Pharmacokinetic/pharmacodynamic (PK/PD) indices of antibiotics predicted by a semimechanistic PKPD model: a step toward model-based dose optimization

scientific article published on August 2011

Pharmacokinetic/pharmacodynamic (PK/PD) indices of antibiotics predicted by a semimechanistic PKPD model: a step toward model-based dose optimization is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/AAC.00182-11
P932PMC publication ID3186970
P698PubMed publication ID21807983

P50authorLena E FribergQ88235607
P2093author name stringOtto Cars
Elisabet I Nielsen
P2860cites workA novel approach to pharmacodynamic assessment of antimicrobial agents: new insights to dosing regimen designQ28476705
Identification of optimal renal dosage adjustments for traditional and extended-infusion piperacillin-tazobactam dosing regimens in hospitalized patients.Q33559047
Semimechanistic pharmacokinetic-pharmacodynamic model with adaptation development for time-kill experiments of ciprofloxacin against Pseudomonas aeruginosaQ33876563
Optimizing aminoglycoside therapy for nosocomial pneumonia caused by gram-negative bacteriaQ33976467
Pharmacodynamic comparisons of levofloxacin, ciprofloxacin, and ampicillin against Streptococcus pneumoniae in an in vitro model of infectionQ33976517
Pharmacodynamics of fluoroquinolones against Streptococcus pneumoniae in patients with community-acquired respiratory tract infectionsQ33983119
Pharmacodynamics of the new fluoroquinolone gatifloxacin in murine thigh and lung infection modelsQ34108149
Animal model pharmacokinetics and pharmacodynamics: a critical reviewQ34615868
Developments in PK/PD: optimising efficacy and prevention of resistance. A critical review of PK/PD in in vitro modelsQ34615883
Predicting in vitro antibacterial efficacy across experimental designs with a semimechanistic pharmacokinetic-pharmacodynamic modelQ34737629
Pharmacodynamic effects of sub-MICs of benzylpenicillin against Streptococcus pyogenes in a newly developed in vitro kinetic modelQ35128808
Pharmacokinetic-pharmacodynamic modeling of activity of ceftazidime during continuous and intermittent infusion.Q35134599
Application of a mathematical model to prevent in vivo amplification of antibiotic-resistant bacterial populations during therapyQ35140423
Predicting efficacy of antiinfectives with pharmacodynamics and Monte Carlo simulationQ35582365
Pharmacodynamics and dosing of aminoglycosidesQ35623060
Semimechanistic pharmacokinetic/pharmacodynamic model for assessment of activity of antibacterial agents from time-kill curve experimentsQ35635652
Pharmacodynamics of a fluoroquinolone antimicrobial agent in a neutropenic rat model of Pseudomonas sepsisQ35810298
Pharmacodynamics of intravenous ciprofloxacin in seriously ill patientsQ35814807
A population pharmacokinetic model for cefuroxime using cystatin C as a marker of renal functionQ35827765
Standardization of pharmacokinetic/pharmacodynamic (PK/PD) terminology for anti-infective drugs: an updateQ36072639
Pharmacokinetics of penicillin G in infants with a gestational age of less than 32 weeks.Q36095091
Impact of pharmacometric reviews on new drug approval and labeling decisions--a survey of 31 new drug applications submitted between 2005 and 2006.Q36720907
First-exposure adaptive resistance to aminoglycoside antibiotics in vivo with meaning for optimal clinical use.Q36752618
Model-based drug developmentQ36830686
Pharmacodynamic modeling of aminoglycosides against Pseudomonas aeruginosa and Acinetobacter baumannii: identifying dosing regimens to suppress resistance developmentQ36949430
Mechanism-based pharmacokinetic-pharmacodynamic modeling of antimicrobial drug effectsQ36956331
Mechanism-based pharmacokinetic-pharmacodynamic (PK-PD) modeling in translational drug research.Q37114216
Pharmacodynamic functions: a multiparameter approach to the design of antibiotic treatment regimensQ37568933
In vitro pharmacodynamic models to determine the effect of antibacterial drugsQ37660762
Class-dependent relevance of tissue distribution in the interpretation of anti-infective pharmacokinetic/pharmacodynamic indicesQ37706727
Use of Monte Carlo simulations to select therapeutic doses and provisional breakpoints of BAL9141.Q37733667
Pharmacokinetic and pharmacodynamic parameters for antimicrobial effects of cefotaxime and amoxicillin in an in vitro kinetic modelQ39478148
Parameters of bacterial killing and regrowth kinetics and antimicrobial effect examined in terms of area under the concentration-time curve relationships: action of ciprofloxacin against Escherichia coli in an in vitro dynamic model.Q39784317
Comparative study with enoxacin and netilmicin in a pharmacodynamic model to determine importance of ratio of antibiotic peak concentration to MIC for bactericidal activity and emergence of resistanceQ39828366
