The product of the c-ets-1 proto-oncogene and the related Ets2 protein act as transcriptional activators of the long terminal repeat of human T cell leukemia virus HTLV-1

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The product of the c-ets-1 proto-oncogene and the related Ets2 protein act as transcriptional activators of the long terminal repeat of human T cell leukemia virus HTLV-1 is …
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scholarly articleQ13442814

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P932PMC publication ID552042
P698PubMed publication ID2209540

P2093author name stringBrady J
Bosselut R
Gégonne A
Ghysdael J
Bailly M
Duvall JF
Hémar A
P2860cites workThe erg gene: a human gene related to the ets oncogeneQ24299030
Leucine zipper structure of the protein CRE-BP1 binding to the cyclic AMP response element in brainQ24305269
The ets sequence from the transforming gene of avian erythroblastosis virus, E26, has unique domains on human chromosomes 11 and 21: both loci are transcriptionally activeQ24609161
Equilibria and kinetics of lac repressor-operator interactions by polyacrylamide gel electrophoresisQ24633932
Mammalian ets-1 and ets-2 genes encode highly conserved proteinsQ24647052
Isolation of biologically active ribonucleic acid from sources enriched in ribonucleaseQ26778460
The leucine zipper: a hypothetical structure common to a new class of DNA binding proteinsQ27860587
Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cellsQ27860607
A new technique for the assay of infectivity of human adenovirus 5 DNAQ27860797
The macrophage and B cell-specific transcription factor PU.1 is related to the ets oncogeneQ28116777
erg, a human ets-related gene on chromosome 21: alternative splicing, polyadenylation, and translationQ28295357
Binding of host-cell factors to DNA sequences in the long terminal repeat of human T-cell leukemia virus type I: implications for viral gene expressionQ33556396
Identification in chicken macrophages of a set of proteins related to, but distinct from, the chicken cellular c-ets-encoded protein p54c-etsQ33880369
Tax1 induction of the HTLV-I 21 bp enhancer requires cooperation between two cellular DNA-binding proteinsQ33918902
Sequence-specific DNA binding of the proto-oncoprotein ets-1 defines a transcriptional activator sequence within the long terminal repeat of the Moloney murine sarcoma virusQ33919687
Rapid and transient expression of Ets2 in mature macrophages following stimulation with cMGF, LPS, and PKC activatorsQ34211047
Tripartite structure of the avian erythroblastosis virus E26 transforming geneQ34255156
A putative second cell-derived oncogene of the avian leukaemia retrovirus E26.Q34255162
Trans-acting transcriptional activation of the long terminal repeat of human T lymphotropic viruses in infected cellsQ34255923
Trans activation of the bovine leukemia virus long terminal repeat in BLV-infected cellsQ34563896
Temporal and tissue-specific expression of mouse ets genesQ34622266
elk, tissue-specific ets-related genes on chromosomes X and 14 near translocation breakpointsQ34666320
Identification and preferential expression in thymic and bursal lymphocytes of a c-ets oncogene-encoded Mr 54,000 cytoplasmic proteinQ35594791
Identification in chickens of an evolutionarily conserved cellular ets-2 gene (c-ets-2) encoding nuclear proteins related to the products of the c-ets proto-oncogene.Q35978588
Mitogenic stimulation of thymocytes results in the calcium-dependent phosphorylation of c-ets-1 proteinsQ35980142
Activation of protein kinase C or cAMP-dependent protein kinase increases phosphorylation of the c-erbA-encoded thyroid hormone receptor and of the v-erbA-encoded proteinQ36063185
A 36-kilodalton cellular transcription factor mediates an indirect interaction of human T-cell leukemia/lymphoma virus type I TAX1 with a responsive element in the viral long terminal repeatQ36720321
Phosphorylation of the ETS-2 protein: regulation by the T-cell antigen receptor-CD3 complexQ36722432
Indirect binding of human T-cell leukemia virus type I tax1 to a responsive element in the viral long terminal repeatQ36761506
