Activated protein synthesis and suppressed protein breakdown signaling in skeletal muscle of critically ill patients

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Activated protein synthesis and suppressed protein breakdown signaling in skeletal muscle of critically ill patients is …
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scholarly articleQ13442814

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P819ADS bibcode2011PLoSO...618090J
P356DOI10.1371/JOURNAL.PONE.0018090
P932PMC publication ID3069050
P698PubMed publication ID21483870
P5875ResearchGate publication ID51042634

P50authorPeter SchjerlingQ41600446
P2093author name stringMichael Kjaer
Frank C Pott
Ulla R Mikkelsen
Jakob Agergaard
Søren Reitelseder
Jakob G Jespersen
Anders Nedergaard
Kasper J Dideriksen
Frederik Kreiner
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Effect of insulin on amino acid uptake and protein turnover in skeletal muscle from septic rats. Evidence for insulin resistance of protein breakdownQ54412371
Whey and casein labeled with L-[1-13C]leucine and muscle protein synthesis: effect of resistance exercise and protein ingestion.Q54636003
Effect of Intensive Insulin Therapy on Insulin Sensitivity in the Critically IllQ57245311
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A descriptive study of skeletal muscle metabolism in critically ill patients: free amino acids, energy-rich phosphates, protein, nucleic acids, fat, water, and electrolytesQ71032735
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Muscle fibre atrophy in critically ill patients is associated with the loss of myosin filaments and the presence of lysosomal enzymes and ubiquitinQ77793916
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Insulin stimulates interleukin-6 and tumor necrosis factor-alpha gene expression in human subcutaneous adipose tissueQ44610001
Extremity hyperinsulinemia stimulates muscle protein synthesis in severely injured patientsQ44686353
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IGF-I stimulates muscle growth by suppressing protein breakdown and expression of atrophy-related ubiquitin ligases, atrogin-1 and MuRF1.Q44853225
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Skeletal muscle FOXO1 (FKHR) transgenic mice have less skeletal muscle mass, down-regulated Type I (slow twitch/red muscle) fiber genes, and impaired glycemic controlQ44991663
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What is the cause of the ageing atrophy? Total number, size and proportion of different fiber types studied in whole vastus lateralis muscle from 15- to 83-year-old men.Q47182433
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The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolismQ29547302
FoxO3 coordinately activates protein degradation by the autophagic/lysosomal and proteasomal pathways in atrophying muscle cellsQ29614482
FoxO3 controls autophagy in skeletal muscle in vivoQ29614483
Intensive insulin therapy in critically ill patientsQ29618795
Foxo transcription factors induce the atrophy-related ubiquitin ligase atrogin-1 and cause skeletal muscle atrophyQ29619282
Transgenic overexpression of locally acting insulin-like growth factor-1 inhibits ubiquitin-mediated muscle atrophy in chronic left-ventricular dysfunctionQ33220571
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FOXO signaling is required for disuse muscle atrophy and is directly regulated by Hsp70Q33589260
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Cachexia: a new definitionQ34013455
Insulin stimulates human skeletal muscle protein synthesis via an indirect mechanism involving endothelial-dependent vasodilation and mammalian target of rapamycin complex 1 signalingQ34032001
Intensive insulin therapy in the medical ICU.Q34490623
Sepsis-induced suppression of skeletal muscle translation initiation mediated by tumor necrosis factor alphaQ34589839
Signaling in muscle atrophy and hypertrophyQ34593198
Smad2 and 3 transcription factors control muscle mass in adulthood.Q34606381
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Mechano-regulated tenascin-C orchestrates muscle repairQ36870043
Sepsis and AMPK Activation by AICAR Differentially Regulate FoxO-1, -3 and -4 mRNA in Striated MuscleQ37000179
FoxO1 induces apoptosis in skeletal myotubes in a DNA-binding-dependent mannerQ37338922
Sepsis increases the expression and activity of the transcription factor Forkhead Box O 1 (FOXO1) in skeletal muscle by a glucocorticoid-dependent mechanismQ39751365
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Orally administered leucine enhances protein synthesis in skeletal muscle of diabetic rats in the absence of increases in 4E-BP1 or S6K1 phosphorylationQ43935389
Inverse regulation of protein turnover and amino acid transport in skeletal muscle of hypercatabolic patientsQ44055226
Necrotizing myopathy in critically-ill patientsQ44440526
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P4510describes a project that usesImageJQ1659584
P433issue3
P407language of work or nameEnglishQ1860
P304page(s)e18090
P577publication date2011-03-31
P1433published inPLOS OneQ564954
P1476titleActivated protein synthesis and suppressed protein breakdown signaling in skeletal muscle of critically ill patients
P478volume6

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