Hepatitis A virus suppresses RIG-I-mediated IRF-3 activation to block induction of beta interferon

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Hepatitis A virus suppresses RIG-I-mediated IRF-3 activation to block induction of beta interferon is …
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scholarly articleQ13442814

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P356DOI10.1128/JVI.79.17.10968-10977.2005
P932PMC publication ID1193608
P698PubMed publication ID16103148
P5875ResearchGate publication ID7657793

P2093author name stringVolker Fensterl
Andreas Dotzauer
Angelika Vallbracht
Dajana Grotheer
Iris Berk
Stefanie Schlemminger
P2860cites workToll/IL-1 receptor domain-containing adaptor inducing IFN-beta (TRIF) associates with TNF receptor-associated factor 6 and TANK-binding kinase 1, and activates two distinct transcription factors, NF-kappa B and IFN-regulatory factor-3...Q24297037
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Virus-dependent phosphorylation of the IRF-3 transcription factor regulates nuclear translocation, transactivation potential, and proteasome-mediated degradationQ24523761
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Regulated nuclear-cytoplasmic localization of interferon regulatory factor 3, a subunit of double-stranded RNA-activated factor 1Q24554197
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The V proteins of paramyxoviruses bind the IFN-inducible RNA helicase, mda-5, and inhibit its activation of the IFN-beta promoterQ24558779
Toll-like receptor signallingQ24570126
Human papillomavirus 16 E6 oncoprotein binds to interferon regulatory factor-3 and inhibits its transcriptional activityQ24599944
The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responsesQ27860685
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NAK is an IkappaB kinase-activating kinaseQ28143033
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IKKepsilon and TBK1 are essential components of the IRF3 signaling pathwayQ28190704
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Association of the adaptor TANK with the I kappa B kinase (IKK) regulator NEMO connects IKK complexes with IKK epsilon and TBK1 kinasesQ28215547
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Retinoic acid-inducible gene-I is induced by interferon-gamma and regulates the expression of interferon-gamma stimulated gene 15 in MCF-7 cellsQ34325109
Blockade of interferon induction and action by the E3L double-stranded RNA binding proteins of vaccinia virus.Q34337534
Upregulation of retinoic acid-inducible gene-I in T24 urinary bladder carcinoma cells stimulated with interferon-gammaQ34339222
Complete nucleotide sequence of an attenuated hepatitis A virus: comparison with wild-type virusQ34615140
IFN-regulatory factor 3-dependent gene expression is defective in Tbk1-deficient mouse embryonic fibroblastsQ35122228
The roles of two IkappaB kinase-related kinases in lipopolysaccharide and double stranded RNA signaling and viral infectionQ36402648
Differential requirement for TANK-binding kinase-1 in type I interferon responses to toll-like receptor activation and viral infectionQ36402672
Human gamma interferon production by cytotoxic T lymphocytes sensitized during hepatitis A virus infectionQ36873055
A FADD-dependent innate immune mechanism in mammalian cellsQ38334155
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Influenza A virus NS1 protein prevents activation of NF-kappaB and induction of alpha/beta interferonQ39593618
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Hepatitis A virus inhibits cellular antiviral defense mechanisms induced by double-stranded RNAQ39686283
Susceptibility of nonprimate cell lines to hepatitis A virus infection.Q40041641
Hepatitis A-virus particles in stools of patients from a natural hepatitis outbreak in GermanyQ40108141
Mechanism for transcriptional synergy between interferon regulatory factor (IRF)-3 and IRF-7 in activation of the interferon-beta gene promoterQ40517966
Rac1 and PAK1 are upstream of IKK-epsilon and TBK-1 in the viral activation of interferon regulatory factor-3.Q40549133
Ligand-regulated chimeric receptor approach reveals distinctive subcellular localization and signaling properties of the Toll-like receptorsQ40587520
TICAM-1, an adaptor molecule that participates in Toll-like receptor 3-mediated interferon-beta inductionQ40675827
Liver-derived cytotoxic T cells in hepatitis A virus infectionQ41261954
The proposed gene for VP1 of HAV encodes for a larger protein than that observed in HAV-infected cells and virionsQ41271834
Clonal analysis of infiltrating T lymphocytes in liver tissue in viral hepatitis A.Q43644002
The cytoplasmic 'linker region' in Toll-like receptor 3 controls receptor localization and signalingQ44958632
Effect of Hepatitis A Virus Infection on Cell Metabolism in VitroQ45796026
Persistent infection of human fibroblasts by hepatitis A virusQ45796986
Hepatitis A virus infection and the interferon systemQ45838616
P433issue17
P407language of work or nameEnglishQ1860
P921main subjecthepatitis AQ157661
Hepatitis A virusQ4112120
P304page(s)10968-10977
P577publication date2005-09-01
P1433published inJournal of VirologyQ1251128
P1476titleHepatitis A virus suppresses RIG-I-mediated IRF-3 activation to block induction of beta interferon
P478volume79