Lentiviral vectors escape innate sensing but trigger p53 in human hematopoietic stem and progenitor cells.

scientific article published on 30 June 2017

Lentiviral vectors escape innate sensing but trigger p53 in human hematopoietic stem and progenitor cells. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.15252/EMMM.201707922
P932PMC publication ID5582409
P698PubMed publication ID28667090

P50authorLuigi NaldiniQ16574299
Elia StupkaQ30089912
Davide CittaroQ38804020
Bernhard GentnerQ39508211
Anna Kajaste-RudnitskiQ43802321
P2093author name stringDejan Lazarevic
Michela Riba
Ivan Cuccovillo
Sara Bartolaccini
Francesco Piras
Carolina Petrillo
P2860cites workATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complexQ24298863
DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune responseQ24317784
Functional interaction of H2AX, NBS1, and p53 in ATM-dependent DNA damage responses and tumor suppressionQ24557573
Primitive hematopoietic cells resist HIV-1 infection via p21Q24681819
Advances in umbilical cord blood manipulation-from niche to bedsideQ26824305
Inflammatory modulation of HSCs: viewing the HSC as a foundation for the immune responseQ27003372
HIV-1 evades innate immune recognition through specific cofactor recruitmentQ27680544
Linear models and empirical bayes methods for assessing differential expression in microarray experimentsQ27860758
Hematopoietic stem cell gene transfer in a tumor-prone mouse model uncovers low genotoxicity of lentiviral vector integrationQ28242708
Guidelines for preventing infectious complications among hematopoietic cell transplantation recipients: a global perspectiveQ28388806
Genomic HIV RNA induces innate immune responses through RIG-I-dependent sensing of secondary-structured RNAQ28740542
Gene editing in human stem cells using zinc finger nucleases and integrase-defective lentiviral vector deliveryQ29014419
p53 regulates hematopoietic stem cell quiescence.Q33732098
p53-mediated hematopoietic stem and progenitor cell competition.Q33857597
Interactions between HIV-1 and the cell-autonomous innate immune system.Q33895123
Hematopoietic stem cell quiescence promotes error-prone DNA repair and mutagenesisQ34076936
Quiescent haematopoietic stem cells are activated by IFN-gamma in response to chronic infectionQ34112414
HIV-1 causes CD4 cell death through DNA-dependent protein kinase during viral integration.Q34348888
Lentiviral hematopoietic stem cell gene therapy benefits metachromatic leukodystrophyQ34356914
Cyclic GMP-AMP synthase is an innate immune sensor of HIV and other retrovirusesQ34362864
DNA-damage-induced type I interferon promotes senescence and inhibits stem cell functionQ34474083
HIV-1-derived lentiviral vectors directly activate plasmacytoid dendritic cells, which in turn induce the maturation of myeloid dendritic cells.Q34623234
Enrichr: interactive and collaborative HTML5 gene list enrichment analysis toolQ34668270
Activation of DNA damage response signaling by condensed chromatinQ34713712
Trex1 exonuclease degrades ssDNA to prevent chronic checkpoint activation and autoimmune diseaseQ34719398
Intracellular transport of recombinant adeno-associated virus vectorsQ35734826
HIV DNA integrationQ36065855
Genome-wide analysis of retroviral DNA integrationQ36263002
Attenuation of miR-126 activity expands HSC in vivo without exhaustion.Q36455274
Homology-driven genome editing in hematopoietic stem and progenitor cells using ZFN mRNA and AAV6 donors.Q36828138
In Vivo Tracking of Human Hematopoiesis Reveals Patterns of Clonal Dynamics during Early and Steady-State Reconstitution PhasesQ37089345
M-CSF improves protection against bacterial and fungal infections after hematopoietic stem/progenitor cell transplantationQ37346652
MAPK signaling pathways in the regulation of hematopoiesisQ37508518
No impact of lentiviral transduction on hematopoietic stem/progenitor cell telomere length or gene expression in the rhesus macaque model.Q37690474
Hematopoiesis: a human perspectiveQ37981372
Cellular innate immunity and restriction of viral infection: implications for lentiviral gene therapy in human hematopoietic cellsQ38390745
Gene therapy returns to centre stageQ38607706
HIV replication: a game of hide and sense.Q38656226
DNA damage primes the type I interferon system via the cytosolic DNA sensor STING to promote anti-microbial innate immunityQ38908391
