| scholarly article | Q13442814 |
| P356 | DOI | 10.1016/S1097-2765(03)00059-5 |
| P8608 | Fatcat ID | release_uhmrycpsmzaijovfjvpjmhl4mu |
| P3181 | OpenCitations bibliographic resource ID | 2172275 |
| P698 | PubMed publication ID | 12620240 |
| P50 | author | Aengus Mac Sweeney | Q42889500 |
| P2093 | author name string | Christophe Briand | |
| Markus G. Grütter | |||
| Mrudula Donepudi | |||
| P2860 | cites work | Three-dimensional structure of the apoptosome: implications for assembly, procaspase-9 binding, and activation. | Q55035703 |
| Stability and oligomeric equilibria of refolded interleukin-1beta converting enzyme | Q71246589 | ||
| An APAF-1.cytochrome c multimeric complex is a functional apoptosome that activates procaspase-9 | Q22009407 | ||
| Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis | Q24310597 | ||
| Caspases: the executioners of apoptosis | Q24530218 | ||
| Molecular mechanisms for the conversion of zymogens to active proteolytic enzymes | Q24673104 | ||
| Caspase-8 specificity probed at subsite S(4): crystal structure of the caspase-8-Z-DEVD-cho complex | Q27626721 | ||
| Crystal structure of a procaspase-7 zymogen: mechanisms of activation and substrate binding | Q27636119 | ||
| Dimer formation drives the activation of the cell death protease caspase 9 | Q27636617 | ||
| Structural basis for the activation of human procaspase-7 | Q27636985 | ||
| Structure and mechanism of interleukin-1 beta converting enzyme | Q27730830 | ||
| Size-Distribution Analysis of Macromolecules by Sedimentation Velocity Ultracentrifugation and Lamm Equation Modeling | Q27860847 | ||
| Mammalian caspases: structure, activation, substrates, and functions during apoptosis | Q28139429 | ||
| The long form of FLIP is an activator of caspase-8 at the Fas death-inducing signaling complex | Q28221276 | ||
| FLICE is activated by association with the CD95 death-inducing signaling complex (DISC). | Q28240752 | ||
| A unified model for apical caspase activation | Q28609101 | ||
| Crystal structure of the cysteine protease interleukin-1 beta-converting enzyme: a (p20/p10)2 homodimer | Q28610354 | ||
| The SWISS-PROT protein sequence database and its supplement TrEMBL in 2000. | Q29547492 | ||
| Spectroscopic Determination of Tryptophan and Tyrosine in Proteins* | Q29555850 | ||
| Size-distribution analysis of proteins by analytical ultracentrifugation: strategies and application to model systems | Q29616418 | ||
| The central effectors of cell death in the immune system | Q33652530 | ||
| Caspases - controlling intracellular signals by protease zymogen activation | Q33857511 | ||
| Apoptosis signaling | Q34019359 | ||
| An induced proximity model for caspase-8 activation. | Q34065853 | ||
| c-FLIP(L) is a dual function regulator for caspase-8 activation and CD95-mediated apoptosis | Q39644966 | ||
| Caspase-9 can be activated without proteolytic processing | Q40966257 | ||
| Caspase assays | Q41750719 | ||
| The structure of procaspase 6 is similar to that of active mature caspase 6. | Q41824992 | ||
| Activation of initiator caspases through a stable dimeric intermediate | Q44193814 | ||
| Removal of the pro-domain does not affect the conformation of the procaspase-3 dimer. | Q44876770 | ||
| Caspase 8: an efficient method for large-scale autoactivation of recombinant procaspase 8 by matrix adsorption and characterization of the active enzyme | Q47850762 | ||
| Autoproteolytic activation of pro-caspases by oligomerization | Q47862735 | ||
| P433 | issue | 2 | |
| P304 | page(s) | 543–549 | |
| P577 | publication date | 2003-02-01 | |
| P1433 | published in | Molecular Cell | Q3319468 |
| P1476 | title | Insights into the regulatory mechanism for caspase-8 activation | |
| P478 | volume | 11 |
| Q34032310 | A death effector domain chain DISC model reveals a crucial role for caspase-8 chain assembly in mediating apoptotic cell death |
| Q28609101 | A unified model for apical caspase activation |
| Q35967192 | A20 ubiquitin ligase-mediated polyubiquitination of RIP1 inhibits caspase-8 cleavage and TRAIL-induced apoptosis in glioblastoma |
| Q33321770 | Activation mechanism and substrate specificity of the Drosophila initiator caspase DRONC. |
| Q34328223 | Activation of caspases-8 and -10 by FLIP(L). |
