Identification of a polypeptide encoded by the avian sarcoma virus src gene

scientific article published on March 1, 1978

Identification of a polypeptide encoded by the avian sarcoma virus src gene is …
instance of (P31):
scholarly articleQ13442814

External links are
P819ADS bibcode1978PNAS...75.1567P
P356DOI10.1073/PNAS.75.3.1567
P953full work available at URLhttps://europepmc.org/articles/PMC411515
https://europepmc.org/articles/PMC411515?pdf=render
https://pnas.org/doi/pdf/10.1073/pnas.75.3.1567
P932PMC publication ID411515
P698PubMed publication ID206909
P5875ResearchGate publication ID22929974

P2093author name stringJ. S. Brugge
R. L. Erikson
E. Erikson
A. F. Purchio
P2860cites workDifferences between the ribonucleic acids of transforming and nontransforming avian tumor virusesQ24632521
Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4Q25938983
Peptide mapping by limited proteolysis in sodium dodecyl sulfate and analysis by gel electrophoresisQ29547747
A Film Detection Method for Tritium-Labelled Proteins and Nucleic Acids in Polyacrylamide GelsQ29547782
An efficient mRNA-dependent translation system from reticulocyte lysatesQ29620557
Temperature sensitive mutants of an avian sarcoma virus.Q34206339
DNA related to the transforming gene(s) of avian sarcoma viruses is present in normal avian DNAQ34581419
Characterization of polyoma virus T antigenQ35014010
Translation of 35S and of subgenomic regions of avian sarcoma virus RNAQ35058766
Avian tumor virus RNA: a comparison of three sarcoma viruses and their transformation-defective derivatives by oligonucleotide fingerprinting and DNA-RNA hybridizationQ35109843
SPECIFIC ADENOVIRUS COMPLEMENT-FIXING ANTIGENS IN VIRUS-FREE HAMSTER AND RAT TUMORSQ36399289
A specific complement-fixing antigen present in SV 40 tumor and transformed cells.Q36402854
Mapping of biological functions on RNA of avian tumor viruses: location of regions required for transformation and determination of host rangeQ37463289
Size and Genetic Content of Viral RNAs in Avian Oncovirus-Infected CellsQ37506980
Heteroduplex analysis of avian RNA tumor virusesQ37581509
Rapid isolation of antigens from cells with a staphylococcal protein A-antibody adsorbent: parameters of the interaction of antibody-antigen complexes with protein AQ39513417
Altered Patterns of Protein Synthesis in Infection by SV40 MutantsQ39947352
Generation of avian myeloblastosis virus structural proteins by proteolytic cleavage of a precursor polypeptideQ39953380
Transformation-defective mutants of avian sarcoma viruses: The genetic relationship between conditional and nonconditional mutantsQ39982165
Characteristics of virus-specific RNA in avian sarcoma virus-transformed BHK-21 cells and revertantsQ40044631
Phosphorylated and nonphosphorylated forms of avian sarcoma virus polypeptide p19Q40081590
Identification of a transformation-specific antigen induced by an avian sarcoma virusQ40101156
The size and genetic composition of virus-specific RNAs in the cytoplasm of cells producing avian sarcoma-leukosis virusesQ40122742
The effects of reciprocal changes in temperature on the transformed state of cells infected with a rous sarcoma virus mutantQ45821194
Rous sarcoma virus: a function required for the maintenance of the transformed stateQ45822415
Studies on the RNA from avian myeloblastosis virusQ45823438
Spontaneous segregation of nontransforming viruses from cloned sarcoma viruses.Q53604593
Immunological identification of two adenovirus 2-induced early proteins possibly involved in cell transformationQ59064234
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectviral transformationQ17162815
viral genesQ71237937
P1104number of pages5
P304page(s)1567-1571
P577publication date1978-03-01
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleIdentification of a polypeptide encoded by the avian sarcoma virus src gene
P478volume75

Reverse relations

cites work (P2860)
Q402669229-(S)-(2,3-Dihydroxypropyl)adenine inhibits the transformation of chick embryo fibroblasts infected with Rous sarcoma virus: Evidence for inhibition of enzymatic activity of isolated cellular protein kinases by the drug
Q45800969A Cellular Protein Phosphorylated by the Avian Sarcoma Virus Transforming Gene Product
Q35298721A brain membrane protein similar to the rat src gene product
Q33933397A cellular protein phosphorylated by the avian sarcoma virus transforming gene product is associated with ribonucleoprotein particles