Purification and characterization of multiple nuclear factors that bind to the TAX-inducible enhancer within the human T-cell leukemia virus type 1 long terminal repeatQ36764496
The ets sequence is required for induction of erythroblastosis in chickens by avian retrovirus E26Q36780332
Response of the human T-cell leukemia virus type 1 long terminal repeat to cyclic AMPQ36791753
Definition of an Ets1 protein domain required for nuclear localization in cells and DNA-binding activity in vitroQ36798329
Activation of the human T-cell leukemia virus type I long terminal repeat by 12-O-tetradecanoylphorbol-13-acetate and by tax (p40x) occurs through similar but functionally distinct target sequencesQ36829290
Utilization of signal transduction pathway by the human T-cell leukemia virus type I transcriptional activator tax.Q36830369
Multiple domains for the chicken cellular sequences homologous to the v-ets oncogene of the E26 retrovirus.Q36835325
A short-lived nuclear phosphoprotein encoded by the human ets-2 proto-oncogene is stabilized by activation of protein kinase C.Q36848613
Alternative splicing within the chicken c-ets-1 locus: implications for transduction within the E26 retrovirus of the c-ets proto-oncogeneQ36872333
Characterization of cellular factors that interact with the human T-cell leukemia virus type I p40x-responsive 21-base-pair sequenceQ36873450
Identification of p40x-responsive regulatory sequences within the human T-cell leukemia virus type I long terminal repeatQ36889867
The proto-oncogene c-ets is preferentially expressed in lymphoid cellsQ36951174
Functional activation of the long terminal repeat of human T-cell leukemia virus type I by a trans-acting factorQ37684060
Molecular and functional characterization of the promoter of ETS2, the human c-ets-2 geneQ37685279
A unique enhancer element for the trans activator (p40tax) of human T-cell leukemia virus type I that is distinct from cyclic AMP- and 12-O-tetradecanoylphorbol-13-acetate-responsive elements.Q40116375
Transforming capacities and defectiveness of avian leukemia viruses OK10 and E 26.Q40277986
Ubiquitous and lymphocyte-specific factors are involved in the induction of the mouse interleukin 2 gene in T lymphocytesQ40817161
Identification of a Ets1 variant protein unaffected in its chromatin and in vitro DNA binding capacities by T cell antigen receptor triggering and intracellular calcium risesQ41203284
The DNA binding domain of the rat liver nuclear protein C/EBP is bipartiteQ41260447
Direct evidence that p40x of human T-cell leukemia virus type I is a trans-acting transcriptional activatorQ42566351
Activation of the HIV-1 LTR by T cell mitogens and the trans-activator protein of HTLV-I.Q43858457
The Drosophila 74EF early puff contains E74, a complex ecdysone-inducible gene that encodes two ets-related proteinsQ45196166
Transformation of both erythroid and myeloid cells by E26, an avian leukemia virus that contains the myb geneQ45798969
Ts mutants of E26 leukemia virus allow transformed myeloblasts, but not erythroblasts or fibroblasts, to differentiate at the nonpermissive temperatureQ45807078
The Drosophila ets-2 gene: molecular structure, chromosomal localization, and developmental expressionQ48324960
Identification of two distinct regulatory regions adjacent to the human β-interferon geneQ48395961
Two distinct enhancers with different cell specificities coexist in the regulatory region of polyoma.Q50586207
A single point mutation in the v-ets oncogene affects both erythroid and myelomonocytic cell differentiationQ51183489
Myeloid and erythroid neoplastic responses to avian defective leukemia viruses in chickens and in quailQ53570198
Tryptophans in myb proteinsQ58990136
The c-ets-1 protein is chromatin associated and binds to DNA in vitroQ69507618
P433issue10
P407language of work or nameEnglishQ1860
P921main subjectleukemiaQ29496
Human T-lymphotropic virus 1Q1280388
P304page(s)3137-3144
P577publication date1990-10-01
P1433published inThe EMBO JournalQ1278554
P1476titleThe product of the c-ets-1 proto-oncogene and the related Ets2 protein act as transcriptional activators of the long terminal repeat of human T cell leukemia virus HTLV-1
P478volume9

