Paneth-cell-disruption-induced necrotizing enterocolitis in mice requires live bacteria and occurs independently of TLR4 signaling

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Paneth-cell-disruption-induced necrotizing enterocolitis in mice requires live bacteria and occurs independently of TLR4 signaling is …
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scholarly articleQ13442814

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P356DOI10.1242/DMM.028589
P932PMC publication ID5483007
P698PubMed publication ID28450472

P50authorPatrick M. SchlievertQ56250633
Steven J McElroyQ58806650
P2093author name stringBrock Pope
Huiyu Gong
Jessica R White
P2860cites workTGF-β2 suppresses macrophage cytokine production and mucosal inflammatory responses in the developing intestineQ24301263
Necrotizing enterocolitis: new insights into pathogenesis and mechanismsQ28079458
Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal nicheQ28239639
Paneth cells constitute the niche for Lgr5 stem cells in intestinal cryptsQ29616197
Deaths: final data for 2000.Q30739448
The roles of bacteria and TLR4 in rat and murine models of necrotizing enterocolitisQ33254555
Toll-like receptor-4 inhibits enterocyte proliferation via impaired beta-catenin signaling in necrotizing enterocolitisQ33618589
Acute necrotizing enterocolitis in infancy: a review of 64 casesQ34300127
Infectious causes of necrotizing enterocolitis.Q35083687
Altered surfactant protein A gene expression and protein metabolism associated with repeat exposure to inhaled endotoxin.Q51658505
Intestinal barrier failure during experimental necrotizing enterocolitis: protective effect of EGF treatment.Q52571670
Paneth cells in the developing gut: when do they arise and when are they immune competent?Q53202442
A critical role for TLR4 in the pathogenesis of necrotizing enterocolitis by modulating intestinal injury and repair.Q53526875
Incidence and Timing of Presentation of Necrotizing Enterocolitis in Preterm InfantsQ55981722
A unifying theory for the cryptQ59095979
Experimental necrotizing enterocolitis: the role of polymorphonuclear neutrophilsQ68044323
A Paneth cell specific zinc-binding protein in the rat. Purification and immunohistochemical localizationQ70602856
Examining the role of Paneth cells in the small intestine by lineage ablation in transgenic miceQ73692219
Epidermal growth factor reduces the development of necrotizing enterocolitis in a neonatal rat modelQ77371874
Intestinal Epithelial TLR-4 Activation Is Required for the Development of Acute Lung Injury after Trauma/Hemorrhagic Shock via the Release of HMGB1 from the GutQ35562915
SIGIRR genetic variants in premature infants with necrotizing enterocolitisQ35650476
Characteristics of patients who die of necrotizing enterocolitisQ35788579
Intact function of Lgr5 receptor-expressing intestinal stem cells in the absence of Paneth cellsQ35845010
Paneth cell differentiation in the developing intestine of normal and transgenic miceQ35849239
Paneth cell ablation in the presence of Klebsiella pneumoniae induces necrotizing enterocolitis (NEC)-like injury in the small intestine of immature mice.Q36051075
Functional intestinal stem cells after Paneth cell ablation induced by the loss of transcription factor Math1 (Atoh1).Q36061304
The ErbB4 ligand neuregulin-4 protects against experimental necrotizing enterocolitis.Q36468741
Trends in Care Practices, Morbidity, and Mortality of Extremely Preterm Neonates, 1993-2012.Q36676402
A critical role for TLR4 induction of autophagy in the regulation of enterocyte migration and the pathogenesis of necrotizing enterocolitisQ36718260
Paneth cells and necrotizing enterocolitis: a novel hypothesis for disease pathogenesisQ36720059
Evaluation of hematologic variables in newborn C57/BL6 mice up to day 35.Q36723176
Tumor necrosis factor inhibits ligand-stimulated EGF receptor activation through a TNF receptor 1-dependent mechanismQ36846486
Mapping the New World of Necrotizing Enterocolitis (NEC): Review and OpinionQ36884751
Innate immune signaling in the pathogenesis of necrotizing enterocolitis.Q36914228
Endothelial TLR4 activation impairs intestinal microcirculatory perfusion in necrotizing enterocolitis via eNOS-NO-nitrite signalingQ36915561
Reciprocal expression and signaling of TLR4 and TLR9 in the pathogenesis and treatment of necrotizing enterocolitisQ37142110
Role of LPS/CD14/TLR4-mediated inflammation in necrotizing enterocolitis: pathogenesis and therapeutic implicationsQ37386502
Enteric defensins are essential regulators of intestinal microbial ecologyQ37483232
Paneth cells, antimicrobial peptides and maintenance of intestinal homeostasisQ37855523
Paneth cells: maestros of the small intestinal cryptsQ38080558
Concurrent bloodstream infections in infants with necrotizing enterocolitisQ38153930
Toll-like receptor regulation of intestinal development and inflammation in the pathogenesis of necrotizing enterocolitisQ38173600
Tumor necrosis factor receptor 1-dependent depletion of mucus in immature small intestine: a potential role in neonatal necrotizing enterocolitisQ38682167
Development of the Neonatal Intestinal Microbiome and Its Association With Necrotizing Enterocolitis.Q38725118
Toll-like receptor 4-related immunostimulatory polysaccharides: Primary structure, activity relationships, and possible interaction models.Q38854103
Immunolocalization of dinitrogenase reductase produced by Klebsiella pneumoniae in association with Zea mays L.Q39485115
Absence of lysozyme (muramidase) in the intestinal Paneth cells of newborn infants with necrotising enterocolitisQ39598721
Selective killing of Paneth cells by intravenous administration of dithizone in ratsQ41154974
Tumor necrosis factor induces developmental stage-dependent structural changes in the immature small intestine.Q41977638
Paneth cells and antibacterial host defense in neonatal small intestineQ42148628
The NFKB1 (g.-24519delATTG) variant is associated with necrotizing enterocolitis (NEC) in premature infants.Q45017555
NECROTIZING ENTEROCOLITIS IN PREMATURE INFANTS.Q47795320
The regulatory niche of intestinal stem cells.Q48058676
Nosocomial colonization with Klebsiella, type 26, in a neonatal intensive-care unit associated with an outbreak of sepsis, meningitis, and necrotizing enterocolitisQ48523606
P275copyright licenseCreative Commons Attribution 3.0 UnportedQ14947546
P6216copyright statuscopyrightedQ50423863
P433issue6
P407language of work or nameEnglishQ1860
P921main subjecttoll-like receptorQ408004
necrotizing enterocolitisQ10859678
P304page(s)727-736
P577publication date2017-04-27
P1433published inDisease Models & MechanismsQ1524006
P1476titlePaneth-cell-disruption-induced necrotizing enterocolitis in mice requires live bacteria and occurs independently of TLR4 signaling
P478volume10

