High viral load in the cerebrospinal fluid and brain correlates with severity of simian immunodeficiency virus encephalitis.

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High viral load in the cerebrospinal fluid and brain correlates with severity of simian immunodeficiency virus encephalitis. is …
instance of (P31):
scholarly articleQ13442814

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P932PMC publication ID113103
P698PubMed publication ID10559366

P50authorAnding ShenQ67465848
P2093author name stringR J Adams
J D Lifson
M Piatak
D L Carter
J E Clements
J L Mankowski
M C Zink
K Suryanarayana
J P Spelman
P2860cites workVirus-specific CD8+ cytotoxic T-lymphocyte activity associated with control of viremia in primary human immunodeficiency virus type 1 infectionQ24645815
Temporal association of cellular immune responses with the initial control of viremia in primary human immunodeficiency virus type 1 syndromeQ24648628
Plasma viral load and CD4+ lymphocytes as prognostic markers of HIV-1 infectionQ34740804
Pathogenesis of SIV encephalitis. Selection and replication of neurovirulent SIVQ35763459
Genotypic selection of simian immunodeficiency virus in macaque infants infected transplacentallyQ35852512
Patterns of viral replication correlate with outcome in simian immunodeficiency virus (SIV)-infected macaques: effect of prior immunization with a trivalent SIV vaccine in modified vaccinia virus Ankara.Q35861490
Molecular and biological characterization of a neurovirulent molecular clone of simian immunodeficiency virusQ35889564
Pathogenesis of simian immunodeficiency virus encephalitis: viral determinants of neurovirulenceQ35890115
Neuropathology of Human Immunodeficiency Virus InfectionQ36476918
Derivation of neurotropic simian immunodeficiency virus from exclusively lymphocytetropic parental virus: pathogenesis of infection in macaquesQ36698054
Analysis of envelope changes acquired by SIVmac239 during neuroadaption in rhesus macaquesQ38874696
Cross-protective immune responses induced in rhesus macaques by immunization with attenuated macrophage-tropic simian immunodeficiency virusQ38948757
Outcome and predictors of failure of highly active antiretroviral therapy: one-year follow-up of a cohort of human immunodeficiency virus type 1-infected personsQ39598890
Dementia in AIDS patients: incidence and risk factors. Multicenter AIDS Cohort Study.Q41063277
Immunocytochemical quantitation of human immunodeficiency virus in the brain: correlations with dementiaQ42474669
Plasma SIV RNA viral load determination by real-time quantification of product generation in reverse transcriptase-polymerase chain reactionQ44244285
Suppression of inflammatory neurotoxins by highly active antiretroviral therapy in human immunodeficiency virus-associated dementiaQ44572012
Brain HIV burden and length of survival after AIDS diagnosisQ44679498
Neurological disorders during HIV-1 infection correlate with viral load in cerebrospinal fluid but not with virus phenotypeQ45755664
Relationship between human immunodeficiency virus-associated dementia and viral load in cerebrospinal fluid and brainQ45759163
Cerebrospinal fluid human immunodeficiency virus type 1 RNA levels are elevated in neurocognitively impaired individuals with acquired immunodeficiency syndrome. HIV Neurobehavioral Research Center GroupQ45759166
Levels of human immunodeficiency virus type 1 RNA in cerebrospinal fluid correlate with AIDS dementia stageQ45764045
Quantitation of human immunodeficiency virus in brains of demented and nondemented patients with acquired immunodeficiency syndromeQ45771406
Lentivirus-induced Pulmonary Lesions in Rhesus Monkeys (Macaca mulatta) Infected with Simian Immunodeficiency VirusQ45857232
Oligonucleotides with fluorescent dyes at opposite ends provide a quenched probe system useful for detecting PCR product and nucleic acid hybridizationQ46960543
Cerebrospinal fluid HIV-1 RNA levels: correlation with HIV encephalitisQ48499698
Cognitive and motor impairments associated with SIV infection in rhesus monkeysQ48509870
Serial pathogenesis study of SIV brain infectionQ48711631
Highly active antiretroviral treatment in HIV infection: benefits for neuropsychological function.Q51993416
Dual infection of the central nervous system by AIDS viruses with distinct cellular tropisms.Q55487007
Sustained cognitive decline in HIV infection: relationship to CD4+ cell count, plasma viremia and p24 antigenemiaQ57446076
Human immunodeficiency virus and the central nervous systemQ67587480
HIV infection of the central nervous system is characterized by rapid turnover of viral RNA in cerebrospinal fluidQ74605060
P433issue12
P407language of work or nameEnglishQ1860
P921main subjectcerebrospinal fluidQ54196
Simian immunodeficiency virusQ1890246
viral loadQ2528140
P304page(s)10480-10488
P577publication date1999-12-01
P1433published inJournal of VirologyQ1251128
P1476titleHigh viral load in the cerebrospinal fluid and brain correlates with severity of simian immunodeficiency virus encephalitis
P478volume73

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cites work (P2860)
Q59353529A Quantitative Approach to SIV Functional Latency in Brain Macrophages
Q40090693A SIV molecular clone that targets the CNS and induces neuroAIDS in rhesus macaques.
