Induction of cell cycle progression and acceleration of apoptosis are two separable functions of c-Myc: transrepression correlates with acceleration of apoptosis

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Induction of cell cycle progression and acceleration of apoptosis are two separable functions of c-Myc: transrepression correlates with acceleration of apoptosis is …
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scholarly articleQ13442814

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P356DOI10.1128/MCB.20.16.6008-6018.2000
P932PMC publication ID86077
P698PubMed publication ID10913183
P5875ResearchGate publication ID12407000

P2093author name stringM O'Leary
A J Wagner
E S Kandel
N Hay
S D Conzen
K Gottlob
P Khanduri
P2860cites workMax: a helix-loop-helix zipper protein that forms a sequence-specific DNA-binding complex with MycQ24294647
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Proteins of the Myc network: essential regulators of cell growth and differentiation.Q41035974
Induction of DNA synthesis and apoptosis are separable functions of E2F-1.Q41099375
The PI 3-kinase/Akt signaling pathway delivers an anti-apoptotic signal.Q41120735
Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB.Q41128352
p53 modulation of anchorage independent growth and experimental metastasis.Q41158020
Myc-mediated apoptosis requires wild-type p53 in a manner independent of cell cycle arrest and the ability of p53 to induce p21waf1/cip1.Q41414258
Mediation of c-Myc-induced apoptosis by p53.Q41441186
Ongoing mutations in the N-terminal domain of c-Myc affect transactivation in Burkitt's lymphoma cell lines.Q41483995
c-Myc induces the expression and activity of ornithine decarboxylase.Q41515721
Constitutive c-myc expression in an IL-3-dependent myeloid cell line suppresses cell cycle arrest and accelerates apoptosisQ41661995
Overexpression of c-Myc inhibits p21WAF1/CIP1 expression and induces S-phase entry in 12-O-tetradecanoylphorbol-13-acetate (TPA)-sensitive human cancer cellsQ42471863
Dissection of c-myc domains involved in S phase induction of NIH3T3 fibroblastsQ42798135
Clustered mutations in the second exon of the MYC gene in sporadic Burkitt's lymphoma.Q48098429
Apaf-1 and caspase-9 in p53-dependent apoptosis and tumor inhibition.Q53425055
Site-specific modulation of c-Myc cotransformation by residues phosphorylated in vivo.Q53474910
Phosphorylation sites mapping in the N-terminal domain of c-myc modulate its transforming potential.Q53476728
Transformation of murine myelomonocytic cells by myc: point mutations in v-myc contribute synergistically to transforming potential.Q53516492
Mechanisms of apoptosis avoidance in cancer.Q54107829
Point mutations in the c-Myc transactivation domain are common in Burkitt's lymphoma and mouse plasmacytomasQ55670934
Myc represses the growth arrest gene gadd45Q58327259
Chimaeras of Myc oncoprotein and steroid receptors cause hormone-dependent transformation of cellsQ59054505
c-Myc induces apoptosis and cell cycle progression by separable, yet overlapping, pathwaysQ71405282
Inhibition of death receptor signals by cellular FLIPQ24316446
Requirement for the CD95 receptor-ligand pathway in c-Myc-induced apoptosisQ24324204
Regulation of c-Myc through phosphorylation at Ser-62 and Ser-71 by c-Jun N-terminal kinaseQ28146223
Transactivation-defective c-MycS retains the ability to regulate proliferation and apoptosisQ28292481
Induction of apoptosis in fibroblasts by c-myc proteinQ29614346
Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalizationQ29614701
The Myc oncoprotein: a critical evaluation of transactivation and target gene regulationQ33667278
Myc-mediated transformation: the repression connectionQ33667285
Mechanisms of apoptosis by c-MycQ33667315
Destruction of Myc by ubiquitin-mediated proteolysis: cancer-associated and transforming mutations stabilize Myc.Q33890400
c-Myc target genes involved in cell growth, apoptosis, and metabolismQ33956988
Akt/Protein kinase B inhibits cell death by preventing the release of cytochrome c from mitochondriaQ33959022
Isolation and characterization of c-myc, a cellular homolog of the oncogene (v-myc) of avian myelocytomatosis virus strain 29Q34055226
Transcriptional activation by the human c-Myc oncoprotein in yeast requires interaction with Max.Q34255569
Apoptotic cell death induced by c-myc is inhibited by bcl-2.Q34255589
Cooperative interaction between c-myc and bcl-2 proto-oncogenesQ34255596
Association of Myn, the murine homolog of Max, with c-Myc stimulates methylation-sensitive DNA binding and ras cotransformationQ34769296
Opposite regulation of gene transcription and cell proliferation by c-Myc and Max.Q36208087
c-Myc transactivation of LDH-A: implications for tumor metabolism and growthQ36238451
Induction of ARF tumor suppressor gene expression and cell cycle arrest by transcription factor DMP1.Q36455981
A link between increased transforming activity of lymphoma-derived MYC mutant alleles, their defective regulation by p107, and altered phosphorylation of the c-Myc transactivation domainQ36553239
Ornithine decarboxylase is a mediator of c-Myc-induced apoptosisQ36664688
Myc-mediated apoptosis is blocked by ectopic expression of Bcl-2Q36678903
Myc represses transcription of the growth arrest gene gas1Q36711272
Neoplastic transformation by the human gene N-mycQ36839740
Definition of regions in human c-myc that are involved in transformation and nuclear localizationQ36839982
A link between c-Myc-mediated transcriptional repression and neoplastic transformationQ37353738
c-Myc represses transcription in vivo by a novel mechanism dependent on the initiator element and Myc box IIQ37635815
Myc inhibits CCAAT/enhancer-binding protein alpha-gene expression in HIB-1B hibernoma cells through interactions with the core promoter region.Q38292228
A modified oestrogen receptor ligand-binding domain as an improved switch for the regulation of heterologous proteinsQ38295120
Sequence-specific transcriptional activation by Myc and repression by Max.Q38322906
Myc and Max associate in vivoQ38331177
Myc and Max proteins possess distinct transcriptional activitiesQ39499398
c-Myc-induced sensitization to apoptosis is mediated through cytochrome c releaseQ40443976
The c-Myc protein induces cell cycle progression and apoptosis through dimerization with Max.Q40874517
P433issue16
P407language of work or nameEnglishQ1860
P921main subjectaccelerationQ11376
apoptotic processQ14599311
P304page(s)6008-6018
P577publication date2000-08-01
P1433published inMolecular and Cellular BiologyQ3319478
P1476titleInduction of cell cycle progression and acceleration of apoptosis are two separable functions of c-Myc: transrepression correlates with acceleration of apoptosis
P478volume20