Pore dilation occurs in TRPA1 but not in TRPM8 channels

scientific article published on 21 January 2009

Pore dilation occurs in TRPA1 but not in TRPM8 channels is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1027378111
P356DOI10.1186/1744-8069-5-3
P932PMC publication ID2633278
P698PubMed publication ID19159452
P5875ResearchGate publication ID23808035

P2093author name stringJun Chen
Donghee Kim
Connie R Faltynek
Bruce R Bianchi
Philip R Kym
Regina M Reilly
Eric J Cavanaugh
P2860cites workTRPV1 channels mediate long-term depression at synapses on hippocampal interneuronsQ24644177
TRPA1 mediates formalin-induced painQ24681557
The vanilloid receptor TRPV1 is tonically activated in vivo and involved in body temperature regulationQ28295455
ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperaturesQ28509578
Transient receptor potential A1 mediates an osmotically activated ion channelQ28573675
Nociceptor and hair cell transducer properties of TRPA1, a channel for pain and hearingQ28588331
Lighting up the senses: FM1-43 loading of sensory cells through nonselective ion channels.Q30310868
Pannexin1 is part of the pore forming unit of the P2X(7) receptor death complexQ30479449
Utility of large-scale transiently transfected cells for cell-based high-throughput screens to identify transient receptor potential channel A1 (TRPA1) antagonistsQ30827889
Inhibition of nociceptors by TRPV1-mediated entry of impermeant sodium channel blockersQ34698238
4-Hydroxynonenal, an endogenous aldehyde, causes pain and neurogenic inflammation through activation of the irritant receptor TRPA1Q35941218
Pain TRPsQ36093784
Molecular determinants of species-specific activation or blockade of TRPA1 channelsQ39984645
TRPV1 shows dynamic ionic selectivity during agonist stimulation.Q39994761
Polyamines are potent ligands for the capsaicin receptor TRPV1.Q40326057
TRPV1 regulators mediate gentamicin penetration of cultured kidney cells.Q40415348
TRPV1 acts as proton channel to induce acidification in nociceptive neuronsQ40549949
Pore dilation of neuronal P2X receptor channelsQ40960421
Neuronal P2X transmitter-gated cation channels change their ion selectivity in seconds.Q41646184
A role of TRPA1 in mechanical hyperalgesia is revealed by pharmacological inhibition.Q41839374
Mitogen-activated protein kinase and caspase signaling pathways are required for P2X7 receptor (P2X7R)-induced pore formation in human THP-1 cellsQ44666463
Density-dependent changes of the pore properties of the P2X2 receptor channelQ44859237
Activation of transient receptor potential A1 channels by mustard oil, tetrahydrocannabinol and Ca2+ reveals different functional channel statesQ46565531
Fire in the hole: pore dilation of the capsaicin receptor TRPV1.Q46626388
Activation of TRPA1 by farnesyl thiosalicylic acidQ46825855
Activation of TRPA1 channels by the fatty acid amide hydrolase inhibitor 3'-carbamoylbiphenyl-3-yl cyclohexylcarbamate (URB597).Q53577604
P304page(s)3
P577publication date2009-01-21
P1433published inMolecular PainQ15766244
P1476titlePore dilation occurs in TRPA1 but not in TRPM8 channels
P478volume5

