3-deazaneplanocin A induces massively increased interferon-alpha production in Ebola virus-infected mice

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3-deazaneplanocin A induces massively increased interferon-alpha production in Ebola virus-infected mice is …
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scholarly articleQ13442814

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P356DOI10.1016/S0166-3542(02)00018-9
P698PubMed publication ID12076759

P50authorMike BrayQ115132999
P2093author name stringRobert O Baker
Jo Lynne Raymond
Tom Geisbert
P2860cites workBroad-spectrum antiviral activities of neplanocin A, 3-deazaneplanocin A, and their 5'-nor derivativesQ28343014
Viruses and interferonsQ29620788
Inhibition of interferon-mediated antiviral responses by influenza A viruses and other negative-strand RNA virusesQ33932047
Experimental therapy of filovirus infectionsQ33957838
Differentiation of filoviruses by electron microscopyQ34063356
Antiviral drug therapy of filovirus infections: S-adenosylhomocysteine hydrolase inhibitors inhibit Ebola virus in vitro and in a lethal mouse modelQ34068520
The virus battles: IFN induction of the antiviral state and mechanisms of viral evasionQ34234077
The Ebola virus VP35 protein functions as a type I IFN antagonist.Q35422223
S-adenosylhomocysteine hydrolase inhibitors as broad-spectrum antiviral agentsQ39661538
Haematological, biochemical and coagulation changes in mice, guinea-pigs and monkeys infected with a mouse-adapted variant of Ebola Zaire virusQ40589954
Pathogenesis of experimental Ebola Zaire virus infection in BALB/c miceQ40589958
The role of the Type I interferon response in the resistance of mice to filovirus infectionQ40602484
Treatment of lethal Ebola virus infection in mice with a single dose of an S-adenosyl-L-homocysteine hydrolase inhibitorQ40621627
3-deazaadenosine, a S-adenosylhomocysteine hydrolase inhibitor, has dual effects on NF-kappaB regulation. Inhibition of NF-kappaB transcriptional activity and promotion of IkappaBalpha degradationQ40945823
3-Deazaadenosine analogues inhibit the production of tumour necrosis factor-alpha in RAW264.7 cells stimulated with lipopolysaccharideQ41146728
Influence of S-adenosylhomocysteine hydrolase inhibitors on S-adenosylhomocysteine and S-adenosylmethionine pool levels in L929 cellsQ41714614
Carbocyclic adenosine analogues as S-adenosylhomocysteine hydrolase inhibitors and antiviral agents: recent advancesQ42540268
Pharmacokinetics of the antiviral agent 3-deazaneplanocin A.Q42635990
A mouse model for evaluation of prophylaxis and therapy of Ebola hemorrhagic feverQ43512403
Adenosine analogs inhibit the guanine-7-methylation of mRNA cap structuresQ45093368
Effects of an S-adenosyl-L-homocysteine hydrolase inhibitor on murine macrophage activation and functionQ72298150
P433issue1
P921main subjectOrthoebolavirus zairenseQ10538943
P304page(s)151-159
P577publication date2002-07-01
P1433published inAntiviral ResearchQ4775352
P1476title3-deazaneplanocin A induces massively increased interferon-alpha production in Ebola virus-infected mice
P478volume55

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