Suppression of HIV-1 infection by a small molecule inhibitor of the ATM kinase

scientific article published on 17 April 2005

Suppression of HIV-1 infection by a small molecule inhibitor of the ATM kinase is …
instance of (P31):
scholarly articleQ13442814

External links are
P6179Dimensions Publication ID1033756787
P356DOI10.1038/NCB1250
P8608Fatcat IDrelease_aebdzogsybf4tanigffvpru2ua
P698PubMed publication ID15834407
P5875ResearchGate publication ID7903574

P50authorStephen P JacksonQ37392575
P2093author name stringDebra L Taylor
Alan Lau
Graeme C M Smith
Mark J O'Connor
Karra M Swinbank
Parvin S Ahmed
P2860cites workAbnormal development of Purkinje cells and lymphocytes in Atm mutant miceQ35109704
Selective inhibition of the DNA-dependent protein kinase (DNA-PK) by the radiosensitizing agent caffeineQ37520990
Poly(ADP-ribose) polymerase 1 is not strictly required for infection of murine cells by retrovirusesQ39686241
Suppression of retroviral infection by the RAD52 DNA repair proteinQ39949544
ATM and DNA-PK function redundantly to phosphorylate H2AX after exposure to ionizing radiationQ40570996
Effect of Ku80 depletion on the preintegrative steps of HIV-1 replication in human cellsQ40707814
A quantitative assay for HIV DNA integration in vivoQ40809319
Overexpression of a kinase-inactive ATR protein causes sensitivity to DNA-damaging agents and defects in cell cycle checkpointsQ41063544
Recombinant ATM protein complements the cellular A-T phenotypeQ41099853
An improved colorimetric assay for cell proliferation and viability utilizing the tetrazolium salt XTT.Q41665498
Direct effects of caffeine and theophylline on p110 delta and other phosphoinositide 3-kinases. Differential effects on lipid kinase and protein kinase activitiesQ44081143
Caffeine inhibits checkpoint responses without inhibiting the ataxia-telangiectasia-mutated (ATM) and ATM- and Rad3-related (ATR) protein kinasesQ44504054
Roles of host cell factors in circularization of retroviral dnaQ63383933
Evaluation of synergism or antagonism for the combined action of antiviral agentsQ68772229
ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathwayQ22253899
Activation of the ATM kinase by ionizing radiation and phosphorylation of p53Q24311891
Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stressQ24597483
Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategyQ27860519
Caffeine abolishes the mammalian G(2)/M DNA damage checkpoint by inhibiting ataxia-telangiectasia-mutated kinase activityQ28140338
ATM and ATR: networking cellular responses to DNA damageQ28143424
Targeted disruption of the cell-cycle checkpoint gene ATR leads to early embryonic lethality in miceQ28143813
The many substrates and functions of ATMQ28205055
DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociationQ28206029
Enhanced phosphorylation of p53 by ATM in response to DNA damageQ28609838
Processing of an HIV replication intermediate by the human DNA replication enzyme FEN1Q28646885
In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vectorQ29547503
ATM and related protein kinases: safeguarding genome integrityQ29547735
Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATMQ29614843
Cell cycle checkpoint signaling through the ATM and ATR kinasesQ29617837
Drug resistance and drug combination features of the human immunodeficiency virus inhibitor, BCH-10652 [(+/-)-2'-deoxy-3'-oxa-4'-thiocytidine, dOTC].Q31430709
A role for DNA-PK in retroviral DNA integrationQ33178144
Wortmannin potentiates integrase-mediated killing of lymphocytes and reduces the efficiency of stable transduction by retroviruses.Q33181589
Evidence that the retroviral DNA integration process triggers an ATR-dependent DNA damage responseQ33186627
Histone H2AX is phosphorylated at sites of retroviral DNA integration but is dispensable for postintegration repair.Q33205906
The ataxia telangiectasia-mutated and Rad3-related protein is dispensable for retroviral integrationQ33717181
DNA damage sensors ATM, ATR, DNA-PKcs, and PARP-1 are dispensable for human immunodeficiency virus type 1 integrationQ33835321
Poly(ADP-ribose) polymerase-1 is required for efficient HIV-1 integrationQ34730830
Role of the non-homologous DNA end joining pathway in the early steps of retroviral infectionQ34770002
Toward maintaining the genome: DNA damage and replication checkpointsQ34995489
P433issue5
P304page(s)493-500
P577publication date2005-04-17
P1433published inNature Cell BiologyQ1574111
P1476titleSuppression of HIV-1 infection by a small molecule inhibitor of the ATM kinase
P478volume7

