Human variability and susceptibility to trichloroethylene

scientific article

Human variability and susceptibility to trichloroethylene is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

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P356DOI10.1289/EHP.00108S2201
P932PMC publication ID1637770
P698PubMed publication ID10807552
P5875ResearchGate publication ID12509374

P2093author name stringPastino GM
Yap WY
Carroquino M
P2860cites workPharmacogenetics of alcohol metabolism and alcoholismQ22242782
Genetic risk and carcinogen exposure: a common inherited defect of the carcinogen-metabolism gene glutathione S-transferase M1 (GSTM1) that increases susceptibility to bladder cancerQ72804213
Gastric acidity in the first day of lifeQ72877168
The potential impact on women from environmental exposuresQ73318693
Pharmacokinetics of dichloroacetate in adult patients with lactic acidosisQ73349039
Lactational transfer of volatile chemicals in breast milkQ73416461
Variation in induction of human placental CYP2E1: possible role in susceptibility to fetal alcohol syndrome?Q73439808
Pharmacokinetics and metabolism of dichloroacetate in the F344 rat after prior administration in drinking waterQ73821175
Breast cancer risk and alcohol consumption: results from a large case-control studyQ73861684
Body water compartments in children: changes during growth and related changes in body compositionQ78841789
Gene deletion of glutathione S-transferase theta: correlation with induced genetic damage and potential role in endogenous mutagenesisQ23922919
Molecular genetics of human aldehyde dehydrogenaseQ24324135
Relationship between the GSTM1 genetic polymorphism and susceptibility to bladder, breast and colon cancerQ28118282
Alcohol dehydrogenase genes: restriction fragment length polymorphisms for ADH4 (pi-ADH) and ADH5 (chi-ADH) and construction of haplotypes among different ADH classesQ28184509
Expression of xenobiotic-metabolizing cytochrome P450 forms in human full-term placentaQ28277417
Detection of cytochrome P450 gene expression in human placenta in first trimester of pregnancyQ28283801
From genes to public health: the applications of genetic technology in disease prevention. Genetics Working GroupQ28301802
A comparative study on the contribution of cytochrome P450 isozymes to metabolism of benzene, toluene and trichloroethylene in rat liverQ28324626
Cardiac teratogenesis of trichloroethylene and dichloroethylene in a mammalian modelQ28331806
Homozygous deletion of gene for glutathione S-transferase M1 in bladder cancer.Q30445553
Retrospective cohort mortality study of workers at an aircraft maintenance facility. I. Epidemiological resultsQ33634501
Retrospective cohort mortality study of workers at an aircraft maintenance facility. II. Exposures and their assessmentQ33634506
Effects of consumption of ethanol on the biological monitoring of exposure to organic solvent vapours: a simulation study with trichloroethyleneQ33634520
Metabolism of trichloroethyleneQ33916680
Modes of action of trichloroethylene for kidney tumorigenesisQ33916696
Mode of action of liver tumor induction by trichloroethylene and its metabolites, trichloroacetate and dichloroacetateQ33916701
Pulmonary toxicity and carcinogenicity of trichloroethylene: species differences and modes of actionQ33916705
Evaluating noncancer effects of trichloroethylene: dosimetry, mode of action, and risk assessmentQ33916719
Developmental expression of CYP2E1 in the human liver. Hypermethylation control of gene expression during the neonatal periodQ34062843
Alcohol consumption and the risk of alcohol related cirrhosis in women.Q34070972
Impaired uptake of glutathione by hepatic mitochondria from chronic ethanol-fed rats. Tracer kinetic studies in vitro and in vivo and susceptibility to oxidant stressQ34180032
Effect of chronic ethanol feeding on glutathione and functional integrity of mitochondria in periportal and perivenous rat hepatocytesQ34234862
Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.Q34330493
An association of human congenital cardiac malformations and drinking water contaminantsQ34339276
Cardiac teratogenesis of halogenated hydrocarbon-contaminated drinking waterQ34363369
A simple estimate of glomerular filtration rate in children derived from body length and plasma creatinineQ34461054
Bile acid metabolism in infants and childrenQ34476750
High blood alcohol levels in women. The role of decreased gastric alcohol dehydrogenase activity and first-pass metabolismQ34637307
Estimating exposure and dose to characterize health risks: the role of human tissue monitoring in exposure assessmentQ34834884
Pharmacokinetics in the childQ35030779
Statistical analysis of Fisher et al. PBPK model of trichloroethylene kineticsQ35134362
Clinical Pharmacokinetics in NeonatesQ35372582
Expression of CYP2E1 during embryogenesis and fetogenesis in human cephalic tissues: implications for the fetal alcohol syndromeQ48627403
Cancer incidence in a population-based cohort of patients hospitalized with diabetes mellitus in Denmark.Q50561038
A human physiologically based pharmacokinetic model for trichloroethylene and its metabolites, trichloroacetic acid and free trichloroethanol.Q50852848
Respiratory symptoms in a susceptible population due to burning of agricultural residue.Q50903199
Differences in lung cancer risk between men and women: examination of the evidence.Q51032996
