Cholesterol selectively activates canonical Wnt signalling over non-canonical Wnt signalling

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Cholesterol selectively activates canonical Wnt signalling over non-canonical Wnt signalling is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode2014NatCo...5.4393S
P6179Dimensions Publication ID1046061124
P356DOI10.1038/NCOMMS5393
P932PMC publication ID4100210
P698PubMed publication ID25024088
P5875ResearchGate publication ID263934615

P2093author name stringHyunjoon Kim
Jin-Kwan Han
Wonhwa Cho
Yong Chen
Junsang Doh
Yang Cui
Wen Tian
Ren Sheng
Yao Xin
Hyeyoon Lee
Jong-Cheol Choi
P2860cites workCaveolin is necessary for Wnt-3a-dependent internalization of LRP6 and accumulation of beta-cateninQ24299047
Wnt induces LRP6 signalosomes and promotes dishevelled-dependent LRP6 phosphorylationQ24310980
Wnt signaling through inhibition of β-catenin degradation in an intact Axin1 complexQ24337717
Super-resolution fluorescence microscopyQ24630861
Wnt/beta-catenin signaling: components, mechanisms, and diseasesQ24630938
Mechanism of activation of the Formin protein Daam1Q24657453
The role of Ryk and Ror receptor tyrosine kinases in Wnt signal transductionQ26852972
Structural basis of the recognition of the dishevelled DEP domain in the Wnt signaling pathwayQ27628766
Direct binding of the PDZ domain of Dishevelled to a conserved internal sequence in the C-terminal region of FrizzledQ27642624
PDZ domains of Par-3 as potential phosphoinositide signaling integratorsQ27649319
A Specific Cholesterol Binding Site Is Established by the 2.8 Å Structure of the Human β2-Adrenergic ReceptorQ27650801
Inhibition of Wnt signaling by Dishevelled PDZ peptidesQ27653983
Inhibition of oncogenic Wnt signaling through direct targeting of  -cateninQ27674587
UCSF Chimera--a visualization system for exploratory research and analysisQ27860666
Wnt/beta-catenin signaling in development and diseaseQ27860784
The Wnt signaling pathway in development and diseaseQ27861019
Phosphoinositides in cell regulation and membrane dynamicsQ27861051
Wnt/Frizzled activation of Rho regulates vertebrate gastrulation and requires a novel Formin homology protein Daam1Q28214701
Membrane-protein interactions in cell signaling and membrane traffickingQ28248356
A mechanism for Wnt coreceptor activationQ28641243
Planar cell polarity signaling: from fly development to human diseaseQ28749129
Towards an integrated view of Wnt signaling in developmentQ29615175
WNT signalling pathways as therapeutic targets in cancerQ29615666
Lipid rafts as a membrane-organizing principleQ29615727
Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancerQ29616163
Protein sensors for membrane sterolsQ29617313
Wnt signalling and its impact on development and cancerQ29619273
Structural insights into the membrane-anchoring mechanism of a cholesterol-dependent cytolysinQ30165165
Structural relationships among proteins with different global topologies and their implications for function annotation strategiesQ30381353
Fluorescence imaging for monitoring the colocalization of two single molecules in living cellsQ30476487
A canonical to non-canonical Wnt signalling switch in haematopoietic stem-cell ageing.Q30582498
Only two amino acids are essential for cytolytic toxin recognition of cholesterol at the membrane surfaceQ33732672
Loss of receptor-mediated lipid uptake via scavenger receptor A or CD36 pathways does not ameliorate atherosclerosis in hyperlipidemic miceQ33905765
Wnt5b-Ryk pathway provides directional signals to regulate gastrulation movement.Q34092446
Wnt signaling requires sequestration of glycogen synthase kinase 3 inside multivesicular endosomesQ34156430
Mesd encodes an LRP5/6 chaperone essential for specification of mouse embryonic polarityQ34176698
The developmental biology of Dishevelled: an enigmatic protein governing cell fate and cell polarityQ34455099
Small-molecule modulation of Wnt signaling via modulating the Axin-LRP5/6 interactionQ34871118
Genome-wide structural analysis reveals novel membrane binding properties of AP180 N-terminal homology (ANTH) domains.Q35310698
Wnt/β-catenin signaling requires interaction of the Dishevelled DEP domain and C terminus with a discontinuous motif in FrizzledQ35887244
Genome-wide functional annotation of dual-specificity protein- and lipid-binding modules that regulate protein interactionsQ36200455
Phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) specifically induces membrane penetration and deformation by Bin/amphiphysin/Rvs (BAR) domainsQ36298326
Plasma membrane phosphoinositide organization by protein electrostaticsQ36327803
Role of cholesterol and lipid organization in diseaseQ36327808
Cholesterol and the interaction of proteins with membrane domains.Q36436022
Cholesterol modulates cell signaling and protein networking by specifically interacting with PDZ domain-containing scaffold proteinsQ36479386
Cholesterol sensing, trafficking, and esterification.Q36497100
PI(3,4,5)P3 and PI(4,5)P2 lipids target proteins with polybasic clusters to the plasma membraneQ36630120
Small-molecule inhibition of Wnt signaling through activation of casein kinase 1αQ36926447
Cellular cholesterol trafficking and compartmentalizationQ37064008
Discovery and characterization of a small molecule inhibitor of the PDZ domain of dishevelled.Q37269189
Dishevelled: The hub of Wnt signalingQ37652897
Cholesterol and ion channelsQ37705156
Alternative Wnt pathways and receptorsQ38039332
Rap2 is required for Wnt/beta-catenin signaling pathway in Xenopus early developmentQ38330721
Ryk cooperates with Frizzled 7 to promote Wnt11-mediated endocytosis and is essential for Xenopus laevis convergent extension movementsQ38360630
Electrochemical cues regulate assembly of the Frizzled/Dishevelled complex at the plasma membrane during planar epithelial polarization.Q39880969
Wnt3a and Dkk1 regulate distinct internalization pathways of LRP6 to tune the activation of beta-catenin signalingQ39964386
Membrane phosphatidylserine regulates surface charge and protein localizationQ40026492
Initiation of Wnt signaling: control of Wnt coreceptor Lrp6 phosphorylation/activation via frizzled, dishevelled and axin functions.Q40036004
PIP(2)-PDZ domain binding controls the association of syntenin with the plasma membraneQ40721942
The DIX domain of Dishevelled confers Wnt signaling by dynamic polymerizationQ41791636
Wnt stabilization of β-catenin reveals principles for morphogen receptor-scaffold assemblies.Q41832911
Proteome-wide mapping of cholesterol-interacting proteins in mammalian cellsQ42212192
Differential roles of phosphatidylserine, PtdIns(4,5)P2, and PtdIns(3,4,5)P3 in plasma membrane targeting of C2 domains. Molecular dynamics simulation, membrane binding, and cell translocation studies of the PKCalpha C2 domainQ42458279
Essential role for beta-arrestin 2 in the regulation of Xenopus convergent extension movementsQ42791086
Wnt-5A/Ror2 regulate expression of XPAPC through an alternative noncanonical signaling pathwayQ42828494
The C-terminal domain of perfringolysin O is an essential cholesterol-binding unit targeting to cholesterol-rich microdomains.Q44243039
Hypercholesterolemia suppresses inwardly rectifying K+ channels in aortic endothelium in vitro and in vivo.Q51242120
Multivesicular GSK3 sequestration upon Wnt signaling is controlled by p120-catenin/cadherin interaction with LRP5/6.Q52646787
P407language of work or nameEnglishQ1860
P304page(s)4393
P577publication date2014-07-15
P1433published inNature CommunicationsQ573880
P1476titleCholesterol selectively activates canonical Wnt signalling over non-canonical Wnt signalling
P478volume5