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cites work (P2860)
Q93047932A direct comparison of mouse and human intestinal development using epithelial gene expression patterns
Q94948584Development of an improved murine model of necrotizing enterocolitis shows the importance of neutrophils in NEC pathogenesis
Q90736124Feeding Formula Eliminates the Necessity of Bacterial Dysbiosis and Induces Inflammation and Injury in the Paneth Cell Disruption Murine NEC Model in an Osmolality-Dependent Manner
Q90181914Fetal exposure to maternal inflammation interrupts murine intestinal development and increases susceptibility to neonatal intestinal injury
Q47546212Lipopolysaccharide-induced maternal inflammation induces direct placental injury without alteration in placental blood flow and induces a secondary fetal intestinal injury that persists into adulthood
Q57061763Loss of murine Paneth cell function alters the immature intestinal microbiome and mimics changes seen in neonatal necrotizing enterocolitis
Q91973010Metaplastic Paneth Cells in Extra-Intestinal Mucosal Niche Indicate a Link to Microbiome and Inflammation
Q91893407Paneth Cell Ablation Aggravates Pancreatic and Intestinal Injuries in a Rat Model of Acute Necrotizing Pancreatitis after Normal and High-Fat Diet
Q92628646Paneth cell ablation increases the small intestinal injury during acute necrotizing pancreatitis in rats
Q88860151Single-Immunoglobulin Interleukin-1-Related Receptor regulates vulnerability to TLR4-mediated necrotizing enterocolitis in a mouse model
Q92062352The Paneth Cell: The Curator and Defender of the Immature Small Intestine
Q89041972The enteric microbiota regulates jejunal Paneth cell number and function without impacting intestinal stem cells
Q49590405The science and necessity of using animal models in the study of necrotizing enterocolitis

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