| Q36162984 | Activity of Uncleaved Caspase-8 Controls Anti-bacterial Immune Defense and TLR-Induced Cytokine Production Independent of Cell Death |
| Q39838985 | Alternative Fas-mediated cell death pathway is dependent on the different cleavage patterns of procaspase-8. |
| Q53604092 | Anaplasma phagocytophilum delays spontaneous human neutrophil apoptosis by modulation of multiple apoptotic pathways. |
| Q36594877 | Apoptosome: a platform for the activation of initiator caspases |
| Q47316430 | Bistability analyses of a caspase activation model for receptor-induced apoptosis |
| Q33907593 | Bortezomib sensitizes human esophageal squamous cell carcinoma cells to TRAIL-mediated apoptosis via activation of both extrinsic and intrinsic apoptosis pathways |
| Q36972627 | Cardiolipin provides an essential activating platform for caspase-8 on mitochondria |
| Q45317886 | Caspase activation via Death Receptors in the presence of ligand |
| Q35845173 | Caspase activation, inhibition, and reactivation: a mechanistic view |
| Q45985569 | Caspase assays: identifying caspase activity and substrates in vitro and in vivo. |
| Q39662035 | Caspase-8 and p38MAPK in DATS-induced apoptosis of human CNE2 cells |
| Q40478589 | Caspase-8 can be activated by interchain proteolysis without receptor-triggered dimerization during drug-induced apoptosis. |
| Q46181249 | Caspase-8 mediates mitochondrial release of pro-apoptotic proteins in a manner independent of its proteolytic activity in apoptosis induced by the protein synthesis inhibitor acetoxycycloheximide in human leukemia Jurkat cells |
| Q50297294 | Caspase-8 processing in the DISC |
| Q50291745 | Caspase-8 processing within TLR3 complex |
| Q50291836 | Caspase-8 processing within TLR4 complex |
| Q33996526 | Caspase-9 holoenzyme is a specific and optimal procaspase-3 processing machine |
| Q36559701 | Caspase-containing complexes in the regulation of cell death and inflammation |
| Q36033218 | Cathepsin D primes caspase-8 activation by multiple intra-chain proteolysis |
| Q30490693 | Characterization of cytoplasmic caspase-2 activation by induced proximity. |
| Q35094229 | Chemotherapeutic approaches for targeting cell death pathways |
| Q33654218 | Constitutive expression of murine c-FLIPR causes autoimmunity in aged mice |
| Q34012966 | Crystal structure of MC159 reveals molecular mechanism of DISC assembly and FLIP inhibition |
| Q27641840 | Crystal structure of caspase-2, apical initiator of the intrinsic apoptotic pathway |
| Q57288119 | Cucurbit[8]uril reactivation of an inactivated caspase-8 mutant reveals differentiated enzymatic substrate processing |
| Q42123656 | Death Receptor 5 Networks Require Membrane Cholesterol for Proper Structure and Function. |
| Q42141887 | Death receptor-induced signaling pathways are differentially regulated by gamma interferon upstream of caspase 8 processing |
| Q38700212 | Demethoxycurcumin in combination with ultraviolet radiation B induces apoptosis through the mitochondrial pathway and caspase activation in A431 and HaCaT cells |
| Q43902939 | Differential involvement of Bax and Bak in TRAIL-mediated apoptosis of leukemic T cells |
| Q45317887 | Dimerization of procaspase-8 |
| Q34324018 | Direct binding of Fas-associated death domain (FADD) to the tumor necrosis factor-related apoptosis-inducing ligand receptor DR5 is regulated by the death effector domain of FADD. |
| Q39125086 | Distinct signaling pathways in TRAIL- versus tumor necrosis factor-induced apoptosis |
| Q35092552 | Effects and mechanisms of alveolar type II epithelial cell apoptosis in severe pancreatitis-induced acute lung injury |
| Q46947457 | Effects of opiate drugs on Fas-associated protein with death domain (FADD) and effector caspases in the rat brain: regulation by the ERK1/2 MAP kinase pathway. |
| Q24798064 | Engineering a dimeric caspase-9: a re-evaluation of the induced proximity model for caspase activation |
| Q38336474 | Enhanced basal AP-1 activity and de-regulation of numerous genes in T cells transgenic for a dominant interfering mutant of FADD/MORT1. |
| Q41828166 | Enzymatically active single chain caspase-8 maintains T-cell survival during clonal expansion |
| Q35840521 | FADD cleavage by NK cell granzyme M enhances its self-association to facilitate procaspase-8 recruitment for auto-processing leading to caspase cascade |
| Q28297969 | FLIP and the death effector domain family |
