Pharmacokinetic/pharmacodynamic modelling approaches in paediatric infectious diseases and immunology

scientific article

Pharmacokinetic/pharmacodynamic modelling approaches in paediatric infectious diseases and immunology is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1016/J.ADDR.2014.01.002
P932PMC publication ID4076844
P698PubMed publication ID24440429
P5875ResearchGate publication ID259806866

P50authorEva GermovsekQ56046230
Charlotte I BarkerQ56046240
Jodi M LestnerQ56856379
Rollo L HoareQ60529522
Joanna LewisQ64685445
P2093author name stringJoseph F Standing
P2860cites workPharmacokinetics and metabolism of cyclophosphamide in paediatric patientsQ68202648
Pharmacokinetics of ticarcillin in patients with cystic fibrosis: a controlled prospective studyQ68692675
Pharmacokinetics, outcome of treatment, and toxic effects of amphotericin B and 5-fluorocytosine in neonatesQ68761188
Pharmacokinetics of amphotericin B in infants and childrenQ69755066
Oral acyclovir to prevent dissemination of varicella in immunocompromised childrenQ70615489
Oral ganciclovir in children: pharmacokinetics, safety, tolerance, and antiviral effects. The Pediatric AIDS Clinical Trials GroupQ73166594
Guidelines for the use of antiretroviral agents in pediatric HIV infection, January 7, 2000Q74599986
Invasive pulmonary aspergillosis in a critically ill neonate: case report and review of invasive aspergillosis during the first 3 months of lifeQ77402921
Immune reconstitution after haematopoietic transplantation with two different doses of pre-graft antithymocyte globulinQ78342706
Rapid immune reconstitution after a reduced-intensity conditioning regimen and a CD3-depleted haploidentical stem cell graft for paediatric refractory haematological malignanciesQ79160640
Population pharmacokinetics and dosing of flucloxacillin in preterm and term neonatesQ79735915
Virologic response to potent antiretroviral therapy and modeling of HIV dynamics in early pediatric infectionQ80407528
Lymphocyte subsets recovery following allogeneic bone marrow transplantation (BMT): CD4+ cell count and transplant-related mortalityQ81436465
Population pharmacokinetic and pharmacodynamic modeling of high-dose intermittent ticarcillin-clavulanate administration in pediatric cystic fibrosis patientsQ82143092
CD31+ cell percentage correlation with speed of CD4+ T-cell count recovery in HIV-infected adults is reversed in children: higher thymic output may be responsibleQ83852425
Impact of viable CD45 cells infused on lymphocyte subset recovery after unrelated cord blood transplantation in childrenQ84521307
Optimal dosage regimen of meropenem for pediatric patients based on pharmacokinetic/pharmacodynamic considerationsQ84540787
Reconstitution rate of absolute CD8+ T lymphocyte counts affects overall survival after pediatric allogeneic hematopoietic stem cell transplantationQ84570852
Cefuroxime Pharmacokinetics in Pediatric Cardiovascular Surgery Patients Undergoing Cardiopulmonary BypassQ85073452
Population pharmacokinetics of liposomal amphotericin B in pediatric patients with malignant diseasesQ24542404
Population pharmacokinetics of meropenem in plasma and cerebrospinal fluid of infants with suspected or complicated intra-abdominal infectionsQ24594815
Determining population and developmental pharmacokinetics of metronidazole using plasma and dried blood spot samples from premature infantsQ24626231
Recommended reading in population pharmacokinetic pharmacodynamicsQ24647906
Voriconazole versus amphotericin B for primary therapy of invasive aspergillosisQ28217179
HIV-1 dynamics in vivo: virion clearance rate, infected cell life-span, and viral generation timeQ29547822
Fluconazole prophylaxis against fungal colonization and infection in preterm infantsQ30308442
Pharmacokinetic changes during extracorporeal membrane oxygenation: implications for drug therapy of neonatesQ30310834
Oseltamivir in the management of influenza.Q30351736
Efficacy, safety, and pharmacokinetics of intravenous peramivir in children with 2009 pandemic H1N1 influenza A virus infectionQ30408582
Pharmacokinetics, safety, and biologic effects of azithromycin in extremely preterm infants at risk for ureaplasma colonization and bronchopulmonary dysplasia.Q30409445