Q36903823A mutation at the ATP-binding site of pp60v-src abolishes kinase activity, transformation, and tumorigenicity
Q72741286A mutation at the major phosphotyrosine in pp60v-src alters oncogenic potential
Q30449054A normal cell protein similar in structure and function to the avian sarcoma virus transforming gene product
Q36947661A short sequence in the p60src N terminus is required for p60src myristylation and membrane association and for cell transformation
Q40128092A single point mutation has pleiotropic effects on pp60v-src function
Q45806377A src-related 120,000-dalton protein expressed in an avian sarcoma virus-transformed rat cell line
Q30452313Accumulation of spliced avian retrovirus mRNA is inhibited in S-adenosylmethionine-depleted chicken embryo fibroblasts
Q35618312Activation of an internal initiation site for protein synthesis during in vitro translation
Q36394145Adhesion plaques of Rous sarcoma virus-transformed cells contain the src gene product
Q40227687An avian oncovirus mutant deficient in genomic RNA: characterization of the packaged RNA as cellular messenger RNA
Q45802546Analysis of avian leukosis virus DNA and RNA in bursal tumors: Viral gene expression is not required for maintenance of the tumor state
Q45796833Analysis of the catalytic domain of phosphotransferase activity of two avian sarcoma virus-transforming proteins
Q36281307Analysis of the sequence of amino acids surrounding sites of tyrosine phosphorylation
Q36505205Analysis of the src gene of sarcoma viruses generated by recombination between transformation-defective mutants and quail cellular sequences
Q72711588Antibodies against synthetic peptides as a tool for functional analysis of the transforming protein pp60src
Q36926320Antiserum specific for the carboxy terminus of the transforming protein of Rous sarcoma virus
Q37603735Association of pp36, a phosphorylated form of the presumed target protein for the src protein of Rous sarcoma virus, with the membrane of chicken cells transformed by Rous sarcoma virus
Q36974125Association of the Transforming Proteins of Rous, Fujinami, and Y73 Avian Sarcoma Viruses with the Same Two Cellular Proteins
Q40177552At least 104 nucleotides are transposed from the 5′ terminus of the avian sarcoma virus genome to the 5′ termini of smaller viral mrnas
Q36508328Avian erythroblastosis virus produces two mRNA's
Q45803653Avian sarcoma virus-transforming protein, pp60src shows protein kinase activity specific for tyrosine
Q72657751Bacterial expression of an enzymatically active protein encoded by RSV src gene
Q35235566Biological properties of "partial" transformation mutants of Rous sarcoma virus and characterization of their pp60src kinase
Q37595633Cell-free synthesis and processing of the proteins of poliovirus
Q37335587Cellular information in the genome of recovered avian sarcoma virus directs the synthesis of transforming protein
Q35991499Characterization of a feline sarcoma virus-coded antigen (FOCMA-S) by radioimmunoassay
Q39523404Characterization of a normal avian cell protein related to the avian sarcoma virus transforming gene product
Q36501941Characterization of an immune complex kinase in immunoprecipitates of avian sarcoma virus-transformed fibroblasts
Q36888377Characterization of pp60src phosphorylation in vitro in Rous sarcoma virus-transformed cell membranes
Q24618435Characterization of sites for tyrosine phosphorylation in the transforming protein of Rous sarcoma virus (pp60v-src) and its normal cellular homologue (pp60c-src)
Q45798442Characterization of the Rous sarcoma virus transforming gene product
Q40193671Characterization of the avian sarcoma virus protein p60src
Q34036059Characterization of the protein kinase activity of avian sarcoma virus src gene product
Q36391058Characterization of the transforming gene of Fujinami sarcoma virus
Q36596600Comparison Between the Viral Transforming Gene (src) of Recovered Avian Sarcoma Virus and Its Cellular Homolog
Q37601190Comparison of the expression of the src gene of Rous sarcoma virus in vitro and in vivo
Q38065985Contributions of microbiology to eucaryotic cell biology: new directions for microbiology
Q39581697Control of myogenic differentiation by cellular oncogenes
Q33925349Correlation of RNA binding affinity of avian oncornavirus p19 proteins with the extent of processing of virus genome RNA in cells
Q36924844DNA sequence of the viral and cellular src gene of chickens. 1. Complete nucleotide sequence of an EcoRI fragment of recovered avian sarcoma virus which codes for gp37 and pp60src.
