scholarly article | Q13442814 |
P50 | author | Francis Collins | Q336658 |
Leslie B Gordon | Q96104451 | ||
Yosef Gruenbaum | Q27836091 | ||
Melissa Mendez | Q37630693 | ||
P2093 | author name string | Michael R Erdos | |
Robert D Goldman | |||
Maria Eriksson | |||
Dale K Shumaker | |||
Anne E Goldman | |||
Satya Khuon | |||
Renée Varga | |||
P2860 | cites work | Nuclear lamins: building blocks of nuclear architecture | Q22065781 |
Alteration of nuclear lamin organization inhibits RNA polymerase II-dependent transcription | Q22066149 | ||
Nuclear lamins A and B1: different pathways of assembly during nuclear envelope formation in living cells | Q22066157 | ||
Pathway of incorporation of microinjected lamin A into the nuclear envelope | Q22066158 | ||
An ectopic human XIST gene can induce chromosome inactivation in postdifferentiation human HT-1080 cells | Q24530726 | ||
Structural analysis of emerin, an inner nuclear membrane protein mutated in X-linked Emery-Dreifuss muscular dystrophy | Q27633552 | ||
The karyopherin Kap142p/Msn5p mediates nuclear import and nuclear export of different cargo proteins | Q27933902 | ||
Recurrent de novo point mutations in lamin A cause Hutchinson–Gilford progeria syndrome | Q28201199 | ||
LMNA mutations in atypical Werner's syndrome | Q28202570 | ||
Protein kinase phosphorylation site sequences and consensus specificity motifs: tabulations | Q29615346 | ||
Identification and characterization of a nuclear pore complex protein | Q29616069 | ||
Congenital Absence of Hair and Mammary Glands with Atrophic Condition of the Skin and its Appendages, in a Boy whose Mother had been almost wholly Bald from Alopecia Areata from the age of Six. | Q34024206 | ||
Nuclear lamins: their structure, assembly, and interactions | Q34067345 | ||
Lamin a truncation in Hutchinson-Gilford progeria. | Q34191501 | ||
The retinoblastoma gene product is a cell cycle-dependent, nuclear matrix-associated protein | Q34973639 | ||
The nucleoskeleton: lamins and actin are major players in essential nuclear functions | Q35145850 | ||
Biochemical and immunological analysis of rapidly purified 10-nm filaments from baby hamster kidney (BHK-21) cells | Q36199689 | ||
Disruption of nuclear lamin organization alters the distribution of replication factors and inhibits DNA synthesis | Q36254659 | ||
Motile properties of vimentin intermediate filament networks in living cells | Q36255537 | ||
Dynamic properties of nuclear lamins: lamin B is associated with sites of DNA replication | Q36534855 | ||
The Hutchinson-Gilford progeria syndrome. Report of 4 cases and review of the literature | Q39914175 | ||
Cardiovascular abnormalities in progeria. Case report and review of the literature. | Q40274950 | ||
Incorporation of the nuclear pore basket protein nup153 into nuclear pore structures is dependent upon lamina assembly: evidence from cell-free extracts of Xenopus eggs | Q40392422 | ||
Nuclear organization of DNA replication in primary mammalian cells. | Q40445454 | ||
DNA polymerase clamp shows little turnover at established replication sites but sequential de novo assembly at adjacent origin clusters | Q40680783 | ||
Maturation of nuclear lamin A involves a specific carboxy-terminal trimming, which removes the polyisoprenylation site from the precursor; implications for the structure of the nuclear lamina | Q42643199 | ||
Nuclear envelope disorganization in fibroblasts from lipodystrophic patients with heterozygous R482Q/W mutations in the lamin A/C gene | Q43855815 | ||
The COPI complex functions in nuclear envelope breakdown and is recruited by the nucleoporin Nup153. | Q47560968 | ||
Expression in Escherichia coli of human lamins A and C: influence of head and tail domains on assembly properties and paracrystal formation. | Q54696205 | ||
Hutchinson-Gilford syndrome. | Q55435736 | ||
Properties of lamin A mutants found in Emery-Dreifuss muscular dystrophy, cardiomyopathy and Dunnigan-type partial lipodystrophy | Q63531530 | ||
P433 | issue | 24 | |
P407 | language of work or name | English | Q1860 |
P921 | main subject | progeria | Q213098 |
P304 | page(s) | 8963-8 | |
P577 | publication date | 2004-06-15 | |
P1433 | published in | Proceedings of the National Academy of Sciences of the United States of America | Q1146531 |
P1476 | title | Accumulation of mutant lamin A causes progressive changes in nuclear architecture in Hutchinson-Gilford progeria syndrome | |
P478 | volume | 101 |
Q34242119 | "Laminopathies": a wide spectrum of human diseases |
Q35590452 | 'Relax and Repair' to restrain aging. |
Q43085717 | 2005 William Allan Award address. No longer just looking under the lamppost |
Q57068930 | A Lamin-Binding Ligand Inhibits Homologous Recombination Repair of DNA Double-Strand Breaks |
Q36260910 | A Novel Lamin A Mutant Responsible for Congenital Muscular Dystrophy Causes Distinct Abnormalities of the Cell Nucleus. |
Q34803249 | A farnesyltransferase inhibitor improves disease phenotypes in mice with a Hutchinson-Gilford progeria syndrome mutation. |
Q24657266 | A farnesyltransferase inhibitor prevents both the onset and late progression of cardiovascular disease in a progeria mouse model |
Q36288663 | A filtering strategy identifies FOXQ1 as a potential effector of lamin A dysfunction |
Q83278310 | A homozygous ZMPSTE24 null mutation in combination with a heterozygous mutation in the LMNA gene causes Hutchinson-Gilford progeria syndrome (HGPS): insights into the pathophysiology of HGPS |
Q35677842 | A lamin A protein isoform overexpressed in Hutchinson-Gilford progeria syndrome interferes with mitosis in progeria and normal cells |
Q34520494 | A mutation abolishing the ZMPSTE24 cleavage site in prelamin A causes a progeroid disorder |
Q50884552 | A novel mutation of the LMNA gene in a family with dilated cardiomyopathy, conduction system disease, and sudden cardiac death of young females. |
Q30412267 | A pathway linking oxidative stress and the Ran GTPase system in progeria |
Q30437843 | A progeria mutation reveals functions for lamin A in nuclear assembly, architecture, and chromosome organization |
Q34454769 | A prospective study of radiographic manifestations in Hutchinson-Gilford progeria syndrome |
Q36249005 | A-type lamin complexes and regenerative potential: a step towards understanding laminopathic diseases? |
Q35934217 | A-type lamins: guardians of the soma? |
Q34047217 | AIM2 inflammasome is activated by pharmacological disruption of nuclear envelope integrity |
Q39743360 | AKT1-mediated Lamin A/C degradation is required for nuclear degradation and normal epidermal terminal differentiation. |
Q33350870 | Abnormal mitosis in hypertetraploid cells causes aberrant nuclear morphology in association with H2O2-induced premature senescence |
Q28268495 | Abnormal nuclear shape and impaired mechanotransduction in emerin-deficient cells |
Q36431867 | Accelerated telomere shortening and replicative senescence in human fibroblasts overexpressing mutant and wild-type lamin A. |
