FTY720 Induces Autophagy-Associated Apoptosis in Human Oral Squamous Carcinoma Cells, in Part, through a Reactive Oxygen Species/Mcl-1-Dependent Mechanism

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FTY720 Induces Autophagy-Associated Apoptosis in Human Oral Squamous Carcinoma Cells, in Part, through a Reactive Oxygen Species/Mcl-1-Dependent Mechanism is …
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scholarly articleQ13442814

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P6179Dimensions Publication ID1090637452
P356DOI10.1038/S41598-017-06047-9
P8608Fatcat IDrelease_vmejfnjr25eahmrzxu35spoxv4
P932PMC publication ID5514089
P698PubMed publication ID28717222

P2093author name stringChang-Fang Chiu
Jing-Ru Weng
Li-Yuan Bai
Po-Chen Chu
Shih-Jiuan Chiu
P2860cites workFTY720 induces apoptosis in hepatocellular carcinoma cells through activation of protein kinase C delta signalingQ40012107
FTY720, a fungus metabolite, inhibits invasion ability of androgen-independent prostate cancer cells through inactivation of RhoA-GTPaseQ40317574
Mcl-1 blocks radiation-induced apoptosis and inhibits clonogenic cell death.Q40389016
FTY720 induces apoptosis of human hepatoma cell lines through PI3-K-mediated Akt dephosphorylationQ40528059
The immune modulator FTY720 targets sphingosine 1-phosphate receptorsQ40736684
Marked prevention of tumor growth and metastasis by a novel immunosuppressive agent, FTY720, in mouse breast cancer models.Q40745321
Association of anti-apoptotic Mcl-1L isoform expression with radioresistance of oral squamous carcinoma cellsQ41531941
FTY720-induced blockage of autophagy enhances anticancer efficacy of milatuzumab in mantle cell lymphoma: is FTY720 the next autophagy-blocking agent in lymphoma treatment?Q42137542
Regulation of cell survival by sphingosine-1-phosphate receptor S1P1 via reciprocal ERK-dependent suppression of Bim and PI-3-kinase/protein kinase C-mediated upregulation of Mcl-1.Q42854212
FTY720: dissection of membrane receptor-operated, stereospecific effects on cell migration from receptor-independent antiproliferative and apoptotic effectsQ43828378
FTY720, a fungus metabolite, inhibits in vivo growth of androgen-independent prostate cancer.Q46573682
LC3 conjugation system in mammalian autophagyQ28278334
Arsenic trioxide selectively induces acute promyelocytic leukemia cell apoptosis via a hydrogen peroxide-dependent pathwayQ28372372
Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonistsQ29618071
Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1Q29619644
FTY720, a novel immunosuppressive agent, induces apoptosis in human glioma cellsQ31952928
Fungal metabolites. Part 11. A potent immunosuppressive activity found in Isaria sinclairii metaboliteQ34339041
FTY720 inhibits proliferation and epithelial-mesenchymal transition in cholangiocarcinoma by inactivating STAT3 signalingQ34459845
Synthesis and immunosuppressive activity of 2-substituted 2-aminopropane-1,3-diols and 2-aminoethanolsQ34510369
Overexpression of Mcl-1L splice variant is associated with poor prognosis and chemoresistance in oral cancersQ34541989
Oxidative stress and apoptosis: impact on cancer therapy.Q34642005
The recurrence and survival of oral squamous cell carcinoma: a report of 275 casesQ34650708
Mcl-1 is an important therapeutic target for oral squamous cell carcinomasQ36140893
FTY720 demonstrates promising preclinical activity for chronic lymphocytic leukemia and lymphoblastic leukemia/lymphomaQ36384629
A triterpenoid from wild bitter gourd inhibits breast cancer cellsQ36634632
Tumor-targeted induction of oxystress for cancer therapyQ36900213
Reactive oxygen species in apoptosis induced by cisplatin: review of physiopathological mechanisms in animal models.Q38010040
FTY720 for cancer therapy (Review).Q38150194
Targeting extracellular ROS signaling of tumor cellsQ38201438
FTY720 induces autophagy-related apoptosis and necroptosis in human glioblastoma cellsQ38879206
Anti-tumor activities of triterpenes from Syzygium kusukusense.Q38926272
Involvement of vacuolar H(+)-ATPase in killing of human melanoma cells by the sphingosine kinase analogue FTY720.Q38943724
G15, a GPR30 antagonist, induces apoptosis and autophagy in human oral squamous carcinoma cellsQ39070441
OSU-A9, an indole-3-carbinol derivative, induces cytotoxicity in acute myeloid leukemia through reactive oxygen species-mediated apoptosis.Q39095049
Regulation of LC3-dependent protective autophagy in ovarian cancer cells by protein phosphatase 2A.Q39177458
Autophagy induced by FTY720 promotes apoptosis in U266 cellsQ39405613
Inhibition of autophagy potentiates the antitumor effect of the multikinase inhibitor sorafenib in hepatocellular carcinomaQ39486469
Different expression patterns of pAkt, NF‐κB and cyclin D1 proteins during the invasion process of head and neck squamous cell carcinoma: an in vitro approachQ39641050
FTY720 induces necrotic cell death and autophagy in ovarian cancer cells: a protective role of autophagy.Q39645996
A novel indole-3-carbinol derivative inhibits the growth of human oral squamous cell carcinoma in vitro.Q39655641
Effects of phosphorylation of immunomodulatory agent FTY720 (fingolimod) on antiproliferative activity against breast and colon cancer cellsQ39976111
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P2507corrigendum / erratumAuthor Correction: FTY720 Induces Autophagy-Associated Apoptosis in Human Oral Squamous Carcinoma Cells, in Part, through a Reactive Oxygen Species/Mcl-1-Dependent MechanismQ89791490
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectautophagyQ288322
reactive oxygen speciesQ424361
P304page(s)5600
P577publication date2017-07-17
P1433published inScientific ReportsQ2261792
P1476titleFTY720 Induces Autophagy-Associated Apoptosis in Human Oral Squamous Carcinoma Cells, in Part, through a Reactive Oxygen Species/Mcl-1-Dependent Mechanism
P478volume7

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cites work (P2860)
Q90293980A Sterol from Soft Coral Induces Apoptosis and Autophagy in MCF-7 Breast Cancer Cells
Q92719314Activation of G protein-coupled receptor 30 protects neurons by regulating autophagy in astrocytes
Q61808759Divaricoside Exerts Antitumor Effects, in Part, by Modulating Mcl-1 in Human Oral Squamous Cell Carcinoma Cells
Q60301445Ergosterol peroxide from marine fungus Phoma sp. induces ROS-dependent apoptosis and autophagy in human lung adenocarcinoma cells
Q91173363FTY720 induces non-canonical phosphatidylserine externalization and cell death in acute myeloid leukemia
Q48347918Inhibition of autophagy potentiates the anti-metastasis effect of phenethyl isothiocyanate through JAK2/STAT3 pathway in lung cancer cells.
Q55281738More than Just an Immunosuppressant: The Emerging Role of FTY720 as a Novel Inducer of ROS and Apoptosis.
Q89977951Sphingolipids and Mitochondrial Dynamic
Q59336713Suppressed OGT expression inhibits cell proliferation while inducing cell apoptosis in bladder cancer
Q49830478miR-142-3p regulates autophagy by targeting ATG16L1 in thymic-derived regulatory T cell (tTreg).

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