Reverse relations

cites work (P2860)
Q24599676A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling
Q33693893A role for the histone deacetylase HDAC4 in the life-cycle of HIV-1-based vectors.
Q40084942AICAR induces phosphorylation of AMPK in an ATM-dependent, LKB1-independent manner
Q31115324ATM and ATR activities maintain replication fork integrity during SV40 chromatin replication
Q34753639ATM kinase is a master switch for the Delta Np63 alpha phosphorylation/degradation in human head and neck squamous cell carcinoma cells upon DNA damage
Q42945209ATM mediates cytotoxicity of a mutant telomerase RNA in human cancer cells
Q33983560ATM regulates NF-κB-dependent immediate-early genes via RelA Ser 276 phosphorylation coupled to CDK9 promoter recruitment
Q40113142ATM supports gammaherpesvirus replication by attenuating type I interferon pathway
Q46469392ATM: HIV-1's Achilles heel?
Q42182598Activation of HIV-1 LTR by Rad51 in microglial cells
Q26769967Activation of the DNA Damage Response by RNA Viruses
Q33904045An E2F1-mediated DNA damage response contributes to the replication of human cytomegalovirus
Q38628801An Overview of Human Immunodeficiency Virus Type 1-Associated Common Neurological Complications: Does Aging Pose a Challenge?
Q97529378Antiviral immunity and nucleic acid sensing in haematopoietic stem cell gene engineering
Q33800169Ataxia telangiectasia mutated (ATM) inhibition transforms human mammary gland epithelial cells
Q35076663Ataxia telangiectasia mutated kinase mediates NF-κB serine 276 phosphorylation and interferon expression via the IRF7-RIG-I amplification loop in paramyxovirus infection.
Q37386581Ataxia telangiectasia-mutated-Rad3-related DNA damage checkpoint signaling pathway triggered by hepatitis B virus infection
Q40362631Ataxia-telangiectasia-mutated (ATM) is a T-antigen kinase that controls SV40 viral replication in vivo
Q34434761Ataxia-telangiectasia-mutated (ATM) protein can enhance human immunodeficiency virus type 1 replication by stimulating Rev function
Q27473132Attacking pathogens through their hosts
Q35177820BRCA1 functions as a novel transcriptional cofactor in HIV-1 infection
Q35531444Baculovirus infection induces a DNA damage response that is required for efficient viral replication
Q37344250Cellular DNA repair cofactors affecting hepatitis B virus infection and replication
Q27657380Cellular inhibition of checkpoint kinase 2 (Chk2) and potentiation of camptothecins and radiation by the novel Chk2 inhibitor PV1019 [7-nitro-1H-indole-2-carboxylic acid {4-[1-(guanidinohydrazone)-ethyl]-phenyl}-amide].
Q33344436Critical involvement of the ATM-dependent DNA damage response in the apoptotic demise of HIV-1-elicited syncytia
Q51722722DNA REPAIR. Drugging DNA repair.
Q36707275DNA damage enhances integration of HIV-1 into macrophages by overcoming integrase inhibition
Q46774661DNA damage induced by topoisomerase inhibitors activates SAMHD1 and blocks HIV-1 infection of macrophages
Q36405094DNA damage: a trigger of innate immunity but a requirement for adaptive immune homeostasis
Q30437599DNA double strand break repair enzymes function at multiple steps in retroviral infection
Q36413050DNA-damage response pathways triggered by viral replication.
Q40274368Deregulation of DNA damage signal transduction by herpesvirus latency-associated M2.
Q59216433Evidence that the Nijmegen breakage syndrome protein, an early sensor of double-strand DNA breaks (DSB), is involved in HIV-1 post-integration repair by recruiting the ataxia telangiectasia-mutated kinase in a process similar to, but distinct from, c
Q30437897Functional and computational assessment of missense variants in the ataxia-telangiectasia mutated (ATM) gene: mutations with increased cancer risk
Q37778386Genomes in Conflict: Maintaining Genome Integrity During Virus Infection
Q36520900HIV Tat controls RNA Polymerase II and the epigenetic landscape to transcriptionally reprogram target immune cells
Q39830948HIV integrase and the swan song of the CD4 T cells?
Q34476144HIV-1 Infection Accelerates Age According to the Epigenetic Clock
Q64388284HIV-1 Vpr induces ATM-dependent cellular signal with enhanced homologous recombination
Q35423449High throughput short interfering RNA (siRNA) screening of the human kinome identifies novel kinases controlling the canonical nuclear factor-κB (NF-κB) activation pathway
Q36746350Host factors exploited by retroviruses
Q35947037Host factors that control long terminal repeat retrotransposons in Saccharomyces cerevisiae: implications for regulation of mammalian retroviruses
