Nitroxyl (HNO): A novel approach for the acute treatment of heart failure

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Nitroxyl (HNO): A novel approach for the acute treatment of heart failure is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1161/CIRCHEARTFAILURE.113.000632
P932PMC publication ID4110196
P698PubMed publication ID24107588

P50authorWilson S ColucciQ46618620
Nazareno PaolocciQ42067397
Carlo Gabriele TocchettiQ42661613
P2093author name stringEiki Takimoto
David A Kass
Ramesh C Gupta
Hani N Sabbah
Richard S Tunin
Mengjun Wang
Reza Mazhari
Samantapudi Daya
Douglas Cowart
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NO- activates soluble guanylate cyclase and Kv channels to vasodilate resistance arteriesQ44438485
Calcitonin gene-related peptide in vivo positive inotropy is attributable to regional sympatho-stimulation and is blunted in congestive heart failureQ45182847
Spontaneous and inducible ventricular arrhythmias in a canine model of chronic heart failure: relation to haemodynamics and sympathoadrenergic activationQ45214282
Hemodynamic, echocardiographic, and neurohormonal effects of istaroxime, a novel intravenous inotropic and lusitropic agent: a randomized controlled trial in patients hospitalized with heart failureQ46556129
Acute heart failure patient profiles, management and in-hospital outcome: results of the Italian Registry on Heart Failure OutcomeQ47339351
Phospholamban thiols play a central role in activation of the cardiac muscle sarcoplasmic reticulum calcium pump by nitroxyl.Q52695418
A canine model of chronic heart failure produced by multiple sequential coronary microembolizationsQ67898469
Ventricular systolic assessment in patients with dilated cardiomyopathy by preload-adjusted maximal power. Validation and noninvasive applicationQ72415144
Nitroxyl increases force development in rat cardiac muscleQ79855253
Mechanism of aerobic decomposition of Angeli's salt (sodium trioxodinitrate) at physiological pHQ81254793
Nitroxyl (HNO): a novel redox signaling moleculeQ83383537
Cardiac myosin activation: a potential therapeutic approach for systolic heart failureQ30583292
Oxidant stress from nitric oxide synthase-3 uncoupling stimulates cardiac pathologic remodeling from chronic pressure loadQ33743649
Nitroxyl anion exerts redox-sensitive positive cardiac inotropy in vivo by calcitonin gene-related peptide signaling.Q33943302
The effects of the cardiac myosin activator, omecamtiv mecarbil, on cardiac function in systolic heart failure: a double-blind, placebo-controlled, crossover, dose-ranging phase 2 trial.Q34209536
Nitroxyl improves cellular heart function by directly enhancing cardiac sarcoplasmic reticulum Ca2+ cyclingQ34586280
Nitroxyl activates SERCA in cardiac myocytes via glutathiolation of cysteine 674.Q34615204
Nitroxyl enhances myocyte Ca2+ transients by exclusively targeting SR Ca2+-cyclingQ34671389
The specificity of nitroxyl chemistry is unique among nitrogen oxides in biological systems.Q34756677
The effectiveness and relative effectiveness of intravenous inotropic drugs acting through the adrenergic pathway in patients with heart failure-a meta-regression analysisQ34776831
Positive inotropic and lusitropic effects of HNO/NO − in failing hearts: Independence from β-adrenergic signalingQ34983537
Nitroxyl-mediated disulfide bond formation between cardiac myofilament cysteines enhances contractile function.Q36314776
S-nitrosylation: integrator of cardiovascular performance and oxygen deliveryQ36497166
HNO enhances SERCA2a activity and cardiomyocyte function by promoting redox-dependent phospholamban oligomerizationQ37204272
A role for nitroxyl (HNO) as an endothelium-derived relaxing and hyperpolarizing factor in resistance arteries.Q37255292
Cardiac inotropes: current agents and future directionsQ37851240
Acute decompensated heart failure - treatments and challenges - .Q37985383
Structure and regulation of soluble guanylate cyclaseQ37992160
Diuretics and ultrafiltration in acute decompensated heart failure.Q38016994
Update on the Management of Acute Decompensated Heart FailureQ39258163
The shy Angeli and his elusive creature: the HNO route to vasodilationQ43123682
Analysis of isovolumic relaxation in failing hearts by monoexponential time constants overestimates lusitropic change and load dependence: mechanisms and advantages of alternative logistic fit.Q43207759
Predictors of in-hospital mortality in patients hospitalized for heart failure: insights from the Organized Program to Initiate Lifesaving Treatment in Hospitalized Patients with Heart Failure (OPTIMIZE-HF).Q43490989
Short-term intravenous milrinone for acute exacerbation of chronic heart failure: a randomized controlled trialQ43930568
Short-term treatment with ranolazine improves mechanical efficiency in dogs with chronic heart failureQ44112800
P433issue6
P921main subjectheart failureQ181754
P304page(s)1250-1258
P577publication date2013-10-09
P1433published inCirculation: Heart FailureQ2865806
P1476titleNitroxyl (HNO): A novel approach for the acute treatment of heart failure
P478volume6

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