Hybrid organic-inorganic inhibitors of a PDZ interaction that regulates the endocytic fate of CFTR.

scientific article published on 14 June 2012

Hybrid organic-inorganic inhibitors of a PDZ interaction that regulates the endocytic fate of CFTR. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1002/ANIE.201202291
P932PMC publication ID3677582
P698PubMed publication ID22700245

P2093author name stringYu Zhao
Dean R Madden
Brian V Popp
Zachary T Ball
Rituparna Kundu
Patrick R Cushing
P2860cites workComputational design of a PDZ domain peptide inhibitor that rescues CFTR activityQ21145315
A Golgi-associated PDZ domain protein modulates cystic fibrosis transmembrane regulator plasma membrane expressionQ24291900
Structure-Based Design of an Organoruthenium Phosphatidyl-inositol-3-kinase Inhibitor Reveals a Switch Governing Lipid Kinase Potency and SelectivityQ27650628
Potent inhibitors of HCV-NS3 protease derived from boronic acidsQ27652966
Structural basis for the design of novel Schiff base metal chelate inhibitors of trypsinQ27660118
Structurally Sophisticated Octahedral Metal Complexes as Highly Selective Protein Kinase InhibitorsQ27667351
Design of potent selective zinc-mediated serine protease inhibitorsQ27748863
Unraveling hot spots in binding interfaces: progress and challengesQ29614463
Bcl-XL-templated assembly of its own protein-protein interaction modulator from fragments decorated with thio acids and sulfonyl azidesQ33371280
Structure-selective modification of aromatic side chains with dirhodium metallopeptide catalystsQ33564837
Engineering Peptide Inhibitors To Overcome PDZ Binding PromiscuityQ33755113
Screening of protein-protein interaction modulators via sulfo-click kinetic target-guided synthesisQ33877498
Metallotherapeutics: novel strategies in drug designQ34775956
Plasma membrane CFTR regulates RANTES expression via its C-terminal PDZ-interacting motifQ34811102
Tethering: fragment-based drug discoveryQ35771569
Specific inhibition of the transcription factor Ci by a cobalt(III) Schiff base-DNA conjugateQ35855730
Interactions of metal-metal-bonded antitumor active complexes with DNA fragments and DNA.Q36040618
The design of coiled-coil structures and assembliesQ36101270
Design and characterization of the anion-sensitive coiled-coil peptideQ36280492
A decade of fragment-based drug design: strategic advances and lessons learnedQ36732253
Orientation and oligomerization specificity of the Bcr coiled-coil oligomerization domainQ36853551
Targeted inhibition of Snail family zinc finger transcription factors by oligonucleotide-Co(III) Schiff base conjugateQ37310555
Metal-directed protein self-assemblyQ37700461
2D NMR spectroscopic evidence for unprecedented interactions of cis-[Rh2(dap)(mu-O2CCH3)2(eta1-O2CCH3)(CH3OH)](O2CCH3) with a DNA oligonucleotide: combination of intercalative and coordinative bindingQ38310393
A PDZ-binding motif is essential but not sufficient to localize the C terminus of CFTR to the apical membraneQ40828205
Inhibition of thermolysin and human alpha-thrombin by cobalt(III) Schiff base complexesQ41678159
The relative binding affinities of PDZ partners for CFTR: a biochemical basis for efficient endocytic recyclingQ41893473
Interaction of [Rh(2)(O(2)CCH(3))(4)(H(2)O)(2)] and [Rh(2)(O(2)CCH(OH)Ph)(2)(phen)(2)(H(2)O)(2)](O(2)C-CH(OH)Ph)(2) With Sulfhydryl Compounds and CeruloplasminQ41979067
A stabilizing influence: CAL PDZ inhibition extends the half-life of ΔF508-CFTR.Q42031640
Potent and selective peptidyl boronic acid inhibitors of the serine protease prostate-specific antigenQ42177972
Helix induction by dirhodium: access to biocompatible metallopeptides with defined secondary structure.Q43089314
Surface recognition of a protein using designed transition metal complexesQ43654052
Designing heterodimeric two-stranded alpha-helical coiled-coils. Effects of hydrophobicity and alpha-helical propensity on protein folding, stability, and specificityQ44077318
Metal ions as cofactors for the binding of inhibitors to methionine aminopeptidase: a critical view of the relevance of in vitro metalloenzyme assaysQ46478854
Iridium complex with antiangiogenic properties.Q54676811
Influencing Receptor−Ligand Binding Mechanisms with Multivalent Ligand ArchitectureQ56656697
Proximity-driven metallopeptide catalysis: Remarkable side-chain scope enables modification of the Fos bZip domainQ58482027
Inhibition of Deamination of Arabinosylcytosine (NSC-63878) by Rhodium(II) AcetateQ67353013
Hydrophobicity of several rhodium(II) carboxylates correlated with their biologic activityQ67587691
The interaction of rhodium(II) carboxylates with enzymesQ68208459
Stabilization of the α-Helical Coiled-coil Domain in Laminin by C-terminal Disulfide BondsQ71849884
Dirhodium(II,II) complexes: molecular characteristics that affect in vitro activityQ79416353
Association of the cystic fibrosis transmembrane regulator with CAL: structural features and molecular dynamicsQ81582178
Controlling peptide structure with coordination chemistry: robust and reversible peptide-dirhodium ligationQ84303921
Polyvalent Interactions in Biological Systems: Implications for Design and Use of Multivalent Ligands and InhibitorsQ88519588
P433issue29
P407language of work or nameEnglishQ1860
P304page(s)7217-7220
P577publication date2012-06-14
P1433published inAngewandte Chemie International EditionQ62023953
P1476titleHybrid organic-inorganic inhibitors of a PDZ interaction that regulates the endocytic fate of CFTR.
P478volume51

Reverse relations

cites work (P2860)
Q41549856Assessing the intracellular fate of rhodium(ii) complexes
Q34066239Chemically modified peptide scaffolds target the CFTR-associated ligand PDZ domain
Q52689243Cysteine modifiers suggest an allosteric inhibitory site on the CAL PDZ domain.
Q27021652Getting in shape: controlling peptide bioactivity and bioavailability using conformational constraints
Q35582339Intracellular Delivery of Peptidyl Ligands by Reversible Cyclization: Discovery of a PDZ Domain Inhibitor that Rescues CFTR Activity
Q38314370Modulating protein-protein interactions: the potential of peptides
Q35235856Molecular recognition in protein modification with rhodium metallopeptides
Q45073074Potent and selective inhibition of SH3 domains with dirhodium metalloinhibitors
Q26866201Protein design: toward functional metalloenzymes
Q37295115Rhodium(II) Proximity-Labeling Identifies a Novel Target Site on STAT3 for Inhibitors with Potent Anti-Leukemia Activity
Q58482019Sequence-specific inhibition of a designed metallopeptide catalyst
Q91913292Specificity in PDZ-peptide interaction networks: Computational analysis and review
Q38539666Structure-Based Design of Inhibitors of Protein-Protein Interactions: Mimicking Peptide Binding Epitopes.

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