Q42478854 | Accumulation of distinct prelamin A variants in human diploid fibroblasts differentially affects cell homeostasis |
Q40160277 | Accumulation of multiple forms of lamin A with down-regulation of FACE-1 suppresses growth in senescent human cells |
Q35923515 | Accumulation of the inner nuclear envelope protein Sun1 is pathogenic in progeric and dystrophic laminopathies |
Q37223285 | Activating the synthesis of progerin, the mutant prelamin A in Hutchinson-Gilford progeria syndrome, with antisense oligonucleotides |
Q37220177 | Adult stem cell maintenance and tissue regeneration in the ageing context: the role for A-type lamins as intrinsic modulators of ageing in adult stem cells and their niches. |
Q46088014 | Age of heart disease presentation and dysmorphic nuclei in patients with LMNA mutations |
Q24537685 | Age-related changes of nuclear architecture in Caenorhabditis elegans |
Q90297312 | Age-related neurodegenerative diseases |
Q28750018 | Ageing-related chromatin defects through loss of the NURD complex |
Q28082599 | Aging and radiation: bad companions |
Q47590157 | Aging as an Epigenetic Phenomenon |
Q39359014 | Aging in hair follicle stem cells and niche microenvironment |
Q35605882 | Aging--RNA in development and disease |
Q30479111 | Alterations in mitosis and cell cycle progression caused by a mutant lamin A known to accelerate human aging |
Q46620985 | Alterations of nuclear envelope and chromatin organization in mandibuloacral dysplasia, a rare form of laminopathy |
Q36802143 | Alterations to nuclear architecture and genome behavior in senescent cells |
Q56342217 | Altered modulation of lamin A/C-HDAC2 interaction and p21 expression during oxidative stress response in HGPS |
Q82300194 | Altered nuclear functions in progeroid syndromes: a paradigm for aging research |
Q42025201 | Alternative nuclear transport for cellular protein quality control |
Q43140936 | An encouraging progress report on the treatment of progeria and its implications for atherogenesis |
Q58376304 | An inheritedLMNAgene mutation in atypical Progeria syndrome |
Q40634162 | An inhibitory role of progerin in the gene induction network of adipocyte differentiation from iPS cells |
Q55004770 | An overview of treatment strategies for Hutchinson-Gilford Progeria syndrome. |
Q26747324 | Anchoring a Leviathan: How the Nuclear Membrane Tethers the Genome |
Q37293792 | Antisense-Based Progerin Downregulation in HGPS-Like Patients' Cells |
Q64955369 | Are There Common Mechanisms Between the Hutchinson-Gilford Progeria Syndrome and Natural Aging? |
Q33577875 | Assessing the efficacy of protein farnesyltransferase inhibitors in mouse models of progeria |
Q35857196 | Automated image analysis of nuclear shape: what can we learn from a prematurely aged cell? |
Q52310788 | Autophagic Removal of Farnesylated Carboxy-Terminal Lamin Peptides. |
Q35771419 | Autophagic degradation of farnesylated prelamin A as a therapeutic approach to lamin-linked progeria. |
Q35883260 | Barrier-to-Autointegration Factor influences specific histone modifications |
Q37885159 | Beyond membrane channelopathies: alternative mechanisms underlying complex human disease |
Q50455443 | Biomechanical Strain Exacerbates Inflammation on a Progeria-on-a-Chip Model. |
Q39297143 | Blocking farnesylation of the prelamin A variant in Hutchinson-Gilford progeria syndrome alters the distribution of A-type lamins |
Q24627329 | Blocking protein farnesylation improves nuclear shape abnormalities in keratinocytes of mice expressing the prelamin A variant in Hutchinson-Gilford progeria syndrome |
Q33895774 | Blocking protein farnesyltransferase improves nuclear blebbing in mouse fibroblasts with a targeted Hutchinson-Gilford progeria syndrome mutation. |
Q33930224 | Blocking protein farnesyltransferase improves nuclear shape in fibroblasts from humans with progeroid syndromes |
Q49126142 | Brain response to traumatic brain injury in wild-type and interleukin-6 knockout mice: a microarray analysis |
Q36864487 | Calcium causes a conformational change in lamin A tail domain that promotes farnesyl-mediated membrane association |
Q51768217 | Cardiac Abnormalities in Patients With Hutchinson-Gilford Progeria Syndrome. |
Q58802918 | Casz1 controls higher-order nuclear organization in rod photoreceptors |
Q37016154 | Cell Mechanosensitivity is Enabled by the LINC Nuclear Complex |
Q55041657 | Cell biology: ageing nucleus gets out of shape. |
Q90351944 | Cellular Mechanotransduction: From Tension to Function |
Q60221810 | Cellular senescence induces replication stress with almost no affect on DNA replication timing |
Q34313449 | Change, Change, Change: Heeding the Call |
Q33287480 | Characterization of lamin mutation phenotypes in Drosophila and comparison to human laminopathies |
Q41230094 | Chromatin and lamin A determine two different mechanical response regimes of the cell nucleus |
Q47344586 | Chromatin histone modifications and rigidity affect nuclear morphology independent of lamins |
Q33588661 | Chromatin modifications: the driving force of senescence and aging? |
Q34342179 | Chromatin remodeling, DNA damage repair and aging. |
Q37361621 | Chromatin structure and transposable elements in organismal aging |
Q34057050 | Chromosomal regions associated with prostate cancer risk localize to lamin B-deficient microdomains and exhibit reduced gene transcription |
Q91140229 | Chromosome territories and the global regulation of the genome |
Q36470519 | Chromosomes at Work: Organization of Chromosome Territories in the Interphase Nucleus. |
Q38257182 | Chronic kidney disease and premature ageing |
Q37091901 | Clinical Trial of the Protein Farnesylation Inhibitors Lonafarnib, Pravastatin, and Zoledronic Acid in Children With Hutchinson-Gilford Progeria Syndrome |
Q37958955 | Clinical and genetic heterogeneity in laminopathies. |
Q34033699 | Clinical trial of a farnesyltransferase inhibitor in children with Hutchinson-Gilford progeria syndrome |
Q37558746 | Comparing lamin proteins post-translational relative stability using a 2A peptide-based system reveals elevated resistance of progerin to cellular degradation |
Q42150749 | Computational image analysis of nuclear morphology associated with various nuclear-specific aging disorders |
Q35145797 | Condensins exert force on chromatin-nuclear envelope tethers to mediate nucleoplasmic reticulum formation in Drosophila melanogaster |
Q34032642 | Conserved cysteine residues in the mammalian lamin A tail are essential for cellular responses to ROS generation |
Q60143966 | Contribution of Retrotransposable Elements to Aging |
Q41087937 | Cooperative Activity of GABP with PU.1 or C/EBPε Regulates Lamin B Receptor Gene Expression, Implicating Their Roles in Granulocyte Nuclear Maturation. |
Q58797371 | Copy Number of Human Ribosomal Genes With Aging: Unchanged Mean, but Narrowed Range and Decreased Variance in Elderly Group |