Cytochrome P4502E1 genetic polymorphisms and risk of nasopharyngeal carcinoma: results from a case-control study conducted in Taiwan.Q51045036
Mortality of aerospace workers exposed to trichloroethylene.Q51513106
Nonadditive developmental toxicity in mixtures of trichloroethylene, Di(2-ethylhexyl) phthalate, and heptachlor in a 5 x 5 x 5 design.Q51595232
Glutathione-dependent metabolism of trichloroethylene in isolated liver and kidney cells of rats and its role in mitochondrial and cellular toxicity.Q51598546
Updated and expanded Swedish cohort study on trichloroethylene and cancer risk.Q51635404
Evaluating the risk of liver cancer in humans exposed to trichloroethylene using physiological models.Q51672014
Subclinical affection of liver and kidney function and solvent exposure.Q51673961
Morphological and biochemical analyses of trichloroethylene hepatotoxicity: differences in ethanol- and phenobarbital-pretreated rats.Q51712493
Physiologically based pharmacokinetic modeling of the lactating rat and nursing pup: a multiroute exposure model for trichloroethylene and its metabolite, trichloroacetic acid.Q51738673
Long-term carcinogenicity bioassays on trichloroethylene administered by inhalation to Sprague-Dawley rats and Swiss and B6C3F1 mice.Q51776366
Venous blood levels of inhaled trichloroethylene in female rats and changes induced by interacting agents.Q51804831
Trichloroethylene occupational exposure: elements for better prevention.Q51848797
Expression, induction, and catalytic activity of the ethanol-inducible cytochrome P450 (CYP2E1) in human fetal liver and hepatocytes.Q52202921
Differences in the developmental expression of rabbit cytochromes P-450 2E1 and 2E2.Q52236349
Teratogenic activity of trichloroacetic acid in the rat.Q52244377
Regulation of rat hepatic cytochrome P-450: age-dependent expression, hormonal imprinting, and xenobiotic inducibility of sex-specific isoenzymes.Q52266254
Gender difference in smoking effects on adult pulmonary function.Q52380913
Public drinking water contamination and birth outcomes.Q52878738
The human CYP2E1 gene and lung cancer: DraI and RsaI restriction fragment length polymorphisms in a Finnish study population.Q53484906
An Rsa I polymorphism in the CYP2E1 gene does not affect lung cancer risk in a Japanese population.Q53766455
Interaction of chloral hydrate and ethanol in man: I. MetabolismQ53834457
Comment: genetics and public healthQ57268041
Hydroxylation of chlorzoxazone as a specific probe for human liver cytochrome P-450IIE1Q67260608
Pseudo-Cushing syndrome caused by alcohol in breast milkQ67418625
Reference dose (RfD): description and use in health risk assessmentsQ68026014
The metabolite ratio as a function of chloral hydrate dose and intracellular redox state in the perfused rat liverQ69163796
Endoscopic findings in alcoholic liver disease: does gender make a difference?Q69403453
Purification and characterization of human liver cytochrome P-450-ALCQ69439745
Chloral hydrate sedation in neonates and infants--clinical and pharmacologic considerationsQ69598481
Role of peroxisomal fatty acid beta-oxidation in ethanol metabolismQ69717450
[Purification and regulation of forms of cytochrome P-450 present specifically in liver microsomes of male and female rats]Q69925907
Increased susceptibility to lung dysfunction in female smokersQ70185472
Age differences in drug binding by plasma proteins: Studies on human foetuses, neonates and adultsQ70681355
The glutathione S-transferase mu polymorphism as a marker for susceptibility to lung carcinomaQ70691847
Chronic toxicity of S-(trans-1,2-dichlorovinyl)-L-cysteine in miceQ70737100
Glutathione-S-transferase (GST) theta polymorphism influences background SCE rateQ70800033
Sex differences in the decline of pulmonary function with ageQ70824394
Glutathione S transferase-theta (GSTT1) genetic polymorphism among Chinese, Malays and Indians in SingaporeQ70905297
Dose-related effects of a single dose of ethanol on the metabolism in rat liver of some aromatic and chlorinated hydrocarbonsQ70926296
Induction of hepatic and renal P4502E1 of neonatal rats exposed translactationally to ethanolQ71130983
A species comparison of chloral hydrate metabolism in blood and liverQ71700657
Drug binding to plasma proteins during human pregnancy and in the perinatal period. Studies on cloxacillin and alprenololQ71762394
The Greater Risk of Alcoholic Cardiomyopathy and Myopathy in Women Compared With MenQ71833587
Elimination of environmental factors or elimination of individuals: biomarkers and preventionQ71914777
Alcohol dehydrogenase from human stomach: variability in normal mucosa and effect of age, gender, ADH3 phenotype and gastric regionQ72108519
Gender comparisons in human lung cancer: analysis of p53 mutations, anti-p53 serum antibodies and C-erbB-2 expressionQ72281000
Development of Alcohol Dehydrogenase Activity in the Human LiverQ72371317
Ethanol consumption by the nursing mother induces cytochrome P-4502E1 in neonatal rat liverQ72578484
Mortality and cancer incidence of aircraft maintenance workers exposed to trichloroethylene and other organic solvents and chemicals: extended follow up.Q35560689
A case-control study of diabetes mellitus and cancer riskQ36080130
The human hepatic cytochromes P450 involved in drug metabolismQ36258518