Q36989920A plasma microRNA signature of acute lentiviral infection: biomarkers of central nervous system disease
Q37829628A simian immunodeficiency virus macaque model of highly active antiretroviral treatment: viral latency in the periphery and the central nervous system
Q34990151A simian immunodeficiency virus-infected macaque model to study viral reservoirs that persist during highly active antiretroviral therapy
Q41924980An SIV/macaque model targeted to study HIV-associated neurocognitive disorders.
Q26767476Animal Models for HIV Cure Research
Q38248592Animal models of HIV peripheral neuropathy
Q37592018Antiretroviral drugs induce oxidative stress and neuronal damage in the central nervous system
Q27342233Attenuation of pathogenic immune responses during infection with human and simian immunodeficiency virus (HIV/SIV) by the tetracycline derivative minocycline
Q40082046Brain Macrophages in Simian Immunodeficiency Virus-Infected, Antiretroviral-Suppressed Macaques: a Functional Latent Reservoir
Q42227332CCR5 inhibition prevents cardiac dysfunction in the SIV/macaque model of HIV.
Q40441954CD4-independent entry and replication of simian immunodeficiency virus in primary rhesus macaque astrocytes are regulated by the transmembrane protein
Q33481045Cell-specific temporal infection of the brain in a simian immunodeficiency virus model of human immunodeficiency virus encephalitis
Q45722309Central nervous system correlates of behavioral deficits following simian immunodeficiency virus infection
Q40148493Central nervous system-specific consequences of simian immunodeficiency virus Gag escape from major histocompatibility complex class I-mediated control
Q36913222Cerebrospinal Fluid Biomarkers of Simian Immunodeficiency Virus Encephalitis : CSF Biomarkers of SIV Encephalitis.
Q35195923Cerebrospinal fluid is an efficient route for establishing brain infection with feline immunodeficiency virus and transfering infectious virus to the periphery
Q34594600Characterization of simian immunodeficiency virus (SIV) that induces SIV encephalitis in rhesus macaques with high frequency: role of TRIM5 and major histocompatibility complex genotypes and early entry to the brain
Q37542200Chronic Binge Alcohol Administration Dysregulates Hippocampal Genes Involved in Immunity and Neurogenesis in Simian Immunodeficiency Virus-Infected Macaques
Q34714277Combination fluconazole/paroxetine treatment is neuroprotective despite ongoing neuroinflammation and viral replication in an SIV model of HIV neurological disease
Q26825814Considerations in the development of nonhuman primate models of combination antiretroviral therapy for studies of AIDS virus suppression, residual virus, and curative strategies
Q33519523Coordinated regulation of SIV replication and immune responses in the CNS.
Q30478136Correlation of acute humoral response with brain virus burden and survival time in pig-tailed macaques infected with the neurovirulent simian immunodeficiency virus SIVsmmFGb
Q42445800Decreased neurotropism of nef long terminal repeat (nef/LTR)-deleted simian immunodeficiency virus
Q35003533Differential induction of rat neuronal excitotoxic cell death by human immunodeficiency virus type 1 clade B and C tat proteins.