Q54917780 | Coronary artery disease in a Werner syndrome-like form of progeria characterized by low levels of progerin, a splice variant of lamin A. |
Q45887442 | Correction of cellular phenotypes of Hutchinson-Gilford Progeria cells by RNA interference |
Q36580567 | Correlated alterations in genome organization, histone methylation, and DNA-lamin A/C interactions in Hutchinson-Gilford progeria syndrome |
Q41230121 | Cross-linked matrix rigidity and soluble retinoids synergize in nuclear lamina regulation of stem cell differentiation |
Q39104972 | Current insights into LMNA cardiomyopathies: Existing models and missing LINCs |
Q41616038 | Cytoskeleton and nuclear lamina affection in recessive osteogenesis imperfecta: A functional proteomics perspective. |
Q34521574 | Cytosol-dependent membrane fusion in ER, nuclear envelope and nuclear pore assembly: biological implications |
Q42101728 | DNA damage responses in progeroid syndromes arise from defective maturation of prelamin A. |
Q34480944 | DNA repair defects and genome instability in Hutchinson-Gilford Progeria Syndrome. |
Q47340315 | DNA replication timing alterations identify common markers between distinct progeroid diseases. |
Q34079464 | DNA-damage accumulation and replicative arrest in Hutchinson-Gilford progeria syndrome |
Q64106731 | Deciphering Nuclear Mechanobiology in Laminopathy |
Q42989281 | Defective DSB repair correlates with abnormal nuclear morphology and is improved with FTI treatment in Hutchinson-Gilford progeria syndrome fibroblasts |
Q33608779 | Defective lamin A-Rb signaling in Hutchinson-Gilford Progeria Syndrome and reversal by farnesyltransferase inhibition |
Q30416354 | Defective nuclear import of Tpr in Progeria reflects the Ran sensitivity of large cargo transport |
Q37463359 | Defective skeletal muscle growth in lamin A/C-deficient mice is rescued by loss of Lap2α. |
Q39838279 | Defects in cell spreading and ERK1/2 activation in fibroblasts with lamin A/C mutations |
Q47997810 | Deformation-based nuclear morphometry: capturing nuclear shape variation in HeLa cells |
Q37459221 | Dephosphorylation of barrier-to-autointegration factor by protein phosphatase 4 and its role in cell mitosis |
Q42142108 | Depleting the methyltransferase Suv39h1 improves DNA repair and extends lifespan in a progeria mouse model |
Q21284168 | Dermal fibroblasts in Hutchinson-Gilford progeria syndrome with the lamin A G608G mutation have dysmorphic nuclei and are hypersensitive to heat stress |
Q42714829 | Determining nuclear shape: the role of farnesylated nuclear membrane proteins |
Q91692029 | Development of a CRISPR/Cas9-based therapy for Hutchinson-Gilford progeria syndrome |
Q33397370 | Differential expression of A-type and B-type lamins during hair cycling |
Q51767576 | Differential stem cell aging kinetics in Hutchinson-Gilford progeria syndrome and Werner syndrome. |
Q34018880 | Differential temporal and spatial progerin expression during closure of the ductus arteriosus in neonates |
Q40009819 | Differentiation of C2C12 myoblasts expressing lamin A mutated at a site responsible for Emery-Dreifuss muscular dystrophy is improved by inhibition of the MEK-ERK pathway and stimulation of the PI3-kinase pathway |
Q89999227 | Diminished Canonical β-Catenin Signaling During Osteoblast Differentiation Contributes to Osteopenia in Progeria |
Q33954902 | Discordant gene expression signatures and related phenotypic differences in lamin A- and A/C-related Hutchinson-Gilford progeria syndrome (HGPS). |
Q33687043 | Diseases of the nuclear envelope |
Q58694537 | Disrupting the LINC complex in smooth muscle cells reduces aortic disease in a mouse model of Hutchinson-Gilford progeria syndrome |
Q39726549 | Disruption of lamin B1 and lamin B2 processing and localization by farnesyltransferase inhibitors. |
Q34772038 | Distinct structural and mechanical properties of the nuclear lamina in Hutchinson-Gilford progeria syndrome |
Q38284300 | Diverse lamin-dependent mechanisms interact to control chromatin dynamics. Focus on laminopathies |
Q46841230 | Drugs affecting prelamin A processing: effects on heterochromatin organization |
Q101166055 | ESCRT-III controls nuclear envelope deformation induced by progerin |
Q57022017 | ESCRT-III mediates budding across the inner nuclear membrane and regulates its integrity |
Q89594871 | ESCRT-III-mediated membrane fusion drives chromosome fragments through nuclear envelope channels |
Q46363038 | Eliminating the synthesis of mature lamin A reduces disease phenotypes in mice carrying a Hutchinson-Gilford progeria syndrome allele. |
Q35093144 | Embryonic expression of the common progeroid lamin A splice mutation arrests postnatal skin development |
Q47414799 | Emerging candidate treatment strategies for Hutchinson-Gilford progeria syndrome |
Q24309728 | Emerin-prelamin A interplay in human fibroblasts |
Q37323331 | Epidermal expression of the truncated prelamin A causing Hutchinson-Gilford progeria syndrome: effects on keratinocytes, hair and skin |
Q38926028 | Epigenetic Mechanisms of Longevity and Aging. |
Q60958004 | Epigenetic Regulation of Skin Cells in Natural Aging and Premature Aging Diseases |
Q61759611 | Epigenetic Significance of Chromatin Organization During Cellular Aging and Organismal Lifespan |
Q26740029 | Epigenetics and aging |
Q37736104 | Epigenetics of the vascular endothelium |
Q55554953 | Erythrocyte Senescence in a Model of Rat Displaying Hutchinson-Gilford Progeria Syndrome. |
Q28287241 | Etiological investigations in apparent type 2 diabetes: when to search for lamin A/C mutations? |
Q55309708 | Everolimus rescues multiple cellular defects in laminopathy-patient fibroblasts. |
Q37785980 | Evolutionary origin of the cell nucleus and its functional architecture. |
Q24626373 | Exome sequencing and functional analysis identifies BANF1 mutation as the cause of a hereditary progeroid syndrome |
Q30480982 | Expansion of the nucleoplasmic reticulum requires the coordinated activity of lamins and CTP:phosphocholine cytidylyltransferase alpha. |
Q38704558 | Expression of progerin does not result in an increased mutation rate |
Q30619979 | Expression of progerin in aging mouse brains reveals structural nuclear abnormalities without detectible significant alterations in gene expression, hippocampal stem cells or behavior |
Q36286147 | Expression of the Hutchinson-Gilford progeria mutation during osteoblast development results in loss of osteocytes, irregular mineralization, and poor biomechanical properties |
Q64261833 | Extranuclear DNA accumulates in aged cells and contributes to senescence and inflammation |
Q34769181 | Familial 1q22 microduplication associated with psychiatric disorders, intellectual disability and late-onset autoimmune inflammatory response |
Q30496796 | Farnesylated nuclear proteins Kugelkern and lamin Dm0 affect nuclear morphology by directly interacting with the nuclear membrane. |
