A metabolic model of the mitochondrion and its use in modelling diseases of the tricarboxylic acid cycle

scientific article published on June 29, 2011

A metabolic model of the mitochondrion and its use in modelling diseases of the tricarboxylic acid cycle is …
instance of (P31):
scholarly articleQ13442814

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P8978DBLP publication IDjournals/bmcsb/SmithR11
P6179Dimensions Publication ID1042195708
P356DOI10.1186/1752-0509-5-102
P953full work available at URLhttps://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-5-102
https://europepmc.org/articles/PMC3152903
https://europepmc.org/articles/PMC3152903?pdf=render
P932PMC publication ID3152903
P698PubMed publication ID21714867
P5875ResearchGate publication ID51453458

P2093author name stringAnthony C. Smith
Alan J. Robinson
P2860cites workComputational prediction of human metabolic pathways from the complete human genomeQ21092879
An expanded genome-scale model of Escherichia coli K-12 (iJR904 GSM/GPR)Q21194867
Mutation of a nuclear succinate dehydrogenase gene results in mitochondrial respiratory chain deficiencyQ24308632
Mutation of the fumarase gene in two siblings with progressive encephalopathy and fumarase deficiencyQ24316130
Cytoscape: a software environment for integrated models of biomolecular interaction networksQ24515682
How mitochondria produce reactive oxygen speciesQ24643882
KEGG for representation and analysis of molecular networks involving diseases and drugsQ24644514
BRENDA, AMENDA and FRENDA the enzyme information system: new content and tools in 2009Q24655817
Deficient fumarase activity in an infant with fumaricacidemia and its distribution between the different forms of the enzyme seen on isoelectric focusingQ24676169
Bioenergetic cost of making an adenosine triphosphate molecule in animal mitochondriaQ27664534
Fumaric aciduria: clinical and imaging featuresQ28144047
The mitochondrial transporter family (SLC25): physiological and pathological implicationsQ28181828
The systems biology markup language (SBML): a medium for representation and exchange of biochemical network modelsQ28212902
A novel mutation in the dihydrolipoamide dehydrogenase E3 subunit gene (DLD) resulting in an atypical form of alpha-ketoglutarate dehydrogenase deficiencyQ28235105
Succinate dehydrogenase deficiency in humanQ28270821
What is flux balance analysis?Q28275348
Fumarase deficiency is an autosomal recessive encephalopathy affecting both the mitochondrial and the cytosolic enzymesQ28279115
Minimum information requested in the annotation of biochemical models (MIRIAM)Q28285448
The Universal Protein Resource (UniProt) in 2010Q28749229
Quantitative prediction of cellular metabolism with constraint-based models: the COBRA ToolboxQ29615372
Reconstruction of metabolic networks from genome data and analysis of their global structure for various organismsQ30763008
Reconstruction and functional characterization of the human mitochondrial metabolic network based on proteomic and biochemical dataQ30939059
Flux-balance analysis of mitochondrial energy metabolism: consequences of systemic stoichiometric constraintsQ31920157
MitoMiner, an integrated database for the storage and analysis of mitochondrial proteomics dataQ33408082
The molecular basis of dominance.Q34283978
Mitochondrial diseaseQ34543745
Alpha-ketoglutarate dehydrogenase deficiency presenting as congenital lactic acidosisQ34564054
2-Ketoglutarate dehydrogenase deficiency, a rare cause of primary hyperlactataemia: report of a new caseQ34729219
Inborn errors of the Krebs cycle: a group of unusual mitochondrial diseases in humanQ34742947
The role and structure of mitochondrial carriersQ35757351
Alterations of myocardial amino acid metabolism in chronic ischemic heart diseaseQ35905152
Fumarase deficiency: two siblings with enlarged cerebral ventricles and polyhydramnios in utero.Q35968221
Myocardial substrate metabolism in the normal and failing heartQ36179008
Group contribution method for thermodynamic analysis of complex metabolic networksQ36783787
Role of cardiolipin peroxidation and Ca2+ in mitochondrial dysfunction and diseaseQ37445214
The Gene Ontology Annotation (GOA) Database--an integrated resource of GO annotations to the UniProt KnowledgebaseQ38522030
Glucose-free fatty acid cycle operates in human heart and skeletal muscle in vivoQ40343651
Gamma-aminobutyric acid (GABA) metabolism in mammalian neural and nonneural tissuesQ40429762
Glutamine metabolism and transport in skeletal muscle and heart and their clinical relevanceQ40994124
A familial progressive neurodegenerative disease with 2-oxoglutaric aciduriaQ42468171
Extreme pathways and Kirchhoff's second law.Q43122158
Non-invasive measurements of myocardial carbon metabolism using in vivo 13C NMR spectroscopyQ43968220
Succinate in dystrophic white matter: a proton magnetic resonance spectroscopy finding characteristic for complex II deficiencyQ44060064
Profiling substrate fluxes in the isolated working mouse heart using 13C-labeled substrates: focusing on the origin and fate of pyruvate and citrate carbonsQ44689992
Mitochondrial pH monitored by a new engineered green fluorescent protein mutant.Q44710648
Candidate metabolic network states in human mitochondria. Impact of diabetes, ischemia, and diet.Q45168694
The effect of hyperpolarized tracer concentration on myocardial uptake and metabolismQ46103916
Complex I is the major site of mitochondrial superoxide production by paraquatQ46881393
A general computational model of mitochondrial metabolism in a whole organelle scaleQ47205738
Fumarate hydratase deficiency in monozygotic twinsQ48459949
Effects of riboflavin in children with complex II deficiencyQ48515664
Fumaric aciduria: a new organic aciduria, associated with mental retardation and speech impairmentQ52094819
Single muscle fibre analyses in 2 brothers with succinate dehydrogenase deficiency.Q54432742
Fumaric aciduria: Clinical and imaging featuresQ56018001
Kearns-Sayre syndrome and complex II deficiencyQ69591998
Biochemical investigations and immunoblot analyses of two unrelated patients with an isolated deficiency in complex II of the mitochondrial respiratory chainQ71004601
Myocardial Exchanges of Glutamate, Alanine and Citrate in Controls and Patients with Coronary Artery DiseaseQ72543442
Glucose and fatty acid metabolism in the isolated working mouse heartQ73071219
Altered metabolism causes cardiac dysfunction in perfused hearts from diabetic (db/db) miceQ73127304
Effects of aminooxyacetate on glutamate compartmentation and TCA cycle kinetics in rat heartsQ74255333
Import of lipids into mitochondriaQ74640249
P4510describes a project that usesCytoscapeQ3699942
P407language of work or nameEnglishQ1860
P921main subjecttricarboxylic acid cycleQ133895
mitochondrionQ39572
modelling biological systemsQ4299308
P304page(s)102
P577publication date2011-06-29
P1433published inBMC Systems BiologyQ4835949
P1476titleA metabolic model of the mitochondrion and its use in modelling diseases of the tricarboxylic acid cycle
P478volume5