| Q50297295 | FLIP(L) and procaspase-8 form heterodimer in TNF signaling |
| Q39694237 | FLIP(L) induces caspase 8 activity in the absence of interdomain caspase 8 cleavage and alters substrate specificity |
| Q28074658 | Fas-Fas Ligand: Checkpoint of T Cell Functions in Multiple Sclerosis |
| Q39776170 | Feedback regulation of mitochondria by caspase-9 in the B cell receptor-mediated apoptosis. |
| Q36286189 | Fibrils colocalize caspase-3 with procaspase-3 to foster maturation |
| Q38214149 | Functions of caspase 8: the identified and the mysterious |
| Q35670756 | Heterogeneity of primary glioblastoma cells in the expression of caspase-8 and the response to TRAIL-induced apoptosis |
| Q90279987 | Heterogeneous responses to low level death receptor activation are explained by random molecular assembly of the Caspase-8 activation platform |
| Q92811019 | High-Concentrate Feeding to Dairy Cows Induces Apoptosis via the NOD1/Caspase-8 Pathway in Mammary Epithelial Cells |
| Q40330319 | Homotypic FADD interactions through a conserved RXDLL motif are required for death receptor-induced apoptosis |
| Q45774762 | Identification and expression profiles of genes and protens in SMMC-7721 cells |
| Q37569430 | In vitro anticancer activity of Spondias pinnata bark on human lung and breast carcinoma |
| Q27334399 | In vivo imaging of hierarchical spatiotemporal activation of caspase-8 during apoptosis |
| Q33883310 | Inducible dimerization and inducible cleavage reveal a requirement for both processes in caspase-8 activation |
| Q33793688 | Induction of apoptosis by Shiga toxins |
| Q44497128 | Infection of neutrophil granulocytes with Leishmania major activates ERK 1/2 and modulates multiple apoptotic pathways to inhibit apoptosis |
| Q44947094 | Interchain proteolysis, in the absence of a dimerization stimulus, can initiate apoptosis-associated caspase-8 activation |
| Q39832029 | Interdimer processing mechanism of procaspase-8 activation. |
| Q34400187 | Intra- and interdimeric caspase-8 self-cleavage controls strength and timing of CD95-induced apoptosis |
| Q24319929 | Lifeguard/neuronal membrane protein 35 regulates Fas ligand-mediated apoptosis in neurons via microdomain recruitment |
| Q40213057 | Loss of caspase-9 reveals its essential role for caspase-2 activation and mitochondrial membrane depolarization |
| Q50337127 | MADD/DENN splice variant of the IG20 gene is a negative regulator of caspase-8 activation. Knockdown enhances TRAIL-induced apoptosis of cancer cells |
| Q26852802 | Membrane trafficking of death receptors: implications on signalling |
| Q45904346 | Methods to analyze the palmitoylated CD95 high molecular weight death-inducing signaling complex. |
| Q39233861 | Mitochondrial pathways are involved in Eimeria tenella-induced apoptosis of chick embryo cecal epithelial cells |
| Q42648231 | Modulation of apoptosis and immune signaling pathways by the Hantaan virus nucleocapsid protein. |
| Q91393767 | Molecular basis of dimerization of initiator caspase was revealed by crystal structure of caspase-8 pro-domain |
| Q41588503 | Molecular determinants involved in activation of caspase 7 |
| Q29617861 | Molecular mechanisms of caspase regulation during apoptosis |
| Q49822760 | Multiple mechanisms of zinc-mediated inhibition for the apoptotic caspases -3, -6, -7, & -8. |
| Q42817747 | Mutational analyses of c-FLIPR, the only murine short FLIP isoform, reveal requirements for DISC recruitment |
| Q28629323 | N-terminal fragment of c-FLIP(L) processed by caspase 8 specifically interacts with TRAF2 and induces activation of the NF-kappaB signaling pathway |
| Q41891932 | NFkappaB activation by Fas is mediated through FADD, caspase-8, and RIP and is inhibited by FLIP. |
| Q34339233 | Necroptotic signaling in adaptive and innate immunity |
| Q38034272 | Programmed necrosis and autophagy in immune function |
| Q37894323 | Proliferative versus apoptotic functions of caspase-8 Hetero or homo: the caspase-8 dimer controls cell fate |
| Q26852301 | Protease signalling: the cutting edge |
| Q36873662 | Proteolytic processing of the caspase-9 zymogen is required for apoptosome-mediated activation of caspase-9 |
| Q33807797 | Quantitative analysis of pathways controlling extrinsic apoptosis in single cells |
| Q38570456 | Redesigning the procaspase-8 dimer interface for improved dimerization |