Reverse relations

cites work (P2860)
Q102071492Activation of WNT signaling restores the facial deficits in a zebrafish with defects in cholesterol metabolism
Q92525146Alkylglycerol monooxygenase, a heterotaxy candidate gene, regulates left-right patterning via Wnt signaling
Q40360370Dietary cholesterol promotes repair of demyelinated lesions in the adult brain
Q39168764Domain 4 (D4) of Perfringolysin O to Visualize Cholesterol in Cellular Membranes-The Update.
Q90277564Effects of FSS on the expression and localization of the core proteins in two Wnt signaling pathways, and their association with ciliogenesis
Q64939214Functional link between plasma membrane spatiotemporal dynamics, cancer biology, and dietary membrane-altering agents.
Q89093935Intracellular biosynthesis of lipids and cholesterol by Scap and Insig in mesenchymal cells regulates long bone growth and chondrocyte homeostasis
Q41046107Lipids Regulate Lck Protein Activity through Their Interactions with the Lck Src Homology 2 Domain
Q36772356Modeling Smith-Lemli-Opitz syndrome with induced pluripotent stem cells reveals a causal role for Wnt/β-catenin defects in neuronal cholesterol synthesis phenotypes
Q52329039Omega-3 fatty acids, membrane remodeling and cancer prevention.
Q38724298Orthogonal lipid sensors identify transbilayer asymmetry of plasma membrane cholesterol
Q50538442PLD1 regulates Xenopus convergent extension movements by mediating Frizzled7 endocytosis for Wnt/PCP signal activation.
Q36782828SH2 Domains Serve as Lipid-Binding Modules for pTyr-Signaling Proteins
Q48513576Synergistic inhibition of colon cancer cell growth by a combination of atorvastatin and phloretin

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