The shy Angeli and his elusive creature: the HNO route to vasodilation

scientific article published on 13 March 2009

The shy Angeli and his elusive creature: the HNO route to vasodilation is …
instance of (P31):
editorialQ871232
scholarly articleQ13442814

External links are
P356DOI10.1152/AJPHEART.00243.2009
P932PMC publication ID2685361
P698PubMed publication ID19286958
P5875ResearchGate publication ID24201497

P50authorNazareno PaolocciQ42067397
P2093author name stringDavid A Wink
P2860cites workVascular smooth muscle relaxation mediated by nitric oxide donors: a comparison with acetylcholine, nitric oxide and nitroxyl ionQ28361019
Nitroxyl anion exerts redox-sensitive positive cardiac inotropy in vivo by calcitonin gene-related peptide signaling.Q33943302
Nitroxyl improves cellular heart function by directly enhancing cardiac sarcoplasmic reticulum Ca2+ cyclingQ34586280
Positive inotropic and lusitropic effects of HNO/NO − in failing hearts: Independence from β-adrenergic signalingQ34983537
Differential actions of L-cysteine on responses to nitric oxide, nitroxyl anions and EDRF in the rat aortaQ35041842
Orthogonal properties of the redox siblings nitroxyl and nitric oxide in the cardiovascular system: a novel redox paradigm.Q35175535
A biochemical rationale for the discrete behavior of nitroxyl and nitric oxide in the cardiovascular systemQ35234291
Coordination chemistry of the HNO ligand with hemes and synthetic coordination complexesQ35983739
Explaining the phenomenon of nitrate toleranceQ36272905
The pharmacology of nitroxyl (HNO) and its therapeutic potential: not just the Janus face of NOQ36408421
Xerogel optical sensor films for quantitative detection of nitroxylQ36580222
Generation of nitroxyl by heme protein-mediated peroxidation of hydroxylamine but not N-hydroxy-L-arginineQ36926046
Examining nitroxyl in biological systemsQ37142384
Identification of nitroxyl-induced modifications in human platelet proteins using a novel mass spectrometric detection methodQ37210656
A role for nitroxyl (HNO) as an endothelium-derived relaxing and hyperpolarizing factor in resistance arteries.Q37255292
Further evidence for distinct reactive intermediates from nitroxyl and peroxynitrite: effects of buffer composition on the chemistry of Angeli's salt and synthetic peroxynitriteQ40726814
The cytotoxicity of nitroxyl: possible implications for the pathophysiological role of NO.Q41058544
Reactive oxygen species and the control of vascular functionQ43157291
Nitric oxide (NO)-induced activation of large conductance Ca2+-dependent K+ channels (BK(Ca)) in smooth muscle cells isolated from the rat mesenteric artery.Q43184397
Nitroxyl affords thiol-sensitive myocardial protective effects akin to early preconditioning.Q44260202
NO- activates soluble guanylate cyclase and Kv channels to vasodilate resistance arteriesQ44438485
Xanthine oxidase converts nitric oxide to nitroxyl that inactivates the enzyme.Q44758055
Nitroxyl triggers Ca2+ release from skeletal and cardiac sarcoplasmic reticulum by oxidizing ryanodine receptorsQ45149127
Calcitonin gene-related peptide in vivo positive inotropy is attributable to regional sympatho-stimulation and is blunted in congestive heart failureQ45182847
The pharmacological activity of nitroxyl: a potent vasodilator with activity similar to nitric oxide and/or endothelium-derived relaxing factorQ45199440
Reaction between S-nitrosothiols and thiols: generation of nitroxyl (HNO) and subsequent chemistry.Q45946745
Redox variants of NO (NO⋅ and HNO) elicit vasorelaxation of resistance arteries via distinct mechanismsQ46104588
Comparison of the NO and HNO donating properties of diazeniumdiolates: primary amine adducts release HNO in VivoQ46860343
NO+, NO, and NO- donation by S-nitrosothiols: implications for regulation of physiological functions by S-nitrosylation and acceleration of disulfide formation.Q51605840
Phospholamban thiols play a central role in activation of the cardiac muscle sarcoplasmic reticulum calcium pump by nitroxyl.Q52695418
Discriminating formation of HNO from other reactive nitrogen oxide speciesQ60133388
Nitric oxide (NO), the only nitrogen monoxide redox form capable of activating soluble guanylyl cyclaseQ71209999
Bioassay discrimination between nitric oxide (NO.) and nitroxyl (NO-) using L-cysteineQ72488285
Arginine conversion to nitroxide by tetrahydrobiopterin-free neuronal nitric-oxide synthase. Implications for mechanismQ74182276
Nitrite reduction to nitric oxide by deoxyhemoglobin vasodilates the human circulationQ79243073
Peroxynitrite and myocardial contractility: in vivo versus in vitro effectsQ79257464
The nitroxyl anion (HNO) is a potent dilator of rat coronary vasculatureQ79451723
Nitroxyl anion donor, Angeli's salt, does not develop tolerance in rat isolated aortaeQ79798643
Nitroxyl increases force development in rat cardiac muscleQ79855253
Mechanism of aerobic decomposition of Angeli's salt (sodium trioxodinitrate) at physiological pHQ81254793
Effect of nitroxyl on human platelets functionQ81438726
P433issue5
P304page(s)H1217-20
P577publication date2009-03-13
P1433published inAmerican Journal of Physiology Heart and Circulatory PhysiologyQ3193662
P1476titleThe shy Angeli and his elusive creature: the HNO route to vasodilation
P478volume296

Reverse relations

cites work (P2860)
Q38613516Angeli's Salt, a nitroxyl anion donor, reverses endothelin-1 mediated vascular dysfunction in murine aorta
Q41903293Aorta from angiotensin II hypertensive mice exhibit preserved nitroxyl anion mediated relaxation responses
Q37438138Enzymatic generation of the NO/HNO-releasing IPA/NO anion at controlled rates in physiological media using β-galactosidase
Q38134537Italian chemists' contributions to named reactions in organic synthesis: an historical perspective.
Q38224809Nitroxyl (HNO) for treatment of acute heart failure
Q33946688Nitroxyl (HNO): A novel approach for the acute treatment of heart failure
Q34756677The specificity of nitroxyl chemistry is unique among nitrogen oxides in biological systems.

Search more.