ATM regulates NF-κB-dependent immediate-early genes via RelA Ser 276 phosphorylation coupled to CDK9 promoter recruitment

scientific article

ATM regulates NF-κB-dependent immediate-early genes via RelA Ser 276 phosphorylation coupled to CDK9 promoter recruitment is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1093/NAR/GKU529
P932PMC publication ID4117761
P698PubMed publication ID24957606
P5875ResearchGate publication ID263355677

P50authorAllan R BrasierQ45390633
P2093author name stringIstvan Boldogh
Chunying Yang
Ling Fang
Chukwudi B Edeh
Yingxin Zhao
Sanjeev Choudhary
P2860cites workTNF-alpha-induced NF-kappaB/RelA Ser(276) phosphorylation and enhanceosome formation is mediated by an ROS-dependent PKAc pathway.Q51581450
A cytoplasmic ATM-TRAF6-cIAP1 module links nuclear DNA damage signaling to ubiquitin-mediated NF-κB activation.Q52901092
DNA double-strand breaks measured in individual cells subjected to gel electrophoresisQ64389970
Tumor necrosis factor and interleukin-1 serum levels during severe sepsis in humansQ69748429
IgG2 deficiency in ataxia-telangiectasiaQ70275985
DNA damage induced by tumour necrosis factor-alpha in L929 cells is mediated by mitochondrial oxygen radical formationQ72333300
Plasma concentrations of tumor necrosis factor-alpha (TNF-alpha) and soluble TNF receptors in patients with anorexia nervosaQ77312555
Reconstitution of the RIG-I pathway reveals a signaling role of unanchored polyubiquitin chains in innate immunityQ24307162
MAVS forms functional prion-like aggregates to activate and propagate antiviral innate immune responseQ24316320
The SCFbeta-TRCP-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in IkappaBalpha and beta-catenin and stimulates IkappaBalpha ubiquitination in vitroQ24608829
RelA Ser276 phosphorylation is required for activation of a subset of NF-kappaB-dependent genes by recruiting cyclin-dependent kinase 9/cyclin T1 complexesQ24658047
NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responsesQ27861101
The human F box protein beta-Trcp associates with the Cul1/Skp1 complex and regulates the stability of beta-catenin.Q27863647
DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociationQ28206029
The NF-kappaB regulatory networkQ28288503
Tumor necrosis factor-alpha-inducible IkappaBalpha proteolysis mediated by cytosolic m-calpain. A mechanism parallel to the ubiquitin-proteasome pathway for nuclear factor-kappab activationQ28292768
Impaired degradation of inhibitory subunit of NF-kappa B (I kappa B) and beta-catenin as a result of targeted disruption of the beta-TrCP1 geneQ28506095
Phosphorylation of NF-kappa B p65 by PKA stimulates transcriptional activity by promoting a novel bivalent interaction with the coactivator CBP/p300Q28619230
Shared principles in NF-kappaB signalingQ29547234
ATM and related protein kinases: safeguarding genome integrityQ29547735
Signaling to NF-kappaBQ29547844
Shaping the nuclear action of NF-kappaBQ29614600
Toll-like receptors and innate immunityQ29615458
Endosomal Nox2 facilitates redox-dependent induction of NF-kappaB by TNF-alphaQ33741068
Phosphorylation of p65(RelA) on Ser(547) by ATM represses NF-κB-dependent transcription of specific genes after genotoxic stressQ34310237
Immunodeficiency and infections in ataxia-telangiectasia.Q34311643
DNA damage-induced activation of ATM and ATM-dependent signaling pathwaysQ34336538
ATM activation in the presence of oxidative stressQ34619774
Activation and regulation of ATM kinase activity in response to DNA double-strand breaksQ34722727
ROS inhibitor N-acetyl-L-cysteine antagonizes the activity of proteasome inhibitorsQ35065984
High throughput short interfering RNA (siRNA) screening of the human kinome identifies novel kinases controlling the canonical nuclear factor-κB (NF-κB) activation pathwayQ35423449
Intracellular pattern recognition receptors in the host responseQ36528528
Post-translational modifications regulating the activity and function of the nuclear factor kappa B pathwayQ36637883
Beyond IkappaBs: alternative regulation of NF-kappaB activityQ36790420
Inducible tumor necrosis factor (TNF) receptor-associated factor-1 expression couples the canonical to the non-canonical NF-κB pathway in TNF stimulationQ36850404
DNA damage-induced activation of ATM promotes β-TRCP-mediated Mdm2 ubiquitination and destructionQ36862753
Many faces of NF-kappaB signaling induced by genotoxic stressQ36868559
Down-regulation of 8-oxoguanine DNA glycosylase 1 expression in the airway epithelium ameliorates allergic lung inflammationQ36918252
Applications of selected reaction monitoring (SRM)-mass spectrometry (MS) for quantitative measurement of signaling pathwaysQ37149443
Immunodeficiency in ataxia telangiectasia is correlated strongly with the presence of two null mutations in the ataxia telangiectasia mutated geneQ37174163
Respiratory syncytial virus infection induces a reactive oxygen species-MSK1-phospho-Ser-276 RelA pathway required for cytokine expressionQ37365383
8-oxoguanine DNA glycosylase-1 augments proinflammatory gene expression by facilitating the recruitment of site-specific transcription factorsQ37619953
The ATM protein kinase and cellular redox signaling: beyond the DNA damage responseQ37955496
Regulation of NF-κB by ubiquitination and degradation of the IκBsQ37995680
Ubiquitination in signaling to and activation of IKK.Q37995681
Two-step cross-linking method for identification of NF-kappaB gene network by chromatin immunoprecipitation.Q38318340
Functional analysis of the nuclear proteome of human A549 alveolar epithelial cells by HPLC-high resolution 2-D gel electrophoresisQ38408002
CDK9-dependent transcriptional elongation in the innate interferon-stimulated gene response to respiratory syncytial virus infection in airway epithelial cellsQ39164217
Quantitation of the dynamic profiles of the innate immune response using multiplex selected reaction monitoring-mass spectrometryQ39192699
Hunting for serine 276-phosphorylated p65.Q39315541
Nuclear IKKβ Is an Adaptor Protein for IκBα Ubiquitination and Degradation in UV-Induced NF-κB ActivationQ39662942
Loss of ATM positively regulates the expression of hypoxia inducible factor 1 (HIF-1) through oxidative stress: Role in the physiopathology of the diseaseQ39672967
TNF-alpha-induced ROS production triggering apoptosis is directly linked to Romo1 and Bcl-X(L).Q39732156
TNF-induced activation of the Nox1 NADPH oxidase and its role in the induction of necrotic cell deathQ40121624
Molecular linkage between the kinase ATM and NF-kappaB signaling in response to genotoxic stimuliQ40312088
Activation of the Ikappa B kinases by RIP via IKKgamma /NEMO-mediated oligomerizationQ40856026
Human fibroblasts release reactive oxygen species in response to interleukin-1 or tumour necrosis factor-alpha.Q41988723
DNA damage recognition via activated ATM and p53 pathway in nonproliferating human prostate tissueQ42478931
Increased oxidative stress in ataxia telangiectasia evidenced by alterations in redox state of brains from Atm-deficient miceQ43561110
Rapid reactive oxygen species production by mitochondria in endothelial cells exposed to tumor necrosis factor-alpha is mediated by ceramideQ43646549
The NF-kappa B activation in lymphotoxin beta receptor signaling depends on the phosphorylation of p65 at serine 536.Q44207683
Suppression of HIV-1 infection by a small molecule inhibitor of the ATM kinaseQ46440743
beta-TrCP binding and processing of NF-kappaB2/p100 involve its phosphorylation at serines 866 and 870.Q46816359
Pathological neoangiogenesis depends on oxidative stress regulation by ATM.Q47382659
P275copyright licenseCreative Commons Attribution 3.0 UnportedQ14947546
P6216copyright statuscopyrightedQ50423863
P433issue13
P407language of work or nameEnglishQ1860
P921main subjectphosphorylationQ242736
immediate early geneQ409638
NF-κBQ411114
P304page(s)8416-8432
P577publication date2014-06-23
P1433published inNucleic Acids ResearchQ135122
P1476titleATM regulates NF-κB-dependent immediate-early genes via RelA Ser 276 phosphorylation coupled to CDK9 promoter recruitment
P478volume42