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cites work (P2860)
Q36766924A new regulatory element that augments the Tax-dependent enhancer of human T-cell leukemia virus type 1 and cloning of cDNAs encoding its binding proteins
Q24300123A novel Ets-related transcription factor, Elf-1, binds to human immunodeficiency virus type 2 regulatory elements that are required for inducible trans activation in T cells
Q37258998A phorbol ester response element within the human T-cell receptor beta-chain enhancer
Q34876868A residue of the ETS domain mutated in the v-ets oncogene is essential for the DNA-binding and transactivating properties of the ETS-1 and ETS-2 proteins.
Q35020209A single amino-acid substitution in the Ets domain alters core DNA binding specificity of Ets1 to that of the related transcription factors Elf1 and E74.
Q36632636A transcriptional regulatory element is associated with a nuclease-hypersensitive site in the pol gene of human immunodeficiency virus type 1.
Q33785951Activation of Human T-Cell Leukemia Virus Type 1 tax Gene Expression in Chronically Infected T Cells
Q36315843Activation of the human T-cell leukemia virus type 1 long terminal repeat by the ternary complex factor Elk-1.
Q36652164Activation of the human T-cell leukemia virus type I enhancer is mediated by binding sites for Elf-1 and the pets factor.
Q40309205Activation of the human immunodeficiency virus type 2 enhancer is dependent on purine box and kappa B regulatory elements
Q38319614Both LyF-1 and an Ets protein interact with a critical promoter element in the murine terminal transferase gene.
Q24293686Characterization of Spi-B, a transcription factor related to the putative oncoprotein Spi-1/PU.1
Q36823531Characterization of the human interleukin-2 receptor beta-chain gene promoter: regulation of promoter activity by ets gene products
Q38358328Constitutive expression of c-fos and c-jun, overexpression of ets-2, and reduced expression of metastasis suppressor gene nm23-H1 in rheumatoid arthritis
Q36644903Cooperative binding of Ets-1 and core binding factor to DNA
Q38330831DNA binding by c-Ets-1, but not v-Ets, is repressed by an intramolecular mechanism
Q36652613DNA-binding and transcriptional activation properties of the EWS-FLI-1 fusion protein resulting from the t(11;22) translocation in Ewing sarcoma
Q40048965Definition of functional domains in P135gag-myb-ets and p48v-myb proteins required to maintain the response of neuroretina cells to basic fibroblast growth factor
Q35938309Different binding site requirements for binding and activation for the bipartite enhancer factor EF-1A
Q31047557Differential Role of PKC-Induced c-Jun in HTLV-1 LTR Activation by 12-O-Tetradecanoylphorbol-13-acetate in Different Human T-cell Lines
Q24318370ETS1 suppresses tumorigenicity of human colon cancer cells
Q40422931Elk-1 protein domains required for direct and SRF-assisted DNA-binding
Q42125962Evolutionarily conserved Ets family members display distinct DNA binding specificities
Q36659956GATA and Ets cis-acting sequences mediate megakaryocyte-specific expression
Q39605657GLI-2 modulates retroviral gene expression
Q24312994HUB1, a novel Kruppel type zinc finger protein, represses the human T cell leukemia virus type I long terminal repeat-mediated expression
Q41945472Identification of a novel interleukin-6 response element containing an Ets-binding site and a CRE-like site in the junB promoter
Q38330363Identification of nucleotide preferences in DNA sequences recognised specifically by c-Ets-1 protein
Q40039922In vivo cooperation of two nuclear oncogenic proteins, P135gag-myb-ets and p61/63myc, leads to transformation and immortalization of chicken myelomonocytic cells
Q36701505In vivo genomic variability of human T-cell leukemia virus type I depends more upon geography than upon pathologies
Q24649585Involvement of transcription factor YB-1 in human T-cell lymphotropic virus type I basal gene expression
Q24534692Krox20 and kreisler co-operate in the transcriptional control of segmental expression of Hoxb3 in the developing hindbrain.
Q38320480Localization of the c-ets-2 transactivation domain
Q38314720Molecular regulation of the human IL-3 gene: inducible T cell-restricted expression requires intact AP-1 and Elf-1 nuclear protein binding sites
Q38327790Multistep regulation of enhancer activity of the 21-base-pair element of human T-cell leukemia virus type I
Q24563107Myb and Ets proteins cooperate in transcriptional activation of the mim-1 promoter
Q39869820Naturally occurring variants of human T-cell leukemia virus type I Tax protein impair its recognition by cytotoxic T lymphocytes and the transactivation function of Tax.
Q38307821Participation of Ets transcription factors in the glucocorticoid response of the rat tyrosine aminotransferase gene.
Q35752816Rapamycin-induced inhibition of HTLV-I LTR activity is rescued by c-Myb
Q33348553RelB-dependent stromal cells promote T-cell leukemogenesis
Q36818661Role of the PU.1 transcription factor in controlling differentiation of Friend erythroleukemia cells
Q36798336Sequence-specific interaction of the Ets1 protein with the long terminal repeat of the human T-lymphotropic virus type I.
Q36646061Sequences downstream of the RNA initiation site regulate human T-cell lymphotropic virus type I basal gene expression
Q34046598Synergistic activation of the HTLV1 LTR Ets-responsive region by transcription factors Ets1 and Sp1.
Q24563066The PR264/c-myb connection: expression of a splicing factor modulated by a nuclear protooncogene
Q41080680The c-Ets oncoprotein activates the stromelysin promoter through the same elements as several non-nuclear oncoproteins
Q36656064The cellular proto-oncogene product Myb acts as transcriptional activator of the long terminal repeat of human T-lymphotropic virus type I
Q34333483The high-affinity Sp1 binding site in the HTLV-1 promoter contributes to Tax-independent basal expression
Q36653668Transactivation of the P2 promoter of parathyroid hormone-related protein by human T-cell lymphotropic virus type I Tax1: evidence for the involvement of transcription factor Ets1.
Q33938049Transcription factor AP-2 activates gene expression of HTLV-I
Q24815940Transcription factor binding sites in the pol gene intragenic regulatory region of HIV-1 are important for virus infectivity
Q36635734Transcription of the human T-cell lymphotropic virus type I promoter by an alpha-amanitin-resistant polymerase
Q36747690Transcriptional activation through ETS domain binding sites in the cytochrome c oxidase subunit IV gene
Q33884193Transcriptional repression of the Neurofibromatosis-1 tumor suppressor by the t(8;21) fusion protein.
Q42070420Transcriptional suppression of the human T-cell leukemia virus type I long terminal repeat occurs by an unconventional interaction of a CREB factor with the R region
Q35830887c-ets1 proto-oncogene is a transcription factor expressed in endothelial cells during tumor vascularization and other forms of angiogenesis in humans
Q39879902cis-Acting inhibitory elements within the pol-env region of human T-cell leukemia virus type 1 possibly involved in viral persistence
Q31117684cis-acting sequences required for inducible interleukin-2 enhancer function bind a novel Ets-related protein, Elf-1.
Q36566985ets-1 in astrocytes: expression and transmitter-evoked phosphorylation

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