| P50 | author | Morgan E Gibbs | Q93053933 |
| P2093 | author name string | Arthur G Roberts | |
| | Laura A Wilt | |
| | Kaitlyn V Ledwitch | |
| P2860 | cites work | The remarkable transport mechanism of P-glycoprotein: a multidrug transporter | Q24547974 |
| | P-glycoprotein efflux transporter activity often displays biphasic dose-response relationships | Q37196500 |
| | The structural basis for homotropic and heterotropic cooperativity of midazolam metabolism by human cytochrome P450 3A4. | Q37308650 |
| | P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs | Q37355653 |
| | Structures of the Multidrug Transporter P-glycoprotein Reveal Asymmetric ATP Binding and the Mechanism of Polyspecificity | Q37591245 |
| | Inhibition of the multidrug resistance P-glycoprotein: time for a change of strategy? | Q37663392 |
| | Role of multidrug transporters in neurotherapeutics | Q37689499 |
| | Opioid transport by ATP-binding cassette transporters at the blood-brain barrier: implications for neuropsychopharmacology | Q37914239 |
| | P-glycoprotein inhibition as a therapeutic approach for overcoming multidrug resistance in cancer: current status and future perspectives. | Q38078058 |
| | Group epitope mapping by saturation transfer difference NMR to identify segments of a ligand in direct contact with a protein receptor | Q38299722 |
| | Conformational and functional characterization of trapped complexes of the P-glycoprotein multidrug transporter. | Q38663274 |
| | Heterogeneous transport of digitalis-like compounds by P-glycoprotein in vesicular and cellular assays. | Q38808713 |
| | Demethoxycurcumin modulates human P-glycoprotein function via uncompetitive inhibition of ATPase hydrolysis activity | Q38919364 |
| | Tariquidar inhibits P-glycoprotein drug efflux but activates ATPase activity by blocking transition to an open conformation | Q38933973 |
| | Interaction of drugs of abuse and maintenance treatments with human P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2). | Q39779618 |
| | In vitro P-glycoprotein assays to predict the in vivo interactions of P-glycoprotein with drugs in the central nervous system | Q40061908 |
| | Passive permeability and P-glycoprotein-mediated efflux differentiate central nervous system (CNS) and non-CNS marketed drugs. | Q40689125 |
| | The importance of cholesterol in maintenance of P-glycoprotein activity and its membrane perturbing influence | Q40767154 |
| | Characterization of the major metabolites of verapamil as substrates and inhibitors of P-glycoprotein | Q40885386 |
| | Competitive and non-competitive inhibition of the multidrug-resistance-associated P-glycoprotein ATPase--further experimental evidence for a multisite model | Q41122874 |
| | Differential involvement of P-glycoprotein (ABCB1) in permeability, tissue distribution, and antinociceptive activity of methadone, buprenorphine, and diprenorphine: in vitro and in vivo evaluation | Q42101445 |
| | Cooperativity between verapamil and ATP bound to the efflux transporter P-glycoprotein | Q42284764 |
| | Interaction of the P-glycoprotein multidrug efflux pump with cholesterol: effects on ATPase activity, drug binding and transport | Q42445797 |
| | Both ATP sites of human P-glycoprotein are essential but not symmetric | Q42479018 |
| | P-Glycoprotein kinetics measured in plasma membrane vesicles and living cells | Q42830949 |
| | Fluorescence intensity calibration using the Raman scatter peak of water. | Q43292480 |
| | Methadone inhibits rhodamine123 transport in Caco-2 cells | Q43641630 |
| | Peripheral antinociceptive action of morphine and the synergistic interaction with lamotrigine | Q43966470 |
| | Variable modulation of opioid brain uptake by P-glycoprotein in mice | Q44344008 |
| | Fluorescence techniques for studying membrane transport proteins: the P-glycoprotein multidrug transporter | Q44490047 |
| | Potential roles of P-gp and calcium channels in loperamide and diphenoxylate transport | Q44652931 |
| | Brain penetration of methadone (R)- and (S)-enantiomers is greatly increased by P-glycoprotein deficiency in the blood-brain barrier of Abcb1a gene knockout mice | Q44719752 |
| | Use of loperamide as a phenotypic probe of mdr1a status in CF-1 mice | Q45155855 |
| | Direct observation of ligand binding to membrane proteins in living cells by a saturation transfer double difference (STDD) NMR spectroscopy method shows a significantly higher affinity of integrin alpha(IIb)beta3 in native platelets than in liposom | Q45228686 |
| | Functional characterization of Escherichia coli MsbA: interaction with nucleotides and substrates | Q46698628 |
| | Insights Into the Molecular Mechanism of Triptan Transport by P-glycoprotein. | Q48269107 |
| | Methods of reconstitution to investigate membrane protein function | Q49895926 |
| | A dearth of new meds. | Q50791248 |
| | Poor Man's Methadone: A Case Report of Loperamide Toxicity. | Q51596517 |
| | P-glycoprotein ATPase activity requires lipids to activate a switch at the first transmission interface. | Q53156653 |
| | Structure of the multidrug resistance P-glycoprotein to 2.5 nm resolution determined by electron microscopy and image analysis. | Q53970603 |
| | Large scale purification of detergent-soluble P-glycoprotein from Pichia pastoris cells and characterization of nucleotide binding properties of wild-type, Walker A, and Walker B mutant proteins. | Q54071315 |
| | Saturation-Transfer Difference (STD) NMR: A Simple and Fast Method for Ligand Screening and Characterization of Protein Binding | Q57634133 |
| | A method for the determination of inorganic phosphate in the presence of labile organic phosphate and high concentrations of protein: application to lens ATPases | Q69825502 |