Population pharmacokinetic-pharmacodynamic target attainment analysis of imipenem plasma and urine data in neonates and childrenQ30626863
Fluconazole for prophylaxis against candidal rectal colonization in the very low birth weight infantQ31832758
Population pharmacokinetic analysis of voriconazole plasma concentration data from pediatric studiesQ33392206
Oral ganciclovir in pediatric transplant recipients: a pharmacokinetic study.Q33501181
Modeling latently infected cell activation: viral and latent reservoir persistence, and viral blips in HIV-infected patients on potent therapyQ33510903
Voriconazole pharmacokinetics and pharmacodynamics in childrenQ33577291
Repeated-dose pharmacokinetics of an oral solution of itraconazole in infants and children.Q33690036
The pharmacokinetics and pharmacodynamics of vancomycin in clinical practice: evidence and uncertainties.Q38068293
Background and rationale for revised clinical and laboratory standards institute interpretive criteria (Breakpoints) for Enterobacteriaceae and Pseudomonas aeruginosa: I. Cephalosporins and AztreonamQ38075482
Pharmacokinetics and pharmacodynamics of oseltamivir in neonates, infants and childrenQ38107016
Maximum likelihood estimation of long-term HIV dynamic models and antiviral responseQ38440550
Nephrotoxicity of aminoglycoside antibiotics.Q38616214
Pharmacokinetics of itraconazole oral solution in neutropenic children during long-term prophylaxisQ39477254
Pharmacokinetic studies of fluconazole in rabbits characterizing doses which achieve peak levels in serum and area under the concentration-time curve values which mimic those of high-dose fluconazole in humans.Q39557816
Immune reconstitution after purified autologous and allogeneic blood stem cell transplantation compared with unmanipulated bone marrow transplantation in childrenQ39766442
Pharmacokinetics of ciprofloxacin in pediatric cystic fibrosis patients.Q39781130
Pharmacokinetics of teicoplanin in pediatric patientsQ39818673
Adaptive resistance following single doses of gentamicin in a dynamic in vitro model.Q39881843
Population pharmacokinetics of ciprofloxacin in pediatric and adolescent patients with acute infectionsQ39913232
Pharmacokinetics of oral valganciclovir solution and intravenous ganciclovir in pediatric renal and liver transplant recipientsQ39920233
Penicillin-binding proteins and the mechanism of action of beta-lactam antibioticsQ40157128
Pharmacokinetic-pharmacodynamic model for gentamicin and its adaptive resistance with predictions of dosing schedules in newborn infantsQ40326667
Factors affecting reconstitution of the T cell compartment in allogeneic haematopoietic cell transplant recipients.Q40552200
Fludarabine: pharmacokinetics, mechanisms of action, and rationales for combination therapiesQ40777942
Population pharmacokinetics of gentamicin in preterm neonates: evaluation of a once-daily dosage regimenQ40794081
Pharmacokinetics of amikacin in infants and pre-school childrenQ41598345
Immune reconstitution after allogeneic hematopoietic stem cell transplantation in children: a single institution study of 59 patientsQ42083118
Vancomycin continuous infusion in neonates: dosing optimisation and therapeutic drug monitoringQ42282104
Population pharmacokinetics of acyclovir in children and young people with malignancy after administration of intravenous acyclovir or oral valacyclovir.Q42286838
Population pharmacokinetics of ciprofloxacin in pediatric patientsQ42603473
The pharmacokinetics of meropenem in infants and children: a population analysisQ42624959
Vancomycin population pharmacokinetics in neonatesQ42626054
Tobramycin population pharmacokinetics in neonates.Q42666715
Pharmacodynamics of levofloxacin: a new paradigm for early clinical trialsQ42671287
Population pharmacokinetics of piperacillin/tazobactam in neonates and young infantsQ42684527
Population pharmacokinetics of gentamicin in premature newborns.Q42688816
Pharmacokinetic and pharmacodynamic assessment of oral valganciclovir in the treatment of symptomatic congenital cytomegalovirus diseaseQ42696550
Drug dosing in renal diseaseQ42738036