| Q40504942 | Redistribution of CD95, DR4 and DR5 in rafts accounts for the synergistic toxicity of resveratrol and death receptor ligands in colon carcinoma cells |
| Q24632980 | Ripped to death |
| Q37826384 | Role of Bcl-2 family proteins and caspases in the regulation of apoptosis. |
| Q37475511 | Role of caspase-8 in thymus function |
| Q35058834 | Role of loop bundle hydrogen bonds in the maturation and activity of (Pro)caspase-3. |
| Q36322794 | SPOTS: signaling protein oligomeric transduction structures are early mediators of death receptor-induced apoptosis at the plasma membrane |
| Q33913756 | Selective inactivation of a Fas-associated death domain protein (FADD)-dependent apoptosis and autophagy pathway in immortal epithelial cells |
| Q40448034 | Selective knockdown of the long variant of cellular FLICE inhibitory protein augments death receptor-mediated caspase-8 activation and apoptosis. |
| Q40632735 | Serine proteases mediate apoptosis-like cell death and phagocytosis under caspase-inhibiting conditions. |
| Q38840371 | Sestrin2 facilitates death receptor-induced apoptosis in lung adenocarcinoma cells through regulation of XIAP degradation. |
| Q33995107 | Src kinase phosphorylates Caspase-8 on Tyr380: a novel mechanism of apoptosis suppression |
| Q51431947 | Structural Insight for Roles of DR5 Death Domain Mutations on Oligomerization of DR5 Death Domain-FADD Complex in the Death-Inducing Signaling Complex Formation: A Computational Study. |
| Q47070537 | Structure and activation mechanism of the Drosophila initiator caspase Dronc |
| Q41957539 | Structure and mechanism of an aspartimide-dependent peptide ligase in human legumain |
| Q43256262 | Studies of the molecular mechanism of caspase-8 activation by solution NMR. |
| Q36742286 | Substrate and inhibitor-induced dimerization and cooperativity in caspase-1 but not caspase-3. |
| Q33820436 | Supplementation with conjugated linoeic acid decreases pig back fat deposition by inducing adipocyte apoptosis |
| Q38446898 | Surviving apoptosis: life-death signaling in single cells. |
| Q40568304 | TNF-alpha-mediated lysosomal permeabilization is FAN and caspase 8/Bid dependent |
| Q50297293 | TNF-mediated dimerization of procaspase-8 |
| Q35756866 | TRAIL and NFkappaB signaling--a complex relationship |
| Q36500552 | Targeting cellular FLICE-like inhibitory protein as a novel approach to the treatment of Hodgkin's lymphoma |
| Q38006283 | The 'complexities' of life and death: death receptor signalling platforms |
| Q40510248 | The C-terminal tails of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and Fas receptors have opposing functions in Fas-associated death domain (FADD) recruitment and can regulate agonist-specific mechanisms of receptor activation |
| Q40330298 | The TRAF3-binding site of human molluscipox virus FLIP molecule MC159 is critical for its capacity to inhibit Fas-induced apoptosis |
| Q40527794 | The biochemical mechanism of caspase-2 activation |
| Q41839673 | The extracellular domains of FasL and Fas are sufficient for the formation of supramolecular FasL-Fas clusters of high stability |
| Q36685165 | The presence of HIV-1 Tat protein second exon delays fas protein-mediated apoptosis in CD4+ T lymphocytes: a potential mechanism for persistent viral production |
| Q35902423 | The protein structures that shape caspase activity, specificity, activation and inhibition |
| Q35657114 | The role of c-FLIP splice variants in urothelial tumours. |
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| Q41482547 | Tumor necrosis factor (TNF) receptor-associated factor 7 is required for TNFα-induced Jun NH2-terminal kinase activation and promotes cell death by regulating polyubiquitination and lysosomal degradation of c-FLIP protein. |
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| Q35996145 | Tyrosine Phosphorylation of Caspase-8 Abrogates Its Apoptotic Activity and Promotes Activation of c-Src |
| Q34454210 | Unique and overlapping substrate specificities of caspase-8 and caspase-10. |
| Q64053358 | c-FLIP and CD95 signaling are essential for survival of renal cell carcinoma |
| Q46954463 | p56Lck tyrosine kinase enhances the assembly of death-inducing signaling complex during Fas-mediated apoptosis. |
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