Oxidation-specific epitopes as targets for biotheranostic applications in humans: biomarkers, molecular imaging and therapeutics

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Oxidation-specific epitopes as targets for biotheranostic applications in humans: biomarkers, molecular imaging and therapeutics is …
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scholarly articleQ13442814

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P356DOI10.1097/MOL.0B013E328364E85A
P932PMC publication ID4085330
P698PubMed publication ID23995232

P50authorSotirios TsimikasQ80167861
P2093author name stringYury I Miller
P2860cites workLipoprotein(a) as a cardiovascular risk factor: current statusQ24623225
Oxidation-specific epitopes and immunological responses: Translational biotheranostic implications for atherosclerosisQ26822962
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Beyond cholesterol. Modifications of low-density lipoprotein that increase its atherogenicityQ29617216
Human-derived anti-oxidized LDL autoantibody blocks uptake of oxidized LDL by macrophages and localizes to atherosclerotic lesions in vivoQ30700059
The haptoglobin 2-2 genotype is associated with increased redox active hemoglobin derived iron in the atherosclerotic plaqueQ33695531
Naturally occurring human plasminogen, like genetically related apolipoprotein(a), contains oxidized phosphatidylcholine adductsQ33886478
Atherogenic lipids and lipoproteins trigger CD36-TLR2-dependent apoptosis in macrophages undergoing endoplasmic reticulum stressQ34346809
A novel function of lipoprotein [a] as a preferential carrier of oxidized phospholipids in human plasmaQ34656639
Targeted iron oxide particles for in vivo magnetic resonance detection of atherosclerotic lesions with antibodies directed to oxidation-specific epitopes.Q34982799
Innate and acquired immunity in atherogenesisQ34986341
Relationship of IgG and IgM autoantibodies and immune complexes to oxidized LDL with markers of oxidation and inflammation and cardiovascular events: results from the EPIC-Norfolk StudyQ35212898
In vivo visualization and attenuation of oxidized lipid accumulation in hypercholesterolemic zebrafishQ35578606
Oxidized phospholipids on apoB-100-containing lipoproteins: a biomarker predicting cardiovascular disease and cardiovascular eventsQ35592510
Oxidized phospholipids are present on plasminogen, affect fibrinolysis, and increase following acute myocardial infarctionQ35905628
In vivo detection of oxidation-specific epitopes in atherosclerotic lesions using biocompatible manganese molecular magnetic imaging probesQ35905632
Differential expression of oxidation-specific epitopes and apolipoprotein(a) in progressing and ruptured human coronary and carotid atherosclerotic lesionsQ36387263
Adaptive immunity in atherogenesis: new insights and therapeutic approachesQ36497196
Complement factor H binds malondialdehyde epitopes and protects from oxidative stressQ36783745
Association between circulating oxidized low-density lipoprotein and incidence of the metabolic syndromeQ36925959
Oxidation-specific biomarkers and risk of peripheral artery diseaseQ37131142
Oxidation-specific epitopes are dominant targets of innate natural antibodies in mice and humansQ37170775
Immunoglobulin M is required for protection against atherosclerosis in low-density lipoprotein receptor-deficient miceQ37385727
Relationship of oxidized phospholipids on apolipoprotein B-100 particles to race/ethnicity, apolipoprotein(a) isoform size, and cardiovascular risk factors: results from the Dallas Heart StudyQ37434626
Lipoprotein modification and macrophage uptake: role of pathologic cholesterol transport in atherogenesisQ37705133
Oxidation-specific epitopes are danger-associated molecular patterns recognized by pattern recognition receptors of innate immunityQ37830940
Oxidized low-density lipoprotein as a biomarker of in vivo oxidative stress: from atherosclerosis to periodontitisQ38026551
Emerging therapeutic agents to lower lipoprotein (a) levelsQ38049987
Oxidation-specific biomarkers, prospective 15-year cardiovascular and stroke outcomes, and net reclassification of cardiovascular eventsQ39526094
Human oxidation-specific antibodies reduce foam cell formation and atherosclerosis progressionQ39601696
Aged garlic extract supplemented with B vitamins, folic acid and L-arginine retards the progression of subclinical atherosclerosis: a randomized clinical trialQ39891810
The influence of pravastatin and atorvastatin on markers of oxidative stress in hypercholesterolemic humansQ40099159
Lysine-phosphatidylcholine adducts in kringle V impart unique immunological and potential pro-inflammatory properties to human apolipoprotein(a).Q40626559
Targeted molecular probes for imaging atherosclerotic lesions with magnetic resonance using antibodies that recognize oxidation-specific epitopesQ41370572
Oxidation-specific biomarkers, lipoprotein(a), and risk of fatal and nonfatal coronary eventsQ42912066
Antisense oligonucleotide lowers plasma levels of apolipoprotein (a) and lipoprotein (a) in transgenic miceQ43922953
Reduced in vivo aortic uptake of radiolabeled oxidation-specific antibodies reflects changes in plaque composition consistent with plaque stabilizationQ45140753
Increased plasma oxidized phospholipid:apolipoprotein B-100 ratio with concomitant depletion of oxidized phospholipids from atherosclerotic lesions after dietary lipid-lowering: a potential biomarker of early atherosclerosis regression.Q45991963
Relationship of IgG and IgM autoantibodies to oxidized low density lipoprotein with coronary artery disease and cardiovascular eventsQ46125332
Lipid lowering reduces oxidative stress and endothelial cell activation in rabbit atheromaQ46200093
Relation of oxidative biomarkers, vascular dysfunction, and progression of coronary artery calciumQ46623191
Recombinant antibodies to an oxidized low-density lipoprotein epitope induce rapid regression of atherosclerosis in apobec-1(-/-)/low-density lipoprotein receptor(-/-) miceQ46859383
Passive immunization with monoclonal IgM antibodies against phosphorylcholine reduces accelerated vein graft atherosclerosis in apolipoprotein E-null miceQ46874178
Conventional B2 B cell depletion ameliorates whereas its adoptive transfer aggravates atherosclerosis.Q54412663
Increased Expression of Oxidation-Specific Epitopes and Apoptosis Are Associated With Haptoglobin GenotypeQ61270643
P433issue5
P921main subjectbiomarkerQ864574
P304page(s)426-437
P577publication date2013-10-01
P1433published inCurrent Opinion in LipidologyQ15758705
P1476titleOxidation-specific epitopes as targets for biotheranostic applications in humans: biomarkers, molecular imaging and therapeutics
P478volume24

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