Interferon alfa-2b in combination with ribavirin for the treatment of chronic hepatitis C in children: efficacy, safety, and pharmacokineticsQ42996149
Pharmacokinetics and dose requirements of vancomycin in neonatesQ43097632
Population pharmacokinetics and pharmacodynamics of meropenem in Japanese pediatric patientsQ43186296
A rapid and sensitive LC-MS/MS method for determination of fluconazole in human plasma and its application in infants with Candida infectionsQ43278204
Toxicodynamics of itraconazole: implications for therapeutic drug monitoringQ43291845
Score tests for exploring complex models: application to HIV dynamics modelsQ43473035
Population pharmacokinetics of gentamicin in neonates using a nonlinear, mixed-effects modelQ43640101
Pharmacokinetics of ganciclovir in renal transplant childrenQ43710488
High-dose, short-duration ribavirin aerosol therapy in children with suspected respiratory syncytial virus infectionQ43783467
Valganciclovir dosing according to body surface area and renal function in pediatric solid organ transplant recipientsQ43849610
Pharmacokinetics of ganciclovir in pediatric renal transplant recipientsQ44300481
Response to combination antiretroviral therapy: variation by age.Q44396687
Clinical response to aminoglycoside therapy: importance of the ratio of peak concentration to minimal inhibitory concentrationQ44483617
Lymphocyte subset reconstitution after unrelated cord blood or bone marrow transplantation in childrenQ44514184
A Bayesian approach to parameter estimation in HIV dynamical modelsQ44542356
Dosing considerations for oral acyclovir following neonatal herpes diseaseQ44557280
Treatment monitoring of HIV-infected patients based on mechanistic modelsQ44581468
Pharmacokinetics of fluconazole in very low birth weight infants during the first two weeks of lifeQ44700606
Immune reconstitution kinetics as an early predictor for mortality using various hematopoietic stem cell sources in children.Q44723819
Valacyclovir and acyclovir pharmacokinetics in immunocompromised childrenQ33776931
Single-dose pharmacokinetics of famciclovir in infants and population pharmacokinetic analysis in infants and childrenQ33826417
Pharmacokinetics of cefotaxime and desacetylcefotaxime in infants during extracorporeal membrane oxygenation.Q33826426
Population pharmacokinetics of micafungin in neonates and young infantsQ33876608
The bactericidal action of penicillin: new clues to an unsolved mysteryQ33934194
Safety, tolerability, and pharmacokinetics of Micafungin (FK463) in febrile neutropenic pediatric patientsQ33938201
Pharmacokinetics of oral acyclovir in neonates and in infants: a population analysisQ33981154
Pharmacodynamics of fluoroquinolones against Streptococcus pneumoniae in patients with community-acquired respiratory tract infectionsQ33983119
Safety, pharmacokinetics, and pharmacodynamics of cyclodextrin itraconazole in pediatric patients with oropharyngeal candidiasisQ34111158
Pharmacokinetics, safety, and tolerability of caspofungin in children and adolescentsQ34123805
Safety and pharmacokinetics of ribavirin for the treatment of la crosse encephalitisQ34182776
Population pharmacokinetics of amphotericin B lipid complex in neonatesQ34228332
Aminoglycoside adaptive resistance: importance for effective dosage regimensQ34277787
Antimicrobial pharmacodynamics: critical interactions of 'bug and drug'.Q34307105
Safety and pharmacokinetics of intravenous anidulafungin in children with neutropenia at high risk for invasive fungal infectionsQ34352100
Population pharmacokinetic analysis of vancomycin in neonates. A new proposal of initial dosage guidelineQ34381352
Fluconazole loading dose pharmacokinetics and safety in infantsQ34807770
Population pharmacokinetics and pharmacodynamics of caspofungin in pediatric patientsQ34932330
Incomplete peripheral CD4+ cell count restoration in HIV-infected patients receiving long-term antiretroviral treatmentQ34937231
In vivo pharmacodynamics of antifungal drugs in treatment of candidiasisQ35091285
Continuous infusion of high-dose acyclovir for serious herpesvirus infectionsQ35345243
Pharmacokinetics of amphotericin B in childrenQ35360830
