DNA polymerases in the mitochondria: A critical review of the evidence.

scientific article

DNA polymerases in the mitochondria: A critical review of the evidence. is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.2741/4510
P932PMC publication ID5485829
P698PubMed publication ID27814640

P2093author name stringWilliam C Copeland
Rachel Krasich
P2860cites workCloning and chromosomal mapping of the human DNA polymerase theta (POLQ), the eighth human DNA polymeraseQ22010228
hRAD30 mutations in the variant form of xeroderma pigmentosumQ22010237
Viral RNA-dependent DNA Polymerase: RNA-dependent DNA Polymerase in Virions of Rous Sarcoma VirusQ22122431
Premature ageing in mice expressing defective mitochondrial DNA polymeraseQ24294365
POLQ (Pol theta), a DNA polymerase and DNA-dependent ATPase in human cellsQ24298399
Evidence for a direct role of the DNA polymerase gamma in the replication of the human mitochondrial DNA in vitroQ24299498
PrimPol bypasses UV photoproducts during eukaryotic chromosomal DNA replicationQ24308876
Human DNA2 is a mitochondrial nuclease/helicase for efficient processing of DNA replication and repair intermediatesQ24312975
Cloning and characterization of the human mitochondrial DNA polymerase, DNA polymerase gammaQ24315156
Homologous-recombination-deficient tumours are dependent on Polθ-mediated repairQ24317107
hPrimpol1/CCDC111 is a human DNA primase-polymerase required for the maintenance of genome integrityQ24338411
PrimPol, an archaic primase/polymerase operating in human cellsQ24339480
Repriming of DNA synthesis at stalled replication forks by human PrimPolQ24339613
DNA polymerase theta (POLQ) can extend from mismatches and from bases opposite a (6-4) photoproductQ42934957
Genetic variation in genes encoding for polymerase ζ subunits associates with breast cancer risk, tumour characteristics and survivalQ43573965
DNA polymerase kappa from Trypanosoma cruzi localizes to the mitochondria, bypasses 8-oxoguanine lesions and performs DNA synthesis in a recombination intermediateQ46248276
Pol eta is required for DNA replication during nucleotide deprivation by hydroxyureaQ46406774
Mitochondrial DNA polymerase POLIB is essential for minicircle DNA replication in African trypanosomes.Q46499579
Mitochondrial DNA integrity is not dependent on DNA polymerase-beta activityQ46705791
Structural insight into the DNA polymerase beta deoxyribose phosphate lyase mechanism.Q46711159
Characterization of the native and recombinant catalytic subunit of human DNA polymerase gamma: identification of residues critical for exonuclease activity and dideoxynucleotide sensitivityQ47813121
Mitochondrial DNA repair and replication proteins revealed by targeted chemical probesQ48219294
Nomenclature of Eukaryotic DNA PolymerasesQ50724290
Disruption of the developmentally regulated Rev3l gene causes embryonic lethality.Q52163744
Disruption of mouse polymerase zeta (Rev3) leads to embryonic lethality and impairs blastocyst development in vitro.Q52541352
Identification of a beta-like DNA polymerase activity in bovine heart mitochondria.Q54063268
The number of mitochondrial deoxyribonucleic acid genomes in mouse L and human HeLa cells. Quantitative isolation of mitochondrial deoxyribonucleic acid.Q54369042
Mitochondrial point mutations do not limit the natural lifespan of mice.Q55043447
Multiple mitochondrial DNA polymerases in Trypanosoma bruceiQ56900777
PDIP38 Associates with Proteins Constituting the Mitochondrial DNA NucleoidQ57649553
A nuclear mutant of Saccharomyces cerevisiae deficient in mitochondrial DNA replication and polymerase activityQ68884334
A beta-like DNA polymerase from the mitochondrion of the trypanosomatid Crithidia fasciculataQ72302941
A DNA polymerase beta in the mitochondrion of the trypanosomatid Crithidia fasciculataQ72591602
Alteration of ultraviolet-induced mutagenesis in yeast through molecular modulation of the REV3 and REV7 gene expressionQ73039820
Construction of transgenic mice with tissue-specific acceleration of mitochondrial DNA mutagenesisQ73076403
DNA polymerase gamma in mitochondrial DNA replication and repairQ73523164
Human DNA polymerase beta deoxyribose phosphate lyase. Substrate specificity and catalytic mechanismQ74615796
Identification and characterization of two DNA polymerase activities present in Trypanosoma brucei mitochondriaQ77089092
DNA polymerases eta and theta function in the same genetic pathway to generate mutations at A/T during somatic hypermutation of Ig genesQ80194521
Identification and functional analysis of human Tom22 for protein import into mitochondriaQ24551299
High-efficiency bypass of DNA damage by human DNA polymerase QQ24561381
The fidelity of DNA synthesis by eukaryotic replicative and translesion synthesis polymerasesQ24630867
Eukaryotic translesion polymerases and their roles and regulation in DNA damage toleranceQ24645172
A mitochondrial protein compendium elucidates complex I disease biologyQ24655079
Origin and evolution of the archaeo-eukaryotic primase superfamily and related palm-domain proteins: structural insights and new membersQ24812840
Bypass of DNA lesions generated during anticancer treatment with cisplatin by DNA polymerase etaQ27648988
Structures of ternary complexes of rat DNA polymerase beta, a DNA template-primer, and ddCTPQ27729369
Crystal structure of rat DNA polymerase beta: evidence for a common polymerase mechanismQ27729370
Sequence and organization of the human mitochondrial genomeQ27860659
Saccharomyces cerevisiae polymerase zeta functions in mitochondriaQ27929832
Replication past O(6)-methylguanine by yeast and human DNA polymerase eta.Q27930712
Cloning and sequencing of the nuclear gene MIP1 encoding the catalytic subunit of the yeast mitochondrial DNA polymerase.Q27933302
Efficient and accurate replication in the presence of 7,8-dihydro-8-oxoguanine by DNA polymerase eta.Q27934276
Role of polymerase η in mitochondrial mutagenesis of Saccharomyces cerevisiaeQ27935312
Role of DNA polymerase eta in the bypass of a (6-4) TT photoproductQ27939380
The structure and replication of kinetoplast DNAQ28273252
Involvement of mouse Rev3 in tolerance of endogenous and exogenous DNA damageQ28507940
Polg2 is essential for mammalian embryogenesis and is required for mtDNA maintenanceQ28510356
