Actomyosin tension exerted on the nucleus through nesprin-1 connections influences endothelial cell adhesion, migration, and cyclic strain-induced reorientation

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Actomyosin tension exerted on the nucleus through nesprin-1 connections influences endothelial cell adhesion, migration, and cyclic strain-induced reorientation is …
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scholarly articleQ13442814

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P356DOI10.1016/J.BPJ.2010.04.011
P932PMC publication ID2895377
P698PubMed publication ID20655839
P5875ResearchGate publication ID45286776

P2093author name stringJiyeon Lee
Charles K Thodeti
Tanmay Lele
T J Chancellor
P2860cites workTumor-derived endothelial cells exhibit aberrant Rho-mediated mechanosensing and abnormal angiogenesis in vitroQ36837467
Dysfunctional connections between the nucleus and the actin and microtubule networks in laminopathic models.Q36981772
A nuclear-envelope bridge positions nuclei and moves chromosomesQ37289478
Disruption of nesprin-1 produces an Emery Dreifuss muscular dystrophy-like phenotype in mice.Q37292920
Nesprin-1 and -2 are involved in the pathogenesis of Emery Dreifuss muscular dystrophy and are critical for nuclear envelope integrityQ40087014
Enaptin, a giant actin-binding protein, is an element of the nuclear membrane and the actin cytoskeletonQ40565474
Dynamic reorientation of cultured cells and stress fibers under mechanical stress from periodic stretchingQ40791529
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Extracellular matrix controls myosin light chain phosphorylation and cell contractility through modulation of cell shape and cytoskeletal prestressQ44755127
Extracellular matrix rigidity governs smooth muscle cell motility in a biphasic fashionQ45255637
Prestress mediates force propagation into the nucleusQ45287305
Decreased mechanical stiffness in LMNA-/- cells is caused by defective nucleo-cytoskeletal integrity: implications for the development of laminopathies.Q51616068
A stochastic model for adhesion-mediated cell random motility and haptotaxis.Q52405286
Altering the cellular mechanical force balance results in integrated changes in cell, cytoskeletal and nuclear shapeQ67993534
Quantitative analysis of adhesion-mediated cell migration in three-dimensional gels of RGD-grafted collagenQ73381764
Here come the SUNs: a nucleocytoskeletal missing linkQ82236243
Nesprins: a novel family of spectrin-repeat-containing proteins that localize to the nuclear membrane in multiple tissuesQ24292172
Myne-1, a spectrin repeat transmembrane protein of the myocyte inner nuclear membrane, interacts with lamin A/CQ24292190
Coupling of the nucleus and cytoplasm: role of the LINC complexQ24299991
Nesprin-1alpha self-associates and binds directly to emerin and lamin A in vitroQ24303760
The nesprins are giant actin-binding proteins, orthologous to Drosophila melanogaster muscle protein MSP-300Q24314644
Structural requirements for the assembly of LINC complexes and their function in cellular mechanical stiffnessQ24318372
Nesprin 4 is an outer nuclear membrane protein that can induce kinesin-mediated cell polarizationQ24320152
Lamin A/C-dependent localization of Nesprin-2, a giant scaffolder at the nuclear envelopeQ24531346
Syne proteins anchor muscle nuclei at the neuromuscular junctionQ24555750
Cell migration: a physically integrated molecular processQ27860682
The biology of VEGF and its receptorsQ27860704
The inner nuclear membrane protein Sun1 mediates the anchorage of Nesprin-2 to the nuclear envelopeQ28265573
Abnormal nuclear shape and impaired mechanotransduction in emerin-deficient cellsQ28268495
Nuclear lamin A/C deficiency induces defects in cell mechanics, polarization, and migrationQ28505944
Nuclear movement regulated by Cdc42, MRCK, myosin, and actin flow establishes MTOC polarization in migrating cellsQ28508708
Syne-1 and Syne-2 play crucial roles in myonuclear anchorage and motor neuron innervationQ28591836
Cell locomotion and focal adhesions are regulated by substrate flexibilityQ29615522
Integrin-ligand binding properties govern cell migration speed through cell-substratum adhesivenessQ29620446
TRPV4 channels mediate cyclic strain-induced endothelial cell reorientation through integrin-to-integrin signalingQ30438420
Directional persistence of EGF-induced cell migration is associated with stabilization of lamellipodial protrusionsQ30447163
Mechanical forces alter zyxin unbinding kinetics within focal adhesions of living cellsQ33227204
The structural and mechanical complexity of cell-growth controlQ33772662
Role of ANC-1 in tethering nuclei to the actin cytoskeleton.Q34647845
SUN1 interacts with nuclear lamin A and cytoplasmic nesprins to provide a physical connection between the nuclear lamina and the cytoskeletonQ34717324
Lamin A/C deficiency causes defective nuclear mechanics and mechanotransduction.Q35632054
Demonstration of mechanical connections between integrins, cytoskeletal filaments, and nucleoplasm that stabilize nuclear structureQ35964554
P4510describes a project that usesImageJQ1659584
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectendotheliumQ111140
cell adhesionQ187640
cell migrationQ189092
P304page(s)115-123
P577publication date2010-07-01
P1433published inBiophysical JournalQ2032955
P1476titleActomyosin tension exerted on the nucleus through nesprin-1 connections influences endothelial cell adhesion, migration, and cyclic strain-induced reorientation
P478volume99

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