Pharmacokinetics of acyclovir suspension in infants and childrenQ35543240
Comparison of pharmacokinetics and safety of voriconazole intravenous-to-oral switch in immunocompromised children and healthy adultsQ35598464
Comparison of pharmacokinetics and safety of voriconazole intravenous-to-oral switch in immunocompromised adolescents and healthy adultsQ35598532
Basic pharmacodynamics of antibacterials with clinical applications to the use of beta-lactams, glycopeptides, and linezolidQ35623055
Posaconazole plasma concentrations in juvenile patients with invasive fungal infectionQ35647678
Population pharmacokinetics of voriconazole in adultsQ35666490
The pharmacokinetics of valganciclovir prophylaxis in pediatric solid organ transplant patients at risk for Epstein-Barr virus diseaseQ35683931
Pharmacodynamics of intravenous ciprofloxacin in seriously ill patientsQ35814807
Population pharmacokinetics of metronidazole evaluated using scavenged samples from preterm infantsQ35867330
Population pharmacokinetics I: background, concepts, and modelsQ35870696
The impact of early CD4+ lymphocyte recovery on the outcome of patients who undergo allogeneic bone marrow or peripheral blood stem cell transplantation.Q35874039
Population pharmacokinetics II: estimation methodsQ35887615
A novel pharmacokinetic approach to predict virologic failure in HIV-1-infected paediatric patientsQ44775929
Population pharmacokinetic analysis of anidulafungin, an echinocandin antifungalQ44897892
Pharmacokinetics of teicoplanin in an ICU population of children and infantsQ45179807
Ganciclovir treatment in children: evidence of subtherapeutic levelsQ45308623
Reconstitution of maturating and regulatory lymphocyte subsets after cord blood and BMT in childrenQ45403029
Neonatal acyclovir pharmacokinetics in patients with herpes virus infectionsQ45800069
Developmental pharmacokinetics of gentamicin in preterm and term neonates: population modelling of a prospective study.Q45984535
Individualised dosing of amikacin in neonates: a pharmacokinetic/pharmacodynamic analysis.Q46078844
Meropenem pharmacokinetics, pharmacodynamics, and Monte Carlo simulation in the neonateQ46470310
Histologic and histochemical changes in articular cartilages of immature beagle dogs dosed with difloxacin, a fluoroquinoloneQ46601415
CD4 cell response before and after HAART initiation according to viral load and growth indicators in HIV-1-infected children in Abidjan, Côte d'IvoireQ46614246
Voriconazole in newborns.Q46681387
Voriconazole therapeutic drug monitoring in patients with invasive mycoses improves efficacy and safety outcomesQ46826187
Population pharmacokinetics and pharmacodynamics of meropenem in pediatric patientsQ46882759
Population pharmacokinetics of intravenous amoxicillin in very low birth weight infantsQ47298320
Population pharmacokinetics of gentamicin in South African newbornsQ47435744
Early lymphocyte reconstitution is associated with improved transplant outcome after cord blood transplantationQ49151311
Effect of ribavirin on the plasma viral DNA load in patients with disseminating adenovirus infection.Q50581300
Antithymocyte globulin pharmacokinetics in pediatric patients after hematopoietic stem cell transplantation.Q50771334
Mechanisms involved in CD4 cell gains in HIV-infected patients switched to raltegravir.Q50975449
Age and CD4 count at initiation of antiretroviral therapy in HIV-infected children: effects on long-term T-cell reconstitution.Q50976272
Indications for a ceftriaxone dosing regimen in Japanese paediatric patients using population pharmacokinetic/pharmacodynamic analysis and simulation.Q51625200
Pharmacokinetic modelling of a once-daily dosing regimen for intravenous tobramycin in paediatric cystic fibrosis patients.Q51756288
Acute graft-versus-host disease transiently impairs thymic output in young patients after allogeneic hematopoietic stem cell transplantation.Q51788059
Drug-sparing regimens for HIV combination therapy: benefits predicted for "drug coasting".Q51912232
Maximum likelihood estimation in dynamical models of HIV.Q51915380
Age-matched lymphocyte subpopulation reference values in childhood and adolescence: application of exponential regression analysis.Q51966954
