In search of a new pharmacological treatment for drug and alcohol addiction: N-methyl-D-aspartate (NMDA) antagonists.

scientific article

In search of a new pharmacological treatment for drug and alcohol addiction: N-methyl-D-aspartate (NMDA) antagonists. is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1016/S0376-8716(99)00107-6
P698PubMed publication ID10706971
P5875ResearchGate publication ID12608714

P50authorAdam BisagaQ39194090
Piotr PopikQ58958272
P2860cites workAcamprosate. A review of its pharmacology and clinical potential in the management of alcohol dependence after detoxificationQ28240310
The neural basis of drug craving: an incentive-sensitization theory of addictionQ29547475
Pharmacological treatment of alcohol dependence: a review of the evidenceQ33596810
A MEDICAL TREATMENT FOR DIACETYLMORPHINE (HEROIN) ADDICTION. A CLINICAL TRIAL WITH METHADONE HYDROCHLORIDE.Q34260580
Excitatory amino acids as a final common pathway for neurologic disorders.Q34321926
Inhibitory effects of ibogaine on cocaine self-administration in ratsQ34344843
The effects of NMDA receptor antagonists and nitric oxide synthase inhibitors on opioid tolerance and withdrawal. Medication development issues for opiate addictionQ34391645
Psychotogenicity and N-methyl-D-aspartate receptor antagonism: implications for neuroprotective pharmacotherapy.Q34415261
Interactions of MK-801 and GYKI 52466 with morphine and amphetamine in place preference conditioning and behavioural sensitizationQ34420110
Molecular and cellular basis of addictionQ34440561
The effect of MK-801 and other antagonists of NMDA-type glutamate receptors on brain-stimulation rewardQ34453945
Acamprosate enhances N-methyl-D-apartate receptor-mediated neurotransmission but inhibits presynaptic GABA(B) receptors in nucleus accumbens neuronsQ34461273
Dextromethorphan. An overview of safety issuesQ35704240
Cellular mechanisms of behavioral sensitization to drugs of abuseQ36330241
Diazepam dependence prevented by glutamate antagonistsQ36437873
Clonidine blocks acute opiate-withdrawal symptomsQ39506991
Medication development of ibogaine as a pharmacotherapy for drug dependence.Q40850975
Are detoxification programmes effective?Q40933216
The NMDA antagonist dizocilpine (M K801) attenuates tolerance to nicotine in rats.Q52300234
Conditioned narcotic withdrawal in humans.Q52307240
d-Cycloserine adjuvant therapy to conventional neuroleptic treatment in schizophrenia: an open-label studyQ57016586
Acamprosate and alcohol: I. Effects on alcohol intake following alcohol deprivation in the ratQ59544956
Evidence for alcohol anti-craving properties of memantineQ59544957
The competitive NMDA receptor antagonist, CGP 39551, inhibits ethanol withdrawal seizuresQ68301427
MK-801 potently inhibits alcohol withdrawal seizures in ratsQ68451317
Clonidine in morphine withdrawal. Differential effects on signs and symptomsQ68944527
The effect of MK-801 and SCH23390 on the expression and sensitization of morphine-induced oral stereotypyQ70865211
Nicotine vs. placebo gum in the alleviation of withdrawal during smoking cessationQ71413936
Acamprosate and alcohol: II. Effects on alcohol withdrawal in the ratQ71546490
The NMDA receptor antagonist dizocilpine (MK-801) stereoselectively inhibits morphine-induced place preference conditioning in miceQ71554229
A pilot study of dextromethorphan in naloxone-precipitated opiate withdrawalQ71605036
Biochemical actions of chronic ethanol exposure in the mesolimbic dopamine systemQ71681032
Excitatory amino acid receptor antagonist kynurenic acid attenuates rewarding potential of morphineQ72113758
MK-801 prevents the development of behavioral sensitization during repeated morphine administrationQ72482348
Meta-analysis on efficacy of nicotine replacement therapies in smoking cessationQ72663094
Opiate withdrawal with dextromethorphanQ73196349
Competitive and glycine/NMDA receptor antagonists attenuate withdrawal-induced behaviours and increased hippocampal acetylcholine efflux in morphine-dependent ratsQ73326348
Ethanol-reinforced behaviour in the rat: effects of uncompetitive NMDA receptor antagonist, memantineQ77354701
The effect of lamotrigine on naloxone-precipitated opiate withdrawalQ77504461
Low-affinity NMDA receptor channel blockers inhibit acquisition of intravenous morphine self-administration in naive miceQ78228737
Efficacy of disulfiram: a reply to Hughes and CookQ95800261
Development and expression of sensitization to cocaine's reinforcing properties: role of NMDA receptors.Q51677120
Amantadine may facilitate detoxification of cocaine addictsQ51683092
Treatment of Cocaine Dependence in Methadone Maintenance Clients: A Pilot Study Comparing the Efficacy of Desipramine and AmantadineQ51701097