Mitochondrial DNA polymerase gamma is essential for mammalian embryogenesisQ28511104
Mechanism of suppression of chromosomal instability by DNA polymerase POLQQ28543483
Mammalian polymerase θ promotes alternative NHEJ and suppresses recombinationQ28593605
Mitochondrial diseases in man and mouseQ29614555
Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian agingQ29616056
Functional analysis of the amino-terminal 8-kDa domain of DNA polymerase beta as revealed by site-directed mutagenesis. DNA binding and 5'-deoxyribose phosphate lyase activitiesQ30430241
Identification of 5'-deoxyribose phosphate lyase activity in human DNA polymerase gamma and its role in mitochondrial base excision repair in vitroQ30431649
The RAD30 cancer susceptibility geneQ30883353
Two-polymerase mechanisms dictate error-free and error-prone translesion DNA synthesis in mammalsQ33400985
REV3L confers chemoresistance to cisplatin in human gliomas: the potential of its RNAi for synergistic therapyQ33574535
Error-free replicative bypass of (6-4) photoproducts by DNA polymerase zeta in mouse and human cellsQ33594119
A role for DNA polymerase θ in promoting replication through oxidative DNA lesion, thymine glycol, in human cellsQ33676609
Mitochondrial genome maintenance in health and disease.Q33821051
In vivo functional analysis of the human mitochondrial DNA polymerase POLG expressed in cultured human cellsQ33903179
Molecular and clinical genetics of mitochondrial diseases due to POLG mutationsQ33936754
DNA repair in mammalian mitochondria: Much more than we thought?Q37764794
Polymerase gamma disease through the agesQ37785515
Minimizing the damage: repair pathways keep mitochondrial DNA intactQ38044810
Inherited peripheral neuropathies due to mitochondrial disorders.Q38207342
Kinetic analysis of human PrimPol DNA polymerase activity reveals a generally error-prone enzyme capable of accurately bypassing 7,8-dihydro-8-oxo-2'-deoxyguanosineQ38303938
Inhibition of REV3 expression induces persistent DNA damage and growth arrest in cancer cellsQ38826337
PrimPol-A new polymerase on the blockQ38866687
A role for DNA polymerase θ in the timing of DNA replication.Q38978675
In situ hybridization to the Crithidia fasciculata kinetoplast reveals two antipodal sites involved in kinetoplast DNA replicationQ39227548
Crosstalk between replicative and translesional DNA polymerases: PDIP38 interacts directly with Poleta.Q39692109
Animal mitochondrial DNA: an extreme example of genetic economyQ39822739
PolDIP2 interacts with human PrimPol and enhances its DNA polymerase activities.Q40404211
Yeast mitochondrial DNA polymerase is related to the family A DNA polymerasesQ40526382
Trypanosoma brucei has two distinct mitochondrial DNA polymerase beta enzymesQ40635878
Polymerase eta and p53 jointly regulate cell survival, apoptosis and Mre11 recombination during S phase checkpoint arrest after UV irradiationQ40679872
Asymmetry of DNA replication and translesion synthesis of UV-induced thymine dimersQ40686398
Yeast mitochondrial DNA mutators with deficient proofreading exonucleolytic activityQ33938120
DNA polymerase of mitochondria is a gamma-polymeraseQ33998369
Eukaryotic DNA polymerases: proposal for a revised nomenclature.Q34093113
RNA-dependent DNA polymerase in virions of RNA tumour virusesQ34206460
Overexpression of DNA polymerase zeta reduces the mitochondrial mutability caused by pathological mutations in DNA polymerase gamma in yeastQ34217894
Erroneous incorporation of oxidized DNA precursors by Y-family DNA polymerasesQ34228142
Defects in mitochondrial DNA replication and human diseaseQ34241192
Further characterization of human DNA polymerase delta interacting protein 38.Q34409092
Molecular dissection of the domain architecture and catalytic activities of human PrimPolQ34412816
Human PrimPol mutation associated with high myopia has a DNA replication defectQ34440697
Mitochondrial DNA polymerase gamma is expressed and translated in the absence of mitochondrial DNA maintenance and replicationQ34604294
A new synthetic RNA-dependent DNA polymerase from human tissue culture cells (HeLa-fibroblast-synthetic oligonucleotides-template-purified enzymes).Q34689792
Inherited mitochondrial diseases of DNA replicationQ34692482
Human PrimPol is a highly error-prone polymerase regulated by single-stranded DNA binding proteins.Q35097955
p53, aerobic metabolism, and cancerQ35151326
Compilation and alignment of DNA polymerase sequencesQ35774285
Human REV3 DNA Polymerase Zeta Localizes to Mitochondria and Protects the Mitochondrial GenomeQ35804949
POLG2 disease variants: analyses reveal a dominant negative heterodimer, altered mitochondrial localization and impaired respiratory capacity.Q35999327
Analysis of Rev1p and Pol zeta in mitochondrial mutagenesis suggests an alternative pathway of damage tolerance.Q36249278
Structure and mechanism of DNA polymerase Beta.Q36389634
MitoCarta2.0: an updated inventory of mammalian mitochondrial proteinsQ36434534
Insights into the Molecular Mechanism of Polymerization and Nucleoside Reverse Transcriptase Inhibitor Incorporation by Human PrimPolQ36439125
Dual role for mammalian DNA polymerase ζ in maintaining genome stability and proliferative responsesQ36637565
Multiple functions of DNA polymerasesQ36667353
Low-fidelity DNA synthesis by human DNA polymerase theta.Q36740110
Removal of oxidative DNA damage via FEN1-dependent long-patch base excision repair in human cell mitochondriaQ36845992
PrimPol prevents APOBEC/AID family mediated DNA mutagenesisQ36959012
Oxidative DNA damage stalls the human mitochondrial replisomeQ37057236
TP53 mutation, mitochondria and cancerQ37266021
Human mitochondrial DNA replication machinery and diseaseQ37322422
Functional roles of DNA polymerases beta and gammaQ37330636
DNA polymerase δ-interacting protein 2 is a processivity factor for DNA polymerase λ during 8-oxo-7,8-dihydroguanine bypassQ37340847
The absence of a pyrimidine dimer repair mechanism in mammalian mitochondriaQ37452565
DNA2 resolves expanding flap in mitochondrial base excision repairQ37668905
P304page(s)692-709
P577publication date2017-01-01
P1433published inFrontiers in BioscienceQ5506062
P1476titleDNA polymerases in the mitochondria: A critical review of the evidence
P478volume22