Q53554563Decreased adenylate cyclase responsiveness of transformed cells correlates with the presence of a viral transforming protein.
Q30452209Deletions and insertions within an amino-terminal domain of pp60v-src inactivate transformation and modulate membrane stability
Q42825265Detection of a transforming gene product in cells transformed by Moloney murine sarcoma virus
Q36495449Detection of the Viral Sarcoma Gene Product in Cells Infected with Various Strains of Avian Sarcoma Virus and of a Related Protein in Uninfected Chicken Cells
Q53551132Direct evidence that oncogenic tyrosine kinases and cyclic AMP-dependent protein kinase have homologous ATP-binding sites.
Q45798470Effect of several nucleotides on the phosphorylating activities of the Rous-sarcoma-virus transforming protein pp60v-sic and its cellular homologue, pp60c-sic
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Q33921742Evidence for the common origin of viral and cellular sequences involved in sarcomagenic transformation
Q45799132Evidence that the Rous sarcoma virus transforming gene product is associated with glycerol kinase activity
Q33986868Evidence that the avian sarcoma virus transforming gene product is a cyclic AMP-independent protein kinase
Q24297885Evidence that the transforming gene of avian sarcoma virus encodes a protein kinase associated with a phosphoprotein
Q35239618Evidence that there exist four classes of RNA tumor viruses which encode proteins with associated tyrosine protein kinase activities
Q72912277Evidence that viral transforming gene products and epidermal growth factor stimulate phosphorylation of the same cellular protein with similar specificity
Q36936361Evidence the pp60src, the product of the Rous sarcoma virus src gene, undergoes autophosphorylation
Q36939158Expression of the PRC II avian sarcoma virus genome
Q36945998Expression of the Rous Sarcoma Virus src Gene in Avian Macrophages Fails to Elicit Transformed Cell Phenotype
Q40132338Forms of pp60v-src isolated from Rous sarcoma virus-transformed cells.
Q36946370Functional Domains of the pp60v-src Protein as Revealed by Analysis of Temperature-Sensitive Rous Sarcoma Virus Mutants
Q40127028Gene-Specific Probes for Avian Retroviruses
Q53552812Growth factors: Mechanism of action and relation to oncogenes
Q36211478Highly specific antibody to Rous sarcoma virus src gene product recognizes a novel population of pp60v-src and pp60c-src molecules
Q36414827Homology exists among the transforming sequences of avian and feline sarcoma viruses
Q72648142Human cells contain two forms of pp60c-src
Q35242161Identification of a Packaged Cellular mRNA in Virions of Rous Sarcoma Virus
Q33974327Identification of a Rous sarcoma virus transformation-related protein in normal avian and mammalian cells
Q40209262Immunofluorescence on avian sarcoma virus-transformed cells: Localization of the src gene product
Q40167541In vitro synthesis of a functional avian sarcoma virus transforming-gene product
Q40660422In vitro synthesis of pp60v-src: myristylation in a cell-free system
Q36837132In vivo effect of sodium orthovanadate on pp60c-src kinase
Q45801955In vivo selection of two agents differing in hepatoma-inducing activity from strain MC29 avian leukosis virus
Q36978316Increase in the Phosphotransferase Specific Activity of Purified Rous Sarcoma Virus pp60v-src Protein After Incubation with ATP Plus Mg2+
Q41461344Influence of transformation by Rous sarcoma virus on the amount, phosphorylation and enzyme kinetic properties of enolase.
Q40266121Inhibition of the transformation-specific kinase in ASV-transformed cells by N-α-tosyl-L-lysyl chloromethyl ketone
Q36935658Interaction Between the Rous Sarcoma Virus Transforming Protein and Two Cellular Phosphoproteins: Analysis of the Turnover and Distribution of This Complex
Q40126755Intracellular localization and processing of pp60v-src proteins expressed by two distinct temperature-sensitive mutants of Rous sarcoma virus
Q30452300Isolation and partial characterization of a monoclonal antibody to the Rous sarcoma virus transforming protein pp60src.