Q37513129Distinct Patterns of Tryptophan Maintenance in Tissues during Kynurenine Pathway Activation in Simian Immunodeficiency Virus-Infected Macaques
Q35149650Dynamics of viral and proviral loads of feline immunodeficiency virus within the feline central nervous system during the acute phase following intravenous infection
Q35083375Dysregulation of mitogen-activated protein kinase signaling pathways in simian immunodeficiency virus encephalitis
Q34404828Early emergence and selection of a SIV-LTR C/EBP site variant in SIV-infected macaques that increases virus infectivity
Q35965672Early minocycline treatment prevents a decrease in striatal dopamine in an SIV model of HIV-associated neurological disease
Q35731648Editorial NeuroAIDS review
Q28246676Effects of human immunodeficiency virus type 1 on astrocyte gene expression and function: potential role in neuropathogenesis
Q34141266Elevated brain monoamine oxidase activity in SIV- and HIV-associated neurological disease
Q44315571Elevated peripheral benzodiazepine receptor expression in simian immunodeficiency virus encephalitis
Q35912988Expansion of a subset of CD14highCD16negCCR2low/neg monocytes functionally similar to myeloid-derived suppressor cells during SIV and HIV infection
Q35020221Expression of simian immunodeficiency virus (SIV) nef in astrocytes during acute and terminal infection and requirement of nef for optimal replication of neurovirulent SIV in vitro
Q38572329Foxp3 and Treg cells in HIV-1 infection and immuno-pathogenesis
Q45735916Functional analyses of natural killer cells in macaques infected with neurovirulent simian immunodeficiency virus
Q33716348Genetic composition of human immunodeficiency virus type 1 in cerebrospinal fluid and blood without treatment and during failing antiretroviral therapy.
Q39031641Genetic diversity and proviral DNA load in different neural compartments of HIV-1 subtype C infection
Q40404098HIV Protease Inhibitors Alter Amyloid Precursor Protein Processing via β-Site Amyloid Precursor Protein Cleaving Enzyme-1 Translational Up-Regulation.
Q40432133HIV and HIV dementia
Q33882450HIV and SIV induce alterations in CNS CaMKII expression and activation: a potential mechanism for cognitive impairment.
Q47563715HIV-1 infection of microglial cells in a reconstituted humanized mouse model and identification of compounds that selectively reverse HIV latency
Q26766448HIV-associated neurocognitive disorder--pathogenesis and prospects for treatment
Q36890075High frequency of virus-specific CD8+ T cells in the central nervous system of macaques chronically infected with simian immunodeficiency virus SIVmac251.
Q24594703Human immunodeficiency virus infection of human astrocytes disrupts blood-brain barrier integrity by a gap junction-dependent mechanism
Q36203752Human immunodeficiency virus type 1 genetic diversity in the nervous system: evolutionary epiphenomenon or disease determinant?
Q35857699Human immunodeficiency virus type 1 subtype C Tat fails to induce intracellular calcium flux and induces reduced tumor necrosis factor production from monocytes
Q35112016Human immunodeficiency virus-associated dementia: an evolving disease
Q35104668Hydrogen bonding at a conserved threonine in lentivirus capsid is required for virus replication
Q39615794Identification and characterization of a macrophage-tropic SIV envelope glycoprotein variant in blood from early infection in SIVmac251-infected macaques.
Q37727880Immune Responses in the Central Nervous System Are Anatomically Segregated in a Non-Human Primate Model of Human Immunodeficiency Virus Infection
Q35188470Induction of innate immune responses by SIV in vivo and in vitro: differential expression and function of RIG-I and MDA5.
