Forward genetic analysis reveals multiple gating mechanisms of TRPV4

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Forward genetic analysis reveals multiple gating mechanisms of TRPV4 is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M110.113936
P932PMC publication ID2888399
P698PubMed publication ID20424166

P50authorZhenwei SuQ59980456
Ching KungQ123764436
P2093author name stringXinliang Zhou
Stephen Loukin
P2860cites workOTRPC4, a nonselective cation channel that confers sensitivity to extracellular osmolarityQ24290380
Alterations in the ankyrin domain of TRPV4 cause congenital distal SMA, scapuloperoneal SMA and HMSN2CQ24595706
Vanilloid receptor-related osmotically activated channel (VR-OAC), a candidate vertebrate osmoreceptorQ24647926
Regulatable promoters of Saccharomyces cerevisiae: comparison of transcriptional activity and their use for heterologous expressionQ28131772
Chaperonin overexpression promotes genetic variation and enzyme evolutionQ28247346
Crystal structure of a mammalian voltage-dependent Shaker family K+ channelQ28260421
Homo- and heterotetrameric architecture of the epithelial Ca2+ channels TRPV5 and TRPV6.Q28586678
An introduction to TRP channelsQ29615753
Mammalian TRPV4 (VR-OAC) directs behavioral responses to osmotic and mechanical stimuli in Caenorhabditis elegansQ30498209
Bisandrographolide from Andrographis paniculata activates TRPV4 channels.Q30821637
Activation of TRPV4 channels (hVRL-2/mTRP12) by phorbol derivativesQ34112760
K(+)-dependent composite gating of the yeast K(+) channel, Tok1.Q34171935
Contribution of the selectivity filter to inactivation in potassium channelsQ34179836
Gain-of-function mutations in TRPV4 cause autosomal dominant brachyolmiaQ34790129
Mutations in the gene encoding the calcium-permeable ion channel TRPV4 produce spondylometaphyseal dysplasia, Kozlowski type and metatropic dysplasiaQ34949511
The TRPV4 channel: structure-function relationship and promiscuous gating behaviour.Q35114819
Cell swelling, heat, and chemical agonists use distinct pathways for the activation of the cation channel TRPV4.Q35123129
Yeast screens show aromatic residues at the end of the sixth helix anchor transient receptor potential channel gateQ36024046
Yeast gain-of-function mutations reveal structure-function relationships conserved among different subfamilies of transient receptor potential channelsQ36288747
One face of a transmembrane helix is crucial in mechanosensitive channel gatingQ36311987
Structure of TRPV1 channel revealed by electron cryomicroscopyQ36677137
A yeast genetic screen reveals a critical role for the pore helix domain in TRP channel gatingQ36710217
Sensing voltage across lipid membranesQ37069037
Molecular mechanisms of TRPV4-mediated neural signalingQ37348481
Uncoupling proton activation of vanilloid receptor TRPV1.Q40046254
A role of the transient receptor potential domain of vanilloid receptor I in channel gating.Q40062691
Outer pore architecture of a Ca2+-selective TRP channelQ40596874
Heat-evoked activation of TRPV4 channels in a HEK293 cell expression system and in native mouse aorta endothelial cellsQ40700786
Hypotonic shocks activate rat TRPV4 in yeast in the absence of polyunsaturated fatty acids.Q41872715
Random mutagenesis reveals a region important for gating of the yeast K+ channel Ykc1.Q42627006
Molecular determinants of permeation through the cation channel TRPV4.Q44047575
Modulation of TRPV4 gating by intra- and extracellular Ca2+.Q44452825
Anandamide and arachidonic acid use epoxyeicosatrienoic acids to activate TRPV4 channelsQ44524443
Comparison of the effects of phorbol dibutyrate and low-frequency stimulation of synaptic inputs on the excitability of myenteric AH neurons.Q44615479
Identification of molecular determinants of channel gating in the transient receptor potential box of vanilloid receptor I.Q46535486
Heat-evoked activation of the ion channel, TRPV4.Q48526032
N-((1S)-1- -3-hydroxypropanoyl)-1-piperazinyl]carbonyl}-3-methylbutyl)-1-benzothiophene-2-carboxamide (GSK1016790A), a Novel and Potent Transient Receptor Potential Vanilloid 4 Channel Agonist Induces Urinary Bladder Contraction and Hyperactivity: PaQ56601579
A transient calcium-dependent chloride current in the immature Xenopus oocyteQ70170735
P433issue26
P407language of work or nameEnglishQ1860
P1104number of pages7
P304page(s)19884-19890
P577publication date2010-04-27
P1433published inJournal of Biological ChemistryQ867727
P1476titleForward genetic analysis reveals multiple gating mechanisms of TRPV4
P478volume285

Reverse relations

cites work (P2860)
Q35910190A channelopathy mechanism revealed by direct calmodulin activation of TrpV4.
Q37369327A competing hydrophobic tug on L596 to the membrane core unlatches S4-S5 linker elbow from TRP helix and allows TRPV4 channel to open
Q92244287Cell sensing and decision-making in confinement: The role of TRPM7 in a tug of war between hydraulic pressure and cross-sectional area
Q29147455Function and regulation of TRPP2 ion channel revealed by a gain-of-function mutant
Q37835109Functional and structural studies of TRP channels heterologously expressed in budding yeast.
Q30276535Gain-of-function mutation in TRPV4 identified in patients with osteonecrosis of the femoral head
Q90213262Human mutations highlight an intersubunit cation-π bond that stabilizes the closed but not open or inactivated states of TRPV channels
Q36514432Human skeletal dysplasia caused by a constitutive activated transient receptor potential vanilloid 4 (TRPV4) cation channel mutation
Q33900735Increased basal activity is a key determinant in the severity of human skeletal dysplasia caused by TRPV4 mutations
Q57178143Investigating Potassium Channels in Budding Yeast: A Genetic Sandbox
Q35212642L596-W733 bond between the start of the S4-S5 linker and the TRP box stabilizes the closed state of TRPV4 channel
Q48600823Sensitisation of TRPV4 by PAR2 is independent of intracellular calcium signalling and can be mediated by the biased agonist neutrophil elastase
Q90833337Structures of TRPV2 in distinct conformations provide insight into role of the pore turret
Q27680762TRPV1 structures in distinct conformations reveal activation mechanisms
Q47208172TRPV4 (Transient Receptor Potential Vanilloid 4) Channel-Dependent Negative Feedback Mechanism Regulates Gq Protein-Coupled Receptor-Induced Vasoconstriction
Q41471829The C-terminal basic residues contribute to the chemical- and voltage-dependent activation of TRPA1.
Q35337561The effect of type-2-diabetes-related vascular endothelial dysfunction on skin physiology and activities of daily living
Q35030683The polymodal ion channel transient receptor potential vanilloid 4 modulates calcium flux, spiking rate, and apoptosis of mouse retinal ganglion cells
Q26849317Transient receptor potential channels as drug targets: from the science of basic research to the art of medicine
Q47228512When size matters: transient receptor potential vanilloid 4 channel as a volume-sensor rather than an osmo-sensor.
Q34094517Wild-type and brachyolmia-causing mutant TRPV4 channels respond directly to stretch force
Q39630828Yeast luminometric and Xenopus oocyte electrophysiological examinations of the molecular mechanosensitivity of TRPV4.

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