Reverse relations

cites work (P2860)
Q41847565ATP-induced P2X Receptor-Dependent Large Pore Formation: How Much Do We Know?
Q30540969Activity-dependent silencing reveals functionally distinct itch-generating sensory neurons
Q30500428Activity-dependent targeting of TRPV1 with a pore-permeating capsaicin analog
Q39344547Agonist-induced changes in Ca(2+) permeation through the nociceptor cation channel TRPA1.
Q48198476Agonist-induced sensitisation of the irritant receptor ion channel TRPA1.
Q39635711Application of Large-Scale Transient Transfection to Cell-Based Functional Assays for Ion Channels and GPCRs
Q33775096Bimodal voltage dependence of TRPA1: mutations of a key pore helix residue reveal strong intrinsic voltage-dependent inactivation
Q39080979Bupivacaine-induced cellular entry of QX-314 and its contribution to differential nerve block.
Q38830295Calcium Entry Through Thermosensory Channels
Q36236703Cellular permeation of large molecules mediated by TRPM8 channels
Q42070719Characterization of a ligand binding site in the human transient receptor potential ankyrin 1 pore
Q62661251Cinnamaldehyde inhibits L-type calcium channels in mouse ventricular cardiomyocytes and vascular smooth muscle cells
Q30975374Comparative effects of heterologous TRPV1 and TRPM8 expression in rat hippocampal neurons
Q41815881Comparison of the transport of QX-314 through TRPA1, TRPM8, and TRPV1 channels
Q88574267Conformational plasticity in the selectivity filter of the TRPV2 ion channel
Q33819204Direct Anandamide Activation of TRPV1 Produces Divergent Calcium and Current Responses
Q41816317Directionality of temperature activation in mouse TRPA1 ion channel can be inverted by single-point mutations in ankyrin repeat six.
Q43067153Dynamic changes in the TRPA1 selectivity filter lead to progressive but reversible pore dilation
Q31109965Effect of cholesterol depletion on the pore dilation of TRPV1.
Q42793564Electroporation-induced inward current in voltage-clamped guinea pig ventricular myocytes
Q41876734Genetic Method for Labeling Electrically Coupled Cells: Application to Retina
Q38069524Genetically encoded calcium indicators and astrocyte calcium microdomains
Q42906393Honey Bee Thermal/Chemical Sensor, AmHsTRPA, Reveals Neofunctionalization and Loss of Transient Receptor Potential Channel Genes
Q26783066How the TRPA1 receptor transmits painful stimuli: Inner workings revealed by electron cryomicroscopy
Q92733278Is TRPA1 Burning Down TRPV1 as Druggable Target for the Treatment of Chronic Pain?
Q30413493Local mechanisms for loud sound-enhanced aminoglycoside entry into outer hair cells.
Q30313395Localization of the gate and selectivity filter of the full-length P2X7 receptor
Q36052386N-glycosylation determines ionic permeability and desensitization of the TRPV1 capsaicin receptor.
Q90193598Noncanonical Ion Channel Behaviour in Pain
Q36770939Permeation and block of TRPV1 channels by the cationic lidocaine derivative QX-314
Q36806245Phenotyping the function of TRPV1-expressing sensory neurons by targeted axonal silencing
Q28821199Physical basis of apparent pore dilation of ATP-activated P2X receptor channels
Q47128203Potential Mechanisms Underlying Inflammation-Enhanced Aminoglycoside-Induced Cochleotoxicity.
Q37835328Properties and therapeutic potential of transient receptor potential channels with putative roles in adversity: focus on TRPC5, TRPM2 and TRPA1.
Q33883232Properties of the TRPML3 channel pore and its stable expansion by the Varitint-Waddler-causing mutation
Q35126683Role of the outer pore domain in transient receptor potential vanilloid 1 dynamic permeability to large cations
Q57144860Selective cold pain inhibition by targeted block of TRPM8-expressing neurons with quaternary lidocaine derivative QX-314
Q36438795Selectively targeting pain in the trigeminal system
Q34089246Structure-functional intimacies of transient receptor potential channels
Q30505420TRPA1 channels regulate astrocyte resting calcium and inhibitory synapse efficacy through GAT-3
Q44840215TRPA1 contributes to specific mechanically activated currents and sensory neuron mechanical hypersensitivity.
Q28482501TRPA1 mediates mechanical sensitization in nociceptors during inflammation
Q37638751TRPA1 modulators in preclinical development
Q38686108TRPing on the pore phenomenon: what do we know about transient receptor potential ion channel-related pore dilation up to now?
Q37362053Targeting Pain-evoking Transient Receptor Potential Channels for the Treatment of Pain
Q37860361Targeting of sodium channel blockers into nociceptors to produce long-duration analgesia: a systematic study and review
Q36185728The Outer Pore and Selectivity Filter of TRPA1
Q93046959The Preclinical Pharmacological Study of a Novel Long-Acting Local Anesthetic, a Fixed-Dose Combination of QX-OH/Levobupivacaine, in Rats
Q37791280The Role of Transient Receptor Potential Cation Channels in Ca2+ Signaling
Q34175932The dynamic TRPA1 channel: a suitable pharmacological pain target?
Q34709039The pore properties of human nociceptor channel TRPA1 evaluated in single channel recordings
Q38045749The transient receptor potential channel TRPA1: from gene to pathophysiology
Q37800508Transient receptor potential ankyrin 1: emerging pharmacology and indications for cardiovascular biology
Q26849317Transient receptor potential channels as drug targets: from the science of basic research to the art of medicine
Q52765711Transient receptor potential vanilloid 4 (TRPV4) channel as a target of crotamiton and its bimodal effects.
Q34618888Voltage- and temperature-dependent activation of TRPV3 channels is potentiated by receptor-mediated PI(4,5)P2 hydrolysis
Q28484900Xanthurenic acid binds to neuronal G-protein-coupled receptors that secondarily activate cationic channels in the cell line NCB-20