| scholarly article | Q13442814 |
| P50 | author | Douglas R. Green | Q19667788 |
| P2093 | author name string | Cristina Pop | |
| Guy S Salvesen | |||
| Jean-Bernard Denault | |||
| Andrew Oberst | |||
| Véronique Blais | |||
| Alexandre G Tremblay | |||
| P2860 | cites work | Caspase-8 prevents sustained activation of NF-kappaB in monocytes undergoing macrophagic differentiation | Q24307493 |
| The Apaf-1*procaspase-9 apoptosome complex functions as a proteolytic-based molecular timer | Q24316930 | ||
| Caspase 3 attenuates XIAP (X-linked inhibitor of apoptosis protein)-mediated inhibition of caspase 9 | Q24669658 | ||
| Structural basis for the substrate specificity of tobacco etch virus protease | Q27639791 | ||
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| Controlled intracellular processing of fusion proteins by TEV protease | Q28139508 | ||
| The P1' specificity of tobacco etch virus protease | Q28205691 | ||
| Tobacco etch virus protease: mechanism of autolysis and rational design of stable mutants with wild-type catalytic proficiency | Q28216587 | ||
| The apoptosome activates caspase-9 by dimerization | Q28235880 | ||
| A unified model for apical caspase activation | Q28609101 | ||
| Insights into the regulatory mechanism for caspase-8 activation | Q28609102 | ||
| Molecular mechanisms of caspase regulation during apoptosis | Q29617861 | ||
| Two CD95 (APO-1/Fas) signaling pathways | Q29619631 | ||
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| An induced proximity model for caspase-8 activation. | Q34065853 | ||
| XIAP discriminates between type I and type II FAS-induced apoptosis | Q34205704 | ||
| Requirement for caspase-8 in NF-kappaB activation by antigen receptor. | Q34399988 | ||
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| Interdimer processing mechanism of procaspase-8 activation. | Q39832029 | ||
| Non-genetic origins of cell-to-cell variability in TRAIL-induced apoptosis | Q39861453 | ||
| Mutation of a self-processing site in caspase-8 compromises its apoptotic but not its nonapoptotic functions in bacterial artificial chromosome-transgenic mice | Q39953264 | ||
| Cleavage of RIP3 inactivates its caspase-independent apoptosis pathway by removal of kinase domain. | Q40103903 | ||
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| Caspase-8 can be activated by interchain proteolysis without receptor-triggered dimerization during drug-induced apoptosis. | Q40478589 | ||
| Improved artificial death switches based on caspases and FADD. | Q40924176 | ||
| Caspase-9 can be activated without proteolytic processing | Q40966257 | ||
| Functional analysis of Fas signaling in vivo using synthetic inducers of dimerization | Q41187958 | ||
| Three-part inventions: intracellular signaling and induced proximity | Q41297022 | ||
| Expression, purification, and characterization of caspases | Q42169768 | ||
| Interchain proteolysis, in the absence of a dimerization stimulus, can initiate apoptosis-associated caspase-8 activation | Q44947094 | ||
| Correction of multi-gene deficiency in vivo using a single 'self-cleaving' 2A peptide-based retroviral vector | Q45874327 | ||
| Human caspase-7 activity and regulation by its N-terminal peptide. | Q46013323 | ||
| Role of proteolysis in caspase-8 activation and stabilization | Q46045848 | ||
| Reconstitution of the death-inducing signaling complex reveals a substrate switch that determines CD95-mediated death or survival | Q50336536 | ||
| Overlapping cleavage motif selectivity of caspases: implications for analysis of apoptotic pathways. | Q50659185 | ||
| In situ trapping of activated initiator caspases reveals a role for caspase-2 in heat shock-induced apoptosis. | Q50744961 | ||
| P433 | issue | 22 | |
| P407 | language of work or name | English | Q1860 |
| P304 | page(s) | 16632-16642 | |
| P577 | publication date | 2010-03-22 | |
| P1433 | published in | Journal of Biological Chemistry | Q867727 |
| P1476 | title | Inducible dimerization and inducible cleavage reveal a requirement for both processes in caspase-8 activation. | |
| P478 | volume | 285 |
| Q33924838 | A bifunctional allosteric site in the dimer interface of procaspase-3 |