Reverse relations

cites work (P2860)
Q95841103"Mitochondrial Toolbox" - A Review of Online Resources to Explore Mitochondrial Genomics
Q59714912DNA Polymerase θ Increases Mutational Rates in Mitochondrial DNA
Q47444998DNA polymerase β: A missing link of the base excision repair machinery in mammalian mitochondria
Q53688741Deoxyribonucleotide Triphosphate Metabolism in Cancer and Metabolic Disease.
Q100316332Extreme heterogeneity of human mitochondrial DNA from organelles to populations
Q47209159Family A and B DNA Polymerases in Cancer: Opportunities for Therapeutic Interventions
Q49918141G4-Interacting DNA Helicases and Polymerases: Potential Therapeutic Targets.
Q96229745Identifying the role of PrimPol in TDF-induced toxicity and implications of its loss of function mutation in an HIV+ patient
Q57753617Mitochondrial DNA replication in mammalian cells: overview of the pathway
Q92122417Mitochondrial DNA: Epigenetics and environment
Q92155153Mitochondrial Gene Expression and Beyond-Novel Aspects of Cellular Physiology
Q91715716Mitochondrial Homeostasis and Cellular Senescence
Q50281263Mitochondrial genome variability: the effect on cellular functional activity.
Q47125109Off-Target Effects of Drugs that Disrupt Human Mitochondrial DNA Maintenance
Q90048049One, No One, and One Hundred Thousand: The Many Forms of Ribonucleotides in DNA
Q92724123Organization of DNA in Mammalian Mitochondria
Q47411965POLB: A new role of DNA polymerase beta in mitochondrial base excision repair
Q64236072PrimPol is required for the maintenance of efficient nuclear and mitochondrial DNA replication in human cells
Q55174541The presence of rNTPs decreases the speed of mitochondrial DNA replication.

Search more.