Bcl-XL-templated assembly of its own protein-protein interaction modulator from fragments decorated with thio acids and sulfonyl azides (scientific article)

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BH3-Only proteins-essential initiators of apoptotic cell death

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In situ click chemistry: a powerful means for lead discovery

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Structural basis of macromolecular recognition

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Dynamic Combinatorial Chemistry

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Using an Enzyme's Active Site To Template Inhibitors This work was supported by the Centre National de la Recherche Scientifique and by the Ecole Polytechnique (predoctoral fellowship to R.N.). We thank Prof. Jean-Marie Lehn for stimulating discussi

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P433

issue

P407

language of work or name

English

Q1860

P921

main subject

protein-protein interaction

Q896177

P304

page(s)

13820-13821

P577

publication date

2008-09-24

P1433

published in

Journal of the American Chemical Society

Q898902

P1476

title

Bcl-XL-templated assembly of its own protein-protein interaction modulator from fragments decorated with thio acids and sulfonyl azides

P478

volume

130

Reverse relations

cites work (P2860)

Q33883864	An integrated microfluidic device for large-scale in situ click chemistry screening
Q34494985	Chemical ligation of epoxide-containing fusicoccins and peptide fragments guided by 14-3-3 protein.
Q30860139	Chitinase inhibitors: extraction of the active framework from natural argifin and use of in situ click chemistry
Q47626141	Discovery and Optimization of Potent, Cell-Active Pyrazole-Based Inhibitors of Lactate Dehydrogenase (LDH).
Q35880102	Discovery of marinopyrrole A (maritoclax) as a selective Mcl-1 antagonist that overcomes ABT-737 resistance by binding to and targeting Mcl-1 for proteasomal degradation
Q37579402	Dynamic template-assisted strategies in fragment-based drug discovery.
Q27675317	Evaluation of Diverse α/β-Backbone Patterns for Functional α-Helix Mimicry: Analogues of the Bim BH3 Domain
Q41916714	Extending foldamer design beyond α-helix mimicry: α/β-peptide inhibitors of vascular endothelial growth factor signaling.
Q37952065	Green chemistry oriented organic synthesis in water
Q41955342	Hybrid organic-inorganic inhibitors of a PDZ interaction that regulates the endocytic fate of CFTR.
Q40525758	Irreversible inhibitors of the 3C protease of Coxsackie virus through templated assembly of protein-binding fragments
Q28072198	Kinetic target-guided synthesis in drug discovery and chemical biology: a comprehensive facts and figures survey
Q38542959	New insights into the kinetic target-guided synthesis of protein ligands
Q39465921	Novel naphthalimide-benzoic acid conjugates as potential apoptosis-inducing agents: design, synthesis, and biological activity
Q91489150	Optimized Inhibitors of MDM2 via an Attempted Protein-Templated Reductive Amination
Q42314613	Protein-Templated Formation of an Inhibitor of the Blood Coagulation Factor Xa through a Background-Free Amidation Reaction
Q34549950	Protein-Templated Fragment Ligations-From Molecular Recognition to Drug Discovery.
Q92096445	Proteintemplat-gesteuerte Fragmentligationen - von der molekularen Erkennung zur Wirkstofffindung
Q34098670	Recent development of two chitinase inhibitors, Argifin and Argadin, produced by soil microorganisms
Q33877498	Screening of protein-protein interaction modulators via sulfo-click kinetic target-guided synthesis
Q27670755	Structural Basis of Bcl-xL Recognition by a BH3-Mimetic α/β-Peptide Generated by Sequence-Based Design
Q33882139	Structural mimicry of the α-helix in aqueous solution with an isoatomic α/β/γ-peptide backbone
Q60917739	The transcription factor STAT5 catalyzes Mannich ligation reactions yielding inhibitors of leukemic cell proliferation