Supernumerary centrosomes nucleate extra cilia and compromise primary cilium signaling

scientific article

Supernumerary centrosomes nucleate extra cilia and compromise primary cilium signaling is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.CUB.2012.06.057
P932PMC publication ID4094149
P698PubMed publication ID22840514
P5875ResearchGate publication ID230575658

P50authorTim StearnsQ27734166
Moe R MahjoubQ56994033
P2093author name stringTim Stearns
Moe R Mahjoub
P2860cites workThe Polo kinase Plk4 functions in centriole duplicationQ24292705
Candidate exome capture identifies mutation of SDCCAG8 as the cause of a retinal-renal ciliopathyQ24299464
Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathwaysQ24302034
Centrosome overduplication and mitotic instability in PKD2 transgenic linesQ24336465
Ciliary and centrosomal defects associated with mutation and depletion of the Meckel syndrome genes MKS1 and MKS3Q24337720
The tuberous sclerosis complexQ24628011
Vertebrate Smoothened functions at the primary ciliumQ27919682
Trafficking to the ciliary membrane: how to get across the periciliary diffusion barrier?Q27967655
A septin diffusion barrier at the base of the primary cilium maintains ciliary membrane protein distributionQ28000024
Intraflagellar transportQ28131775
Hamartin, the tuberous sclerosis complex 1 gene product, interacts with polo-like kinase 1 in a phosphorylation-dependent mannerQ28285939
The ciliary pocket: an endocytic membrane domain at the base of primary and motile ciliaQ28504947
Patched1 regulates hedgehog signaling at the primary ciliumQ29547515
Morphogenesis and oncogenesis of MCF-10A mammary epithelial acini grown in three-dimensional basement membrane culturesQ29547700
Ciliopathies: an expanding disease spectrumQ34626170
Subcellular spatial regulation of canonical Wnt signalling at the primary ciliumQ35022258
Cilium, centrosome and cell cycle regulation in polycystic kidney disease.Q35112926
Tuberous sclerosis complex: neurological, renal and pulmonary manifestationsQ36239644
Small-molecule inhibitors reveal multiple strategies for Hedgehog pathway blockadeQ37291730
Loss of polycystin-1 causes centrosome amplification and genomic instabilityQ37294781
Targeting proteins to the ciliary membrane.Q37369328
Centrosomes and cancer: how cancer cells divide with too many centrosomes.Q37373434
Centriole maturation and transformation to basal bodyQ37549168
The trypanosome flagellar pocket.Q37608926
The life cycle of centriolesQ37627202
The ciliary pocket: a once-forgotten membrane domain at the base of ciliaQ37833125
Strange as it may seem: the many links between Wnt signaling, planar cell polarity, and ciliaQ37834841
The imidazopyridine derivative JK184 reveals dual roles for microtubules in Hedgehog signalingQ39883111
The tuberous sclerosis proteins regulate formation of the primary cilium via a rapamycin-insensitive and polycystin 1-independent pathwayQ39930668
P4510describes a project that usesImageJQ1659584
P433issue17
P407language of work or nameEnglishQ1860
P304page(s)1628-1634
P577publication date2012-07-26
P1433published inCurrent BiologyQ1144851
P1476titleSupernumerary centrosomes nucleate extra cilia and compromise primary cilium signaling
P478volume22