Q39983752 | Farnesyltransferase inhibitor treatment restores chromosome territory positions and active chromosome dynamics in Hutchinson-Gilford progeria syndrome cells. |
Q35914168 | Fission yeast Lem2 and Man1 perform fundamental functions of the animal cell nuclear lamina |
Q42507259 | Focal dermal hypoplasia: ultrastructural abnormalities of the connective tissue |
Q58319815 | FoxM1 repression during human aging leads to mitotic decline and aneuploidy-driven full senescence |
Q37383083 | Fraying at the edge mouse models of diseases resulting from defects at the nuclear periphery |
Q60670847 | From human genetics and genomics to pharmacogenetics and pharmacogenomics: past lessons, future directions |
Q36895328 | From old organisms to new molecules: integrative biology and therapeutic targets in accelerated human ageing. |
Q34977317 | From the rarest to the most common: insights from progeroid syndromes into skin cancer and aging. |
Q34137401 | Functional Coupling between the Extracellular Matrix and Nuclear Lamina by Wnt Signaling in Progeria |
Q34081419 | Functions and dysfunctions of the nuclear lamin Ig-fold domain in nuclear assembly, growth, and Emery-Dreifuss muscular dystrophy. |
Q55289204 | GATA4-dependent regulation of the secretory phenotype via MCP-1 underlies lamin A-mediated human mesenchymal stem cell aging. |
Q36815721 | Gene silencing at the nuclear periphery |
Q36191582 | Gene-rich chromosomal regions are preferentially localized in the lamin B deficient nuclear blebs of atypical progeria cells |
Q35052074 | Generation of induced pluripotent stem cell lines from 3 distinct laminopathies bearing heterogeneous mutations in lamin A/C |
Q80368699 | Genome instability in progeria: when repair gets old |
Q33511965 | Genomic instability and DNA damage responses in progeria arising from defective maturation of prelamin A. |
Q57752770 | Genomic instability and DNA replication defects in progeroid syndromes |
Q91681614 | Genomic instability and innate immune responses to self-DNA in progeria |
Q28258404 | Genomic instability in laminopathy-based premature aging |
Q34504529 | Genomics tools for unraveling chromosome architecture |
Q46113326 | Gliotoxin reverses age-dependent nuclear morphology phenotypes, ameliorates motility, but fails to affect lifespan of adult Caenorhabditis elegans |
Q36665423 | Global genome splicing analysis reveals an increased number of alternatively spliced genes with aging |
Q33284379 | Gold-nanoparticle-assisted laser perturbation of chromatin assembly reveals unusual aspects of nuclear architecture within living cells |
Q43105986 | Gone with the Wnt/Notch: stem cells in laminopathies, progeria, and aging |
Q36514514 | Guilt by association: the nuclear envelope proteome and disease |
Q33728360 | HP1α mediates defective heterochromatin repair and accelerates senescence in Zmpste24-deficient cells |
Q26740026 | Hallmarks of progeroid syndromes: lessons from mice and reprogrammed cells |
Q28505849 | Heterozygosity for Lmna deficiency eliminates the progeria-like phenotypes in Zmpste24-deficient mice |
Q93007880 | HiPLA: High-throughput imaging proximity ligation assay |
Q27005208 | Higher order chromatin organization in cancer |
Q34014679 | Higher-order genome organization in human disease |
Q34333644 | Homozygous and compound heterozygous mutations in ZMPSTE24 cause the laminopathy restrictive dermopathy |
Q28276671 | Human laminopathies: nuclei gone genetically awry |
Q53542805 | Human lipodystrophies linked to mutations in A-type lamins and to HIV protease inhibitor therapy are both associated with prelamin A accumulation, oxidative stress and premature cellular senescence. |
Q64242806 | Hutchinson-Gilford Progeria Syndrome-Current Status and Prospects for Gene Therapy Treatment |
Q38665343 | Hutchinson-Gilford Progeria Syndrome: A Premature Aging Disease |
Q38885070 | Hutchinson-Gilford Progeria Syndrome: A premature aging disease caused by LMNA gene mutations. |
Q91828655 | Hutchinson-Gilford Progeria Syndrome: Rejuvenating old drugs to fight accelerated ageing |
Q42380772 | Hutchinson-Gilford progeria is a skeletal dysplasia |
Q24541467 | Hutchinson-Gilford progeria mutant lamin A primarily targets human vascular cells as detected by an anti-Lamin A G608G antibody |
Q42826076 | Hutchinson-Gilford progeria syndrome alters nuclear shape and reduces cell motility in three dimensional model substrates |
Q38578682 | Hutchinson-Gilford progeria syndrome as a model for vascular aging |
Q38089892 | Hutchinson-Gilford progeria syndrome through the lens of transcription |
Q28299394 | Hutchinson-Gilford progeria syndrome: clinical findings in three patients carrying the G608G mutation in LMNA and review of the literature |
Q37147814 | Hutchinson-Gilford progeria syndrome: oral and craniofacial phenotypes |
Q34521593 | Identification of differential protein interactors of lamin A and progerin |
Q38062398 | Imaging characteristics of cerebrovascular arteriopathy and stroke in Hutchinson-Gilford progeria syndrome |
Q91943122 | Imbalanced nucleocytoskeletal connections create common polarity defects in progeria and physiological aging |
Q30481145 | Immobility, inheritance and plasticity of shape of the yeast nucleus |
Q33847777 | Impact of farnesylation inhibitors on survival in Hutchinson-Gilford progeria syndrome. |
Q99587072 | Impairment of nuclear F-actin formation and its relevance to cellular phenotypes in Hutchinson-Gilford progeria syndrome |
Q37958975 | In vitro pathological modelling using patient-specific induced pluripotent stem cells: the case of progeria. |
Q30478576 | In vivo and in vitro examination of the functional significances of novel lamin gene mutations in heart failure patients |
Q40837071 | Increased Expression of Lamin A/C Correlate with Regions of High Wall Stress in Abdominal Aortic Aneurysms |
Q39890385 | Increased expression of the Hutchinson-Gilford progeria syndrome truncated lamin A transcript during cell aging |
Q37117975 | Increased mechanosensitivity and nuclear stiffness in Hutchinson-Gilford progeria cells: effects of farnesyltransferase inhibitors |
Q53556427 | Increased progerin expression associated with unusual LMNA mutations causes severe progeroid syndromes. |
Q37334608 | Increasing the length of progerin's isoprenyl anchor does not worsen bone disease or survival in mice with Hutchinson-Gilford progeria syndrome |
Q44662688 | Influence of nuclear blebs and micronuclei status on the growth kinetics of human mesenchymal stem cells |
Q24531946 | Inhibiting farnesylation of progerin prevents the characteristic nuclear blebbing of Hutchinson-Gilford progeria syndrome |
Q34063471 | Inhibiting farnesylation reverses the nuclear morphology defect in a HeLa cell model for Hutchinson-Gilford progeria syndrome |
Q91329650 | Inhibition of DNA damage response at telomeres improves the detrimental phenotypes of Hutchinson-Gilford Progeria Syndrome |
Q61806041 | Inhibition of FAK Signaling Elicits Lamin A/C-Associated Nuclear Deformity and Cellular Senescence |
