A mutation causing Brugada syndrome identifies a mechanism for altered autonomic and oxidant regulation of cardiac sodium currents

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A mutation causing Brugada syndrome identifies a mechanism for altered autonomic and oxidant regulation of cardiac sodium currents is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1161/CIRCGENETICS.113.000480
P932PMC publication ID4114079
P698PubMed publication ID24795344

P2093author name stringDavid Edwards
Takeshi Aiba
Gordon F Tomaselli
Geoffrey G Hesketh
Geran Kostecki
Leslie Tung
Subrata Biswas
Federica Farinelli
P2860cites workThe Brugada ECG pattern: a marker of channelopathy, structural heart disease, or neither? Toward a unifying mechanism of the Brugada syndrome.Q37765381
Calcium-mediated dual-mode regulation of cardiac sodium channel gating.Q39876525
Prevalence of a Brugada pattern electrocardiogram in an urban population in the United StatesQ39890314
Cardiac metabolic state and Brugada syndrome: a link revealedQ43264856
Successful prevention of recurrent ventricular fibrillation by intravenous isoproterenol in a patient with Brugada syndromeQ43720591
Update on genetic analysis in Brugada syndromeQ43736095
Adeno-associated virus and lentivirus vectors mediate efficient and sustained transduction of cultured mouse and human dorsal root ganglia sensory neurons.Q44073196
Lentiviral vector-mediated expression of GFP or Kir2.1 alters the electrophysiology of neonatal rat ventricular myocytes without inducing cytotoxicityQ44091579
Phosphorylation and putative ER retention signals are required for protein kinase A-mediated potentiation of cardiac sodium currentQ44145608
Electrical storm in Brugada syndrome successfully treated using isoprenaline.Q44798187
Executive summary: HRS/EHRA/APHRS expert consensus statement on the diagnosis and management of patients with inherited primary arrhythmia syndromesQ45027885
Gene transfer of connexin43 mutants attenuates coupling in cardiomyocytes: novel basis for modulation of cardiac conduction by gene therapyQ45867972
Ionic mechanism of the effects of hydrogen peroxide in rat ventricular myocytes.Q51543526
Properties of toxin-resistant sodium channels produced by chemical modification in frog skeletal muscleQ51875256
Chemical modification reduces the conductance of sodium channels in nerve.Q51877899
Blocking late sodium current reduces hydrogen peroxide-induced arrhythmogenic activity and contractile dysfunction.Q53630608
Cardiomyocyte cultures with controlled macroscopic anisotropy: a model for functional electrophysiological studies of cardiac muscleQ78655218
Mutation in glycerol-3-phosphate dehydrogenase 1 like gene (GPD1-L) decreases cardiac Na+ current and causes inherited arrhythmiasQ24298971
Cardiac Na+ current regulation by pyridine nucleotidesQ24315557
GPD1L links redox state to cardiac excitability by PKC-dependent phosphorylation of the sodium channel SCN5AQ24323030
A method and server for predicting damaging missense mutationsQ27860835
Genetic basis and molecular mechanism for idiopathic ventricular fibrillationQ28265902
Amino acid difference formula to help explain protein evolutionQ29614440
Sudden cardiac arrest associated with early repolarizationQ33156255
Prevalence of Brugada sign and syndrome in patients presenting with arrhythmic symptoms at a Heart Rhythm Clinic in SingaporeQ33157271
Autonomic and antiarrhythmic drug modulation of ST segment elevation in patients with Brugada syndromeQ33174622
Na+ channel regulation by Ca2+/calmodulin and Ca2+/calmodulin-dependent protein kinase II in guinea-pig ventricular myocytesQ33573637
Reactive oxygen species originating from mitochondria regulate the cardiac sodium channel.Q34204033
Brugada syndrome: report of the second consensus conference: endorsed by the Heart Rhythm Society and the European Heart Rhythm Association.Q34385271
Arrhythmogenic marker for the sudden unexplained death syndrome in Thai men.Q34444862
Ventricular fibrillation without apparent heart disease: description of six casesQ34472563
Activation of protein kinase C alters the intracellular distribution and mobility of cardiac Na+ channelsQ35964944
Mitochondrial dysfunction causing cardiac sodium channel downregulation in cardiomyopathyQ36678600
IK1 heterogeneity affects genesis and stability of spiral waves in cardiac myocyte monolayersQ37460954
Spontaneous Brugada electrocardiogram patterns are rare in the German general population: results from the KORA studyQ37572102
P433issue3
P921main subjectBrugada syndromeQ599683
P304page(s)249-256
P577publication date2014-05-02
P1433published inCirculation: Cardiovascular GeneticsQ15816430
P1476titleA mutation causing Brugada syndrome identifies a mechanism for altered autonomic and oxidant regulation of cardiac sodium currents
P478volume7