Q70340248Isolation and partial characterization of a nuclear antigen (68/6.3) from the Namalwa cell line (a Burkitt lymphoma)
Q36947955Isolation of a cDNA clone complementary to sequences for a 34-kilodalton protein which is a pp60v-src substrate
Q45802309Isolation of an avian sarcoma virus-specific protein kinase from virus particles
Q39814290Isolation of monoclonal antibodies against avian oncornaviral protein p19
Q45797801Local mutagenesis of Rous sarcoma virus: The major sites of tyrosine and serine phosphorylation of p60src are dispensable for transformation
Q53576277Malignant transformation and protein phosphorylation
Q36494662Messenger Activity of Virion RNA for Avian Leukosis Viral Envelope Glycoprotein
Q44901027Modification of gap junctions in cells transformed by a temperature-sensitive mutant of Rous sarcoma virus
Q35564732Modulation of fibronectin gene activity in chick embryo fibroblasts transformed by a temperature-sensitive strain (ts68) of Rous sarcoma virus
Q40122286Molecular events in cells transformed by Rous Sarcoma virus
Q40241826Mutants of rous sarcoma virus with extensive deletions of the viral genome
Q36910596Neither arginine nor histidine can carry out the function of lysine-295 in the ATP-binding site of p60src
Q36957166No activation of new initiation points for deoxyribonucleic acid replication in BALB/c 3T3 cells transformed by Kirsten sarcoma virus
Q53558210Oncogenes in retroviruses and cells
Q67269766Only membrane-associated RSV src proteins have amino-terminally bound lipid
Q36204906Organization of pp60src and selected cytoskeletal proteins within adhesion plaques and junctions of Rous sarcoma virus-transformed rat cells
Q45800401Participation of 5'-terminal leader sequences in in vitro translation of Rous sarcoma virus RNA
Q37601583Peptide analysis of the transformation-specific antigen from avian sarcoma virus-transformed cells
Q39611817Perspectives in physiology: cell growth
Q36915975Phenotypic change from transformed to normal induced by benzoquinonoid ansamycins accompanies inactivation of p60src in rat kidney cells infected with Rous sarcoma virus
Q35585097Phosphorylation and inactivation of protein phosphatase 1 by pp60v-src
Q36971036Phosphorylation of a 36,000 Mr Cellular Protein in Cells Infected with Partial Transformation Mutants of Rous Sarcoma Virus
Q35589954Phosphorylation of tyrosine in the carboxyl-terminal tryptic peptide of pp60c-src
Q35610368Phosphorylation of tyrosine residues of calmodulin in Rous sarcoma virus-transformed cells
Q36905099Phosphotyrosine-containing proteins and expression of transformation parameters in cells infected with partial transformation mutants of Rous sarcoma virus
Q45804702Physical modification of purified rous sarcoma virus pp60v-src protein after incubation with ATP/Mg2+
Q36496786Polymorphism of avian sarcoma virus src proteins
Q36502242Preparation of syngeneic tumor regressor serum reactive with the unique determinants of the Abelson murine leukemia virus-encoded P120 protein at the cell surface
Q35990965Processing of 60,000-dalton sarc gene protein synthesized by cell-free translation
Q36497032Product of in vitro translation of the Rous sarcoma virus src gene has protein kinase activity
Q52845987Professor Hamao Umezawa opened up a new road for the development of molecularly targeted therapeutic drugs for cancers.
Q45800309Properties of the src kinase purified from Rous sarcoma virus-induced rat tumors
Q37584831Protein kinase activity associated with the avian sarcoma virus src gene product
Q45800311Purification of a tyrosine-specific protein kinase from Rous sarcoma virus-induced rat tumor
Q37673451Purification of the Rous sarcoma virus src kinase by casein-agarose and tyrosine-agarose affinity chromatography
Q38963349Regulation of pulmonary endothelial barrier function by kinases
Q38058829Role of cyclic nucleotides in regulating lymphocytes
Q45805381Rous sarcoma virus transforming protein, p60src, expressed in E. coli, functions as a protein kinase
Q45800797Rous sarcoma virus-induced phosphorylation of a 50,000-molecular weight cellular protein
Q34103644Selected glimpses into the activation and function of Src kinase
Q30452348Selective inhibition of avian sarcoma virus protein synthesis in 3-deazaadenosine-treated infected chicken embryo fibroblasts
Q30452305Site-directed mutagenesis of the src gene of Rous sarcoma virus: construction and characterization of a deletion mutant temperature sensitive for transformation.