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| Q42423646 | Activation and specificity of human caspase-10. |
| Q34412566 | Activation of caspase-9, but not caspase-2 or caspase-8, is essential for heat-induced apoptosis in Jurkat cells |
| Q36162984 | Activity of Uncleaved Caspase-8 Controls Anti-bacterial Immune Defense and TLR-Induced Cytokine Production Independent of Cell Death |
| Q34764471 | Apoptosis as a Mechanism for Liver Disease Progression |
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| Q38818426 | Caspase-10 Negatively Regulates Caspase-8-Mediated Cell Death, Switching the Response to CD95L in Favor of NF-κB Activation and Cell Survival |
| Q51450898 | Caspase-3 feeds back on caspase-8, Bid and XIAP in type I Fas signaling in primary mouse hepatocytes. |
| Q37785346 | Caspase-8 as a therapeutic target in cancer |
| Q41218122 | Caspase-8 cleaves its substrates from the plasma membrane upon CD95-induced apoptosis |
| Q38423395 | Caspase-8 functions as a key mediator of inflammation and pro-IL-1β processing via both canonical and non-canonical pathways |
| Q50297294 | Caspase-8 processing in the DISC |
| Q50291745 | Caspase-8 processing within TLR3 complex |
| Q50291836 | Caspase-8 processing within TLR4 complex |
| Q41670854 | Caspase-8 tyrosine-380 phosphorylation inhibits CD95 DISC function by preventing procaspase-8 maturation and cycling within the complex |
| Q28584976 | Catalytic activity of the caspase-8-FLIP(L) complex inhibits RIPK3-dependent necrosis |
| Q36033218 | Cathepsin D primes caspase-8 activation by multiple intra-chain proteolysis |
| Q38655649 | Cell Death Signaling |
| Q39567110 | Cellular FLICE-inhibitory protein (cFLIP) isoforms block CD95- and TRAIL death receptor-induced gene induction irrespective of processing of caspase-8 or cFLIP in the death-inducing signaling complex |
| Q39833736 | Co-operative and Hierarchical Binding of c-FLIP and Caspase-8: A Unified Model Defines How c-FLIP Isoforms Differentially Control Cell Fate |
| Q28509135 | Complementary roles of Fas-associated death domain (FADD) and receptor interacting protein kinase-3 (RIPK3) in T-cell homeostasis and antiviral immunity |
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| Q26796544 | DED or alive: assembly and regulation of the death effector domain complexes |
| Q50520868 | Death receptors and mitochondria: life depends on the liver. |
| Q41999028 | Differential affinity of FLIP and procaspase 8 for FADD's DED binding surfaces regulates DISC assembly |
| Q60046188 | Dimerization and auto-processing induce caspase-11 protease activation within the non-canonical inflammasome |
| Q45317887 | Dimerization of procaspase-8 |
| Q42358231 | Dual role of DR5 in death and survival signaling leads to TRAIL resistance in cancer cells |
| Q38911753 | Dying cells actively regulate adaptive immune responses |
| Q39363894 | EMT phenotype is induced by increased Src kinase activity via Src-mediated caspase-8 phosphorylation |
| Q35938641 | Effects of cucurbitacins on cell morphology are associated with sensitization of renal carcinoma cells to TRAIL-induced apoptosis |
| Q38502519 | Evolutionary analyses of caspase-8 and its paralogs: Deep origins of the apoptotic signaling pathways |
| Q55245977 | Exploiting Cell Death Pathways for Inducible Cell Elimination to Modulate Graft-versus-Host-Disease. |
| Q90382743 | FADD in Cancer: Mechanisms of Altered Expression and Function, and Clinical Implications |
| Q39694237 | FLIP(L) induces caspase 8 activity in the absence of interdomain caspase 8 cleavage and alters substrate specificity |
| Q36286189 | Fibrils colocalize caspase-3 with procaspase-3 to foster maturation |
| Q37663725 | Glutathione depletion regulates both extrinsic and intrinsic apoptotic signaling cascades independent from multidrug resistance protein 1. |
| Q27334399 | In vivo imaging of hierarchical spatiotemporal activation of caspase-8 during apoptosis |
| Q50062526 | Inflammatory cell death in intestinal pathologies |
| Q34400187 | Intra- and interdimeric caspase-8 self-cleavage controls strength and timing of CD95-induced apoptosis |
| Q42415096 | Intrinsic cleavage of receptor-interacting protein kinase-1 by caspase-6. |