Adaptive resistance following single doses of gentamicin in a dynamic in vitro model.Q39881843
Role of mechanistically-based pharmacokinetic/pharmacodynamic models in drug development : a case study of a therapeutic proteinQ40349907
Interrelationship between pharmacokinetics and pharmacodynamics in determining dosage regimens for broad-spectrum cephalosporinsQ40431109
The importance of pharmacokinetic/pharmacodynamic surrogate markers to outcome. Focus on antibacterial agentsQ40517235
Pharmacokinetics and pharmacodynamics of antibiotics in otitis mediaQ41148314
Pharmacokinetic/pharmacodynamic parameters: rationale for antibacterial dosing of mice and men.Q41696128
Concentration-effect relationship of ceftazidime explains why the time above the MIC is 40 percent for a static effect in vivo.Q41879559
Comparative antibiotic dose-effect relations at several dosing intervals in murine pneumonitis and thigh-infection modelsQ42169493
Development and qualification of a pharmacodynamic model for the pronounced inoculum effect of ceftazidime against Pseudomonas aeruginosaQ43215544
Correlation of antimicrobial pharmacokinetic parameters with therapeutic efficacy in an animal modelQ43617611
Pharmacokinetic-pharmacodynamic modeling and simulation for bactericidal effect in an in vitro dynamic modelQ43804203
"Continuous" vs. "discontinuous" therapy with penicillin; the effect of the interval between injections on therapeutic efficacyQ44157139
Clinical response to aminoglycoside therapy: importance of the ratio of peak concentration to minimal inhibitory concentrationQ44483617
Population pharmacokinetics of moxifloxacin in plasma and bronchial secretions in patients with severe bronchopneumoniaQ44611157
Selection of a moxifloxacin dose that suppresses drug resistance in Mycobacterium tuberculosis, by use of an in vitro pharmacodynamic infection model and mathematical modelingQ44662037
"Getting the dose right": facts, a blueprint, and encouragementsQ44911801
Pharmacodynamics of vancomycin and other antimicrobials in patients with Staphylococcus aureus lower respiratory tract infectionsQ45127594
Assessment of pharmacokinetic-pharmacodynamic target attainment of gemifloxacin against Streptococcus pneumoniaeQ45209303
Developmental pharmacokinetics of gentamicin in preterm and term neonates: population modelling of a prospective study.Q45984535
Pharmacokinetics of intravenous erythromycinQ46349003
Simultaneous modeling of pharmacokinetics and pharmacodynamics: application to d-tubocurarineQ52437136
A pharmacodynamic model for the activity of antibiotics against microorganisms under nonsaturable conditions.Q52623628
Population pharmacokinetics of vancomycin in Japanese pediatric patients.Q54112702
Pharmacodynamics of amikacin in vitro and in mouse thigh and lung infectionsQ54297609
Adaptive resistance to aminoglycoside antibiotics from first-exposure down-regulation.Q54319060
Antimicrobial Resistance: Pharmacokinetics‐Pharmacodynamics of Antimicrobial Therapy: It’s Not Just for Mice AnymoreQ58033538
Evidence for a Slow Elimination Phase for Penicillin GQ68438201
Experimental infection with Streptococcus pneumoniae in mice: correlation of in vitro activity and pharmacokinetic parameters with in vivo effect for 14 cephalosporinsQ69572281
Netilmicin and gentamicin multidose kinetics in normal subjectsQ71064703
AUIC--the universal parameter within the constraint of a reasonable dosing intervalQ71697436
Assessment of different antibacterial effect measures used in in vitro models of infection and subsequent use in pharmacodynamic correlations for moxifloxacinQ73959840
Pharmacokinetic/pharmacodynamic modeling of in vitro activity of azithromycin against four different bacterial strainsQ79459866
Streptococcus pneumoniae bacteraemia: pharmacodynamic correlations with outcome and macrolide resistance--a controlled studyQ80517469
Observational trial of a 48-hour gentamicin dosing regimen derived from Monte Carlo simulations in infants born at less than 28 weeks' gestationQ81549728
P433issue10
P407language of work or nameEnglishQ1860
P921main subjectantibioticQ12187
pharmacokineticsQ323936
pharmacodynamicsQ725307
P304page(s)4619-4630
P577publication date2011-08-01
P1433published inAntimicrobial Agents and ChemotherapyQ578004
P1476titlePharmacokinetic/pharmacodynamic (PK/PD) indices of antibiotics predicted by a semimechanistic PKPD model: a step toward model-based dose optimization
P478volume55

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cites work (P2860)
Q91344581A dose response model for quantifying the infection risk of antibiotic-resistant bacteria
Q38966188A mechanism-based pharmacokinetic/pharmacodynamic model allows prediction of antibiotic killing from MIC values for WT and mutants
Q36684146A multistate tuberculosis pharmacometric model: a framework for studying anti-tubercular drug effects in vitro.
