scholarly article | Q13442814 |
P2093 | author name string | Richard T Lee | |
Serguei Kozlov | |||
Jan Lammerding | |||
P Christian Schulze | |||
Colin L Stewart | |||
Janet Hsiao | |||
P2860 | cites work | Mutations in the gene encoding lamin A/C cause autosomal dominant Emery-Dreifuss muscular dystrophy | Q22009039 |
Btf, a novel death-promoting transcriptional repressor that interacts with Bcl-2-related proteins | Q22010049 | ||
Nesprin-2 is a multi-isomeric protein that binds lamin and emerin at the nuclear envelope and forms a subcellular network in skeletal muscle | Q24292752 | ||
Emerin caps the pointed end of actin filaments: evidence for an actin cortical network at the nuclear inner membrane | Q24301949 | ||
Nesprin-1alpha self-associates and binds directly to emerin and lamin A in vitro | Q24303760 | ||
Emerin binding to Btf, a death-promoting transcriptional repressor, is disrupted by a missense mutation that causes Emery-Dreifuss muscular dystrophy | Q24315475 | ||
Identification of a novel X-linked gene responsible for Emery-Dreifuss muscular dystrophy | Q24317622 | ||
Lamin A/C-dependent localization of Nesprin-2, a giant scaffolder at the nuclear envelope | Q24531346 | ||
The cell cycle dependent mislocalisation of emerin may contribute to the Emery-Dreifuss muscular dystrophy phenotype | Q77627024 | ||
Syne proteins anchor muscle nuclei at the neuromuscular junction | Q24555750 | ||
Accumulation of mutant lamin A causes progressive changes in nuclear architecture in Hutchinson-Gilford progeria syndrome | Q24562621 | ||
Homozygous defects in LMNA, encoding lamin A/C nuclear-envelope proteins, cause autosomal recessive axonal neuropathy in human (Charcot-Marie-Tooth disorder type 2) and mouse | Q24632769 | ||
Loss of A-type lamin expression compromises nuclear envelope integrity leading to muscular dystrophy | Q24681029 | ||
Missense mutations in the rod domain of the lamin A/C gene as causes of dilated cardiomyopathy and conduction-system disease | Q28139053 | ||
Nuclear lamin A/C R482Q mutation in canadian kindreds with Dunnigan-type familial partial lipodystrophy | Q28139598 | ||
Recurrent de novo point mutations in lamin A cause Hutchinson–Gilford progeria syndrome | Q28201199 | ||
Emerin interacts in vitro with the splicing-associated factor, YT521-B | Q28205048 | ||
Life at the edge: the nuclear envelope and human disease | Q28216767 | ||
Transcriptional repressor germ cell-less (GCL) and barrier to autointegration factor (BAF) compete for binding to emerin in vitro | Q28218537 | ||
Aberrant intracellular targeting and cell cycle-dependent phosphorylation of emerin contribute to the Emery-Dreifuss muscular dystrophy phenotype | Q28262405 | ||
Nuclear membrane protein LAP2beta mediates transcriptional repression alone and together with its binding partner GCL (germ-cell-less) | Q28586861 | ||
Defects in nuclear structure and function promote dilated cardiomyopathy in lamin A/C-deficient mice | Q28591672 | ||
Assessment of strain field in endothelial cells subjected to uniaxial deformation of their substrate | Q32065406 | ||
ANChors away: an actin based mechanism of nuclear positioning | Q33185450 | ||
Lamin a truncation in Hutchinson-Gilford progeria. | Q34191501 | ||
Actin is part of pre-initiation complexes and is necessary for transcription by RNA polymerase II. | Q34361619 | ||
Role of ANC-1 in tethering nuclei to the actin cytoskeleton. | Q34647845 | ||
Lamin A/C deficiency causes defective nuclear mechanics and mechanotransduction. | Q35632054 | ||
Multiple and surprising new functions for emerin, a nuclear membrane protein | Q35705383 | ||
Demonstration of mechanical connections between integrins, cytoskeletal filaments, and nucleoplasm that stabilize nuclear structure | Q35964554 | ||
Essential roles for Caenorhabditis elegans lamin gene in nuclear organization, cell cycle progression, and spatial organization of nuclear pore complexes | Q38490249 | ||
Enaptin, a giant actin-binding protein, is an element of the nuclear membrane and the actin cytoskeleton | Q40565474 | ||
Staurosporine treatment and serum starvation promote the cleavage of emerin in cultured mouse myoblasts: involvement of a caspase-dependent mechanism | Q40762197 | ||
Both emerin and lamin C depend on lamin A for localization at the nuclear envelope | Q40771969 | ||
