinases, myosin phosphatase and Rho proteins: curiouser and curiouserQ24651458
X-ray structure determination of telokin, the C-terminal domain of myosin light chain kinase, at 2.8 A resolutionQ27642145
Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertensionQ29614247
Overcoming expression and purification problems of RhoGDI using a family of "parallel" expression vectorsQ29617999
Signal transduction by G-proteins, rho-kinase and protein phosphatase to smooth muscle and non-muscle myosin II.Q30304611
G protein-mediated inhibition of myosin light-chain phosphatase in vascular smooth muscleQ30439909
Role of guanine nucleotide-binding proteins--ras-family or trimeric proteins or both--in Ca2+ sensitization of smooth muscleQ30453921
Arachidonic acid and diacylglycerol release associated with inhibition of myosin light chain dephosphorylation in rabbit smooth muscle.Q30464099
Signal transduction and regulation in smooth muscleQ30465812
Acceleration of myosin light chain dephosphorylation and relaxation of smooth muscle by telokin. Synergism with cyclic nucleotide-activated kinaseQ30471988
Sites of interaction between kinase-related protein and smooth muscle myosin.Q38342805
Direct regulation of smooth muscle contractile elements by second messengersQ43427989
Cyclic GMP-dependent stimulation reverses G-protein-coupled inhibition of smooth muscle myosin light chain phosphateQ45096208
Purification and characterization of PCPP-260: a Purkinje cell-enriched cyclic AMP-regulated membrane phosphoprotein of Mr 260,000.Q48164640
Purification and characterization of a smooth muscle myosin light chain kinase-phosphatase complex.Q55066926
Phosphorylation of telokin by cyclic nucleotide kinases and the identification of in vivo phosphorylation sites in smooth muscleQ56929346
P433issue27
P407language of work or nameEnglishQ1860
P921main subjectphosphorylationQ242736
P1104number of pages6
P304page(s)24519-24524
P577publication date2001-05-09
P1433published inJournal of Biological ChemistryQ867727
P1476titleSite-specific phosphorylation and point mutations of telokin modulate its Ca2+-desensitizing effect in smooth muscle
P478volume276

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cites work (P2860)
Q42507586Activation of myosin light chain phosphatase in intact arterial smooth muscle during nitric oxide-induced relaxation
Q35229772Contractile force is enhanced in Aortas from pendrin null mice due to stimulation of angiotensin II-dependent signaling
Q36923928Contractile protein phosphorylation predicts human heart disease phenotypes
Q44321365Increased myofibrillar protein phosphatase-1 activity impairs rat aortic smooth muscle activation after hypoxia.
Q38344069Kinase-related protein/telokin inhibits Ca2+-independent contraction in Triton-skinned guinea pig taenia coli
Q33428533Losartan decreases p42/44 MAPK signaling and preserves LZ+ MYPT1 expression
Q30434302Modulation of smooth muscle contractility by CHASM, a novel member of the smoothelin family of proteins
Q28265662Molecular mechanism of telokin-mediated disinhibition of myosin light chain phosphatase and cAMP/cGMP-induced relaxation of gastrointestinal smooth muscle
Q30434723Myosin light chain kinase knockout
Q90663896Nitric oxide and its role as a non-adrenergic, non-cholinergic inhibitory neurotransmitter in the gastrointestinal tract
Q43261551Nitric oxide relaxes circular smooth muscle of rat distal colon through RhoA/Rho-kinase independent Ca2+ desensitisation
Q28246127Regulation of myosin light chain kinase and telokin expression in smooth muscle tissues
Q30309468RhoA-mediated Ca2+ sensitization in erectile function
Q30278873Role of Telokin in Regulating Murine Gastric Fundus Smooth Muscle Tension
Q44358184Smooth muscle myosin filament assembly under control of a kinase-related protein (KRP) and caldesmon.
Q30439447Smooth muscle of telokin-deficient mice exhibits increased sensitivity to Ca2+ and decreased cGMP-induced relaxation
Q44934588Smooth muscle phosphatase is regulated in vivo by exclusion of phosphorylation of threonine 696 of MYPT1 by phosphorylation of Serine 695 in response to cyclic nucleotides
Q33683217Systematic Synergy of Glucose and GLP-1 to Stimulate Insulin Secretion Revealed by Quantitative Phosphoproteomics
Q30436139Telokin mediates Ca2+-desensitization through activation of myosin phosphatase in phasic and tonic smooth muscle
Q37361567The potential role of MLC phosphatase and MAPK signalling in the pathogenesis of vascular dysfunction in heart failure
Q37942765The promise of inhibition of smooth muscle tone as a treatment for erectile dysfunction: where are we now?
Q33758291The role of the calponin homology domain of smoothelin-like 1 (SMTNL1) in myosin phosphatase inhibition and smooth muscle contraction
Q30436817Thromboxane A2-induced bi-directional regulation of cerebral arterial tone
Q44180685Uncoupling protein-1: involvement in a novel pathway for beta-adrenergic, cAMP-mediated intestinal relaxation
Q44608924Unzipping the Role of Myosin Light Chain Phosphatase in Smooth Muscle Cell Relaxation
Q34432730Vascular smooth muscle phenotypic diversity and function
Q34244951cGMP-dependent protein kinases and cGMP phosphodiesterases in nitric oxide and cGMP action
Q36127830cGMP-dependent protein kinases in drug discovery

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