Tethering: fragment-based drug discovery

scientific article published on January 2004

Tethering: fragment-based drug discovery is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

External links are
P356DOI10.1146/ANNUREV.BIOPHYS.33.110502.140409
P698PubMed publication ID15139811
P5875ResearchGate publication ID8565817

P2093author name stringJames A Wells
Daniel A Erlanson
Andrew C Braisted
P921main subjectdrug discoveryQ1418791
P304page(s)199-223
P577publication date2004-01-01
P1433published inAnnual Review of Biophysics and Biomolecular StructureQ26853798
P1476titleTethering: fragment-based drug discovery
P478volume33

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cites work (P2860)
Q44528059A century at the chemistry-biology interface
Q34595353A common allosteric site and mechanism in caspases
Q36732253A decade of fragment-based drug design: strategic advances and lessons learned
Q31145317A family of phosphodiesterase inhibitors discovered by cocrystallography and scaffold-based drug design
Q35175346A fragment-based method to discover irreversible covalent inhibitors of cysteine proteases
Q27684920A method for the second-site screening of K-Ras in the presence of a covalently attached first-site ligand
Q34541773A multipronged approach for compiling a global map of allosteric regulation in the apoptotic caspases
Q33924947A novel potential therapeutic avenue for autism: design, synthesis and pharmacophore generation of SSRIs with dual action
Q33547251A rapid oxime linker-based library approach to identification of bivalent inhibitors of the Yersinia pestis protein-tyrosine phosphatase, YopH.
Q27664106A remote arene-binding site on prostate specific membrane antigen revealed by antibody-recruiting small molecules
Q24644915A tethering mechanism for length control in a processive carbohydrate polymerization
Q28287639Advances in Bioconjugation
Q35848043Advantages of crystallographic fragment screening: functional and mechanistic insights from a powerful platform for efficient drug discovery
Q36884733Allosteric Inhibition of Bcr-Abl Kinase by High Affinity Monobody Inhibitors Directed to the Src Homology 2 (SH2)-Kinase Interface
Q27680467Allosteric Inhibition of the NS2B-NS3 Protease from Dengue Virus
Q30370820Allosteric regulation and catalysis emerge via a common route.
Q33601580Allosteric regulation of protease activity by small molecules.
Q36083038An NMR-Guided Screening Method for Selective Fragment Docking and Synthesis of a Warhead Inhibitor.
Q56395829An expanded allosteric network in PTP1B by multitemperature crystallography, fragment screening, and covalent tethering
Q98771871Application of Fragment-Based Drug Discovery to Versatile Targets
Q46774673Challenges facing the biologist doing chemical genetics
Q36685852Chemical crosshairs on the central dogma
Q57307431Chemical space of Escherichia coli dihydrofolate reductase inhibitors: New approaches for discovering novel drugs for old bugs
Q34598558Combined mass spectrometry and dynamic chemistry approach to identify metalloenzyme inhibitors
Q27650049Comprehensive Mechanistic Analysis of Hits from High-Throughput and Docking Screens against β-Lactamase
Q38364115Computer applications for prediction of protein-protein interactions and rational drug design.
Q42225889Computer-aided design and discovery of protein-protein interaction inhibitors as agents for anti-HIV therapy
Q37401733Conduits of life's spark: a perspective on ion channel research since the birth of neuron
Q57751804Conservation of coactivator engagement mechanism enables small-molecule allosteric modulators
Q36072400Covalent Tethering of Fragments For Covalent Probe Discovery
Q37394041Covalent capture: merging covalent and noncovalent synthesis
Q33710476Covalent conjugation of a peptide triazole to HIV-1 gp120 enables intramolecular binding site occupancy
Q34414451Covalent small molecule inhibitors of Ca(2+)-bound S100B.
Q33515335Creating protein affinity reagents by combining peptide ligands on synthetic DNA scaffolds
Q88815851Cryptic binding sites on proteins: definition, detection, and druggability
Q79314147Deconstructing fragment-based inhibitor discovery
Q29038357Dependence of Effective Molarity on Linker Length for an Intramolecular Protein−Ligand System
Q33417723Design of compound libraries for fragment screening
Q58837454Developing Small-Molecule Inhibitors of HECT-Type Ubiquitin Ligases for Therapeutic Applications: Challenges and Opportunities
Q26784027Direct and Propagated Effects of Small Molecules on Protein-Protein Interaction Networks
Q40523781Discovery of a Potent Allosteric Kinase Modulator by Combining Computational and Synthetic Methods
Q30831384Discovery of an allosteric site in the caspases
