| scholarly article | Q13442814 |
| P819 | ADS bibcode | 2017NatCo...816063H |
| P6179 | Dimensions Publication ID | 1090351104 |
| P356 | DOI | 10.1038/NCOMMS16063 |
| P932 | PMC publication ID | 5504286 |
| P698 | PubMed publication ID | 28677678 |
| P50 | author | Pamela Shaw | Q20716854 |
| Kurt J De Vos | Q37379258 | ||
| Johnathan Cooper-Knock | Q38322650 | ||
| Janine Kirby | Q38322672 | ||
| Laura Ferraiuolo | Q41574303 | ||
| Mimoun Azzouz | Q42850479 | ||
| Alexander J. Whitworth | Q42943935 | ||
| Ke Ning | Q58333877 | ||
| Alvaro Sanchez-Martinez | Q58836306 | ||
| Guillaume M Hautbergue | Q59572053 | ||
| Monika A Myszczynska | Q64682980 | ||
| Kathrin Meyer | Q96017543 | ||
| P2093 | author name string | Brian K Kaspar | |
| Sherif F El-Khamisy | |||
| Evangelia Karyka | |||
| Jayanth S Chandran | |||
| Adrian Higginbottom | |||
| Adrian M Isaacs | |||
| Ya-Hui Lin | |||
| Claudia S Bauer | |||
| Lydia M Castelli | |||
| Emma F Smith | |||
| Jennifer E Dodd | |||
| Matthew J Stopford | |||
| Pierre Garneret | |||
| Sarah M Alam | |||
| P2860 | cites work | The crystal structure of the exon junction complex reveals how it maintains a stable grip on mRNA | Q24300447 |
| Recruitment of the human TREX complex to mRNA during splicing | Q24306879 | ||
| Chtop is a component of the dynamic TREX mRNA export complex | Q24307827 | ||
| Luzp4 defines a new mRNA export pathway in cancer cells | Q24318387 | ||
| Adaptor Aly and co-adaptor Thoc5 function in the Tap-p15-mediated nuclear export of HSP70 mRNA | Q24320299 | ||
| UIF, a New mRNA export adaptor that works together with REF/ALY, requires FACT for recruitment to mRNA | Q24336514 | ||
| A molecular link between SR protein dephosphorylation and mRNA export | Q24561984 | ||
| RNA toxicity from the ALS/FTD C9ORF72 expansion is mitigated by antisense intervention | Q24562489 | ||
| Unconventional translation of C9ORF72 GGGGCC expansion generates insoluble polypeptides specific to c9FTD/ALS | Q24608159 | ||
| Expanded GGGGCC hexanucleotide repeat in noncoding region of C9ORF72 causes chromosome 9p-linked FTD and ALS | Q24633692 | ||
| A hexanucleotide repeat expansion in C9ORF72 is the cause of chromosome 9p21-linked ALS-FTD | Q24634583 | ||
| Structural and functional analysis of RNA and TAP binding to SF2/ASF | Q24683765 | ||
| An amyloid-like cascade hypothesis for C9orf72 ALS/FTD | Q26778174 | ||
| The role of TREX in gene expression and disease | Q28078160 | ||
| A genome-wide transgenic RNAi library for conditional gene inactivation in Drosophila | Q28236209 | ||
| Mutually exclusive interactions drive handover of mRNA from export adaptors to TAP | Q28512678 | ||
| REF, an evolutionary conserved family of hnRNP-like proteins, interacts with TAP/Mex67p and participates in mRNA nuclear export. | Q28587508 | ||
| Loss of C9ORF72 impairs autophagy and synergizes with polyQ Ataxin-2 to induce motor neuron dysfunction and cell death | Q28854599 | ||
| The ALS/FTLD associated protein C9orf72 associates with SMCR8 and WDR41 to regulate the autophagy-lysosome pathway | Q29465536 | ||
| Mitochondrial pathology and apoptotic muscle degeneration in Drosophila parkin mutants | Q29615627 | ||
| Directed differentiation of embryonic stem cells into motor neurons | Q29616200 | ||
| The C9orf72 repeat expansion disrupts nucleocytoplasmic transport. | Q29871482 | ||
| Sequestration of multiple RNA recognition motif-containing proteins by C9orf72 repeat expansions | Q33784052 | ||
| Robust RT-qPCR data normalization: validation and selection of internal reference genes during post-experimental data analysis | Q33851389 | ||
| Targeting RNA foci in iPSC-derived motor neurons from ALS patients with a C9ORF72 repeat expansion | Q33878156 | ||
| Primer-BLAST: a tool to design target-specific primers for polymerase chain reaction | Q34307627 | ||
| The C9orf72 GGGGCC repeat is translated into aggregating dipeptide-repeat proteins in FTLD/ALS. | Q34326849 | ||
| Non-ATG-initiated translation directed by microsatellite expansions | Q34471662 | ||
| GGGGCC repeat expansion in C9orf72 compromises nucleocytoplasmic transport | Q34491033 | ||
| The solution structure of REF2-I reveals interdomain interactions and regions involved in binding mRNA export factors and RNA. | Q35110861 | ||