Reverse relations

cites work (P2860)
Q46297052ATM-activated autotaxin (ATX) propagates inflammation and DNA damage in lung epithelial cells: a new mode of action for silica-induced DNA damage?
Q35076663Ataxia telangiectasia mutated kinase mediates NF-κB serine 276 phosphorylation and interferon expression via the IRF7-RIG-I amplification loop in paramyxovirus infection.
Q92514832Ataxia telangiectasia mutated pathway disruption affects hepatic DNA and tissue damage in nonalcoholic fatty liver disease
Q38721807BRD4 Couples NF-κB/RelA with Airway Inflammation and the IRF-RIG-I Amplification Loop in Respiratory Syncytial Virus Infection.
Q39236663BRD4 mediates NF-κB-dependent epithelial-mesenchymal transition and pulmonary fibrosis via transcriptional elongation
Q52339069Central Role of the NFκB Pathway in the Scgb1a1-Expressing Epithelium in Mediating Respiratory Syncytial Virus-induced Airway Inflammation.
Q26738556DNA Repair and Cytokines: TGF-β, IL-6, and Thrombopoietin as Different Biomarkers of Radioresistance
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Q92114791Interleukin 6-triggered ataxia-telangiectasia mutated kinase activation facilitates epithelial-to-mesenchymal transition in lung cancer by upregulating vimentin expression
Q98172163Loss of Function Genetic Screen Identifies ATM Kinase as a Positive Regulator of TLR3-Mediated NF-κB Activation
Q104064539Non-epigenetic induction of HEXIM1 by DNMT1 inhibitors and functional relevance
Q47803583PIKKing a way to regulate inflammation
Q36174095PPM1G Binds 7SK RNA and Hexim1 To Block P-TEFb Assembly into the 7SK snRNP and Sustain Transcription Elongation.
Q64075661Precise Gene Editing Preserves Hematopoietic Stem Cell Function following Transient p53-Mediated DNA Damage Response
Q38960921Prolonged inflammatory microenvironment is crucial for pro-neoplastic growth and genome instability: a detailed review
Q57257741Roles of DNA repair enzyme OGG1 in innate immunity and its significance for lung cancer
Q41070253Self-inflicted DNA double-strand breaks sustain tumorigenicity and stemness of cancer cells
Q99551730The role of reactive oxygen species in cognitive impairment associated with sleep apnea
Q58753850Transcriptional outcomes and kinetic patterning of gene expression in response to NF-κB activation

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