Single dose pharmacokinetics of linezolid in infants and children.Q52142272
Prophylactic oral ganciclovir after renal transplantation-dosing and pharmacokinetics.Q52247289
In vivo uptake kinetics of aminoglycosides in the kidney cortex of rats.Q52429639
The impact of early viral infections and graft-versus-host disease on immune reconstitution following paediatric stem cell transplantation.Q53267898
Itraconazole oral solution as antifungal prophylaxis in children undergoing stem cell transplantation or intensive chemotherapy for haematological disorders.Q53921471
Determinants of response to first HAART regimen in antiretroviral-naive patients with an estimated time since HIV seroconversionQ56530204
Metronidazole Population Pharmacokinetics in Preterm Neonates Using Dried Blood-Spot SamplingQ60428210
Influence of Intrauterine Maturation on the Pharmacokinetics of Amikacin in the Neonatal PeriodQ61713352
Multivariate analyses of immune reconstitution in children after allo-SCT: risk-estimation based on age-matched leukocyte sub-populationsQ61907216
Population pharmacokinetics of tobramycin administered thrice daily and once daily in children and adults with cystic fibrosisQ61912446
Pharmacokinetics of teicoplanin in childrenQ61943786
Immune recovery in children undergoing allogeneic stem cell transplantation: absolute CD8+CD3+ count reconstitution is associated with survivalQ63386801
A limited sampling schedule to estimate individual pharmacokinetic parameters of fludarabine in hematopoietic cell transplant patientsQ37390905
Population pharmacokinetics and optimal design of paediatric studies for famciclovir.Q37427931
Pharmacokinetics and effects of ribavirin following intraventricular administration for treatment of subacute sclerosing panencephalitisQ37624520
PENTA 2009 guidelines for the use of antiretroviral therapy in paediatric HIV-1 infectionQ37624875
Pharmacokinetic optimization of antiretroviral therapy in children and adolescentsQ37835819
Impact of pharmacometric analyses on new drug approval and labelling decisions: a review of 198 submissions between 2000 and 2008.Q37927016
Kinetics and dose calculations of amikacin in the newbornQ67462285
Itraconazole therapy for disseminated candidiasis in a very low birthweight neonateQ67493977
Population pharmacokinetics of gentamicin in premature infantsQ67564632
Safety and pharmacokinetics of fluconazole in children with neoplastic diseasesQ68136211
Single-dose pharmacokinetics of intravenous itraconazole and hydroxypropyl-beta-cyclodextrin in infants, children, and adolescentsQ35912756
Population pharmacokinetics III: design, analysis, and application of population pharmacokinetic StudiesQ35928858
Therapeutic monitoring of voriconazole in children less than three years of age: a case report and summary of voriconazole concentrations for ten childrenQ35973543
Integrated population pharmacokinetic analysis of voriconazole in children, adolescents, and adultsQ36018595
Vancomycin pharmacokinetics in preterm neonates and the prediction of adult clearanceQ36024899
New dosing strategies for antibacterial agents in the neonateQ36035169
Population pharmacokinetics of micafungin in pediatric patients and implications for antifungal dosingQ36094957
Correlation of the MIC and dose/MIC ratio of fluconazole to the therapeutic response of patients with mucosal candidiasis and candidemiaQ36094974
Pharmacokinetics of penicillin G in infants with a gestational age of less than 32 weeks.Q36095091
Antiviral therapies in children: has their time arrived?Q36145050
Short versus long infusion of meropenem in very-low-birth-weight neonatesQ36172523
An Evaluation of Gentamicin, Tobramycin, and Amikacin Pharmacokinetic/Pharmacodynamic Parameters in HIV-Infected ChildrenQ36311367
Population clinical pharmacology of children: modelling covariate effects.Q36522932
Population clinical pharmacology of children: general principles.Q36522936
Target concentration intervention is needed for tobramycin dosing in paediatric patients with cystic fibrosis--a population pharmacokinetic studyQ36536423
Paediatric use of mycophenolate mofetilQ36562448