Q44252405 | Inhibition of lamin A/C attenuates osteoblast differentiation and enhances RANKL-dependent osteoclastogenesis |
Q57973344 | Inhibition of the acetyltransferase NAT10 normalizes progeric and aging cells by rebalancing the Transportin-1 nuclear import pathway |
Q36546343 | Insights into the role of immunosenescence during varicella zoster virus infection (shingles) in the aging cell model |
Q34245085 | Integrity matters: linking nuclear architecture to lifespan |
Q41900779 | Interfacial binding and aggregation of lamin A tail domains associated with Hutchinson-Gilford progeria syndrome. |
Q33284286 | Intermediate filaments: a historical perspective |
Q42371472 | Intermittent treatment with farnesyltransferase inhibitor and sulforaphane improves cellular homeostasis in Hutchinson-Gilford progeria fibroblasts |
Q33757351 | Interphase phosphorylation of lamin A. |
Q28822028 | Interruption of progerin-lamin A/C binding ameliorates Hutchinson-Gilford progeria syndrome phenotype |
Q35015891 | Investigating the purpose of prelamin A processing |
Q41877882 | Involvement of the nuclear pore complex in morphology of the plant nucleus |
Q33298574 | Involvement of xeroderma pigmentosum group A (XPA) in progeria arising from defective maturation of prelamin A. |
Q39726676 | Jumping over the fence: RNA nuclear export revisited |
Q34333224 | Knock-down of methyl CpG-binding protein 2 (MeCP2) causes alterations in cell proliferation and nuclear lamins expression in mammalian cells |
Q36845695 | LEM-Domain proteins: new insights into lamin-interacting proteins |
Q53565805 | LMNA Mutation c.917T>G (p.L306R) Leads to Deleterious Hyper-Assembly of Lamin A/C and Associates with Severe Right Ventricular Cardiomyopathy and Premature Aging. |
Q28277676 | Lamin A and ZMPSTE24 (FACE-1) defects cause nuclear disorganization and identify restrictive dermopathy as a lethal neonatal laminopathy |
Q48357964 | Lamin A and microtubules collaborate to maintain nuclear morphology |
Q33586103 | Lamin A rod domain mutants target heterochromatin protein 1alpha and beta for proteasomal degradation by activation of F-box protein, FBXW10 |
Q37922871 | Lamin A, farnesylation and aging |
Q24681309 | Lamin A-dependent nuclear defects in human aging |
Q38913735 | Lamin A/C-dependent interaction with 53BP1 promotes cellular responses to DNA damage |
Q47071460 | Lamin C and chromatin organization in Drosophila |
Q50501494 | Lamin misexpression upregulates three distinct ubiquitin ligase systems that degrade ATR kinase in HeLa cells. |
Q37503436 | Lamin-B1 contributes to the proper timing of epicardial cell migration and function during embryonic heart development |
Q38174396 | Lamina-associated polypeptide (LAP)2α and nucleoplasmic lamins in adult stem cell regulation and disease |
Q27687804 | Lamina-associated polypeptide (LAP)2α and other LEM proteins in cancer biology |
Q35923554 | Laminopathies |
Q28251294 | Laminopathies and the long strange trip from basic cell biology to therapy |
Q34569468 | Laminopathies: multiple disorders arising from defects in nuclear architecture |
Q36346720 | Laminopathies: multisystem dystrophy syndromes |
Q37827754 | Laminopathies: the molecular background of the disease and the prospects for its treatment. |
Q64881706 | Lamins and Lamin-Associated Proteins in Gastrointestinal Health and Disease. |
Q36440522 | Lamins in development, tissue maintenance and stress. |
Q38698252 | Lamins in the nuclear interior - life outside the lamina |
Q37907728 | Lamins, laminopathies and disease mechanisms: possible role for proteasomal degradation of key regulatory proteins |
Q34651253 | Lipid posttranslational modifications. Farnesyl transferase inhibitors |
Q51759528 | Lipodystrophic syndromes due to LMNA mutations: recent developments on biomolecular aspects, pathophysiological hypotheses and therapeutic perspectives. |
Q38012480 | Lonafarnib for cancer and progeria |
Q37141911 | Looking for disease being a model of human aging. |
Q64295438 | Loss of CRWN Nuclear Proteins Induces Cell Death and Salicylic Acid Defense Signaling |
Q36210071 | Loss of H3K9me3 Correlates with ATM Activation and Histone H2AX Phosphorylation Deficiencies in Hutchinson-Gilford Progeria Syndrome |
Q99365348 | Loss of MTX2 causes mandibuloacral dysplasia and links mitochondrial dysfunction to altered nuclear morphology |
Q46447976 | Loss of ZMPSTE24 (FACE-1) causes autosomal recessive restrictive dermopathy and accumulation of Lamin A precursors. |
Q33913256 | Loss of lamin B1 results in prolongation of S phase and decondensation of chromosome territories |
Q35218759 | Low levels of the reverse transactivator fail to induce target transgene expression in vascular smooth muscle cells |
Q30541249 | Lysosome-mediated processing of chromatin in senescence. |
Q41601030 | MG132-induced progerin clearance is mediated by autophagy activation and splicing regulation. |
Q34662262 | Males absent on the first (MOF): from flies to humans. |
Q24319820 | Mammalian SUN protein interaction networks at the inner nuclear membrane and their role in laminopathy disease processes |
Q36237237 | Mapping of lamin A- and progerin-interacting genome regions |
Q36653907 | Mechanical model of blebbing in nuclear lamin meshworks |
Q33730599 | Mechanisms controlling the smooth muscle cell death in progeria via down-regulation of poly(ADP-ribose) polymerase 1. |
Q88640354 | Mechanisms of allelic and clinical heterogeneity of lamin A/C phenotypes |
Q33895715 | Mechanobiology and the microcirculation: cellular, nuclear and fluid mechanics |
Q39121085 | Mechanobiology of Chromatin and the Nuclear Interior. |
Q92732473 | Mechanotransduction: from the cell surface to the nucleus via RhoA |
Q37196129 | Mediators of reprogramming: transcription factors and transitions through mitosis |
Q89660120 | Metabolic Dysfunction in Hutchinson-Gilford Progeria Syndrome |
Q46418627 | Metformin alleviates ageing cellular phenotypes in Hutchinson-Gilford progeria syndrome dermal fibroblasts |
Q38811951 | Methylene blue alleviates nuclear and mitochondrial abnormalities in progeria |
Q40995573 | Microinjection of Antibodies Targeting the Lamin A/C Histone-Binding Site Blocks Mitotic Entry and Reveals Separate Chromatin Interactions with HP1, CenpB and PML. |
Q35147918 | Micromechanics of human mitotic chromosomes |
Q90398636 | Mitochondria in the Nuclei of Rat Myocardial Cells |
Q39363647 | Mitotic Dysfunction Associated with Aging Hallmarks |
Q24644033 | Model of human aging: recent findings on Werner's and Hutchinson-Gilford progeria syndromes |
Q58562640 | Modeling Skeletal Muscle Laminopathies Using Human Induced Pluripotent Stem Cells Carrying Pathogenic Mutations |
Q42541299 | Modeling nuclear blebs in a nucleoskeleton of independent filament networks |
Q34567458 | Molecular bases of progeroid syndromes. |
Q36507152 | Molecular genetics of autosomal-recessive axonal Charcot-Marie-Tooth neuropathies. |