Q30452297Site-directed point mutation in the src gene oF rous sarcoma virus results in an inactive src gene product
Q33924889Sites of synthesis of viral proteins in avian sarcoma virus-infected chicken cells
Q30412370Specific proteolytic fragmentation of p60v-src in transformed cell lysates
Q46892829Src family kinases play multiple roles in differentiation of trophoblasts from human term placenta.
Q34481586Src inhibitors: genomics to therapeutics
Q39605666Src kinase mediates productive endocytic sorting of reovirus during cell entry.
Q36493768Structural analysis of the avian sarcoma virus transforming protein: sites of phosphorylation
Q36894563Structural and functional modification of pp60c-src associated with polyoma middle tumor antigen from infected or transformed cells
Q36945448Structurally and functionally modified forms of pp60v-src in Rous sarcoma virus-transformed cell lysates
Q40294393Studies on the Structure and Function of the Avian Sarcoma Virus Transforming Gene Product
Q33919398Suppression of murine retrovirus polypeptide termination: effect of amber suppressor tRNA on the cell-free translation of Rauscher murine leukemia virus, Moloney murine leukemia virus, and Moloney murine sarcoma virus 124 RNA.
Q35236412Synthesis of murine mammary tumor viral proteins in vitro
Q43898206Temperature-sensitive kinase activity associated with various mutants of avian sarcoma viruses which are temperature sensitive for transformation
Q40123262The Oncogenic Function of Mammalian Sarcoma Viruses
Q40137529The Pathogenesis of Oncogenic Avian Retrovirusesxs
Q36956336The Same Normal Cell Protein Is Phosphorylated After Transformation by Avian Sarcoma Viruses with Unrelated Transforming Genes
Q40127021The Transforming Protein of Avian Sarcoma Viruses and Its Homologue in Normal Cells
Q35885766The cancer cell and its control by the embryo. Rous-Whipple Award lecture
Q36938146The leader sequence of the subgenomic mRNA's of Rous sarcoma virus is approximately 390 nucleotides
Q54544326The overall synthesis of L-5,6-dihydroorotate by multienzymatic protein pyr1-3 from hamster cells. Kinetic studies, substrate channeling, and the effects of inhibitors
Q39740844The pathophysiology of murine retrovirus-induced leukemias
Q45802887The purified product of the transforming gene of avian sarcoma virus phosphorylates tyrosine
Q45801434The specific interaction of the Rous sarcoma virus transforming protein, pp60src, with two cellular proteins
Q40255094The src gene product of transformed and morphologically reverted ASV-infected mammalian cells
Q36392358Transformation-related antigens identified by monoclonal antibodies
Q59096503Transformation-specific secreted phosphoproteins
Q39553304Transformed mammalian cells secrete specific proteins and phosphoproteins
Q36940284Tumorigenicity of partial transformation mutants of Rous sarcoma virus
Q40679227Tyrosine Phosphorylation of a 50K Cellular Polypeptide Associated with the Rous Sarcoma Virus Transforming Protein pp60src
Q53575128Uninfected avian cells contain structurally unrelated progenitors of viral sarcoma genes
Q24597268Uninfected vertebrate cells contain a protein that is closely related to the product of the avian sarcoma virus transforming gene (src)
Q40245741Virus-specific messenger RNAs in permissive cells infected by avian sarcoma virus
Q33944240Zinc induces a Src family kinase-mediated up-regulation of NMDA receptor activity and excitotoxicity
Q61207337c-Src and IL-6 inhibit osteoblast differentiation and integrate IGFBP5 signalling
Q33916006env Gene of Rous sarcoma virus: identification of the gene product by cell-free translation
Q37601620gag-Related polypeptides encoded by replication-defective avian oncoviruses
Q35240614src Genes of Ten Rous Sarcoma Virus Strains, Including Two Reportedly Transduced from the Cell, Are Completely Allelic; Putative Markers of Transduction Are Not Detected
Q37317019src gene product from different strains of avain sarcoma virus: Kinetics and possible mechanism of heat inactivation of protein kinase activity from cells infected by transformation-defective, temperature-sensitive mutant and wild-type virus

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