Q31059319A pharmacokinetic-pharmacodynamic (PKPD) model based on in vitro time-kill data predicts the in vivo PK/PD index of colistin
Q51118472A pharmacokinetic/pharmacodynamic model developed for the effect of colistin on Pseudomonas aeruginosa in vitro with evaluation of population pharmacokinetic variability on simulated bacterial killing.
Q34596526A population pharmacokinetic modeling approach shows that serum penicillin G concentrations are below inhibitory concentrations by two weeks after benzathine penicillin G injection in the majority of young adults
Q39451172Activity of cefquinome against extended-spectrum β-lactamase-producing Klebsiella pneumoniae in neutropenic mouse thigh model
Q48528055Amikacin Pharmacokinetic-Pharmacodynamic (PK-PD) Analysis in Pediatric Cancer Patients
Q38316070Antimicrobial susceptibility testing for bovine respiratory disease: getting more from diagnostic results
Q26753831Application of PK/PD Modeling in Veterinary Field: Dose Optimization and Drug Resistance Prediction
Q36171772Application of a loading dose of colistin methanesulfonate in critically ill patients: population pharmacokinetics, protein binding, and prediction of bacterial kill
Q38420688Applications of physiologically based pharmacokinetic modeling for the optimization of anti-infective therapies.
Q33905531Are children undergoing cardiac surgery receiving antibiotics at subtherapeutic levels?
Q40108765Biofilm formation and antibiotic susceptibility in dispersed cells versus planktonic cells from clinical, industry and environmental origins.
Q47897914Can a pharmacokinetic/pharmacodynamic (PKPD) model be predictive across bacterial densities and strains? External evaluation of a PKPD model describing longitudinal in vitro data.
Q35864589Computational pharmacokinetics/pharmacodynamics of rifampin in a mouse tuberculosis infection model
Q47371115Concentrations of cefuroxime in brain tissue of neurointensive care patients.
Q52595189Differential Activity of the Combination of Vancomycin and Amikacin on Planktonic vs. Biofilm-Growing Staphylococcus aureus Bacteria in a Hollow Fiber Infection Model.
Q48722683Dosage Optimization of Nemolizumab Using Population Pharmacokinetic and Pharmacokinetic-Pharmacodynamic Modeling and Simulation
Q89982252Dose Optimization of Cefpirome Based on Population Pharmacokinetics and Target Attainment during Extracorporeal Membrane Oxygenation
Q36109394Editorial Comment to Postoperative infectious complications in patients undergoing holmium laser enucleation of the prostate: Risk factors and microbiological analysis
Q38121142Emerging drugs on methicillin-resistant Staphylococcus aureus
Q54251919Exploring the Use of C-Reactive Protein to Estimate the Pharmacodynamics of Vancomycin.
Q64912442Forecasting Clinical Dose-Response From Preclinical Studies in Tuberculosis Research: Translational Predictions With Rifampicin.
Q40857961Gentamicin dosing strategy in patients with end-stage renal disease receiving haemodialysis: evaluation using a semi-mechanistic pharmacokinetic/pharmacodynamic model
Q36413575Impact of growth matrix on pharmacodynamics of antimicrobial drugs for pig pneumonia pathogens
Q92302869In vitro Pharmacodynamics and PK/PD in Animals
Q34299028In vivo activity of cefquinome against Escherichia coli in the thighs of neutropenic mice
Q40330083In vivo activity of cefquinome against Riemerella anatipestifer using the pericarditis model in the duck
Q36198218Mathematical model on Alzheimer's disease
Q47273930Mechanism-based Pharmacokinetic/Pharmacodynamic Modeling of Aerosolized Colistin in a Mouse Lung Infection Model.
Q59808257Microbiological Analysis from a Phase 2 Randomized Study in Adults Evaluating Single Oral Doses of Gepotidacin in the Treatment of Uncomplicated Urogenital Gonorrhea Caused by Neisseria gonorrhoeae
Q101327707Model-informed drug development for antimicrobials: Translational PK and PKPD modelling to predict an efficacious human dose for apramycin
Q47273948Modeling the emergence of antibiotic resistance in the environment: an analytical solution for the minimum selection concentration.
