Activation of human ether-a-go-go related gene (hERG) potassium channels by small molecules

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Activation of human ether-a-go-go related gene (hERG) potassium channels by small molecules is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P6179Dimensions Publication ID1005296826
P356DOI10.1038/APS.2011.70
P932PMC publication ID4085723
P698PubMed publication ID21623390
P5875ResearchGate publication ID51175535

P2093author name stringMin Li
Zhao-bing Gao
Joseph Babcock
Lian-qing Liu
Ping-zheng Zhou
P2860cites workMechanisms of pharmacological rescue of trafficking-defective hERG mutant channels in human long QT syndromeQ24299159
A mechanistic link between an inherited and an acquired cardiac arrhythmia: HERG encodes the IKr potassium channelQ24316252
The inward rectification mechanism of the HERG cardiac potassium channelQ24320034
A family of potassium channel genes related to eag in Drosophila and mammalsQ24563554
The HERG K+ channel: progress in understanding the molecular basis of its unusual gating kineticsQ27642109
The genetic basis of long QT and short QT syndromes: a mutation updateQ28262724
Treatment with NS3623, a novel Cl-conductance blocker, ameliorates erythrocyte dehydration in transgenic SAD mice: a possible new therapeutic approach for sickle cell diseaseQ32061803
Drug-induced prolongation of the QT intervalQ33151147
The amiodarone derivative KB130015 activates hERG1 potassium channels via a novel mechanismQ33716230
Systems pharmacology of arrhythmiasQ34111154
Discovery of a small molecule activator of the human ether-a-go-go-related gene (HERG) cardiac K+ channelQ34368794
Is restoration of intracellular trafficking clinically feasible in the long QT syndrome?: The example of HERG mutations.Q35115334
Structural basis of action for a human ether-a-go-go-related gene 1 potassium channel activator.Q35963083
Voltage sensor movement in the hERG K+ channel.Q36210620
The congenital long QT syndromes from genotype to phenotype: clinical implicationsQ36335249
Fast and slow voltage sensor movements in HERG potassium channelsQ36412334
Targeted therapy for short QT syndromeQ36481056
A single amino acid difference between ether-a-go-go- related gene channel subtypes determines differential sensitivity to a small molecule activatorQ36839526
The hERG channel and risk of drug-acquired cardiac arrhythmia: an overviewQ37264949
Human ether-a-go-go related gene (hERG) K+ channels: function and dysfunctionQ37332774
PD-118057 contacts the pore helix of hERG1 channels to attenuate inactivation and enhance K+ conductanceQ37446552
Probing the binding sites and mechanisms of action of two human ether-a-go-go-related gene channel activators, 1,3-bis-(2-hydroxy-5-trifluoromethyl-phenyl)-urea (NS1643) and 2-[2-(3,4-dichloro-phenyl)-2,3-dihydro-1H-isoindol-5-ylamino]-nicotinic aciQ37464272
Voltage-gated potassium channels as therapeutic targetsQ37464784
Delayed rectifier K(+) currents and cardiac repolarization.Q37580457
Revealing the structural basis of action of hERG potassium channel activators and blockersQ37774138
Electrophysiologic characterization of a novel hERG channel activatorQ39854832
Biophysical characterization of the new human ether-a-go-go-related gene channel opener NS3623 [N-(4-bromo-2-(1H-tetrazol-5-yl)-phenyl)-N'-(3'-trifluoromethylphenyl)urea].Q40258104
High affinity HERG K(+) channel blockade by the antiarrhythmic agent dronedarone: resistance to mutations of the S6 residues Y652 and F656.Q40492856
Multiple mechanisms in the long-QT syndrome. Current knowledge, gaps, and future directions. The SADS Foundation Task Force on LQTS.Q40923240
Modulation of K+ current by frequency and external [K+]: a tale of two inactivation mechanisms.Q41290065
Novel potent human ether-a-go-go-related gene (hERG) potassium channel enhancers and their in vitro antiarrhythmic activityQ42660591
Pharmacological removal of human ether-à-go-go-related gene potassium channel inactivation by 3-nitro-N-(4-phenoxyphenyl) benzamide (ICA-105574).Q43266815
Dynamic conformational changes of extracellular S5-P linkers in the hERG channelQ44913448
Tryptophan scanning mutagenesis of the HERG K+ channel: the S4 domain is loosely packed and likely to be lipid exposedQ46705938
Mechanism of action of a novel human ether-a-go-go-related gene channel activatorQ46801187
2-[2-(3,4-dichloro-phenyl)-2,3-dihydro-1H-isoindol-5-ylamino]-nicotinic acid (PD-307243) causes instantaneous current through human ether-a-go-go-related gene potassium channelsQ46879302
Mallotoxin is a novel human ether-a-go-go-related gene (hERG) potassium channel activator.Q51804614
Effectiveness and limitations of beta-blocker therapy in congenital long-QT syndromeQ73396897
[HERG K+ channel, the target of anti-arrhythmias drugs]Q81327520
P433issue6
P304page(s)781-788
P577publication date2011-05-30
P1433published inActa Pharmacologica SinicaQ15749885
P1476titleActivation of human ether-a-go-go related gene (hERG) potassium channels by small molecules
P478volume32

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Q58695621Identification of small-molecule ion channel modulators in C. elegans channelopathy models
Q35222104Kinetic model for NS1643 drug activation of WT and L529I variants of Kv11.1 (hERG1) potassium channel
Q26798018Neuronal and Cardiovascular Potassium Channels as Therapeutic Drug Targets: Promise and Pitfalls
Q38909233Pharmacological and electrophysiological characterization of AZSMO-23, an activator of the hERG K(+) channel
Q37172414The gating charge pathway of an epilepsy-associated potassium channel accommodates chemical ligands
Q93074045The molecular determinants of R-roscovitine block of hERG channels
Q27008208Translational toxicology and rescue strategies of the hERG channel dysfunction: biochemical and molecular mechanistic aspects

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