Q26768972 | Molecular insights into the premature aging disease progeria |
Q64114104 | Monitoring of chromatin organization in live cells by FRIC. Effects of the inner nuclear membrane protein Samp1 |
Q34015228 | Morphological analysis of 13 LMNA variants identified in a cohort of 324 unrelated patients with idiopathic or familial dilated cardiomyopathy |
Q26829927 | Mouse models of laminopathies |
Q64951524 | Multicompartment cell-based modeling of confined migration: regulation by cell intrinsic and extrinsic factors. |
Q36997997 | Muscle-derived stem/progenitor cell dysfunction in Zmpste24-deficient progeroid mice limits muscle regeneration |
Q36187275 | Mutant lamin A links prophase to a p53 independent senescence program |
Q34652089 | Mutant nuclear lamin A leads to progressive alterations of epigenetic control in premature aging |
Q36856331 | Myopathic lamin mutations impair nuclear stability in cells and tissue and disrupt nucleo-cytoskeletal coupling. |
Q51778118 | N6-isopentenyladenosine improves nuclear shape in fibroblasts from humans with progeroid syndromes by inhibiting the farnesylation of prelamin A. |
Q34489171 | NET23/STING promotes chromatin compaction from the nuclear envelope |
Q84607704 | NURD keeps chromatin young |
Q42365487 | Naïve adult stem cells from patients with Hutchinson-Gilford progeria syndrome express low levels of progerin in vivo |
Q36170446 | Neonatal progeria: increased ratio of progerin to lamin A leads to progeria of the newborn |
Q39000180 | Nesprin-1 role in DNA damage response |
Q36724244 | Nesprin-2G, a Component of the Nuclear LINC Complex, Is Subject to Myosin-Dependent Tension |
Q89505850 | Neuropeptide Y Enhances Progerin Clearance and Ameliorates the Senescent Phenotype of Human Hutchinson-Gilford Progeria Syndrome Cells |
Q28082302 | New approaches for understanding the nuclear force balance in living, adherent cells |
Q30856192 | Nonlinear osmotic properties of the cell nucleus |
Q46593831 | Novel LMNA mutations cause an aggressive atypical neonatal progeria without progerin accumulation |
Q39654743 | Novel LMNA mutations in patients with Emery-Dreifuss muscular dystrophy and functional characterization of four LMNA mutations |
Q62570659 | Nuclear Domains and DNA Repair |
Q38077664 | Nuclear damages and oxidative stress: new perspectives for laminopathies |
Q36258265 | Nuclear envelope, nuclear lamina, and inherited disease |
Q38297406 | Nuclear lamina remodelling and its implications for human disease |
Q34136884 | Nuclear lamins |
Q34925545 | Nuclear lamins and chromatin: when structure meets function. |
Q35831988 | Nuclear lamins: key regulators of nuclear structure and activities |
Q34766646 | Nuclear lamins: major factors in the structural organization and function of the nucleus and chromatin |
Q33638752 | Nuclear localization signal deletion mutants of lamin A and progerin reveal insights into lamin A processing and emerin targeting |
Q36144958 | Nuclear mechanics in disease |
Q34504147 | Nuclear physics (of the cell, not the atom) |
Q27348460 | Nuclear pore proteins nup153 and megator define transcriptionally active regions in the Drosophila genome |
Q47799769 | Nuclear protein import is reduced in cells expressing nuclear envelopathy-causing lamin A mutants |
Q37183946 | Nuclear shape, mechanics, and mechanotransduction |
Q90575138 | Nuclear shape, protrusive behaviour and in vivo retention of human bone marrow mesenchymal stromal cells is controlled by Lamin-A/C expression |
Q48661312 | Nuclear stiffening and chromatin softening with progerin expression leads to an attenuated nuclear response to force |
Q41808764 | Nuclear stiffening inhibits migration of invasive melanoma cells. |
Q92543471 | Nucleolar and Ribosomal Dysfunction-A Common Pathomechanism in Childhood Progerias? |
Q41565087 | Nucleolar expansion and elevated protein translation in premature aging |
Q39731192 | Nucleoplasmic LAP2alpha-lamin A complexes are required to maintain a proliferative state in human fibroblasts |
Q34654052 | Nucleoplasmic lamins and their interaction partners, LAP2alpha, Rb, and BAF, in transcriptional regulation. |
Q48183623 | Nucleoplasmic lamins define growth-regulating functions of lamina-associated polypeptide 2α in progeria cells |
Q34574178 | Nucleoskeleton mechanics at a glance |
Q89561506 | Order and disorder: abnormal 3D chromatin organization in human disease |
Q30453322 | Otologic and audiologic manifestations of Hutchinson-Gilford progeria syndrome |
Q91910292 | Outcomes of 4 years of molecular genetic diagnosis on a panel of genes involved in premature aging syndromes, including laminopathies and related disorders |
Q38674896 | Outer nuclear membrane protein Kuduk modulates the LINC complex and nuclear envelope architecture. |
Q35656882 | Overexpression of Lamin B Receptor Results in Impaired Skin Differentiation |
Q91839756 | Overexpression of Progerin Results in Impaired Proliferation and Invasion of Non-Small Cell Lung Cancer Cells |
Q37037865 | Partial lipodystrophy with severe insulin resistance and adult progeria Werner syndrome |
Q42129441 | Periodicity of nuclear morphology in human fibroblasts |
Q36681467 | Permanent farnesylation of lamin A mutants linked to progeria impairs its phosphorylation at serine 22 during interphase |
Q36856294 | Perturbation of wild-type lamin A metabolism results in a progeroid phenotype |
Q89669919 | Pharmacotherapy to gene editing: potential therapeutic approaches for Hutchinson-Gilford progeria syndrome |
Q24607381 | Phenotype and course of Hutchinson-Gilford progeria syndrome |
Q41457647 | Phenotype-Dependent Coexpression Gene Clusters: Application to Normal and Premature Ageing |
Q90621864 | Phosphorylated Lamin A/C in the Nuclear Interior Binds Active Enhancers Associated with Abnormal Transcription in Progeria |
Q51810368 | Physical Signals May Affect Mesenchymal Stem Cell Differentiation via Epigenetic Controls. |
Q92310565 | Physicochemical mechanotransduction alters nuclear shape and mechanics via heterochromatin formation |
Q28071818 | Physiological and Pathological Aging Affects Chromatin Dynamics, Structure and Function at the Nuclear Edge |
Q90162875 | Polymer Modeling Predicts Chromosome Reorganization in Senescence |
Q33888878 | Porcine LMNA Is a Positional Candidate Gene Associated with Growth and Fat Deposition |
Q28391383 | Potential therapeutic approaches for modulating expression and accumulation of defective lamin A in laminopathies and age-related diseases |
Q37533593 | Prelamin A Accumulation Attenuates Rac1 Activity and Increases the Intrinsic Migrational Persistence of Aged Vascular Smooth Muscle Cells. |
Q24311723 | Prelamin A acts to accelerate smooth muscle cell senescence and is a novel biomarker of human vascular aging |
Q34416396 | Prelamin A and lamin A appear to be dispensable in the nuclear lamina |
Q40505214 | Prelamin A endoproteolytic processing in vitro by recombinant Zmpste24 |
Q28272957 | Prelamin A farnesylation and progeroid syndromes |