Repeated exposures intensify rather than diminish the rewarding effects of amphetamine, morphine, and cocaine.Q51761695
Double-blind comparison of amantadine and bromocriptine for ambulatory withdrawal from cocaine dependence.Q51797471
Dizocilpine prevents the development of tolerance to ethanol-induced error on a circular maze test.Q52048274
Inhibition of Morphine Tolerance and Dependence by the NMDA Receptor Antagonist MK-801Q52052445
The NMDA receptor antagonist dizocilpine differentially affects environment-dependent and environment-independent ethanol tolerance.Q52059714
Blockade of chronic tolerance to ethanol by the NMDA antagonist, (+)-MK-801.Q52065479
Modifications of the behavioral profile of non-competitive NMDA receptor antagonists, memantine, amantadine and (+)MK-801 after chronic administration.Q52168905
The anti-craving drug acamprosate inhibits the conditioned place aversion induced by naloxone-precipitated morphine withdrawal in rats.Q52184014
Chronic acamprosate eliminates the alcohol deprivation effect while having limited effects on baseline responding for ethanol in rats.Q52191419
NMDA receptor antagonists prevent conditioned activation of intracranial self-stimulation in rats.Q52194439
The expression of both amphetamine-conditioned place preference and pentylenetetrazol-conditioned place aversion is attenuated by the NMDA receptor antagonist (+/-)-CPP.Q52201682
N-methyl-D-aspartic acid-receptor antagonists block morphine-induced conditioned place preference in rats.Q52207692
An NMDA receptor antagonist reduces ethanol preference in untrained but not trained rats.Q52211639
The noncompetitive NMDA antagonist MK-801 fails to block amphetamine-induced place conditioning in rats.Q52217463
Development of both conditioning and sensitization of the behavioral activating effects of amphetamine is blocked by the non-competitive NMDA receptor antagonist, MK-801.Q52228738
Possible abuse potential of the NMDA antagonist MK-801.Q52245224
The dysphoria of heroin addiction.Q52264921
Factors that predict individual vulnerability to amphetamine self-administration.Q52266857
Reinforcing properties of morphine and naloxone revealed by conditioned place preferences: a procedural examination.Q52277966
A preliminary investigation of ibogaine: case reports and recommendations for further studyQ41028052
N-methyl-D-aspartate (NMDA) receptors, mu and kappa opioid tolerance, and perspectives on new analgesic drug developmentQ41070644
Pharmacotherapy for cocaine-abusing methadone-maintained patients using amantadine or desipramineQ41104236
Ibogaine and cocaine abuse: pharmacological interactions at dopamine and serotonin receptorsQ41313856
Aminoadamantanes as NMDA receptor antagonists and antiparkinsonian agents--preclinical studies.Q41509275
Neurobiological similarities in depression and drug dependence: a self-medication hypothesisQ41705103
The role of excitatory amino acids in behavioral sensitization to psychomotor stimulantsQ41749963
Safety review of adult clinical trial experience with lamotrigineQ41753210
Behavioural and neurochemical adaptations to nicotine in rats: influence of NMDA antagonistsQ41851245
Possible involvement of NMDA receptor-mediated transmission in barbiturate physical dependenceQ42271310
Lesions of the basolateral amygdala abolish the ability of drug associated cues to reinstate responding during withdrawal from self-administered cocaineQ42547161
Comparison of Amantadine and Desipramine Combined with Psychotherapy for Treatment of Cocaine DependenceQ43860906
2-Amino-7-phosphonoheptanoic acid, a selective antagonist of N-methyl-D-aspartate, prevents barbital withdrawal-induced convulsions and the elevation of cerebellar cyclic GMP in dependent ratsQ44188325
The NMDA antagonist dizocilpine (MK801) attenuates motivational as well as somatic aspects of naloxone precipitated opioid withdrawalQ44333382
Inhibition of reinforcing effects of morphine and naloxone-precipitated opioid withdrawal by novel glycine site and uncompetitive NMDA receptor antagonistsQ44350688
Pharmacotherapy improves treatment outcome in depressed cocaine addicts.Q45986086
Does dizocilpine (MK-801) selectively block the enhanced responsiveness to repeated amphetamine administration?Q46204457
GABA and nucleus accumbens glutamate neurotransmission modulate ethanol self-administration in ratsQ46270538
Acamprosate (calcium acetylhomotaurinate) enhances the N-methyl-D-aspartate component of excitatory neurotransmission in rat hippocampal CA1 neurons in vitroQ46457268
Mechanism of action of acamprosate. Part II. Ethanol dependence modifies effects of acamprosate on NMDA receptor binding in membranes from rat cerebral cortexQ47861304
Mechanism of action of acamprosate. Part I. Characterization of spermidine-sensitive acamprosate binding site in rat brainQ47861314