| C9ORF72 GGGGCC Expanded Repeats Produce Splicing Dysregulation which Correlates with Disease Severity in Amyotrophic Lateral Sclerosis | Q35643260 | ||
| Antisense RNA foci in the motor neurons of C9ORF72-ALS patients are associated with TDP-43 proteinopathy. | Q35746397 | ||
| Pur alpha binds to rCGG repeats and modulates repeat-mediated neurodegeneration in a Drosophila model of fragile X tremor/ataxia syndrome. | Q36014935 | ||
| FTD/ALS-associated poly(GR) protein impairs the Notch pathway and is recruited by poly(GA) into cytoplasmic inclusions | Q36073654 | ||
| Differential Toxicity of Nuclear RNA Foci versus Dipeptide Repeat Proteins in a Drosophila Model of C9ORF72 FTD/ALS. | Q36108576 | ||
| RAN Translation in Huntington Disease | Q36386897 | ||
| Retention of hexanucleotide repeat-containing intron in C9orf72 mRNA: implications for the pathogenesis of ALS/FTD | Q36616570 | ||
| Distinct brain transcriptome profiles in C9orf72-associated and sporadic ALS. | Q36795394 | ||
| Intrinsic GTP hydrolysis is observed for a switch 1 variant of Cdc42 in the presence of a specific GTPase inhibitor. | Q36997845 | ||
| C9orf72 repeat expansions cause neurodegeneration in Drosophila through arginine-rich proteins | Q37094833 | ||
| RAN proteins and RNA foci from antisense transcripts in C9ORF72 ALS and frontotemporal dementia | Q37409251 | ||
| Direct conversion of patient fibroblasts demonstrates non-cell autonomous toxicity of astrocytes to motor neurons in familial and sporadic ALS | Q37495227 | ||
| Hexanucleotide repeats in ALS/FTD form length-dependent RNA foci, sequester RNA binding proteins, and are neurotoxic | Q37503127 | ||
| Molecular pathways of motor neuron injury in amyotrophic lateral sclerosis | Q37952528 | ||
| Gene expression profiling in human neurodegenerative disease | Q38034387 | ||
| Invited review: decoding the pathophysiological mechanisms that underlie RNA dysregulation in neurodegenerative disorders: a review of the current state of the art. | Q38260614 | ||
| C9orf72 expansions in frontotemporal dementia and amyotrophic lateral sclerosis | Q38339081 | ||
| Drosophila screen connects nuclear transport genes to DPR pathology in c9ALS/FTD. | Q38379408 | ||
| IGD: a resource for intronless genes in the human genome | Q38500749 | ||
| Control of mammalian gene expression by selective mRNA export | Q38529724 | ||
| Unstable repeat expansions in neurodegenerative diseases: nucleocytoplasmic transport emerges on the scene | Q38753593 | ||
| SR proteins are NXF1 adaptors that link alternative RNA processing to mRNA export. | Q38788828 | ||
| Insights into the pathogenic mechanisms of Chromosome 9 open reading frame 72 (C9orf72) repeat expansions | Q38789426 | ||
| The C9orf72 protein interacts with Rab1a and the ULK1 complex to regulate initiation of autophagy | Q39662062 | ||
| REF1/Aly and the additional exon junction complex proteins are dispensable for nuclear mRNA export | Q40689151 | ||
| TREX exposes the RNA-binding domain of Nxf1 to enable mRNA export | Q40711565 | ||
| Disruption of an SF2/ASF-dependent exonic splicing enhancer in SMN2 causes spinal muscular atrophy in the absence of SMN1. | Q40741164 | ||
| Self-inactivating lentiviral vectors with enhanced transgene expression as potential gene transfer system in Parkinson's disease | Q40904090 | ||
| The Ref/Aly proteins are dispensable for mRNA export and development in Caenorhabditis elegans | Q41836703 | ||
| CGG repeat-associated translation mediates neurodegeneration in fragile X tremor ataxia syndrome | Q42068973 | ||
| C9orf72 is required for proper macrophage and microglial function in mice | Q42364302 | ||
| Modifiers of C9orf72 dipeptide repeat toxicity connect nucleocytoplasmic transport defects to FTD/ALS. | Q42925023 | ||
| RNA-binding proteins hnRNP A2/B1 and CUGBP1 suppress fragile X CGG premutation repeat-induced neurodegeneration in a Drosophila model of FXTAS. | Q42975231 | ||
| SR splicing factors serve as adapter proteins for TAP-dependent mRNA export | Q44384538 | ||
| hnRNP A3 binds to GGGGCC repeats and is a constituent of p62-positive/TDP43-negative inclusions in the hippocampus of patients with C9orf72 mutations | Q44742682 | ||