Q42648385 | Prelamin A processing and functional effects in restrictive dermopathy |
Q37028510 | Prelamin A processing, accumulation and distribution in normal cells and laminopathy disorders |
Q34457223 | Prelamin A, Zmpste24, misshapen cell nuclei, and progeria--new evidence suggesting that protein farnesylation could be important for disease pathogenesis |
Q38296605 | Prenyltransferase Inhibitors: Treating Human Ailments from Cancer to Parasitic Infections |
Q91660240 | Presence and distribution of progerin in HGPS cells is ameliorated by drugs that impact on the mevalonate and mTOR pathways |
Q33684177 | Prestressed Nuclear Organization in Living Cells |
Q40175421 | Primary laminopathy fibroblasts display altered genome organization and apoptosis. |
Q89767892 | Progeria: A Rare Genetic Syndrome |
Q37000095 | Progeria: a laminopathy of special interest |
Q47917390 | Progeria: a paradigm for translational medicine. |
Q34303172 | Progeria: translational insights from cell biology |
Q24634195 | Progerin and telomere dysfunction collaborate to trigger cellular senescence in normal human fibroblasts |
Q36852109 | Progerin elicits disease phenotypes of progeria in mice whether or not it is farnesylated. |
Q41134538 | Progerin impairs chromosome maintenance by depleting CENP-F from metaphase kinetochores in Hutchinson-Gilford progeria fibroblasts. |
Q91946092 | Progerin in muscle leads to thermogenic and metabolic defects via impaired calcium homeostasis |
Q55111725 | Progerin phosphorylation in interphase is lower and less mechanosensitive than lamin-A,C in iPS-derived mesenchymal stem cells. |
Q36048936 | Progerin reduces LAP2α-telomere association in Hutchinson-Gilford progeria. |
Q34532121 | Progerin, the protein responsible for the Hutchinson-Gilford progeria syndrome, increases the unrepaired DNA damages following exposure to ionizing radiation |
Q36366471 | Progerin-Induced Replication Stress Facilitates Premature Senescence in Hutchinson-Gilford Progeria Syndrome |
Q90315228 | Proline rich 11 drives F-actin assembly by recruiting the actin-related protein 2/3 complex in human non-small cell lung carcinoma |
Q36350870 | Promoter hypermethylation as a mechanism for Lamin A/C silencing in a subset of neuroblastoma cells. |
Q34413791 | Promotion of tumor development in prostate cancer by progerin |
Q47626666 | Protein sequestration at the nuclear periphery as a potential regulatory mechanism in premature aging. |
Q47219337 | Pubertal Progression in Adolescent Females with Progeria. |
Q38874161 | Quantification of the Spatial Organization of the Nuclear Lamina as a Tool for Cell Classification. |
Q91942877 | Rapamycin Rescues Age-Related Changes in Muscle-Derived Stem/Progenitor Cells from Progeroid Mice |
Q35911400 | Rapamycin activates autophagy in Hutchinson-Gilford progeria syndrome: implications for normal aging and age-dependent neurodegenerative disorders |
Q89184684 | Rapamycin increases oxidative metabolism and enhances metabolic flexibility in human cardiac fibroblasts |
Q34196369 | Rapamycin reverses cellular phenotypes and enhances mutant protein clearance in Hutchinson-Gilford progeria syndrome cells |
Q40985709 | Rare progerin-expressing preadipocytes and adipocytes contribute to tissue depletion over time |
Q28068068 | Recent advances in understanding the role of lamins in health and disease |
Q59330318 | RefCell: multi-dimensional analysis of image-based high-throughput screens based on 'typical cells' |
Q37951794 | Regulating the levels of key factors in cell cycle and DNA repair: new pathways revealed by lamins. |
Q38185206 | Regulation of Myelination in the Central Nervous System by Nuclear Lamin B1 and Non-coding RNAs |
Q35320096 | Regulation of nuclear NF-κB oscillation by a diffusion coefficient and its biological implications |
Q46138874 | Repetitive disruptions of the nuclear envelope invoke temporary loss of cellular compartmentalization in laminopathies. |
Q36396535 | Reprogramming progeria fibroblasts re-establishes a normal epigenetic landscape. |
Q42013273 | Rescue of heterochromatin organization in Hutchinson-Gilford progeria by drug treatment |
Q39550057 | Retinoblastoma-independent regulation of cell proliferation and senescence by the p53-p21 axis in lamin A /C-depleted cells. |
Q34521584 | Reversal of age-dependent nuclear morphology by inhibition of prenylation does not affect lifespan in Caenorhabditis elegans |
Q24539118 | Reversal of the cellular phenotype in the premature aging disease Hutchinson-Gilford progeria syndrome |
Q33337126 | Role for A-type lamins in herpesviral DNA targeting and heterochromatin modulation |
Q38233240 | Role of nuclear Lamin A/C in cardiomyocyte functions |
Q37188083 | Role of nuclear lamins in nuclear organization, cellular signaling, and inherited diseases |
Q34124543 | Role of progerin-induced telomere dysfunction in HGPS premature cellular senescence |
Q34632599 | Role of the nuclear envelope in genome organization and gene expression |
Q37961727 | Roles for nuclear organization in the maintenance of genome stability |
Q27329601 | Roles of endothelial A-type lamins in migration of T cells on and under endothelial layers |
Q47262393 | Separate roles for chromatin and lamins in nuclear mechanics. |
Q36059159 | Shared phenotypes among segmental progeroid syndromes suggest underlying pathways of aging |
Q33746623 | Shear stress-induced mechanotransduction protein deregulation and vasculopathy in a mouse model of progeria |
Q91141600 | Single molecule analysis of lamin dynamics |
Q83225430 | Site-specific phosphorylation and caspase cleavage of GFAP are new markers of Alexander disease severity |
Q37472616 | Sizing up the nucleus: nuclear shape, size and nuclear-envelope assembly |
Q89972733 | Skeletal maturation and long-bone growth patterns of patients with progeria: a retrospective study |
Q28082981 | Skin Disease in Laminopathy-Associated Premature Aging |
Q54289708 | Skin and sural nerve biopsies: ultrastructural findings in the first genetically confirmed cases of CADASIL in Serbia. |
Q50188862 | Smurf2 regulates stability and the autophagic-lysosomal turnover of lamin A and its disease-associated form progerin |
Q36861511 | Sp1 transcription factor interaction with accumulated prelamin a impairs adipose lineage differentiation in human mesenchymal stem cells: essential role of sp1 in the integrity of lipid vesicles |
Q38675558 | Speeding up the clock: The past, present and future of progeria |
Q92851797 | Striatal Projection Neurons Require Huntingtin for Synaptic Connectivity and Survival |
Q42133558 | Structure and stability of the lamin A tail domain and HGPS mutant |
Q35549134 | Subcellular localization of SREBP1 depends on its interaction with the C-terminal region of wild-type and disease related A-type lamins |
Q35080536 | Sulforaphane enhances progerin clearance in Hutchinson-Gilford progeria fibroblasts |