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cites work (P2860)
Q51175854A design automation framework for computational bioenergetics in biological networks.
Q34906417A panoramic overview of mitochondria and mitochondrial redox biology
Q28384122Bioanalysis of Eukaryotic Organelles
Q36228895Cancer cell growth and survival as a system-level property sustained by enhanced glycolysis and mitochondrial metabolic remodeling
Q34396816CardioNet: a human metabolic network suited for the study of cardiomyocyte metabolism
Q39428664Deficits in the mitochondrial enzyme α-ketoglutarate dehydrogenase lead to Alzheimer's disease-like calcium dysregulation
Q39316985Effect of essential fatty acids on glucose-induced cytotoxicity to retinal vascular endothelial cells
Q47603942Fumarase Deficiency: A Safe and Potentially Disease Modifying Effect of High Fat/Low Carbohydrate Diet
Q35859412Fumarate is cardioprotective via activation of the Nrf2 antioxidant pathway.
Q38711911Genome-scale metabolic models applied to human health and disease
Q34447034Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS.
Q47954316Isolation of Functional Mitochondria from Cultured Cells and Mouse Tissues
Q38056722Mechanistic modeling of aberrant energy metabolism in human disease
Q41840468Metabolic flexibility of mitochondrial respiratory chain disorders predicted by computer modelling
Q34781444Metabolomic profiling analysis reveals chamber-dependent metabolite patterns in the mouse heart
Q47151205MitoCore: a curated constraint-based model for simulating human central metabolism
Q34084587MitoMiner: a data warehouse for mitochondrial proteomics data
Q36877638Mitochondrial Reactive Oxygen Species Mediate Cardiac Structural, Functional, and Mitochondrial Consequences of Diet-Induced Metabolic Heart Disease
Q46368801Modeling oxygen requirements in ischemic cardiomyocytes.
Q44501708Modelling pyruvate dehydrogenase under hypoxia and its role in cancer metabolism.
Q35777348Multi-Target Analysis and Design of Mitochondrial Metabolism.
Q44448314On the role of the mitochondrial 2-oxoglutarate dehydrogenase complex in amino acid metabolism
Q50783539Pedagogical view of model metabolic cycles
Q91815266Rescue of TCA Cycle Dysfunction for Cancer Therapy
Q57462280Screening of candidate substrates and coupling ions of transporters by thermostability shift assays
Q46637268Succinate: A Promising Therapeutic Target for Reperfusion Injury
Q61803767Systems Biology Approaches Toward Understanding Primary Mitochondrial Diseases
Q39076595Traditional and novel tools to probe the mitochondrial metabolism in health and disease
Q34032854Up-regulation of 2-oxoglutarate dehydrogenase as a stress response
Q37412089l-Citrulline Protects from Kidney Damage in Type 1 Diabetic Mice

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