Nitric oxide synthesis inhibition does not affect brain stimulation rewardQ48109955
Mesolimbic NMDA receptors are implicated in the expression of conditioned morphine rewardQ48200288
Morphine-induced potentiation of brain stimulation reward is enhanced by MK-801.Q48230956
Dextromethorphan blocks N-methyl-D-aspartate-induced currents and voltage-operated inward currents in cultured cortical neuronsQ48248162
Coadministration of MK-801 with amphetamine, cocaine or morphine prevents rather than transiently masks the development of behavioral sensitizationQ48267682
Acamprosate (calciumacetylhomotaurinate) decreases postsynaptic potentials in the rat neocortex: possible involvement of excitatory amino acid receptors.Q48344658
NMDA receptors in the nucleus accumbens modulate intravenous cocaine but not heroin self-administration in the ratQ48418437
The involvement of NMDA receptors in acute and chronic effects of ethanolQ48476370
Behavioural and biochemical adaptations to nicotine in rats: influence of MK801, an NMDA receptor antagonistQ48586006
Homologies and differences in the action of drugs of abuse and a conventional reinforcer (food) on dopamine transmission: an interpretative framework of the mechanism of drug dependence.Q48608728
The NMDA antagonist, dizocilpine, enhances cocaine reinforcement without influencing mesoaccumbens dopamine transmissionQ48612417
Repeated administration of MK-801 produces sensitization to its own locomotor stimulant effects but blocks sensitization to amphetamineQ48638665
Synergistic effects of cocaine and dizocilpine (MK-801) on brain stimulation rewardQ48682122
Acamprosate suppresses the expression of morphine-induced sensitization in rats but does not affect heroin self-administration or relapse induced by heroin or stressQ48710539
Conditioning factors in drug abuse: can they explain compulsion?Q48722496
Further in vivo studies on attenuating morphine withdrawal: isoform-selective nitric oxide synthase inhibitors differ in efficacyQ48729145
NMDA antagonist inhibits rapid tolerance to ethanolQ48760472
Effects of post-ethanol administration of NMDA and non-NMDA receptor antagonists on the development of ethanol tolerance in C57B1 miceQ48813495
Intraaccumbens administration of NMDA receptor antagonist (+/-)-CPP prevents locomotor activation conditioned by morphine and amphetamine in ratsQ48896168
Effects of dopaminergic and glutamatergic receptor antagonists on the establishment and expression of conditioned locomotion to cocaine in ratsQ48939856
The NMDA antagonist memantine blocks the expression and maintenance of morphine dependenceQ49021766
D-cycloserine acts as a partial agonist at the glycine modulatory site of the NMDA receptor expressed in Xenopus oocytesQ49095632
The effects of memantine on the subjective, reinforcing and cardiovascular effects of cocaine in humans.Q51484451
Dextromethorphan reduces intravenous cocaine self-administration in the rat.Q51546243
Effects of nitric oxide synthase inhibitors on cocaine sensitization.Q51550015
Systemic pretreatment with MK-801 (dizocilpine) increases breaking points for self-administration of cocaine on a progressive-ratio schedule in rats.Q51558396
Amantadine in the early treatment of cocaine dependence: a double-blind, placebo-controlled trial.Q51571420
Inhibition of nitric oxide synthesis reduces intravenous cocaine self-administration in the rat.Q51580592
Drugs of abuse and stress increase the expression of GluR1 and NMDAR1 glutamate receptor subunits in the rat ventral tegmental area: common adaptations among cross-sensitizing agents.Q51584375
D-cycloserine enhances rapid tolerance to ethanol motor incoordination.Q51590732
Amantadine does not reduce cocaine use or craving in cocaine-dependent methadone maintenance patients.Q51593046
The NMDA receptor and cocaine: Evidence that MK-801 can induce behavioral sensitization effectsQ51597277
Evidence for N-methyl-d-aspartate receptor mediation of cocaine induced corticosterone release and cocaine conditioned stimulant effectsQ51602273
Differential symptom reduction in depressed cocaine abusers treated with psychotherapy and pharmacotherapy.Q51607358
L-NAME and MK-801 attenuate sensitization to the locomotor-stimulating effect of cocaine.Q51675396
P433issue1
P304page(s)1-15
P577publication date2000-04-01
P1433published inDrug and Alcohol DependenceQ5308875
P1476titleIn search of a new pharmacological treatment for drug and alcohol addiction: N-methyl-D-aspartate (NMDA) antagonists
P478volume59

Reverse relations

cites work (P2860)
Q50540419A Nonrewarding NMDA Receptor Antagonist Impairs the Acquisition, Consolidation, and Expression of Morphine Conditioned Place Preference in Mice.