Q92225778Infectious Virus Persists in CD4+ T Cells and Macrophages in Antiretroviral Therapy-Suppressed Simian Immunodeficiency Virus-Infected Macaques
Q41130300Initiation of HAART during acute simian immunodeficiency virus infection rapidly controls virus replication in the CNS by enhancing immune activity and preserving protective immune responses
Q43984822Innate immune responses and control of acute simian immunodeficiency virus replication in the central nervous system
Q34434339Is the central nervous system a reservoir of HIV-1?
Q34755001Lentiviral neuropathogenesis: comparative neuroinvasion, neurotropism, neurovirulence, and host neurosusceptibility
Q34590964Longitudinal analysis of monocyte/macrophage infection in simian immunodeficiency virus-infected, CD8+ T-cell-depleted macaques that develop lentiviral encephalitis
Q36691098Longitudinal in vivo positron emission tomography imaging of infected and activated brain macrophages in a macaque model of human immunodeficiency virus encephalitis correlates with central and peripheral markers of encephalitis and areas of synapti
Q37661792Loss of immune homeostasis dictates SHIV rebound after stem-cell transplantation
Q47566977Lymphocyte-Dominant Encephalitis and Meningitis in Simian Immunodeficiency Virus-Infected Macaques Receiving Antiretroviral Therapy
Q41489433Macaque species susceptibility to simian immunodeficiency virus: increased incidence of SIV central nervous system disease in pigtailed macaques versus rhesus macaques
Q33840048Macaques with rapid disease progression and simian immunodeficiency virus encephalitis have a unique cytokine profile in peripheral lymphoid tissues
Q35474314Macrophage-mediated dorsal root ganglion damage precedes altered nerve conduction in SIV-infected macaques
Q37182704Macrophages in Progressive Human Immunodeficiency Virus/Simian Immunodeficiency Virus Infections
Q32066108Macrophages relate presynaptic and postsynaptic damage in simian immunodeficiency virus encephalitis
Q34893901Measles viral load may reflect SSPE disease progression
Q37064542Mechanisms of minocycline-induced suppression of simian immunodeficiency virus encephalitis: inhibition of apoptosis signal-regulating kinase 1.
Q37968178Monocyte mobilization, activation markers, and unique macrophage populations in the brain: observations from SIV infected monkeys are informative with regard to pathogenic mechanisms of HIV infection in humans
Q35634100Multiplexed Component Analysis to Identify Genes Contributing to the Immune Response during Acute SIV Infection
Q24647731Natural host genetic resistance to lentiviral CNS disease: a neuroprotective MHC class I allele in SIV-infected macaques
Q35177355Neuroimmunity and the blood-brain barrier: molecular regulation of leukocyte transmigration and viral entry into the nervous system with a focus on neuroAIDS.
Q34734802Neuroinflammation and virus replication in the spinal cord of simian immunodeficiency virus-infected macaques
Q35886296Neuropathology of wild-type and nef-attenuated T cell tropic simian immunodeficiency virus (SIVmac32H) and macrophage tropic neurovirulent SIVmac17E-Fr in cynomolgus macaques
Q42268235Neuroprotective maraviroc monotherapy in simian immunodeficiency virus-infected macaques: reduced replicating and latent SIV in the brain
Q36597909Neuropsychological test performance before and after HIV-1 seroconversion: the Multicenter AIDS Cohort Study
Q44195653Neurovirulence depends on virus input titer in brain in feline immunodeficiency virus infection: evidence for activation of innate immunity and neuronal injury
Q38932858Non-human primate models of SIV infection and CNS neuropathology
Q37264017Nonhuman primate models of NeuroAIDS
Q26852969Paving the path to HIV neurotherapy: Predicting SIV CNS disease
Q36167247Persistent Peripheral Nervous System Damage in Simian Immunodeficiency Virus-Infected Macaques Receiving Antiretroviral Therapy
Q45418066Platelet decline: an early predictive hematologic marker of simian immunodeficiency virus central nervous system disease
Q34162407PrPC, the Cellular Isoform of the Human Prion Protein, Is a Novel Biomarker of HIV-Associated Neurocognitive Impairment and Mediates Neuroinflammation
Q33580220Proton magnetic resonance spectroscopy reveals neuroprotection by oral minocycline in a nonhuman primate model of accelerated NeuroAIDS
Q40734962Quantitation of Productively Infected Monocytes and Macrophages of Simian Immunodeficiency Virus-Infected Macaques
Q27307670Quantitation of gene expression in formaldehyde-fixed and fluorescence-activated sorted cells
Q35883306Quinolinic acid/tryptophan ratios predict neurological disease in SIV-infected macaques and remain elevated in the brain under cART.