Relationship between apoptosis and the cell cycle in lymphocytes: roles of protein kinase C, tyrosine phosphorylation, and AP1. | Q41545239 | ||
Identification of IEX-1 as a biomechanically controlled nuclear factor-kappaB target gene that inhibits cardiomyocyte hypertrophy | Q43948827 | ||
CDNA microarray analysis of gene expression in fibroblasts of patients with X-linked Emery-Dreifuss muscular dystrophy | Q44819938 | ||
Actin is closely associated with RNA polymerase II and involved in activation of gene transcription | Q45052244 | ||
Nuclear envelope alterations in fibroblasts from LGMD1B patients carrying nonsense Y259X heterozygous or homozygous mutation in lamin A/C gene | Q47352477 | ||
Ultrastructural abnormality of sarcolemmal nuclei in Emery-Dreifuss muscular dystrophy (EDMD). | Q47699129 | ||
Decreased mechanical stiffness in LMNA-/- cells is caused by defective nucleo-cytoskeletal integrity: implications for the development of laminopathies. | Q51616068 | ||
LMNA, encoding lamin A/C, is mutated in partial lipodystrophy. | Q54064162 | ||
Properties of lamin A mutants found in Emery-Dreifuss muscular dystrophy, cardiomyopathy and Dunnigan-type partial lipodystrophy | Q63531530 | ||
Molecular characterization of the stretch-induced adaptation of cultured cardiac cells. An in vitro model of load-induced cardiac hypertrophy | Q68056099 | ||
Elliptic fourier analysis of cell and nuclear shapes | Q69720081 | ||
Mechanical strain tightly controls fibroblast growth factor-2 release from cultured human vascular smooth muscle cells | Q71933756 | ||
Architectural abnormalities in muscle nuclei. Ultrastructural differences between X-linked and autosomal dominant forms of EDMD | Q73366593 | ||
Rapid induction and translocation of Egr-1 in response to mechanical strain in vascular smooth muscle cells | Q77215405 | ||
Nuclear envelope defects associated with LMNA mutations cause dilated cardiomyopathy and Emery-Dreifuss muscular dystrophy | Q77493431 | ||
P433 | issue | 5 | |
P407 | language of work or name | English | Q1860 |
P921 | main subject | cell biology | Q7141 |
mechanotransduction | Q11936292 | ||
P304 | page(s) | 781-91 | |
P577 | publication date | 2005-08-29 | |
P1433 | published in | Journal of Cell Biology | Q1524550 |
P1476 | title | Abnormal nuclear shape and impaired mechanotransduction in emerin-deficient cells | |
P478 | volume | 170 |
Q34242119 | "Laminopathies": a wide spectrum of human diseases |
Q92159992 | A multistage sequencing strategy pinpoints novel candidate alleles for Emery-Dreifuss muscular dystrophy and supports gene misregulation as its pathomechanism |
Q37419142 | A perinuclear actin cap regulates nuclear shape. |
Q57804538 | A versatile image analysis platform for three-dimensional nuclear reconstruction |
Q33954299 | Actomyosin tension exerted on the nucleus through nesprin-1 connections influences endothelial cell adhesion, migration, and cyclic strain-induced reorientation |
Q88959747 | Adjustable viscoelasticity allows for efficient collective cell migration |
Q37220177 | Adult stem cell maintenance and tissue regeneration in the ageing context: the role for A-type lamins as intrinsic modulators of ageing in adult stem cells and their niches. |
Q46088014 | Age of heart disease presentation and dysmorphic nuclei in patients with LMNA mutations |
Q37785157 | Altered mechanical properties of the nucleus in disease |
Q52654324 | Altered nuclear structure in myotonic dystrophy type 1-derived fibroblasts. |
Q36175286 | Altering lamina assembly reveals lamina-dependent and -independent functions for A-type lamins. |
Q92661913 | An Emerin LEM-Domain Mutation Impairs Cell Response to Mechanical Stress |
Q33290327 | An emerin "proteome": purification of distinct emerin-containing complexes from HeLa cells suggests molecular basis for diverse roles including gene regulation, mRNA splicing, signaling, mechanosensing, and nuclear architecture. |
Q52957148 | Analysis of Gill Structure from a Fresh Water Fish (Heteropneustes fossilis) Exposed to Bleached Sulfite Pulp Mill Effluents. |
Q33838220 | Attenuated hypertrophic response to pressure overload in a lamin A/C haploinsufficiency mouse |
Q34831528 | Biology of the Mi-2/NuRD Complex in SLAC (Stemness, Longevity/Ageing, and Cancer). |
Q35591191 | Biophysical assays to probe the mechanical properties of the interphase cell nucleus: substrate strain application and microneedle manipulation |
