Brain microvascular P-glycoprotein and a revised model of multidrug resistance in brain

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Brain microvascular P-glycoprotein and a revised model of multidrug resistance in brain is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P6179Dimensions Publication ID1018361202
P356DOI10.1023/A:1007093521681
P698PubMed publication ID10696508
P5875ResearchGate publication ID12618165

P50authorWilliam M PardridgeQ33489592
P2093author name stringGolden PL
P2860cites workBiochemistry of multidrug resistance mediated by the multidrug transporterQ29616476
Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sitesQ33832954
Immunohistochemical localization in normal tissues of different epitopes in the multidrug transport protein P170: evidence for localization in brain capillaries and crossreactivity of one antibody with a muscle proteinQ34040187
Human insulin receptor monoclonal antibody undergoes high affinity binding to human brain capillaries in vitro and rapid transcytosis through the blood-brain barrier in vivo in the primateQ34058435
Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugsQ34059522
MDR1 gene expression in brain of patients with medically intractable epilepsyQ34059935
Quantitative assessment of blood-brain barrier damage during microdialysisQ34379223
Evidence for P-glycoprotein-modulated penetration of morphine-6-glucuronide into brain capillary endotheliumQ34402344
A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutantsQ34488592
P-glycoprotein as the drug efflux pump in primary cultured bovine brain capillary endothelial cellsQ34538994
Expression of a multidrug-resistance gene in human tumors and tissuesQ34586576
In vivo evidence for ATP-dependent and P-glycoprotein-mediated transport of cyclosporin A at the blood-brain barrierQ34725577
The human multidrug resistance-associated protein MRP is a plasma membrane drug-efflux pumpQ35749376
Substantial excretion of digoxin via the intestinal mucosa and prevention of long-term digoxin accumulation in the brain by the mdr 1a P-glycoproteinQ35884806
Microvessels Isolated from Rat Brain: Localization of Astrocyte Processes by Immunohistochemical TechniquesQ36587677
A new mammalian DNA topoisomerase I poison Hoechst 33342: cytotoxicity and drug resistance in human cell cultures.Q36770732
P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugsQ37355653
Clinical trials of modulation of multidrug resistance. Pharmacokinetic and pharmacodynamic considerationsQ40618716
Modulation of drug sensitivity by dipyridamole in multidrug resistant tumor cells in vitro.Q41175649
Brain-type glucose transporter (GLUT-1) is selectively localized to the blood-brain barrier. Studies with quantitative western blotting and in situ hybridizationQ41206360
Use of rhodamine 123 to examine the functional activity of P-glycoprotein in primary cultured brain microvessel endothelial cell monolayersQ41245940
P-glycoprotein of blood brain barrier: cross-reactivity of Mab C219 with a 190 kDa protein in bovine and rat isolated brain capillariesQ41379122
Physical-chemical properties shared by compounds that modulate multidrug resistance in human leukemic cells.Q41912189
Functional involvement of P-glycoprotein in blood-brain barrierQ41969434
Detection of P-glycoprotein in multidrug-resistant cell lines by monoclonal antibodiesQ42812351
Isoform I (mdr3) is the major form of P-glycoprotein expressed in mouse brain capillaries. Evidence for cross-reactivity of antibody C219 with an unrelated proteinQ42822886
Purification of P-glycoprotein from plasma membrane vesicles of Chinese hamster ovary cell mutants with reduced colchicine permeabilityQ43857798
Uptake and retention of daunomycin by mouse leukemic cells as factors in drug responseQ45113193
P-glycoprotein expression in brain capillary endothelial cells after focal ischaemia in the rat.Q48116094
Cyclosporin A markedly changes the distribution of doxorubicin in mice and rats.Q48143376
High levels of P-glycoprotein detected in isolated brain capillariesQ48233025
Expression and functional activity of P-glycoprotein in cultured cerebral capillary endothelial cellsQ48394828
Restrictive transport of a lipid-soluble peptide (cyclosporin) through the blood-brain barrierQ48431164
Selective transport of an anti-transferrin receptor antibody through the blood-brain barrier in vivoQ48643049
Brain microvascular and astrocyte localization of P-glycoproteinQ48793395
The multidrug-resistance gene MDR1 is expressed in human glial tumorsQ48819555
Expression of the multidrug resistance gene product (P-glycoprotein) in human normal and tumor tissuesQ48913115
Specialized localization of P-glycoprotein recognized by MRK 16 monoclonal antibody in endothelial cells of the brain and the spinal cordQ48930125
Mouse multidrug resistance 1a/3 gene is the earliest known endothelial cell differentiation marker during blood-brain barrier development.Q52210355
Restricted transport of cyclosporin A across the blood-brain barrier by a multidrug transporter, P-glycoprotein.Q54231039
Topology of P-glycoprotein as determined by epitope mapping of MRK-16 monoclonal antibodyQ54249527
Cellular localization of P-glycoprotein in brain versus gonadal capillariesQ71175387
Interaction of drugs with P-glycoprotein in brain capillariesQ71598892
Comparisons of P‐glycoprotein expression in isolated rat brain microvessels and in primary cultures of endothelial cells derived from microvasculature of rat brain, epididymal fat pad and from aortaQ71816143
Microvessels Isolated from Brain: Localization of Muscarinic Sites by Radioligand Binding and Immunofluorescent TechniquesQ71825428
Effect of the p-glycoprotein inhibitor, cyclosporin A, on the distribution of rhodamine-123 to the brain: an in vivo microdialysis study in freely moving ratsQ71840015
P433issue2
P921main subjectmultiple drug resistanceQ643839
microvesselQ6840468
P304page(s)165-181
P577publication date2000-04-01
P1433published inCellular and Molecular NeurobiologyQ2333197
P1476titleBrain microvascular P-glycoprotein and a revised model of multidrug resistance in brain
P478volume20

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