An integrated microfluidic device for large-scale in situ click chemistry screening

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An integrated microfluidic device for large-scale in situ click chemistry screening is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1039/B907430A
P8608Fatcat IDrelease_hq7zfuprpncftidg3iac2d75se
P932PMC publication ID2878189
P698PubMed publication ID19636457
P5875ResearchGate publication ID26699464

P50authorHartmuth C. KolbQ15431265
Wei-Yu LinQ55459940
P2093author name stringKym F Faull
Matthias Selke
Michael E Phelps
Kan Liu
Hsian-Rong Tseng
Xing-Zhong Zhao
Nangang Zhang
Yanju Wang
Rachel J Lin
Clifton K F Shen
P2860cites workClick chemistry as a route to cyclic tetrapeptide analogues: synthesis of cyclo-[Pro-Val-psi(triazole)-Pro-Tyr]Q82631750
A click chemistry approach to tetrazoles by Huisgen 1,3-dipolar cycloaddition: synthesis of 5-sulfonyl tetrazoles from azides and sulfonyl cyanidesQ84545888
Site-directed ligand discoveryQ27626501
Formation of droplets of alternating composition in microfluidic channels and applications to indexing of concentrations in droplet-based assaysQ28394998
The origins and the future of microfluidicsQ29617319
Drug discovery by dynamic combinatorial librariesQ31096767
A potent and highly selective inhibitor of human alpha-1,3-fucosyltransferase via click chemistryQ33188039
Rapid assembly and in situ screening of bidentate inhibitors of protein tyrosine phosphatasesQ33233529
Proteomic profiling of metalloprotease activities with cocktails of active-site probesQ33237686
Integrated microfluidics for parallel screening of an in situ click chemistry libraryQ33254920
A two stage click-based library of protein tyrosine phosphatase inhibitorsQ33260614
Counting low-copy number proteins in a single cellQ33268264
Bcl-XL-templated assembly of its own protein-protein interaction modulator from fragments decorated with thio acids and sulfonyl azidesQ33371280
Formation of droplets and bubbles in a microfluidic T-junction-scaling and mechanism of break-upQ34498942
Chemistry in microstructured reactorsQ35634704
Activity-based probes for the proteomic profiling of metalloproteasesQ35970483
Virtual combinatorial libraries: dynamic generation of molecular and supramolecular diversity by self-assemblyQ36032281
The application of micro reactors for organic synthesisQ36052130
Control and detection of chemical reactions in microfluidic systemsQ36548316
Greener approaches to organic synthesis using microreactor technologyQ36764864
Multiphase organic synthesis in microchannel reactorsQ36794488
Microreactors as tools for synthetic chemists-the chemists' round-bottomed flask of the 21st century?Q40285921
Monolithic microfabricated valves and pumps by multilayer soft lithographyQ41728801
Self-assembling cytotoxinsQ42217095
Multistep synthesis of a radiolabeled imaging probe using integrated microfluidicsQ43907737
Microfluidic large-scale integrationQ44156086
In situ click chemistry: enzyme inhibitors made to their own specificationsQ45093957
In situ click chemistry: enzyme-generated inhibitors of carbonic anhydrase II.Q45187955
In situ selection of lead compounds by click chemistry: target-guided optimization of acetylcholinesterase inhibitorsQ46470318
Flash chemistry: fast chemical synthesis by using microreactorsQ47657172
Advanced organic synthesis using microreactor technologyQ60368657
Dynamic combinatorial chemistryQ73673756
Click chemistry in situ: acetylcholinesterase as a reaction vessel for the selective assembly of a femtomolar inhibitor from an array of building blocksQ78687582
Inhibitors of HIV-1 protease by using in situ click chemistryQ82316996
P433issue16
P921main subjectmicrofluidicsQ138845
click chemistryQ912270
microfluidic deviceQ105460056
P1104number of pages5
P304page(s)2281-2285
P577publication date2009-06-17
P1433published inLab on a ChipQ3214277
P1476titleAn integrated microfluidic device for large-scale in situ click chemistry screening
P478volume9

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cites work (P2860)
Q448632743D printing of liquid metals as fugitive inks for fabrication of 3D microfluidic channels
Q40443531A 3D microblade structure for precise and parallel droplet splitting on digital microfluidic chips
Q41572844A High-Throughput Platform for Formulating and Screening Multifunctional Nanoparticles Capable of Simultaneous Delivery of Genes and Transcription Factors
Q33536471A small library of DNA-encapsulated supramolecular nanoparticles for targeted gene delivery
Q38209736Accessing new chemical entities through microfluidic systems
Q38029121Advances in microfluidics for drug discovery
Q51545711Asymmetric organocatalysis and analysis on a single microfluidic nanospray chip
Q47780833Automating drug discovery
Q52579071Cell-Based Kinetic Target-Guided Synthesis of an Enzyme Inhibitor
Q30457639Chip in a lab: Microfluidics for next generation life science research
Q34932130Delivery of intact transcription factor by using self-assembled supramolecular nanoparticles
Q34972459Development of a microfluidic "click chip" incorporating an immobilized Cu(I) catalyst
Q38018817Digital microfluidics: a versatile tool for applications in chemistry, biology and medicine
Q58584940Electrical Tweezer for Droplet Transportation, Extraction, Merging and DNA Analysis
Q50467477Fish in chips: an automated microfluidic device to study drug dynamics in vivo using zebrafish embryos
Q40864618In Situ Click Chemistry for the Identification of a Potent D-Amino Acid Oxidase Inhibitor
Q33537994Integrated Microfluidic Reactors
Q37707912Integrated microfluidic and imaging platform for a kinase activity radioassay to analyze minute patient cancer samples
Q92888217Investigation of the Influence of Glucose Concentration on Cancer Cells by Using a Microfluidic Gradient Generator without the Induction of Large Shear Stress
Q36590531Microfabricated Systems and Assays for Studying the Cytoskeletal Organization, Micromechanics, and Motility Patterns of Cancerous Cells
Q37941326Microfluidic devices: useful tools for bioprocess intensification.
Q37774061Microfluidics for positron emission tomography probe development
Q30463697Molecular Imaging Probe Development using Microfluidics.
Q27679971Observation of the controlled assembly of preclick components in the in situ click chemistry generation of a chitinase inhibitor
Q48192297On-chip integration of organic synthesis and HPLC/MS analysis for monitoring stereoselective transformations at the micro-scale.
Q47442360Organ-On-A-Chip Platforms: A Convergence of Advanced Materials, Cells, and Microscale Technologies
Q30557385Pneumatic oscillator circuits for timing and control of integrated microfluidics
Q28075935Recent Advances in Recoverable Systems for the Copper-Catalyzed Azide-Alkyne Cycloaddition Reaction (CuAAC)
Q36520996Screening applications in drug discovery based on microfluidic technology.
Q33877498Screening of protein-protein interaction modulators via sulfo-click kinetic target-guided synthesis
Q40062260Semi-autonomous liquid handling via on-chip pneumatic digital logic
Q90170351Tailored therapeutics based on 1,2,3-1H-triazoles: a mini review
Q46497666Temperature-driven self-actuated microchamber sealing system for highly integrated microfluidic devices
Q47673030Why microfluidics? Merits and trends in chemical synthesis

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