Properties of the TRPML3 channel pore and its stable expansion by the Varitint-Waddler-causing mutation

scientific article

Properties of the TRPML3 channel pore and its stable expansion by the Varitint-Waddler-causing mutation is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1074/JBC.M109.078204
P932PMC publication ID2878031
P698PubMed publication ID20378547

P2093author name stringInsuk So
Qin Li
Hyun Jin Kim
Shmuel Muallem
Soichiro Yamaguchi
P2860cites workMutations in Mcoln3 associated with deafness and pigmentation defects in varitint-waddler (Va) miceQ24538566
A novel mode of TRPML3 regulation by extracytosolic pH absent in the varitint-waddler phenotypeQ24646638
The varitint-waddler (Va) deafness mutation in TRPML3 generates constitutive, inward rectifying currents and causes cell degenerationQ24657402
Molecular physiology of P2X receptorsQ28203477
P2X receptors as cell-surface ATP sensors in health and diseaseQ28255603
Transient receptor potential cation channels in diseaseQ28284143
Ionic selectivity of native ATP-activated (P2X) receptor channels in dissociated neurones from rat parasympathetic gangliaQ28344020
TRP channelsQ29616673
Constitutive activity of the human TRPML2 channel induces cell degenerationQ33594064
The calcium channel mucolipin-3 is a novel regulator of trafficking along the endosomal pathwayQ34204293
The Ca(2+) channel TRPML3 regulates membrane trafficking and autophagyQ34359731
Gain-of-function mutation in TRPML3 causes the mouse Varitint-Waddler phenotypeQ34706891
Activating mutation in a mucolipin transient receptor potential channel leads to melanocyte loss in varitint-waddler mice.Q36157007
A helix-breaking mutation in TRPML3 leads to constitutive activity underlying deafness in the varitint-waddler mouseQ36288732
The permeability of the endplate channel to organic cations in frog muscleQ36408149
Permeation properties of a Ca(2+)-blockable monovalent cation channel in the ectoderm of the chick embryo: pore size and multioccupancy probed with organic cations and Ca2+.Q36435502
TRPML3 and hearing loss in the varitint-waddler mouseQ36747614
The varitint-waddler mouse phenotypes and the TRPML3 ion channel mutation: cause and consequenceQ37173807
Agonist-induced changes in Ca(2+) permeation through the nociceptor cation channel TRPA1.Q39344547
Tunable calcium current through TRPV1 receptor channelsQ39942483
TRPV1 shows dynamic ionic selectivity during agonist stimulation.Q39994761
Outer pore architecture of a Ca2+-selective TRP channelQ40596874
Pore dilation of neuronal P2X receptor channelsQ40960421
Pore dilation occurs in TRPA1 but not in TRPM8 channelsQ42086231
Identification of the gene causing mucolipidosis type IV.Q52165526
P433issue22
P407language of work or nameEnglishQ1860
P304page(s)16513-16520
P577publication date2010-04-08
P1433published inJournal of Biological ChemistryQ867727
P1476titleProperties of the TRPML3 channel pore and its stable expansion by the Varitint-Waddler-causing mutation
P478volume285

Reverse relations

cites work (P2860)
Q42214079A helix-breaking mutation in the epithelial Ca(2+) channel TRPV5 leads to reduced Ca(2+)-dependent inactivation
Q35013825Constitutive activity of TRP channels methods for measuring the activity and its outcome
Q28727456Constitutive activity of TRPML2 and TRPML3 channels versus activation by low extracellular sodium and small molecules
Q47438098Cryo-EM structures of the human endolysosomal TRPML3 channel in three distinct states
Q46706138Cryo-electron microscopy structure of the lysosomal calcium-permeable channel TRPML3.
Q61812437Endolysosomal Ca Signalling and Cancer Hallmarks: Two-Pore Channels on the Move, TRPML1 Lags Behind!
Q40643402How does NAADP release lysosomal Ca2+?
Q38830313Modulation of Calcium Entry by the Endo-lysosomal System
Q38111283TRP channels
Q35190170TRPML: transporters of metals in lysosomes essential for cell survival?
Q38830274The TRPCs, Orais and STIMs in ER/PM Junctions
Q36430235The intracellular Ca²⁺ channels of membrane traffic
Q36470745The mucolipin-2 (TRPML2) ion channel: a tissue-specific protein crucial to normal cell function.
Q35067713Transient receptor potential mucolipin 1 (TRPML1) and two-pore channels are functionally independent organellar ion channels

Search more.