Q40171175 | Survival and death of mature avian motoneurons in organotypic slice culture: trophic requirements for survival and different types of degeneration. |
Q36191257 | Sustained accumulation of prelamin A and depletion of lamin A/C both cause oxidative stress and mitochondrial dysfunction but induce different cell fates |
Q43235347 | Synaptic activity induces dramatic changes in the geometry of the cell nucleus: interplay between nuclear structure, histone H3 phosphorylation, and nuclear calcium signaling |
Q35119345 | Systematic identification of pathological lamin A interactors |
Q29147479 | TRF2 and lamin A/C interact to facilitate the functional organization of chromosome ends |
Q64446570 | Telomere elongation through hTERT immortalization leads to chromosome repositioning in control cells and genomic instability in Hutchinson‐Gilford progeria syndrome fibroblasts, expressing a novel SUN1 isoform |
Q28468499 | Temsirolimus Partially Rescues the Hutchinson-Gilford Progeria Cellular Phenotype |
Q39932341 | Tethering by lamin A stabilizes and targets the ING1 tumour suppressor |
Q37023583 | The A- and B-type nuclear lamin networks: microdomains involved in chromatin organization and transcription |
Q64256257 | The Cutting Edge: The Role of mTOR Signaling in Laminopathies |
Q59137488 | The Emerging Role of Lamin C as an Important Isoform in Mechanophenotype |
Q90513427 | The JAK1/2 inhibitor ruxolitinib delays premature aging phenotypes |
Q36949552 | The Mechanobiology of Aging |
Q87868450 | The Novel Nuclear Envelope Protein KAKU4 Modulates Nuclear Morphology in Arabidopsis |
Q64243970 | The Nuclear Lamina as an Organizer of Chromosome Architecture |
Q38763221 | The Nucleoskeleton |
Q96304690 | The Putative Type III Secreted Chlamydia abortus Virulence-Associated Protein CAB063 Targets Lamin and Induces Apoptosis |
Q21090227 | The cell nucleus and aging: tantalizing clues and hopeful promises |
Q33627935 | The central role of chromatin maintenance in aging |
Q83525426 | The curious case of the ageing cells |
Q24628974 | The epidemiology of premature aging and associated comorbidities |
Q90462509 | The functional importance of lamins, actin, myosin, spectrin and the LINC complex in DNA repair |
Q35920672 | The functions of the nuclear envelope in mediating the molecular crosstalk between the nucleus and the cytoplasm |
Q38041831 | The great unravelling: chromatin as a modulator of the aging process |
Q36562914 | The highly conserved nuclear lamin Ig-fold binds to PCNA: its role in DNA replication |
Q33760885 | The insulator protein SU(HW) fine-tunes nuclear lamina interactions of the Drosophila genome |
Q36021030 | The intrinsic stiffness of human trabecular meshwork cells increases with senescence. |
Q35006984 | The leukocyte nuclear envelope proteome varies with cell activation and contains novel transmembrane proteins that affect genome architecture |
Q42006226 | The muscle dystrophy-causing ΔK32 lamin A/C mutant does not impair the functions of the nucleoplasmic lamin-A/C-LAP2α complex in mice |
Q21144407 | The mutant form of lamin A that causes Hutchinson-Gilford progeria is a biomarker of cellular aging in human skin |
Q21284427 | The nuclear envelopathies and human diseases |
Q36840615 | The nuclear envelope and transcriptional control. |
Q26853003 | The nuclear envelope as a chromatin organizer |
Q34390408 | The nuclear lamina comes of age. |
Q33758494 | The posttranslational processing of prelamin A and disease. |
Q34234762 | The role of DNA damage in laminopathy progeroid syndromes |
Q39381492 | The role of epigenetics in renal ageing. |
Q36189915 | The role of lamin B1 for the maintenance of nuclear structure and function |
Q33275295 | The role of mitochondrial DNA mutations in mammalian aging |
Q35642054 | The role of nuclear lamin B1 in cell proliferation and senescence. |
Q34494982 | The truncated prelamin A in Hutchinson-Gilford progeria syndrome alters segregation of A-type and B-type lamin homopolymers |
Q33943379 | Therapeutic intervention based on protein prenylation and associated modifications |
Q42368505 | Three-dimensional genome architecture and emerging technologies: looping in disease |
Q21090234 | Three-dimensional maps of all chromosomes in human male fibroblast nuclei and prometaphase rosettes |
Q52057017 | Tight skin and limited joint movements as early presentation of Hutchinson-Gilford progeria in a 7-week-old infant. |
Q36873650 | Tissue-specific defects are caused by loss of the Drosophila MAN1 LEM domain protein. |
Q42514932 | Transcriptional Regulation by Nrf2. |
Q92454007 | Transient introduction of human telomerase mRNA improves hallmarks of progeria cells |
Q37447814 | Transmembrane protein-free membranes fuse into xenopus nuclear envelope and promote assembly of functional pores |
Q36695378 | Truncated prelamin A expression in HGPS-like patients: a transcriptional study. |
Q36272165 | Twenty years of progress in biogerontology research |
Q35030979 | Type B mandibuloacral dysplasia with congenital myopathy due to homozygous ZMPSTE24 missense mutation |
Q34450925 | Ubiquitin ligase RNF123 mediates degradation of heterochromatin protein 1α and β in lamin A/C knock-down cells |
Q43681084 | Ultrastructural skin changes in Egyptian mandibuloacral dysplasia patients with p.Arg527Leu LMNA mutation and in their asymptomatic heterozygotic mothers |
Q55447827 | Upregulation of the aging related LMNA splice variant progerin in dilated cardiomyopathy. |
Q34818981 | Vascular aging: insights from studies on cellular senescence, stem cell aging, and progeroid syndromes |
Q64946222 | Vascular smooth muscle cell-specific progerin expression in a mouse model of Hutchinson-Gilford progeria syndrome promotes arterial stiffness: Therapeutic effect of dietary nitrite. |
Q37412836 | Vertical nanopillars for in situ probing of nuclear mechanics in adherent cells. |
Q41416839 | Vitamin D receptor signaling improves Hutchinson-Gilford progeria syndrome cellular phenotypes |
Q36798321 | Werner and Hutchinson-Gilford progeria syndromes: mechanistic basis of human progeroid diseases. |
Q89752915 | When function follows form: Nuclear compartment structure and the epigenetic landscape of the aging neuron |
Q47417713 | Xeroderma Pigmentosa Group A (XPA), Nucleotide Excision Repair and Regulation by ATR in Response to Ultraviolet Irradiation |
Q53853271 | [Laminopathies: lipodystrophies, insulin resistance, syndromes of accelerated ageing... and others]. |
Q49229670 | miR‑342‑5p promotes Zmpste24‑deficient mouse embryonic fibroblasts proliferation by suppressing GAS2. |
Q91645670 | p53 Isoforms in Cellular Senescence- and Ageing-Associated Biological and Physiological Functions |
Q50074502 | p53 isoforms regulate premature aging in human cells. |
Q35689748 | p53 targets identified by protein expression profiling |
Q38735593 | p63 Transcription Factor Regulates Nuclear Shape and Expression of Nuclear Envelope-Associated Genes in Epidermal Keratinocytes |