Complementary DNA and protein sequences of ethanol-inducible rat and human cytochrome P-450s. Transcriptional and post-transcriptional regulation of the rat enzymeQ36480753
Body composition during growth. In vivo measurements and biochemical data correlated to differential anatomical growthQ36562844
Consideration of the Target Organ Toxicity of Trichloroethylene in Terms of Metabolite Toxicity and PharmacokineticsQ37008371
Oxidation of toxic and carcinogenic chemicals by human cytochrome P-450 enzymesQ37362341
Genetics of human alcohol-metabolizing enzymesQ37716793
Polymorphism of human CYP2D genes involved in drug metabolism: possible relationship to individual cancer risk.Q37764579
Fetal alcohol syndrome: current status of pathogenesisQ38014467
The pharmacology of dichloroacetateQ38300732
Genetic polymorphism of cytochrome P4502E1 in a Swedish population. Relationship to incidence of lung cancerQ38320804
Excess risk of primary liver cancer in patients with diabetes mellitusQ38506217
Increased incidence of renal cell tumors in a cohort of cardboard workers exposed to trichloroetheneQ38574060
Ethanol metabolismQ39671448
Trichloroethylene--a review of the literature from a health effects perspectiveQ40372107
An update on incidence of FAS: FAS is not an equal opportunity birth defectQ40416343
Diagnosis of polymorphisms in carcinogen-activating and inactivating enzymes and cancer susceptibility-a reviewQ40442625
Induction of cytochrome P450 by tolueneQ40612732
Mechanisms of carcinogenesis and individual susceptibility to cancerQ40662235
Pharmacogenetic phenotyping and genotyping. Present status and future potential.Q40730354
Bioactivation of halogenated hydrocarbons by cytochrome P4502E1.Q40895567
Risk assessment for people exposed from different environmentsQ40897219
Risk assessment: toxicity from chemical exposure resulting from enhanced expression of CYP2E1.Q40951469
Evaluating human variability in chemical risk assessment: hazard identification and dose-response assessment for noncancer oral toxicity of trichloroethyleneQ41035617
Expression of CYP1B1 in human adult and fetal tissues and differential inducibility of CYP1B1 and CYP1A1 by Ah receptor ligands in human placenta and cultured cellsQ41130298
Effect of ethanol on the metabolism of trichloroethyleneQ41282755
Cytochrome P-4502E1: its physiological and pathological roleQ41441345
Acute renal failure due to trichloroethylene poisoningQ41464022
Cancer incidence among Finnish workers exposed to halogenated hydrocarbonsQ41667678
Enzymes induced by ethanol differently affect the pharmacokinetics of trichloroethylene and 1,1,1-trichloroethaneQ41835293
Mechanism of activation of pyruvate dehydrogenase by dichloroacetate and other halogenated carboxylic acidsQ41945381
Mutagenicity of amino acid and glutathione S-conjugates in the Ames testQ42202583
Interaction between ethanol and carbohydrate on the metabolism in rat liver of aromatic and chlorinated hydrocarbonsQ42259810
Glutathione S-transferase GSTM1 phenotypes and protection against cutaneous tumoursQ42490961
Influence of polymorphisms of GSTM1 and GSTT1 for risk of renal cell cancer in workers with long-term high occupational exposure to trichloroetheneQ42547835
Cytochrome P450-related differences between rats and mice in the metabolism of benzene, toluene and trichloroethylene in liver microsomesQ42558794
Human glutathione S-transferase theta (GSTT1): cDNA cloning and the characterization of a genetic polymorphismQ42834608
The swift increase in alcohol metabolism. Time course for the increase in hepatic oxygen uptake and the involvement of glycolysisQ42879983
Association between Restriction Fragment Length Polymorphism of the Human Cytochrome P450IIE1 Gene and Susceptibility to Lung CancerQ43904565
Ethanol-induced enhancement of trichloroethylene metabolism and hepatotoxicity: difference from the effect of phenobarbitalQ43918493
Expression of CYP2E1 during human fetal development: methylation of the CYP2E1 gene in human fetal and adult liver samplesQ43941745
Metabolism of trichloroethylene in man. III. Interaction of trichloroethylene and ethanolQ43986487
Metabolism of N-nitrosodialkylamines by human liver microsomes.Q44171099
Glutathione S-transferases in normal and cancerous human colon tissueQ44247828
Cytochrome P450IIE1 genetic polymorphisms, racial variation, and lung cancer riskQ44293824
Ethnic distribution of the glutathione transferase Mu 1-1 (GSTM1) null genotype in 1473 individuals and application to bladder cancer susceptibilityQ44696853
Nonviral Risk Factors for Hepatocellular Carcinoma in a Low-Risk Population, the Non-Asians of Los Angeles County, CaliforniaQ46175640
Ethnic differences in the prevalence of the homozygous deleted genotype of glutathione S-transferase thetaQ46334194
Ethnic variation in the CYP2E1 gene: polymorphism analysis of 695 African-Americans, European-Americans and Taiwanese.Q46354158
Polymorphisms in the glutathione S-transferase class mu and theta genes interact and increase susceptibility to lung cancer in minority populations (Texas, United States).Q46772859
P921main subjectgenetic variationQ349856
hydrocarbonQ43648
environmental carcinogensQ50429902
P304page(s)201-214
P577publication date2000-05-01
P1433published inEnvironmental Health PerspectivesQ1345904
P1476titleHuman variability and susceptibility to trichloroethylene
P478volume108 Suppl 2