Q34800912 | Biophysical regulation of histone acetylation in mesenchymal stem cells |
Q37678536 | Broken nuclei--lamins, nuclear mechanics, and disease. |
Q38891711 | Causes and consequences of nuclear envelope alterations in tumour progression |
Q53554488 | Cell nuclei spin in the absence of lamin b1. |
Q36224478 | Cell shape dependent regulation of nuclear morphology |
Q34614178 | Cellular mechanosensing: getting to the nucleus of it all. |
Q42503937 | Cellular strain avoidance is mediated by a functional actin cap - observations in an Lmna-deficient cell model. |
Q37695969 | Collective cell traction force analysis on aligned smooth muscle cell sheet between three-dimensional microwalls. |
Q39104972 | Current insights into LMNA cardiomyopathies: Existing models and missing LINCs |
Q91786551 | DYT1 Dystonia Patient-Derived Fibroblasts Have Increased Deformability and Susceptibility to Damage by Mechanical Forces |
Q36857698 | Dependence of diffusional mobility of integral inner nuclear membrane proteins on A-type lamins |
Q27334775 | Design of a microfluidic device to quantify dynamic intra-nuclear deformation during cell migration through confining environments |
Q34521501 | Direct actin binding to A- and B-type lamin tails and actin filament bundling by the lamin A tail |
Q37766246 | Directed stem cell differentiation: the role of physical forces |
Q38991463 | Diseases of the Nucleoskeleton. |
Q24304005 | Distinct functional domains in nesprin-1alpha and nesprin-2beta bind directly to emerin and both interactions are disrupted in X-linked Emery-Dreifuss muscular dystrophy |
Q34772038 | Distinct structural and mechanical properties of the nuclear lamina in Hutchinson-Gilford progeria syndrome |
Q47070958 | Drosophila Nesprin-1 controls glutamate receptor density at neuromuscular junctions. |
Q36981772 | Dysfunctional connections between the nucleus and the actin and microtubule networks in laminopathic models. |
Q35259539 | Emerin in health and disease |
Q57454036 | Emerin induces nuclear breakage in Xenopus extract and early embryos |
Q36099092 | Emerin is hyperphosphorylated and redistributed in herpes simplex virus type 1-infected cells in a manner dependent on both UL34 and US3. |
Q52569974 | Emerin modulates spatial organization of chromosome territories in cells on softer matrices. |
Q40427155 | Emerin self-assembly mechanism: role of the LEM domain. |
Q79543221 | Emery-Dreifuss muscular dystrophy |
Q91997396 | Emery-Dreifuss muscular dystrophy |
Q35406548 | Evolution: functional evolution of nuclear structure. |
Q37156605 | Experimental techniques for study of chromatin mechanics in intact nuclei and living cells |
Q39311831 | Focal adhesion kinase knockdown modulates the response of human corneal epithelial cells to topographic cues |
Q37383083 | Fraying at the edge mouse models of diseases resulting from defects at the nuclear periphery |
Q36119056 | Functional association of Sun1 with nuclear pore complexes |
Q53423711 | Gaussian Curvature Directs Stress Fiber Orientation and Cell Migration. |
Q36497170 | Genetic mutations and mechanisms in dilated cardiomyopathy |
Q36514514 | Guilt by association: the nuclear envelope proteome and disease |
Q90325049 | High-throughput microfluidic micropipette aspiration device to probe time-scale dependent nuclear mechanics in intact cells |
Q38089892 | Hutchinson-Gilford progeria syndrome through the lens of transcription |
Q28267181 | Identification of an emerin-beta-catenin complex in the heart important for intercalated disc architecture and beta-catenin localisation |
Q90443566 | Image analysis of the nuclear characteristics of emerin protein and the correlation with nuclear grooves and intranuclear cytoplasmic inclusions in lung adenocarcinoma |
Q41882073 | In vitro contracture test results and anaesthetic management of a patient with emery-dreifuss muscular dystrophy for cardiac transplantation |
Q37117975 | Increased mechanosensitivity and nuclear stiffness in Hutchinson-Gilford progeria cells: effects of farnesyltransferase inhibitors |
Q34245085 | Integrity matters: linking nuclear architecture to lifespan |
Q38245736 | Intermediate filaments: a dynamic network that controls cell mechanics |
Q33859070 | Isolated nuclei adapt to force and reveal a mechanotransduction pathway in the nucleus. |
