Mycobacterium tuberculosis PhoY Proteins Promote Persister Formation by Mediating Pst/SenX3-RegX3 Phosphate Sensing.

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Mycobacterium tuberculosis PhoY Proteins Promote Persister Formation by Mediating Pst/SenX3-RegX3 Phosphate Sensing. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/MBIO.00494-17
P932PMC publication ID5513712
P698PubMed publication ID28698272

P50authorAnna D. TischlerQ43013732
P2093author name stringAlisha M Aagesen
Sarah R Elliott
Sarah B Namugenyi
P2860cites workThe role of the novel exopolyphosphatase MT0516 in Mycobacterium tuberculosis drug tolerance and persistenceQ21134950
Inorganic polyphosphate: a molecule of many functionsQ28139415
Cellular impermeability and uptake of biocides and antibiotics in Gram-positive bacteria and mycobacteriaQ28217016
The phosphate regulon and bacterial virulence: a regulatory network connecting phosphate homeostasis and pathogenesisQ28267290
The effect of directly observed therapy on the rates of drug resistance and relapse in tuberculosisQ72319787
The senX3-regX3 two-component regulatory system of Mycobacterium tuberculosis is required for virulenceQ28486347
Phosphate depletion: a novel trigger for Mycobacterium tuberculosis persistenceQ28487208
PhoY2 but not PhoY1 is the PhoU homologue involved in persisters in Mycobacterium tuberculosisQ28487517
Bacterial persistence as a phenotypic switchQ29618111
Persister cellsQ30018300
Why is long-term therapy required to cure tuberculosis?Q33280142
The three RelE homologs of Mycobacterium tuberculosis have individual, drug-specific effects on bacterial antibiotic toleranceQ33648717
Characterization and transcriptome analysis of Mycobacterium tuberculosis persistersQ35058352
Spontaneous phthiocerol dimycocerosate-deficient variants of Mycobacterium tuberculosis are susceptible to gamma interferon-mediated immunity.Q35328837
Stochastic induction of persister cells by HipA through (p)ppGpp-mediated activation of mRNA endonucleases.Q35549303
Deficiency of the novel exopolyphosphatase Rv1026/PPX2 leads to metabolic downshift and altered cell wall permeability in Mycobacterium tuberculosisQ35677431
High-dose rifampicin kills persisters, shortens treatment duration, and reduces relapse rate in vitro and in vivoQ35768944
The two-component regulatory system senX3-regX3 regulates phosphate-dependent gene expression in Mycobacterium smegmatis.Q35949277
Use of the rep technique for allele replacement to construct mutants with deletions of the pstSCAB-phoU operon: evidence of a new role for the PhoU protein in the phosphate regulonQ36123277
Eradication of bacterial persisters with antibiotic-generated hydroxyl radicals.Q36132703
Multidrug-resistant tuberculosis (MDR-TB): epidemiology, prevention and treatmentQ36163221
Microbial persistence. II. Characteristics of the sterile state of tubercle bacilliQ36268037
Mycobacterium tuberculosis requires phosphate-responsive gene regulation to resist host immunity.Q36506132
PhoY2 of mycobacteria is required for metabolic homeostasis and stress responseQ36558835
Mycobacterium tuberculosis Resists Stress by Regulating PE19 ExpressionQ36631326
Inorganic polyphosphate kinase is required to stimulate protein degradation and for adaptation to amino acid starvation in Escherichia coliQ36741989
Polyphosphate deficiency in Mycobacterium tuberculosis is associated with enhanced drug susceptibility and impaired growth in guinea pigsQ36969514
Acid-susceptible mutants of Mycobacterium tuberculosis share hypersusceptibility to cell wall and oxidative stress and to the host environmentQ37051339
Employment of a promoter-swapping technique shows that PhoU modulates the activity of the PstSCAB2 ABC transporter in Escherichia coliQ37075612
The PhoU protein from Escherichia coli interacts with PhoR, PstB, and metals to form a phosphate-signaling complex at the membrane.Q37713140
Targeting persisters for tuberculosis controlQ37990720
phoU inactivation in Pseudomonas aeruginosa enhances accumulation of ppGpp and polyphosphateQ39518819
Accumulation of inorganic polyphosphate in phoU mutants of Escherichia coli and Synechocystis sp. strain PCC6803.Q39640227
Differential regulation of the two-component regulatory system senX3-regX3 in Mycobacterium tuberculosis.Q40088108
Phosphate starvation: a novel signal that triggers ESX-5 secretion in Mycobacterium tuberculosisQ40821571
Physiological Roles of the Dual Phosphate Transporter Systems in Low and High Phosphate Conditions and in Capsule Maintenance of Streptococcus pneumoniae D39Q42628602
PhoU is a persistence switch involved in persister formation and tolerance to multiple antibiotics and stresses in Escherichia coliQ42748156
Polyphosphate kinase 1 is a pathogenesis determinant in Campylobacter jejuniQ42910189
Polyphosphate kinase 1, a central node in the stress response network of Mycobacterium tuberculosis, connects the two-component systems MprAB and SenX3-RegX3 and the extracytoplasmic function sigma factor, sigma E.Q43465463
Distinguishing between resistance, tolerance and persistence to antibiotic treatment.Q53789924
RETRACTED: (p)ppGpp Controls Bacterial Persistence by Stochastic Induction of Toxin-Antitoxin ActivityQ56761766
P433issue4
P921main subjectMycobacterium tuberculosisQ130971
P577publication date2017-07-11
P1433published inmBioQ15817061
P1476titleMycobacterium tuberculosis PhoY Proteins Promote Persister Formation by Mediating Pst/SenX3-RegX3 Phosphate Sensing
P478volume8

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cites work (P2860)
Q90000755Adaptation of Mycobacterium tuberculosis to Biofilm Growth Is Genetically Linked to Drug Tolerance
Q95322518Clinically relevant mutations in mycobacterial LepA cause rifampicin-specific phenotypic resistance
Q57657193Mechanisms of Bacterial Tolerance and Persistence in the Gastrointestinal and Respiratory Environments
Q91688547Mycobacterium bovis BCG Surface Antigens Expressed under the Granuloma-Like Conditions as Potential Inducers of the Protective Immunity
Q48540812Mycobacterium smegmatis PhoU Proteins Have Overlapping Functions in Phosphate Signaling and Are Essential
Q55380367Mycobacterium tuberculosis Pst/SenX3-RegX3 Regulates Membrane Vesicle Production Independently of ESX-5 Activity.
Q90646017PhoPR Contributes to Staphylococcus aureus Growth during Phosphate Starvation and Pathogenesis in an Environment-Specific Manner
Q93107143Protein post-translational modifications in bacteria
Q95288819Recent Developments in the Application of Flow Cytometry to Advance our Understanding of Mycobacterium tuberculosis Physiology and Pathogenesis
Q97518299Staphylococcus aureus PhoU Homologs Regulate Persister Formation and Virulence
Q51409861The 24th Annual Midwest Microbial Pathogenesis Meeting.
Q92494243The potassium transporter KdpA affects persister formation by regulating ATP levels in Mycobacterium marinum

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