Application of antimicrobial pharmacodynamic concepts into clinical practice: focus on beta-lactam antibiotics: insights from the Society of Infectious Diseases PharmacistsQ36582692
Oseltamivir pharmacokinetics, dosing, and resistance among children aged <2 years with influenzaQ36584645
Total and active rabbit antithymocyte globulin (rATG;Thymoglobulin) pharmacokinetics in pediatric patients undergoing unrelated donor bone marrow transplantationQ36645945
Does the piperacillin minimum inhibitory concentration for Pseudomonas aeruginosa influence clinical outcomes of children with pseudomonal bacteremia?Q36853968
Pharmacodynamic implications for use of antifungal agentsQ36872633
Ciclosporin kinetics in children after stem cell transplantationQ36922221
Optimizing drug development of anti-cancer drugs in children using modelling and simulationQ36987975
Facilitation of drug evaluation in children by population methods and modellingQ37108169
Pharmacokinetics and safety of caspofungin in neonates and infants less than 3 months of age.Q37115709
Pharmacokinetics of amoxicillin in maternal, umbilical cord, and neonatal seraQ37144784
Pharmacokinetics and safety of famciclovir in children with herpes simplex or varicella-zoster virus infectionQ37190818
Antifungal therapeutic drug monitoring: established and emerging indicationsQ37310029
Therapeutic drug monitoring for triazolesQ37315204
Pharmacokinetics of high-dose i.v. treosulfan in children undergoing treosulfan-based preparative regimen for allogeneic haematopoietic SCT.Q37315405
Meropenem pharmacokinetics in the newborn.Q37333159
Pharmacokinetics of alemtuzumab and the relevance in clinical practiceQ37340406
Homeostasis of naive and memory T cellsQ37356053
P275copyright licenseCreative Commons Attribution-NonCommercial-NoDerivs 3.0 UnportedQ19125045
P407language of work or nameEnglishQ1860
P921main subjectpharmacokineticsQ323936
infectionQ166231
immunologyQ101929
infectious diseaseQ18123741
pharmacodynamicsQ725307
biomedical investigative techniqueQ66648976
P5008on focus list of Wikimedia projectScienceSourceQ55439927
P304page(s)127-139
P577publication date2014-01-17
P1433published inAdvanced Drug Delivery ReviewsQ2825362
P1476titlePharmacokinetic/pharmacodynamic modelling approaches in paediatric infectious diseases and immunology
P478volume73

Reverse relations

cites work (P2860)
Q37358644A Population and Developmental Pharmacokinetic Analysis To Evaluate and Optimize Cefotaxime Dosing Regimen in Neonates and Young Infants
Q31119393An Algorithm and R Program for Fitting and Simulation of Pharmacokinetic and Pharmacodynamic Data
Q38857191Children in clinical trials: towards evidence-based pediatric pharmacotherapy using pharmacokinetic-pharmacodynamic modeling.
Q38641774Determining the optimal vancomycin daily dose for pediatrics: a meta-analysis.
Q47689223Development of a Novel Multipenicillin Assay and Assessment of the Impact of Analyte Degradation: Lessons for Scavenged Sampling in Antimicrobial Pharmacokinetic Study Design.
Q52637932Dosing of Ceftriaxone and Metronidazole for Children With Severe Acute Malnutrition.
Q36322918Effect of Kidney Function on Drug Kinetics and Dosing in Neonates, Infants, and Children
Q50465181Medicines for Pediatric Patients-Biopharmaceutical, Developmental, and Regulatory Considerations
Q40786820Paediatric Virology: A new paediatric subspecialty? A proposal at the Workshop on Paediatric Virology, Athens, October 10, 2015.
Q52575612Pharmacokinetic-Pharmacodynamic Modeling in Pediatric Drug Development, and the Importance of Standardized Scaling of Clearance.
Q38696468Pharmacometric Approaches to Personalize Use of Primarily Renally Eliminated Antibiotics in Preterm and Term Neonates
Q90226052Population Pharmacokinetics and Dosing Optimization of Amoxicillin in Neonates and Young Infants
Q41494950Stochastic process pharmacodynamics: dose timing in neonatal gentamicin therapy as an example
Q35105787Systemic antifungal prescribing in neonates and children: outcomes from the Antibiotic Resistance and Prescribing in European Children (ARPEC) Study
Q55360869Useful pharmacodynamic endpoints in children: selection, measurement, and next steps.

Search more.