| Q37947994 | It cuts both ways: reconciling the dual roles of caspase 8 in cell death and survival |
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| Q35682077 | Lyapunov exponents and phase diagrams reveal multi-factorial control over TRAIL-induced apoptosis |
| Q34264949 | Lysosomal pathways to cell death and their therapeutic applications. |
| Q39149351 | Metacaspases versus caspases in development and cell fate regulation |
| Q29615459 | Mitochondria and cell death: outer membrane permeabilization and beyond |
| Q34680233 | Modifying caspase-3 activity by altering allosteric networks |
| Q50221065 | Molecular Cell Biology of Apoptosis and Necroptosis in Cancer |
| Q41588503 | Molecular determinants involved in activation of caspase 7 |
| Q47843948 | Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018. |
| Q49822760 | Multiple mechanisms of zinc-mediated inhibition for the apoptotic caspases -3, -6, -7, & -8. |
| Q36002031 | Neuronal caspase 2 activity and function requires RAIDD, but not PIDD |
| Q35853714 | On the TRAIL to successful cancer therapy? Predicting and counteracting resistance against TRAIL-based therapeutics |
| Q39441692 | Oral malodorous compound causes caspase-8 and -9 mediated programmed cell death in osteoblasts |
| Q33695003 | Plasminogen activator urokinase expression reveals TRAIL responsiveness and supports fractional survival of cancer cells |
| Q38034272 | Programmed necrosis and autophagy in immune function |
| Q37894323 | Proliferative versus apoptotic functions of caspase-8 Hetero or homo: the caspase-8 dimer controls cell fate |
| Q26852301 | Protease signalling: the cutting edge |
| Q37146270 | Proteasomal regulation of caspase-8 in cancer cell apoptosis |
| Q27026600 | RIPK-dependent necrosis and its regulation by caspases: a mystery in five acts |
| Q30679385 | RIPK1 and NF-κB signaling in dying cells determines cross-priming of CD8⁺ T cells. |
| Q38987871 | RIPK1 both positively and negatively regulates RIPK3 oligomerization and necroptosis. |
| Q38987874 | RIPK1- and RIPK3-induced cell death mode is determined by target availability |
| Q37121662 | Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME. |
| Q38570456 | Redesigning the procaspase-8 dimer interface for improved dimerization |
| Q24632980 | Ripped to death |
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| Q47168390 | Secretory stressors induce intracellular death receptor accumulation to control apoptosis. |
| Q46956935 | Signaling by cell surface death receptors: Alterations in head and neck cancer. |
| Q59329073 | Structural basis for dimerization of the death effector domain of the F122A mutant of Caspase-8 |
| Q38231217 | Targeting apoptosis in autoimmune hepatitis |
| Q38006283 | The 'complexities' of life and death: death receptor signalling platforms |
| Q37357126 | The HECTD3 E3 ubiquitin ligase facilitates cancer cell survival by promoting K63-linked polyubiquitination of caspase-8 |
| Q46027540 | The New Chemical Reporter 6-Alkynyl-6-deoxy-GlcNAc Reveals O-GlcNAc Modification of the Apoptotic Caspases That Can Block the Cleavage/Activation of Caspase-8. |
| Q34354511 | The TRAIL of oncogenes to apoptosis |
| Q34236748 | The caspase-8 dimerization/dissociation balance is a highly potent regulator of caspase-8, -3, -6 signaling |
| Q33931170 | The caspase-8 homolog Dredd cleaves Imd and Relish but is not inhibited by p35 |
| Q43245304 | The chains of death: a new view on caspase-8 activation at the DISC. |
| Q38782511 | The molecular pathway of psoralidin-induced apoptosis in HepG2 cell line. |
| Q35196956 | Turning on caspases with genetics and small molecules |
| Q39369740 | Type 1 inositol-1,4,5-trisphosphate receptor is a late substrate of caspases during apoptosis |
| Q40042412 | Vaccinia virus encodes a novel inhibitor of apoptosis that associates with the apoptosome. |
| Q27010127 | Viral infection and the evolution of caspase 8-regulated apoptotic and necrotic death pathways |
| Q39057521 | Widespread mitochondrial depletion via mitophagy does not compromise necroptosis |
| Q24311676 | cIAPs block Ripoptosome formation, a RIP1/caspase-8 containing intracellular cell death complex differentially regulated by cFLIP isoforms |
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