Extranuclear DNA accumulates in aged cells and contributes to senescence and inflammation

scientific article published on 31 January 2019

Extranuclear DNA accumulates in aged cells and contributes to senescence and inflammation is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1111/ACEL.12901
P932PMC publication ID6413746
P698PubMed publication ID30706626

P50authorNir HacohenQ42799920
James M HeatherQ56480292
P2093author name stringThomas Eisenhaure
Raktima Raychowdhury
Yuk Yuen Lan
David Lieb
Christopher Stuart Garris
P2860cites workIFI16 acts as a nuclear pathogen sensor to induce the inflammasome in response to Kaposi Sarcoma-associated herpesvirus infectionQ24302985
DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblastsQ24336806
Accumulation of mutant lamin A causes progressive changes in nuclear architecture in Hutchinson-Gilford progeria syndromeQ24562621
Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpointsQ29617405
Oxygen sensitivity severely limits the replicative lifespan of murine fibroblastsQ29618748
Transient nuclear envelope rupturing during interphase in human cancer cells.Q30513945
Lysosome-mediated processing of chromatin in senescence.Q30541249
A human-like senescence-associated secretory phenotype is conserved in mouse cells dependent on physiological oxygenQ33532644
cGAS is essential for cellular senescenceQ33790789
Accumulation of DNA damage in hematopoietic stem and progenitor cells during human agingQ33847654
Ionizing radiation-induced long-term expression of senescence markers in mice is independent of p53 and immune statusQ33949558
Gene regulation and DNA damage in the ageing human brainQ34326236
DNA-damage-induced type I interferon promotes senescence and inhibits stem cell functionQ34474083
Differential roles for the interferon-inducible IFI16 and AIM2 innate immune sensors for cytosolic DNA in cellular senescence of human fibroblastsQ34987881
Inflammatory markers in population studies of agingQ34995451
Nuclear envelope budding enables large ribonucleoprotein particle export during synaptic Wnt signalingQ36020221
Sequence-specific activation of the DNA sensor cGAS by Y-form DNA structures as found in primary HIV-1 cDNAQ36345491
Interferome v2.0: an updated database of annotated interferon-regulated genesQ36491580
Suppression of Type I Interferon Signaling Overcomes Oncogene-Induced Senescence and Mediates Melanoma Development and ProgressionQ36784394
Aging. Aging-induced type I interferon response at the choroid plexus negatively affects brain functionQ36907335
Catastrophic nuclear envelope collapse in cancer cell micronuclei.Q37111701
Crosstalk between the cGAS DNA sensor and Beclin-1 autophagy protein shapes innate antimicrobial immune responsesQ37632327
IFI16 and cGAS cooperate in the activation of STING during DNA sensing in human keratinocytes.Q37651854
DNA damage primes the type I interferon system via the cytosolic DNA sensor STING to promote anti-microbial innate immunityQ38908391
Innate immune sensing of cytosolic chromatin fragments through cGAS promotes senescence.Q40036388
Escherichia coli induces DNA double-strand breaks in eukaryotic cells.Q40244785
Senescing human cells and ageing mice accumulate DNA lesions with unrepairable double-strand breaksQ40593721
Dnase2a deficiency uncovers lysosomal clearance of damaged nuclear DNA via autophagyQ42060185
Depletion of the 26S proteasome adaptor Ecm29 increases Toll-like receptor 3 signalingQ42265452
Repetitive disruptions of the nuclear envelope invoke temporary loss of cellular compartmentalization in laminopathies.Q46138874
Cytoplasmic chromatin triggers inflammation in senescence and cancerQ46165767
Type I interferon-mediated autoinflammation due to DNase II deficiencyQ47108722
Downregulation of cytoplasmic DNases is implicated in cytoplasmic DNA accumulation and SASP in senescent cells.Q52624885
ESCRT III repairs nuclear envelope ruptures during cell migration to limit DNA damage and cell death.Q52878590
DNA damage response and cellular senescence in tissues of aging miceQ60284563
Cytokines, insulin-like growth factor 1, sarcopenia, and mortality in very old community-dwelling men and women: the Framingham Heart StudyQ61663307
Increased cytokine production in mononuclear cells of healthy elderly peopleQ72921117
The cGAS-cGAMP-STING pathway connects DNA damage to inflammation, senescence, and cancerQ88286449
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectinflammationQ101991
Dnase2aQ18250188
P304page(s)e12901
P577publication date2019-01-31
P1433published inAging CellQ2221073
P1476titleExtranuclear DNA accumulates in aged cells and contributes to senescence and inflammation
P478volume18

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cites work (P2860)
Q90204208Barrier-to-Autointegration Factor 1 Protects against a Basal cGAS-STING Response
Q92267263DNA sensing by the cGAS-STING pathway in health and disease
Q90457744Damaged DNA marching out of aging nucleus
Q92653030Growth hormone in the tumor microenvironment
Q98779115Lamivudine Inhibits Alu RNA-induced Retinal Pigment Epithelium Degeneration via Anti-inflammatory and Anti-senescence Activities
Q91585373Putative stem cells in the hemolymph and in the intestinal submucosa of the solitary ascidian Styela plicata
Q92859248Recent advances in understanding the mechanisms determining longevity
Q94921871Research Advances in How the cGAS-STING Pathway Controls the Cellular Inflammatory Response

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