Q50906211A pilot double-blind treatment trial of memantine for alcohol dependence.
Q35417660A placebo controlled trial of memantine as an adjunct to oral naltrexone for opioid dependence
Q35965884A placebo-controlled trial of dextromethorphan as an adjunct in opioid-dependent patients undergoing methadone maintenance treatment
Q44049015A randomized, double-blind, placebo-controlled safety study of high-dose dextromethorphan in methadone-maintained male inpatients
Q44609217Acute effects of memantine in combination with alcohol in moderate drinkers.
Q36032904Acute opioid dependence: characterizing the early adaptations underlying drug withdrawal
Q35906903Assessing the efficacy of medical treatments for alcohol use disorders
Q36897242Cingulate NMDA NR2B receptors contribute to morphine-induced analgesic tolerance
Q34967718Conantokin-Br from Conus brettinghami and selectivity determinants for the NR2D subunit of the NMDA receptor
Q30418597Dextromethorphan and quinidine combination for heroin detoxification
Q43205099Effect of metabolic blockade on the psychoactive effects of dextromethorphan
Q50270080Effects of a Rhodiola rosea L. extract on acquisition and expression of morphine tolerance and dependence in mice
Q44916718Effects of memantine, haloperidol, and cocaine on primary and conditioned reinforcement associated with cocaine in rhesus monkeys
Q46890768Effects of the NMDA receptor antagonist memantine on the expression and development of acute opiate dependence as assessed by withdrawal-potentiated startle and hyperalgesia
Q34489831Endogenous opiates: 2000.
Q44512657Endothelin receptor antagonists restore morphine analgesia in morphine tolerant rats
Q36100597Evaluation of the reinforcing and subjective effects of heroin in combination with dextromethorphan and quinidine
Q47131605Experimental Gene Therapy with Serine-Histogranin and Endomorphin 1 for the Treatment of Chronic Neuropathic Pain.
Q35738165Gender differences in paclitaxel-induced neuropathic pain behavior and analgesic response in rats
Q28081726Glutamate Transporter GLT-1 as a Therapeutic Target for Substance Use Disorders
Q48881068Heterozygous deletion of NR1 subunit of the NMDA receptor alters ethanol-related behaviors and regional expression of NR2 subunits in the brain.
Q44551772Ibogaine attenuation of morphine withdrawal in mice: role of glutamate N-methyl-D-aspartate receptors
Q34435889Ibogaine: a review
Q43061771Intraperitoneal Administration of Ethanol as a Means of Euthanasia for Neonatal Mice (Mus musculus).
Q34486676Memantine reduces consumption of highly palatable food in a rat model of binge eating
Q44357517Morphine tolerance and reward but not expression of morphine dependence are inhibited by the selective glutamate carboxypeptidase II (GCP II, NAALADase) inhibitor, 2-PMPA.
Q46906799NMDA receptor antagonists inhibit opiate antinociceptive tolerance and locomotor sensitization in rats
Q28277165New Pharmacological Agents to Aid Smoking Cessation and Tobacco Harm Reduction: What Has Been Investigated, and What Is in the Pipeline?
Q44366019Ohmefentanyl stereoisomers induce changes of CREB phosphorylation in hippocampus of mice in conditioned place preference paradigm
Q46713313Opposite effects of MK-801 on the expression of food and morphine-induced conditioned place preference in rats
Q37268726Oral glycine administration increases brain glycine/creatine ratios in men: a proton magnetic resonance spectroscopy study
Q50574530Patterns and Perceptions of Dextromethorphan Use in Adult Members of an Online Dextromethorphan Community.
Q35991046Patterns of tobacco use and dual use in US young adults: the missing link between youth prevention and adult cessation.
Q34988391Perturbation of the glutamate-glutamine system in alcohol dependence and remission
Q42152146Reduction of the Morphine Maintenance by Blockade of the NMDA Receptors during Extinction Period in Conditioned Place Preference Paradigm of Rats
Q46484673Reinstatement of morphine-conditioned reward is blocked by memantine
Q36499757Role of altered structure and function of NMDA receptors in development of alcohol dependence
Q24674933Selective agonist of group II glutamate metabotropic receptors, LY354740, inhibits tolerance to analgesic effects of morphine in mice
Q38496804Subtype-selective antagonism of N-methyl-D-aspartate receptor ion channels by synthetic conantokin peptides
Q35164063The neurobiology of opiate tolerance, dependence and sensitization: mechanisms of NMDA receptor-dependent synaptic plasticity
Q30491487The role of NMDA receptor antagonists in nicotine tolerance, sensitization, and physical dependence: a preclinical review
Q34075093Therapeutic potential of NMDA receptor antagonists in the treatment of alcohol and substance use disorders
Q26824393Zebrafish as an emerging model for studying complex brain disorders