MCC-555-induced NAG-1 expression is mediated in part by KLF4.

scientific article

MCC-555-induced NAG-1 expression is mediated in part by KLF4. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.EJPHAR.2010.03.055
P932PMC publication ID2878920
P698PubMed publication ID20385121
P5875ResearchGate publication ID43130334

P2093author name stringSeung Joon Baek
Michael F McEntee
Maria Cekanova
Seong-Ho Lee
P2860cites workOverexpression of Krüppel-like factor 4 in the human colon cancer cell line RKO leads to reduced tumorigenecityQ24649675
The gut-enriched Kruppel-like factor (Kruppel-like factor 4) mediates the transactivating effect of p53 on the p21WAF1/Cip1 promoterQ24653488
Ligands for peroxisome proliferator-activated receptorgamma and retinoic acid receptor inhibit growth and induce apoptosis of human breast cancer cells in vitro and in BNX miceQ28368272
Haploinsufficiency of Krüppel-like factor 4 promotes adenomatous polyposis coli dependent intestinal tumorigenesisQ28592219
Oncogene expression cloning by retroviral transduction of adenovirus E1A-immortalized rat kidney RK3E cells: transformation of a host with epithelial features by c-MYC and the zinc finger protein GKLF.Q30727226
15-deoxy-Delta12,14 prostaglandin J2 up-regulates Kruppel-like factor 4 expression independently of peroxisome proliferator-activated receptor gamma by activating the mitogen-activated protein kinase kinase/extracellular signal-regulated kinase signQ30858775
Gut-enriched Krüppel-like factor represses cyclin D1 promoter activity through Sp1 motifQ33617171
Increase of GKLF messenger RNA and protein expression during progression of breast cancerQ33927101
Identification of Krüppel-like factor 4 as a potential tumor suppressor gene in colorectal cancerQ34290018
Drastic down-regulation of Krüppel-like factor 4 expression is critical in human gastric cancer development and progressionQ34408251
The KLF4 tumour suppressor is a transcriptional repressor of p53 that acts as a context-dependent oncogeneQ34462232
Altered expression of the KLF4 in colorectal cancersQ34543574
PPAR dual agonists: are they opening Pandora's Box?Q34618271
Cellular and molecular consequences of peroxisome proliferator-activated receptor-gamma activation in ovarian cancer cellsQ35249254
Gene alterations by peroxisome proliferator-activated receptor gamma agonists in human colorectal cancer cellsQ36825482
Peroxisome proliferator-activated receptor ligand MCC-555 suppresses intestinal polyps in ApcMin/+ mice via extracellular signal-regulated kinase and peroxisome proliferator-activated receptor-dependent pathwaysQ37001526
ESE-1/EGR-1 pathway plays a role in tolfenamic acid-induced apoptosis in colorectal cancer cellsQ37098082
KLF4-dependent, PPARgamma-induced expression of GPA33 in colon cancer cell lines.Q37468620
Troglitazone, a peroxisome proliferator-activated receptor gamma (PPAR gamma ) ligand, selectively induces the early growth response-1 gene independently of PPAR gamma. A novel mechanism for its anti-tumorigenic activity.Q38359904
2-cyano-lup-1-en-3-oxo-20-oic acid, a cyano derivative of betulinic acid, activates peroxisome proliferator-activated receptor gamma in colon and pancreatic cancer cellsQ40088710
Structure-dependent activity of glycyrrhetinic acid derivatives as peroxisome proliferator-activated receptor {gamma} agonists in colon cancer cellsQ40130462
1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes inhibit ovarian cancer cell growth through peroxisome proliferator-activated receptor-dependent and independent pathwaysQ40286893
Peroxisome proliferator-activated receptor-gamma (PPAR(gamma)) inhibits tumorigenesis by reversing the undifferentiated phenotype of metastatic non-small-cell lung cancer cells (NSCLC).Q40479158
RWJ-241947 (MCC-555), a unique peroxisome proliferator-activated receptor-gamma ligand with antitumor activity against human prostate cancer in vitro and in beige/nude/ X-linked immunodeficient mice and enhancement of apoptosis in myeloma cells induQ40587179
Placental transforming growth factor-beta is a downstream mediator of the growth arrest and apoptotic response of tumor cells to DNA damage and p53 overexpressionQ40884700
Cyclooxygenase inhibitors regulate the expression of a TGF-beta superfamily member that has proapoptotic and antitumorigenic activities.Q42501465
Molecular cloning and characterization of human nonsteroidal anti-inflammatory drug-activated gene promoter. Basal transcription is mediated by Sp1 and Sp3.Q42507061
Resveratrol enhances the expression of non-steroidal anti-inflammatory drug-activated gene (NAG-1) by increasing the expression of p53.Q43918569
Dual function of nonsteroidal anti-inflammatory drugs (NSAIDs): inhibition of cyclooxygenase and induction of NSAID-activated geneQ44002371
Peroxisome proliferator-activated receptor gamma agonists induce proteasome-dependent degradation of cyclin D1 and estrogen receptor alpha in MCF-7 breast cancer cells.Q44342291
Indole-3-carbinol and 3,3'-diindolylmethane induce expression of NAG-1 in a p53-independent mannerQ45238294
Loss-of-Function Mutations in PPARγ Associated with Human Colon CancerQ57567933
Nonsteroidal anti-inflammatory drug-activated gene-1 over expression in transgenic mice suppresses intestinal neoplasiaQ79353945
Loss of Klf4 in mice causes altered proliferation and differentiation and precancerous changes in the adult stomachQ81640280
A novel peroxisome proliferator-activated receptor gamma ligand, MCC-555, induces apoptosis via posttranscriptional regulation of NAG-1 in colorectal cancer cellsQ83862119
P433issue1-3
P407language of work or nameEnglishQ1860
P304page(s)30-37
P577publication date2010-04-10
P1433published inEuropean Journal of PharmacologyQ1376712
P1476titleMCC-555-induced NAG-1 expression is mediated in part by KLF4.
P478volume637

Reverse relations

cites work (P2860)
Q36238466A peroxisome proliferator-activated receptor ligand MCC-555 imparts anti-proliferative response in pancreatic cancer cells by PPARgamma-independent up-regulation of KLF4.
Q36497247CDX2-driven leukemogenesis involves KLF4 repression and deregulated PPARγ signaling
Q55486841CRP Stimulates GDF15 Expression in Endothelial Cells through p53.
Q42768698Ethanol-induced changes in poly (ADP ribose) polymerase and neuronal developmental gene expression
Q55504431Mutations of p53 decrease sensitivity to the anthracycline treatments in bladder cancer cells.
Q34168476Nuclear receptors and pathogenesis of pancreatic cancer.
Q36596231Peroxisome proliferator-activated receptor γ agonists induce cell cycle arrest through transcriptional regulation of Kruppel-like factor 4 (KLF4)
Q38790569Secreted growth differentiation factor 15 as a potential biomarker for mitochondrial dysfunctions in aging and age-related disorders

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