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cites work (P2860)
Q390214185-HT6 receptor blockade regulates primary cilia morphology in striatal neurons.
Q57651406A centriolar FGR1 oncogene partner-like protein required for paraflagellar rod assembly, but not axoneme assembly in African trypanosomes
Q35877495A conserved role for Notch signaling in priming the cellular response to Shh through ciliary localisation of the key Shh transducer Smo.
Q27308959An Asp-CaM complex is required for centrosome-pole cohesion and centrosome inheritance in neural stem cells
Q22001107An inducible CiliaGFP mouse model for in vivo visualization and analysis of cilia in live tissue.
Q38763176Anticystogenic activity of a small molecule PAK4 inhibitor may be a novel treatment for autosomal dominant polycystic kidney disease
Q26824247Atypical centrioles during sexual reproduction
Q36392131C-NAP1 and rootletin restrain DNA damage-induced centriole splitting and facilitate ciliogenesis.
Q33959946Causes and consequences of centrosome abnormalities in cancer
Q34504028Cby1 promotes Ahi1 recruitment to a ring-shaped domain at the centriole-cilium interface and facilitates proper cilium formation and function
Q35627209Cell context-specific expression of primary cilia in the human testis and ciliary coordination of Hedgehog signalling in mouse Leydig cells
Q64898314Centriolar satellites are required for efficient ciliogenesis and ciliary content regulation.
Q37415464Centrosomal abnormalities characterize human and rodent cystic cholangiocytes and are associated with Cdc25A overexpression.
Q38993086Centrosome Amplification Is Sufficient to Promote Spontaneous Tumorigenesis in Mammals
Q64950616Centrosome amplification disrupts renal development and causes cystogenesis.
Q35911257Centrosome amplification induces high grade features and is prognostic of worse outcomes in breast cancer
Q38780267Centrosome amplification: a suspect in breast cancer and racial disparities
Q35127960Centrosome-kinase fusions promote oncogenic signaling and disrupt centrosome function in myeloproliferative neoplasms
Q38614245Centrosomes and cancer: revisiting a long-standing relationship
Q52972875Centrosomes and mitotic spindle poles: a recent liaison?
Q38650721Centrosomes in the DNA damage response--the hub outside the centre
Q41001236Chromosomal contacts connect loci associated with autism, BMI and head circumference phenotypes
Q36183766Ciliary abnormalities in senescent human fibroblasts impair proliferative capacity
Q41919525Consequences of Centrosome Dysfunction During Brain Development
Q58697477Cyclin-dependent kinase control of motile ciliogenesis
Q24295076Discovering regulators of centriole biogenesis through siRNA-based functional genomics in human cells
Q39363632Dividing with Extra Centrosomes: A Double Edged Sword for Cancer Cells.
Q36305968Epidermal development, growth control, and homeostasis in the face of centrosome amplification
Q30584680Excess centrosomes disrupt endothelial cell migration via centrosome scattering.
Q36629765Genetic background of nonmutant Piebald-Virol-Glaxo rats does not influence nephronophthisis phenotypes
Q27005693How do cilia organize signalling cascades?
Q35797268Katanin p80 regulates human cortical development by limiting centriole and cilia number
Q30416758Myb promotes centriole amplification and later steps of the multiciliogenesis program.
Q49831825Once and only once: mechanisms of centriole duplication and their deregulation in disease
Q30580976Oncogene-like induction of cellular invasion from centrosome amplification
Q41868756Over-expression of Plk4 induces centrosome amplification, loss of primary cilia and associated tissue hyperplasia in the mouse.
Q47368506PLK4: a link between centriole biogenesis and cancer
Q47675920Parthenogenesis in Insects: The Centriole Renaissance
Q34665151Q&A: Who needs a centrosome?
Q41040305Reduced primary cilia length and altered Arl13b expression are associated with deregulated chondrocyte Hedgehog signaling in alkaptonuria.
Q57454257Resting cells rely on the DNA helicase component MCM2 to build cilia
Q33976747SAS-6 assembly templated by the lumen of cartwheel-less centrioles precedes centriole duplication
Q36746500Sonic Hedgehog promotes proliferation of Notch-dependent monociliated choroid plexus tumour cells.
Q38732648Spatial Control of Primary Ciliogenesis by Subdistal Appendages Alters Sensation-Associated Properties of Cilia
Q34489758Targeting of CRMP-2 to the primary cilium is modulated by GSK-3β.
Q36648746The E2F-DP1 Transcription Factor Complex Regulates Centriole Duplication in Caenorhabditis elegans.
Q38661406The Janus soul of centrosomes: a paradoxical role in disease?
Q41933102The RhoD to centrosomal duplication
Q28592935The Rilp-like proteins Rilpl1 and Rilpl2 regulate ciliary membrane content.
Q52694987The SKP1-Cullin-F-box E3 ligase βTrCP and CDK2 cooperate to control STIL abundance and centriole number.
Q38222110The centrosome duplication cycle in health and disease.
Q37179516The ciliary GTPase Arl13b regulates cell migration and cell cycle progression
Q35166357The ciliary proteins Meckelin and Jouberin are required for retinoic acid-dependent neural differentiation of mouse embryonic stem cells
Q38118793The importance of a single primary cilium.
Q38638093The interplay between centrosomes and the Hippo tumor suppressor pathway
Q42440588The nucleotide-binding proteins Nubp1 and Nubp2 are negative regulators of ciliogenesis.
Q33575782The origin of the second centriole in the zygote of Drosophila melanogaster
Q92808222The toxic effect of cytostatics on primary cilia frequency and multiciliation
Q30616560Tubulin transport by IFT is upregulated during ciliary growth by a cilium-autonomous mechanism

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