Q63346417Monitoring of Tobramycin Exposure: What is the Best Estimation Method and Sampling Time for Clinical Practice?
Q30911044Mutant prevention concentration, pharmacokinetic-pharmacodynamic integration, and modeling of enrofloxacin data established in diseased buffalo calves
Q38880229Necessity of Bumped Kinase Inhibitor Gastrointestinal Exposure in Treating Cryptosporidium Infection
Q49894254On the analysis of complex biological supply chains: From Process Systems Engineering to Quantitative Systems Pharmacology
Q38786623Optimization of linezolid treatment regimens for Gram-positive bacterial infections based on pharmacokinetic/pharmacodynamic analysis
Q36083619Pharmacokinetic and Pharmacodynamic Principles of Anti-infective Dosing.
Q39108922Pharmacokinetic and pharmacodynamic characterization of ceftiofur crystalline-free acid following subcutaneous administration in domestic goats
Q40326667Pharmacokinetic-pharmacodynamic model for gentamicin and its adaptive resistance with predictions of dosing schedules in newborn infants
Q36383878Pharmacokinetic/pharmacodynamic integration and modelling of florfenicol for the pig pneumonia pathogens Actinobacillus pleuropneumoniae and Pasteurella multocida
Q39019096Pharmacokinetic/pharmacodynamic integration and modelling of oxytetracycline for the porcine pneumonia pathogens Actinobacillus pleuropneumoniae and Pasteurella multocida
Q93035816Pharmacokinetics and In Vivo Efficacy of Pyrazolopyrimidine, Pyrrolopyrimidine, and 5-Aminopyrazole-4-Carboxamide Bumped Kinase Inhibitors against Toxoplasmosis
Q92740182Pharmacokinetics and Target Attainment of Antibiotics in Critically Ill Children: A Systematic Review of Current Literature
Q38664871Pharmacokinetics and pharmacodynamics in antibiotic dose optimization.
Q44361727Pharmacokinetics and residue depletion of erythromycin in gilthead sea bream Sparus aurata L. after oral administration
Q46983972Pharmacokinetics and residue depletion of erythromycin in rainbow trout Oncorhynchus mykiss (Walbaum).
Q88674308Pharmacokinetics of cefuroxime in infants and neonates undergoing cardiac surgery
Q49791998Pharmacokinetics of penicillin G in preterm and term neonates
Q39071799Population pharmacokinetic modelling, Monte Carlo simulation and semi-mechanistic pharmacodynamic modelling as tools to personalize gentamicin therapy.
Q49064586Population pharmacokinetics and dosing simulations of cefuroxime in critically ill patients: non-standard dosing approaches are required to achieve therapeutic exposures
Q38699731Prediction of marbofloxacin dosage for the pig pneumonia pathogens Actinobacillus pleuropneumoniae and Pasteurella multocida by pharmacokinetic/pharmacodynamic modelling.
Q47236751Protein-inspired antibiotics active against vancomycin- and daptomycin-resistant bacteria.
Q35169043Pyridodiazepine amines are selective therapeutic agents for helicobacter pylori by suppressing growth through inhibition of glutamate racemase but are predicted to require continuous elevated levels in plasma to achieve clinical efficacy
Q48514081Quantitative analysis of gentamicin exposure in neonates and infants calls into question its current dosing recommendations.
Q41967888Semiphysiological versus empirical modelling of the population pharmacokinetics of free and total cefazolin during pregnancy
Q40087805Simulation-Based Evaluation of PK/PD Indices for Meropenem Across Patient Groups and Experimental Designs.
Q92430053Therapeutic Efficacy of LN-1-255 in Combination with Imipenem in Severe Infection Caused by Carbapenem-Resistant Acinetobacter baumannii
Q39039505Translational PK/PD of anti-infective therapeutics.
Q38853629Translational Pharmacometric Evaluation of Typical Antibiotic Broad-Spectrum Combination Therapies Against Staphylococcus Aureus Exploiting In Vitro Information
Q38246118Treatment option for sepsis in children in the era of antibiotic resistance
Q36242447Using Chemical Reaction Kinetics to Predict Optimal Antibiotic Treatment Strategies
Q89728720Using machine learning to optimize antibiotic combinations: dosing strategies for meropenem and polymyxin B against carbapenem-resistant Acinetobacter baumannii
Q64904032VetCAST Method for Determination of the Pharmacokinetic-Pharmacodynamic Cut-Off Values of a Long-Acting Formulation of Florfenicol to Support Clinical Breakpoints for Florfenicol Antimicrobial Susceptibility Testing in Cattle.
Q84230576[Musculoskeletal infections in the era of multiresistant pathogens]

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