| | Both P-glycoprotein Nucleotide-binding Sites Are Catalytically Active | Q71824170 |
| | Functional dissection of P-glycoprotein nucleotide-binding domains in chimeric and mutant proteins. Modulation of drug resistance profiles | Q71891887 |
| | Cooperativity in the inhibition of P-glycoprotein-mediated daunorubicin transport: evidence for half-of-the-sites reactivity | Q73244821 |
| | Structure-activity relationships of P-glycoprotein interacting drugs: kinetic characterization of their effects on ATPase activity | Q73705879 |
| | Competitive, non-competitive and cooperative interactions between substrates of P-glycoprotein as measured by its ATPase activity | Q73705884 |
| | Communication between multiple drug binding sites on P-glycoprotein | Q74206620 |
| | Role of P-glycoprotein in cyclosporine cytotoxicity in the cyclosporine-sirolimus interaction | Q79894700 |
| | Direct detection of ligand binding to Sepharose-immobilised protein using saturation transfer double difference (STDD) NMR spectroscopy | Q80489622 |
| | Quantitative targeted absolute proteomics of human blood-brain barrier transporters and receptors | Q83364209 |
| | Structure of P-glycoprotein reveals a molecular basis for poly-specific drug binding | Q24657908 |
| | Flexibility in the ABC transporter MsbA: Alternating access with a twist | Q24676413 |
| | Cryo-EM Analysis of the Conformational Landscape of Human P-glycoprotein (ABCB1) During its Catalytic Cycle. | Q27345028 |
| | Crystal structure of the multidrug transporter P-glycoprotein from Caenorhabditis elegans | Q27673547 |
| | Structures of P-glycoprotein reveal its conformational flexibility and an epitope on the nucleotide-binding domain | Q27679289 |
| | Refined structures of mouse P-glycoprotein | Q27680445 |
| | Gradient-tailored excitation for single-quantum NMR spectroscopy of aqueous solutions | Q27860828 |
| | Using linear and non-linear regression to fit biochemical data | Q28291693 |
| | A gene optimization strategy that enhances production of fully functional P-glycoprotein in Pichia pastoris | Q28476421 |
| | Intrinsic fluorescence of the P-glycoprotein multidrug transporter: sensitivity of tryptophan residues to binding of drugs and nucleotides. | Q30327578 |
| | Opioids in pain management | Q33678609 |
| | Methadone: outpatient titration and monitoring strategies in cancer patients | Q33786199 |
| | Ligand-mediated tertiary structure changes of reconstituted P-glycoprotein. A tryptophan fluorescence quenching analysis | Q33864499 |
| | Functional expression and localization of P-glycoprotein at the blood brain barrier | Q33960099 |
| | Interaction of morphine, fentanyl, sufentanil, alfentanil, and loperamide with the efflux drug transporter P-glycoprotein | Q34124678 |
| | Role of P-glycoprotein in pharmacokinetics: clinical implications | Q35029495 |
| | Distinct conformational spectrum of homologous multidrug ABC transporters | Q35152093 |
| | Conformational analysis of human ATP-binding cassette transporter ABCB1 in lipid nanodiscs and inhibition by the antibodies MRK16 and UIC2. | Q35604412 |
| | Identification and characterization of the binding sites of P-glycoprotein for multidrug resistance-related drugs and modulators | Q35644350 |
| | Dynamic ligand-induced conformational rearrangements in P-glycoprotein as probed by fluorescence resonance energy transfer spectroscopy | Q35668939 |
| | The effect of quinidine, used as a probe for the involvement of P-glycoprotein, on the intestinal absorption and pharmacodynamics of methadone | Q35826102 |
| | P-glycoprotein-based loperamide-cyclosporine drug interaction at the rat blood-brain barrier: prediction from in vitro studies and extrapolation to humans | Q35840052 |
| | Functional expression and localization of P-glycoprotein in the central nervous system: relevance to the pathogenesis and treatment of neurological disorders | Q35883770 |
| | Opioid Analgesics and P-Glycoprotein Efflux Transporters: A Potential Systems-Level Contribution to Analgesic Tolerance | Q36107418 |
| | The ATPase activity of the P-glycoprotein drug pump is highly activated when the N-terminal and central regions of the nucleotide-binding domains are linked closely together | Q36137412 |
| | Unravelling the complex drug-drug interactions of the cardiovascular drugs, verapamil and digoxin, with P-glycoprotein | Q36691249 |
| | P-glycoprotein is fully active after multiple tryptophan substitutions | Q36699096 |
| | Global marine pollutants inhibit P-glycoprotein: Environmental levels, inhibitory effects, and cocrystal structure | Q36839792 |
| | Uptake or extrusion: crystal structures of full ABC transporters suggest a common mechanism | Q36853161 |
| | Positively cooperative sites for drug transport by P-glycoprotein with distinct drug specificities | Q36895030 |
| | Structure-based interpretation of the mutagenesis database for the nucleotide binding domains of P-glycoprotein. | Q37012298 |
| | Modulation of P-glycoprotein at the blood-brain barrier: opportunities to improve central nervous system pharmacotherapy | Q37080236 |
| | Competitive substrates for P-glycoprotein and organic anion protein transporters differentially reduce blood organ transport of fentanyl and loperamide: pharmacokinetics and pharmacodynamics in Sprague-Dawley rats | Q37087970 |
| | Use of NMR saturation transfer difference spectroscopy to study ligand binding to membrane proteins | Q37135922 |
| P433 | issue | 7 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | loperamide | Q423751 |
| P304 | page(s) | 1937-1947 | |
| P577 | publication date | 2018-02-28 | |
| P1433 | published in | Journal of Pharmaceutical Sciences | Q3186933 |
| P1476 | title | A Conformationally Gated Model of Methadone and Loperamide Transport by P-Glycoprotein | |
| P478 | volume | 107 | |