| Bidirectional transcripts of the expanded C9orf72 hexanucleotide repeat are translated into aggregating dipeptide repeat proteins | Q46797980 | ||
| Loss of function of C9orf72 causes motor deficits in a zebrafish model of amyotrophic lateral sclerosis. | Q47073323 | ||
| C9orf72 plays a central role in Rab GTPase-dependent regulation of autophagy. | Q51371013 | ||
| Spinal muscular atrophy: clinical validation of a single-tube multiplex real time PCR assay for determination of SMN1 and SMN2 copy numbers. | Q54339239 | ||
| Structure and function of mRNA export adaptors | Q82514342 | ||
| P275 | copyright license | Creative Commons Attribution 4.0 International | Q20007257 |
| P6216 | copyright status | copyrighted | Q50423863 |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | neurodegeneration | Q1755122 |
| Splicing factor 2 Dmel_CG6987 | Q29817370 | ||
| P304 | page(s) | 16063 | |
| P577 | publication date | 2017-07-05 | |
| P1433 | published in | Nature Communications | Q573880 |
| P1476 | title | SRSF1-dependent nuclear export inhibition of C9ORF72 repeat transcripts prevents neurodegeneration and associated motor deficits | |
| P478 | volume | 8 |
| Q90447298 | A High-throughput and Pathophysiologically Relevant Astrocyte-motor Neuron Co-culture Assay for Amyotrophic Lateral Sclerosis Therapeutic Discovery |
| Q61135883 | Abnormal RNA stability in amyotrophic lateral sclerosis |
| Q56531747 | Amyotrophic lateral sclerosis |
| Q64230186 | Astrocyte adenosine deaminase loss increases motor neuron toxicity in amyotrophic lateral sclerosis |
| Q47882860 | C9ORF72 GGGGCC repeat-associated non-AUG translation is upregulated by stress through eIF2α phosphorylation. |
| Q64948055 | C9orf72-mediated ALS and FTD: multiple pathways to disease. |
| Q90524749 | CRISPR-Cas9 Screens Identify the RNA Helicase DDX3X as a Repressor of C9ORF72 (GGGGCC)n Repeat-Associated Non-AUG Translation |
| Q58566969 | Control of CNS functions by RNA-binding proteins in neurological diseases |
| Q91618402 | Drosophila Ref1/ALYREF regulates transcription and toxicity associated with ALS/FTD disease etiologies |
| Q92813735 | Glial Cells-The Strategic Targets in Amyotrophic Lateral Sclerosis Treatment |
| Q91771220 | Mechanism and Regulation of Co-transcriptional mRNP Assembly and Nuclear mRNA Export |
| Q64261334 | Micro-RNAs secreted through astrocyte-derived extracellular vesicles cause neuronal network degeneration in C9orf72 ALS |
| Q90359225 | Models and mechanisms of repeat expansion disorders: a worm's eye view |
| Q61816243 | Molecular Mechanisms of Neurodegeneration Related to Hexanucleotide Repeat Expansion |
| Q91910728 | Molecular signature of different lesion types in the brain white matter of patients with progressive multiple sclerosis |
| Q98177370 | Multifaceted Genes in Amyotrophic Lateral Sclerosis-Frontotemporal Dementia |
| Q90220036 | Next Generation Precision Medicine: CRISPR-mediated Genome Editing for the Treatment of Neurodegenerative Disorders |
| Q89720831 | Nucleocytoplasmic Proteomic Analysis Uncovers eRF1 and Nonsense-Mediated Decay as Modifiers of ALS/FTD C9orf72 Toxicity |
| Q99616699 | Oxidative switch drives mitophagy defects in dopaminergic parkin mutant patient neurons |
| Q47313248 | RAN translation at C9orf72-associated repeat expansions is selectively enhanced by the integrated stress response |
| Q41542861 | RNA biology of disease-associated microsatellite repeat expansions |
| Q89068599 | Repeat-Associated Non-ATG Translation in Neurological Diseases |
| Q92607005 | Repeat-Associated Non-ATG Translation: Molecular Mechanisms and Contribution to Neurological Disease |
| Q48145508 | Sense and antisense RNA are not toxic in Drosophila models of C9orf72-associated ALS/FTD. |
| Q92634114 | Splicing Players Are Differently Expressed in Sporadic Amyotrophic Lateral Sclerosis Molecular Clusters and Brain Regions |
| Q49314473 | Unraveling the Role of RNA Mediated Toxicity of C9orf72 Repeats in C9-FTD/ALS. |
| Q91771235 | View from an mRNP: The Roles of SR Proteins in Assembly, Maturation and Turnover |
| Q64087037 | eIF4B and eIF4H mediate GR production from expanded G4C2 in a Drosophila model for C9orf72-associated ALS |
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