Q37284227RON receptor tyrosine kinase, a negative regulator of inflammation, is decreased during simian immunodeficiency virus-associated central nervous system disease
Q33593821Regulation of SIV mac 239 basal long terminal repeat activity and viral replication in macrophages: functional roles of two CCAAT/enhancer-binding protein beta sites in activation and interferon beta-mediated suppression
Q38886489Role of microglial cells in selective replication of simian immunodeficiency virus genotypes in the brain
Q37175209Roles of MCP-1 in development of HIV-dementia
Q36645459SAMHD1 transcript upregulation during SIV infection of the central nervous system does not associate with reduced viral load.
Q54209057SIV Latency in Macrophages in the CNS.
Q37155048SIV replication is directly downregulated by four antiviral miRNAs.
Q90003262SIV-Induced Immune Activation and Metabolic Alterations in the Dorsal Root Ganglia During Acute Infection
Q35242182SIV/macaque model of HIV infection in cocaine users: minimal effects of cocaine on behavior, virus replication, and CNS inflammation
Q45409291Sequence variation in the CC-chemokine ligand 2 promoter of pigtailed macaques is not associated with the incidence or severity of neuropathology in a simian immunodeficiency virus model of human immunodeficiency virus central nervous system disease
Q36315704Severe depletion of CD4+ CD25+ regulatory T cells from the intestinal lamina propria but not peripheral blood or lymph nodes during acute simian immunodeficiency virus infection
Q42716884Simian immunodeficiency virus infection in the brain and lung leads to differential type I IFN signaling during acute infection
Q33850643Simian immunodeficiency virus replicates to high levels in naturally infected African green monkeys without inducing immunologic or neurologic disease
Q33893665Simian immunodeficiency virus-infected macaques treated with highly active antiretroviral therapy have reduced central nervous system viral replication and inflammation but persistence of viral DNA
Q41873622Splenic Damage during SIV Infection: Role of T-Cell Depletion and Macrophage Polarization and Infection
Q37605089Suppressor of cytokine signaling 3 inhibits antiviral IFN-beta signaling to enhance HIV-1 replication in macrophages
Q36594100Systemic and brain macrophage infections in relation to the development of simian immunodeficiency virus encephalitis
Q36991469The ART of HIV therapies: dopaminergic deficits and future treatments for HIV pediatric encephalopathy
Q37264024The accelerated simian immunodeficiency virus macaque model of human immunodeficiency virus-associated neurological disease: from mechanism to treatment
Q45434391The central nervous system is a viral reservoir in simian immunodeficiency virus--infected macaques on combined antiretroviral therapy: a model for human immunodeficiency virus patients on highly active antiretroviral therapy
Q37781306Thinking about HIV: the intersection of virus, neuroinflammation and cognitive dysfunction
Q37646891Tissue-resident macrophages can contain replication-competent virus in antiretroviral-naive, SIV-infected Asian macaques
Q36515464Tissue-specific interferon alpha subtype response to SIV infection in brain, spleen, and lung
Q42114039Transmigration of macrophages across the choroid plexus epithelium in response to the feline immunodeficiency virus
Q37153550Tristetraprolin expression and microRNA-mediated regulation during simian immunodeficiency virus infection of the central nervous system
Q35857688Unique pathology in simian immunodeficiency virus-infected rapid progressor macaques is consistent with a pathogenesis distinct from that of classical AIDS.
Q37264013Virus-host interaction in the simian immunodeficiency virus-infected brain
Q33343967YKL-40, a marker of simian immunodeficiency virus encephalitis, modulates the biological activity of basic fibroblast growth factor

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