Ligand-mediated tertiary structure changes of reconstituted P-glycoprotein. A tryptophan fluorescence quenching analysis

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Ligand-mediated tertiary structure changes of reconstituted P-glycoprotein. A tryptophan fluorescence quenching analysis is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.274.25.17649
P698PubMed publication ID10364203
P5875ResearchGate publication ID274627333

P2093author name stringV Ling
J M Ruysschaert
A B Shapiro
N Sonveaux
C Vigano
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A simplification of the protein assay method of Lowry et al. which is more generally applicableQ29615220
Photoaffinity labeling of the multidrug-resistance-related P-glycoprotein with photoactive analogs of verapamilQ33651186
The catalytic cycle of P-glycoproteinQ34370183
Evidence for two nonidentical drug-interaction sites in the human P-glycoproteinQ36589430
Reconstitution of Drug Transport by Purified P-glycoproteinQ36687072
P-glycoprotein function involves conformational transitions detectable by differential immunoreactivityQ36712329
Cellular uptake, cytotoxicity, and transport kinetics of anthracyclines in human sensitive and multidrug-resistant K562 cellsQ36817416
P-glycoprotein-mediated Hoechst 33342 transport out of the lipid bilayer.Q36895019
Positively cooperative sites for drug transport by P-glycoprotein with distinct drug specificitiesQ36895030
Topological folding and proteolysis profile of P-glycoprotein in membranes of multidrug-resistant cells: implications for the drug-transport mechanism.Q38355020
Transmembrane organization of mouse P-glycoprotein determined by epitope insertion and immunofluorescenceQ38358911
The biochemistry of P-glycoprotein-mediated multidrug resistanceQ38364215
ATP-dependent transport systems in bacteria and humans: relevance to cystic fibrosis and multidrug resistanceQ40384605
Conformational changes of P-glycoprotein by nucleotide bindingQ41067952
P-glycoprotein--a mediator of multidrug resistance in tumour cellsQ41078108
MDR1 gene expression in solid tumoursQ41078192
Covalent modification of human P-glycoprotein mutants containing a single cysteine in either nucleotide-binding fold abolishes drug-stimulated ATPase activityQ41293154
P-glycoprotein Is Stably Inhibited by Vanadate-induced Trapping of Nucleotide at a Single Catalytic SiteQ41310191
Membrane topology of a cysteine-less mutant of human P-glycoproteinQ41380800
The P-glycoprotein efflux pump: how does it transport drugs?Q41678834
Mechanism of action of human P-glycoprotein ATPase activity. Photochemical cleavage during a catalytic transition state using orthovanadate reveals cross-talk between the two ATP sitesQ47922050
Site-directed fluorescence labeling of P-glycoprotein on cysteine residues in the nucleotide binding domains.Q50535941
Dissection of drug-binding-induced conformational changes in P-glycoprotein.Q54127126
Transmembrane aromatic amino acid distribution in P-glycoprotein. A functional role in broad substrate specificity.Q54216853
P433issue25
P407language of work or nameEnglishQ1860
P921main subjectfluorescence quenchingQ585536
P304page(s)17649-17654
P577publication date1999-06-01
P1433published inJournal of Biological ChemistryQ867727
P1476titleLigand-mediated tertiary structure changes of reconstituted P-glycoprotein. A tryptophan fluorescence quenching analysis
P478volume274

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cites work (P2860)
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