Q36109210 | Keeping the LINC: the importance of nucleocytoskeletal coupling in intracellular force transmission and cellular function |
Q36845695 | LEM-Domain proteins: new insights into lamin-interacting proteins |
Q34558130 | LINC complexes in health and disease |
Q64278906 | Lamin A/C and Emerin depletion impacts chromatin organization and dynamics in the interphase nucleus |
Q34036586 | Lamin A/C and emerin regulate MKL1-SRF activity by modulating actin dynamics |
Q34072629 | Lamin B1 overexpression increases nuclear rigidity in autosomal dominant leukodystrophy fibroblasts |
Q47131489 | Lamin B2 binding to minichromosome maintenance complex component 7 promotes non-small cell lung carcinogenesis |
Q33752204 | Lamin-binding Proteins |
Q38341565 | Lamins at the crossroads of mechanosignaling |
Q33551452 | Linker of nucleoskeleton and cytoskeleton complex proteins in cardiac structure, function, and disease |
Q57171613 | Linker of nucleoskeleton and cytoskeleton complex proteins in cardiomyopathy |
Q34577033 | Lmo7 is an emerin-binding protein that regulates the transcription of emerin and many other muscle-relevant genes |
Q90632667 | Local, transient tensile stress on the nuclear membrane causes membrane rupture |
Q30489484 | Loss of GATA6 leads to nuclear deformation and aneuploidy in ovarian cancer |
Q52029127 | Loss of emerin at the nuclear envelope disrupts the Rb1/E2F and MyoD pathways during muscle regeneration. |
Q47639598 | Luma is not essential for murine cardiac development and function. |
Q24319820 | Mammalian SUN protein interaction networks at the inner nuclear membrane and their role in laminopathy disease processes |
Q38691260 | Material Cues as Potent Regulators of Epigenetics and Stem Cell Function |
Q36318027 | Mechanical activation of cells induces chromatin remodeling preceding MKL nuclear transport |
Q41847622 | Mechanical properties of interphase nuclei probed by cellular strain application |
Q35606724 | Mechanical properties of the cell nucleus and the effect of emerin deficiency |
Q36617270 | Mechanical regulation of nuclear structure and function. |
Q36144966 | Mechanics of the nucleus |
Q88640354 | Mechanisms of allelic and clinical heterogeneity of lamin A/C phenotypes |
Q92378153 | Mechanosensing and Mechanoregulation of Endothelial Cell Functions |
Q39043810 | Mechanosensing by the nucleus: From pathways to scaling relationships. |
Q86899397 | Mechanotransduction |
Q38790844 | Mechanotransduction and nuclear function |
Q37158222 | Mechanotransduction gone awry |
Q43177507 | Mitochondria as a source of mechanical signals in cardiomyocytes. |
Q35942479 | Mouse models of the laminopathies. |
Q21134152 | Multiple novel nesprin-1 and nesprin-2 variants act as versatile tissue-specific intracellular scaffolds |
Q36908213 | Muscular Dystrophy Mutations Impair the Nuclear Envelope Emerin Self-assembly Properties |
Q33552186 | Nesprin 1 is critical for nuclear positioning and anchorage |
Q40087014 | Nesprin-1 and -2 are involved in the pathogenesis of Emery Dreifuss muscular dystrophy and are critical for nuclear envelope integrity |
Q35908957 | Networking in the nucleus: a spotlight on LEM-domain proteins |
Q52583668 | New biological research and understanding of Papanicolaou's test. |
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Q38077664 | Nuclear damages and oxidative stress: new perspectives for laminopathies |
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Q33856490 | Nuclear envelope structural defects cause chromosomal numerical instability and aneuploidy in ovarian cancer |
Q28468582 | Nuclear envelope structural proteins facilitate nuclear shape changes accompanying embryonic differentiation and fidelity of gene expression |
Q34669322 | Nuclear forces and cell mechanosensing. |
Q35831988 | Nuclear lamins: key regulators of nuclear structure and activities |
Q37444772 | Nuclear mechanics and mechanotransduction in health and disease |
Q53542772 | Nuclear mechanics and methods. |
Q36116300 | Nuclear mechanics in cancer |
Q37183946 | Nuclear shape, mechanics, and mechanotransduction |
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Q41670145 | Progress in Integrative Biomaterial Systems to Approach Three-Dimensional Cell Mechanotransduction. |
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