Reverse relations

cites work (P2860)
Q39232459A case of occupational hypersensitivity pneumonitis associated with trichloroethylene.
Q46981486An example of model structure differences using sensitivity analyses in physiologically based pharmacokinetic models of trichloroethylene in humans
Q36976099Concentration of trichloroethylene in breast milk and household water from Nogales, Arizona
Q36987092Difficulty of mode of action determination for trichloroethylene: An example of complex interactions of metabolites and other chemical exposures
Q99563502Drug use disorder following early life exposure to tetrachloroethylene (PCE)-contaminated drinking water: a retrospective cohort study
Q44871446Editor's Highlight: Collaborative Cross Mouse Population Enables Refinements to Characterization of the Variability in Toxicokinetics of Trichloroethylene and Provides Genetic Evidence for the Role of PPAR Pathway in Its Oxidative Metabolism.
Q48614010Estimating risk during showering exposure to VOCs of workers in a metal-degreasing facility
Q52692154Ethical Dilemmas in Protecting Susceptible Subpopulations From Environmental Health Risks: Liberty, Utility, Fairness, and Accountability for Reasonableness.
Q34601385Interstrain differences in the liver effects of trichloroethylene in a multistrain panel of inbred mice
Q37396395Liquid chromatography electrospray ionization tandem mass spectrometry analysis method for simultaneous detection of trichloroacetic acid, dichloroacetic acid, S-(1,2-dichlorovinyl)glutathione and S-(1,2-dichlorovinyl)-L-cysteine
Q23912002Occupational exposure to trichloroethylene and cancer risk for workers at the Paducah Gaseous Diffusion Plant
Q24820786PULMONARY BIOACTIVATION OF TRICHLOROETHYLENE TO CHLORAL HYDRATE: RELATIVE CONTRIBUTIONS OF CYP2E1, CYP2F, AND CYP2B1
Q37333030Pharmacokinetic analysis of trichloroethylene metabolism in male B6C3F1 mice: Formation and disposition of trichloroacetic acid, dichloroacetic acid, S-(1,2-dichlorovinyl)glutathione and S-(1,2-dichlorovinyl)-L-cysteine
Q28389958Target Organ Metabolism, Toxicity, and Mechanisms of Trichloroethylene and Perchloroethylene: Key Similarities, Differences, and Data Gaps
Q24671489Trichloroethylene health risks--state of the science
Q48450744USE OF NATIVE PLANTS FOR REMEDIATION OF TRICHLOROETHYLENE: II. CONIFEROUS TREES.

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