Q33211921Disulfide trapping to localize small-molecule agonists and antagonists for a G protein-coupled receptor
Q28553211Disulfide-Trapping Identifies a New, Effective Chemical Probe for Activating the Nuclear Receptor Human LRH-1 (NR5A2)
Q34464112Dynamic combinatorial chemistry: a tool to facilitate the identification of inhibitors for protein targets.
Q34389280Dynamic combinatorial/covalent chemistry: a tool to read, generate and modulate the bioactivity of compounds and compound mixtures
Q37579402Dynamic template-assisted strategies in fragment-based drug discovery.
Q46276303Engineering peptide ligase specificity by proteomic identification of ligation sites.
Q35009555Evolutions in fragment-based drug design: the deconstruction-reconstruction approach
Q27936541Exploitation of latent allostery enables the evolution of new modes of MAP kinase regulation
Q53834774Exploring the structural origins of cryptic sites on proteins.
Q90257936Extending the Detection Limit in Fragment Screening of Proteins Using Reverse Micelle Encapsulation
Q39085729FP Tethering: a screening technique to rapidly identify compounds that disrupt protein-protein interactions
Q26996645Features of protein-protein interactions that translate into potent inhibitors: topology, surface area and affinity
Q33325589Flexible nets: disorder and induced fit in the associations of p53 and 14-3-3 with their partners
Q90299052Fragment Pose Prediction Using Non-equilibrium Candidate Monte Carlo and Molecular Dynamics Simulations
Q27676351Fragment deconstruction of small, potent factor Xa inhibitors: exploring the superadditivity energetics of fragment linking in protein-ligand complexes
Q37995087Fragment informatics and computational fragment-based drug design: an overview and update
Q26826945Fragment screening and HIV therapeutics
Q27676592Fragment-Based Screening for Inhibitors of PDE4A Using Enthalpy Arrays and X-ray Crystallography
Q34345451Fragment-based drug discovery using NMR spectroscopy
Q28262032Fragment-based lead discovery: leads by design
Q38211688Harnessing allostery: a novel approach to drug discovery
Q52685551High-Throughput Kinetic Analysis for Target-Directed Covalent Ligand Discovery.
Q41955342Hybrid organic-inorganic inhibitors of a PDZ interaction that regulates the endocytic fate of CFTR.
Q27674057Identification of Cys255 in HIF-1α as a novel site for development of covalent inhibitors of HIF-1α/ARNT PasB domain protein-protein interaction
Q40836289Identification of specific tethered inhibitors for caspase-5.
Q92443122Identifying Ortholog Selective Fragment Molecules for Bacterial Glutaredoxins by NMR and Affinity Enhancement by Modification with an Acrylamide Warhead
Q47750102Impact of a Central Scaffold on the Binding Affinity of Fragment Pairs Isolated from DNA-Encoded Self-Assembling Chemical Libraries.
Q27655287Impact of linker strain and flexibility in the design of a fragment-based inhibitor
Q38029118In silico fragment-based drug design
Q34626302In situ click chemistry: a powerful means for lead discovery
Q58488710In vitro selection of a peptide aptamer that potentiates inhibition of cyclin-dependent kinase 2 by purvalanol
Q36731111Inhibiting transient protein-protein interactions: lessons from the Cdc25 protein tyrosine phosphatases
Q46691166Inhibition of the calcineurin-NFAT interaction by small organic molecules reflects binding at an allosteric site
Q28656132Inhibitor of MYC identified in a Kröhnke pyridine library
Q87406316Kinetic template-guided tethering of fragments
Q35616254Ligand deconstruction: Why some fragment binding positions are conserved and others are not
Q36677212Ligand-based vascular targeting of disease
Q27664411Loop-Swapped Chimeras of the Agouti-Related Protein and the Agouti Signaling Protein Identify Contacts Required for Melanocortin 1 Receptor Selectivity and Antagonism
Q51239957Metal ion site engineering indicates a global toggle switch model for seven-transmembrane receptor activation.
Q33261442Mimicking damaged DNA with a small molecule inhibitor of human UNG2.
Q27649995Minimal Pharmacophoric Elements and Fragment Hopping, an Approach Directed at Molecular Diversity and Isozyme Selectivity. Design of Selective Neuronal Nitric Oxide Synthase Inhibitors
Q60458527Modulating the masters: chemical tools to dissect CBP and p300 function
Q43232912Molecular basis of cytokine signalling--theme and variations
Q28079554Motif mediated protein-protein interactions as drug targets
Q37149486Multivalency-assisted control of intracellular signaling pathways: application for ubiquitin- dependent N-end rule pathway
Q48166476NMR-Fragment Based Virtual Screening: A Brief Overview
Q28298611Navigating chemical space for biology and medicine
