Pharmacokinetic-pharmacodynamic model for gentamicin and its adaptive resistance with predictions of dosing schedules in newborn infants

scientific article published on 28 October 2011

Pharmacokinetic-pharmacodynamic model for gentamicin and its adaptive resistance with predictions of dosing schedules in newborn infants is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/AAC.00694-11
P932PMC publication ID3256057
P698PubMed publication ID22037853

P50authorLena E FribergQ88235607
P2093author name stringOtto Cars
Elisabet I Nielsen
Ami F Mohamed
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Extended-interval dosing of gentamicin for treatment of neonatal sepsis in developed and developing countries.Q37237625
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Pharmacokinetic/pharmacodynamic (PK/PD) indices of antibiotics predicted by a semimechanistic PKPD model: a step toward model-based dose optimizationQ38626980
MexXY-OprM efflux pump is necessary for a adaptive resistance of Pseudomonas aeruginosa to aminoglycosides.Q39743310
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Comparative study with enoxacin and netilmicin in a pharmacodynamic model to determine importance of ratio of antibiotic peak concentration to MIC for bactericidal activity and emergence of resistanceQ39828366
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The frequency of persisters in Escherichia coli reflects the kinetics of awakening from dormancyQ42738008
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Pharmacokinetic basis for the use of extended interval dosage regimens of gentamicin in neonates.Q51997391
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Adaptive resistance to aminoglycoside antibiotics from first-exposure down-regulation.Q54319060
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The effect of aminoglycoside-induced adaptive resistance on the antibacterial activity of other antibiotics against Pseudomonas aeruginosa in vitroQ71876778
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Application of a combined effect compartment and binding model for gastric acid inhibition of AR-HO47108: a potassium competitive acid blocker, and its active metabolite AR-HO47116 in the dogQ79871588
Aminoglycoside/beta-lactam combinations in clinical practiceQ81341829
Observational trial of a 48-hour gentamicin dosing regimen derived from Monte Carlo simulations in infants born at less than 28 weeks' gestationQ81549728
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectpharmacokineticsQ323936
gentamicinQ422482
pharmacodynamicsQ725307
P304page(s)179-188
P577publication date2011-10-28
P1433published inAntimicrobial Agents and ChemotherapyQ578004
P1476titlePharmacokinetic-pharmacodynamic model for gentamicin and its adaptive resistance with predictions of dosing schedules in newborn infants
P478volume56

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