Q42733201Host protein Ku70 binds and protects HIV-1 integrase from proteasomal degradation and is required for HIV replication
Q54977040Human Kinase/Phosphatase-Wide RNAi Screening Identified Checkpoint Kinase 2 as a Cellular Factor Facilitating Japanese Encephalitis Virus Infection.
Q40199767Human cytomegalovirus disrupts both ataxia telangiectasia mutated protein (ATM)- and ATM-Rad3-related kinase-mediated DNA damage responses during lytic infection
Q28480882Human monocytes undergo excessive apoptosis following temozolomide activating the ATM/ATR pathway while dendritic cells and macrophages are resistant
Q45367096Identification of SNF2h, a chromatin-remodeling factor, as a novel binding protein of Vpr of human immunodeficiency virus type 1.
Q64387799Immunodeficiency, radiosensitivity, and the XCIND syndrome
Q24336239Induction of a pro-apoptotic ATM-NF-kappaB pathway and its repression by ATR in response to replication stress
Q34019744Inhibition of HIV-1 gene expression by Ciclopirox and Deferiprone, drugs that prevent hypusination of eukaryotic initiation factor 5A.
Q34434681Inhibition of the ATM/p53 signal transduction pathway by Kaposi's sarcoma-associated herpesvirus interferon regulatory factor 1.
Q33340808Integration site selection by retroviral vectors: molecular mechanism and clinical consequences
Q37500155Interaction between viral proteins and hosts and its disturbance in the cellular responses to ionising radiation
Q35171923Interplay of Rad51 with NF-κB pathway stimulates expression of HIV-1.
Q40175902Ku70/80 modulates ATM and ATR signaling pathways in response to DNA double strand breaks
Q40139019Lentiviral vectors escape innate sensing but trigger p53 in human hematopoietic stem and progenitor cells.
Q33799605MYST family lysine acetyltransferase facilitates ataxia telangiectasia mutated (ATM) kinase-mediated DNA damage response in Toxoplasma gondii
Q35625099Mixed-effects model of epithelial-mesenchymal transition reveals rewiring of signaling networks
Q39016168Nanosilver based anionic linear globular dendrimer with a special significant antiretroviral activity.
Q39490275P38MAPK is a major determinant of the balance between apoptosis and autophagy triggered by 5-fluorouracil: implication in resistance
Q47382659Pathological neoangiogenesis depends on oxidative stress regulation by ATM.
Q90079629Potential of the NKG2D/NKG2DL Axis in NK Cell-Mediated Clearance of the HIV-1 Reservoir
Q89787350Pulsatile MAPK Signaling Modulates p53 Activity to Control Cell Fate Decisions at the G2 Checkpoint for DNA Damage
Q93272658RNA sequencing of CD4 T-cells reveals the relationships between lncRNA-mRNA co-expression in elite controller vs. HIV-positive infected patients
Q37746052Role of host cell factors in flavivirus infection: Implications for pathogenesis and development of antiviral drugs
Q36316468S-phase checkpoint pathways stimulate the mobility of the retrovirus-like transposon Ty1.
Q34352727TRF2 inhibits a cell-extrinsic pathway through which natural killer cells eliminate cancer cells
Q28260348Targeted cancer therapies based on the inhibition of DNA strand break repair
Q38178966The DNA Damage Response: A Common Pathway in the Regulation of NKG2D and DNAM-1 Ligand Expression in Normal, Infected, and Cancer Cells.
Q26825363The DNA damage response induced by infection with human cytomegalovirus and other viruses
Q24318659The DNA damage sensors ataxia-telangiectasia mutated kinase and checkpoint kinase 2 are required for hepatitis C virus RNA replication
Q24606586The DNA-damage response in human biology and disease
Q34061457The human LINE-1 retrotransposon creates DNA double-strand breaks.
Q38281980The human immunodeficiency virus type 1 Vpr protein upregulates PVR via activation of the ATR-mediated DNA damage response pathway
Q35143730The role of unintegrated DNA in HIV infection
Q41301287Toward system-level understanding of baculovirus-host cell interactions: from molecular fundamental studies to large-scale proteomics approaches
Q44399593Tripeptidyl-peptidase II controls DNA damage responses and in vivo gamma-irradiation resistance of tumors
Q33726954Up-regulation of HIV-1 transduction in nondividing cells by double-strand DNA break-inducing agents.
Q42410834Uracil-directed ligand tethering: an efficient strategy for uracil DNA glycosylase (UNG) inhibitor development
Q37301053Viral manipulation of DNA repair and cell cycle checkpoints
Q41727514p53 as a retrovirus-induced oxidative stress modulator

Search more.