Q47214042Novel K-Ras G12C Switch-II covalent binders destabilize Ras and accelerate nucleotide exchange
Q36723089On-Demand Targeting: Investigating Biology with Proximity-Directed Chemistry
Q38195457Oncogenic protein interfaces: small molecules, big challenges.
Q34930997Perspectives on NMR in drug discovery: a technique comes of age
Q34522767Plucking the high hanging fruit: a systematic approach for targeting protein-protein interactions
Q38199945Probing secondary interactions in biomolecular recognition by dynamic combinatorial chemistry
Q42284251Profiling the dynamic interfaces of fluorinated transcription complexes for ligand discovery and characterization
Q42747306Protein binding: Antibody surrogates click into place
Q26738763Protein-Directed Dynamic Combinatorial Chemistry: A Guide to Protein Ligand and Inhibitor Discovery
Q46403752Quantifying Escherichia coli glutaredoxin-3 substrate specificity using ligand-induced stability
Q33259490Random mutagenesis of the complement factor 5a (C5a) receptor N terminus provides a structural constraint for C5a docking
Q91796904Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening
Q33432440Rapid identification of improved protein ligands using peptoid microarrays
Q46107918Ras Binder Induces a Modified Switch-II Pocket in GTP and GDP States
Q47687205Reduced dimensionality (4,3)D-hnCOCANH experiment: an efficient backbone assignment tool for NMR studies of proteins
Q33530277Seamless bead to microarray screening: rapid identification of the highest affinity protein ligands from large combinatorial libraries
Q33230098Selective delivery of therapeutic agents for the diagnosis and treatment of cancer
Q42645907Selective, rapid and optically switchable regulation of protein function in live mammalian cells.
Q80891407Sensitized detection of inhibitory fragments and iterative development of non-peptidic protease inhibitors by dynamic ligation screening
Q48913104Silent, fluorescent labeling of native neuronal receptors
Q45154618Site-specific disulfide capture of agonist and antagonist peptides on the C5a receptor
Q26785992Small Molecule Targeting of Protein-Protein Interactions through Allosteric Modulation of Dynamics
Q34311126Small molecule ion channel match making: a natural fit for new ASIC ligands.
Q34263719Small-molecule inhibitors of protein-protein interactions: progressing toward the reality
Q36908318Solid-phase glycan isolation for glycomics analysis
Q42675145Some Trends in Chem(o)informatics
Q40144153Specific modulation of protein activity by using a bioorthogonal reaction
Q35738960State-of-the-art strategies for targeting protein-protein interactions by small-molecule inhibitors
Q30992306Strategies for stabilizing superoxide dismutase (SOD1), the protein destabilized in the most common form of familial amyotrophic lateral sclerosis
Q42411842Structural analysis of caspase-1 inhibitors derived from Tethering.
Q27649211Structural genomics of protein phosphatases
Q38784214Structure and reactivity of Trypanosoma brucei pteridine reductase: inhibition by the archetypal antifolate methotrexate
Q56970008Structure-Based Drug Discovery Without Structure: Working Around the Paradox to Disrupt Protein-Protein Associations
Q35654150Structure-based redesign of an edema toxin inhibitor
Q90170351Tailored therapeutics based on 1,2,3-1H-triazoles: a mini review
Q34347892Targeting protein-protein interactions as an anticancer strategy
Q33935824Temperature-sensitive protein-DNA dimerizers
Q34520855The GABA(A) receptor as a target for photochromic molecules
Q60921637The chemical diversity and structure-based discovery of allosteric modulators for the PIF-pocket of protein kinase PDK1
Q34274356The impact of click chemistry in medicinal chemistry
Q28472769The overlap of small molecule and protein binding sites within families of protein structures
Q26995817The pharmacological landscape and therapeutic potential of serine hydrolases
Q54484266The three-dimensional structures of tick carboxypeptidase inhibitor in complex with A/B carboxypeptidases reveal a novel double-headed binding mode.
Q34373258Therapeutic Targeting of Myc.
Q27667313Turning a protein kinase on or off from a single allosteric site via disulfide trapping
Q36494279Unique MAP Kinase binding sites
Q64327308Using Fragment-Based Approaches to Discover New Antibiotics
Q91666995Vinyl sulfonamide synthesis for irreversible tethering via a novel α-selenoether protection strategy
Q30864246Virtual fragment screening: an exploration of various docking and scoring protocols for fragments using Glide
Q34368348Virtual fragment screening: exploration of MM-PBSA re-scoring

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