Risk stratification for invasive fungal infections in patients with hematological malignancies: SEIFEM recommendations.Q38967328
Novel strategies for improving hematopoietic reconstruction after allogeneic hematopoietic stem cell transplantation or intensive chemotherapyQ39031745
Lentiviral haemopoietic stem-cell gene therapy in early-onset metachromatic leukodystrophy: an ad-hoc analysis of a non-randomised, open-label, phase 1/2 trial.Q39691004
Distinct routes of lineage development reshape the human blood hierarchy across ontogenyQ39745504
The TLR1/2 agonist PAM(3)CSK(4) instructs commitment of human hematopoietic stem cells to a myeloid cell fateQ39819090
Efficient Ex Vivo Engineering and Expansion of Highly Purified Human Hematopoietic Stem and Progenitor Cell Populations for Gene TherapyQ40279626
Molecular linkage between the kinase ATM and NF-kappaB signaling in response to genotoxic stimuliQ40312088
Coordinate dual-gene transgenesis by lentiviral vectors carrying synthetic bidirectional promoters.Q40477022
CRISPR/Cas9 β-globin gene targeting in human haematopoietic stem cellsQ40486239
CpG-ODN 2006 and human parvovirus B19 genome consensus sequences selectively inhibit growth and development of erythroid progenitor cellsQ40907249
Exit from dormancy provokes DNA-damage-induced attrition in haematopoietic stem cells.Q41468517
Cyclosporin a and rapamycin relieve distinct lentiviral restriction blocks in hematopoietic stem and progenitor cellsQ41721059
Single-stranded DNA orchestrates an ATM-to-ATR switch at DNA breaksQ42021074
A TLR and non-TLR mediated innate response to lentiviruses restricts hepatocyte entry and can be ameliorated by pharmacological blockadeQ42119020
ELDA: extreme limiting dilution analysis for comparing depleted and enriched populations in stem cell and other assaysQ43536416
IFNalpha activates dormant haematopoietic stem cells in vivo.Q44358922
Gene transfer by lentiviral vectors is limited by nuclear translocation and rescued by HIV-1 pol sequencesQ44491759
A synthetic double-stranded RNA, poly I:C, induces a rapid apoptosis of human CD34(+) cellsQ44523378
miRNA-126 Orchestrates an Oncogenic Program in B Cell Precursor Acute Lymphoblastic LeukemiaQ45855195
Silencing p21(Waf1/Cip1/Sdi1) expression increases gene transduction efficiency in primitive human hematopoietic cellsQ45883358
Hematopoietic stem cells reversibly switch from dormancy to self-renewal during homeostasis and repairQ46210604
Suppression of HIV-1 infection by a small molecule inhibitor of the ATM kinaseQ46440743
A distinctive DNA damage response in human hematopoietic stem cells reveals an apoptosis-independent role for p53 in self-renewal.Q51904571
Signaling through toll-like receptor 7/8 induces the differentiation of human bone marrow CD34+ progenitor cells along the myeloid lineage.Q54575672
HIV-1 genome nuclear import is mediated by a central DNA flapQ73726795
Stem Cells and DNA Damage: Persist or Perish?Q84691536
P4510describes a project that usesCytoscapeQ3699942
P433issue9
P304page(s)1198-1211
P577publication date2017-09-01
P1433published inEMBO Molecular MedicineQ15817279
P1476titleLentiviral vectors escape innate sensing but trigger p53 in human hematopoietic stem and progenitor cells
P478volume9

Reverse relations

cites work (P2860)
Q97529378Antiviral immunity and nucleic acid sensing in haematopoietic stem cell gene engineering
Q91632497Assessing the Impact of Cyclosporin A on Lentiviral Transduction and Preservation of Human Hematopoietic Stem Cells in Clinically Relevant Ex Vivo Gene Therapy Settings
Q95329207Cas9 activates the p53 pathway and selects for p53-inactivating mutations
Q60306229Cyclosporine H Overcomes Innate Immune Restrictions to Improve Lentiviral Transduction and Gene Editing In Human Hematopoietic Stem Cells
Q92239257Episomal vectors based on S/MAR and the β-globin Replicator, encoding a synthetic transcriptional activator, mediate efficient γ-globin activation in haematopoietic cells
Q64109055Gene Therapy Approaches to Functional Cure and Protection of Hematopoietic Potential in HIV Infection
Q92283987Gene therapy targeting haematopoietic stem cells for inherited diseases: progress and challenges
Q64240820Genetic engineering of hematopoiesis: current stage of clinical translation and future perspectives
Q64075661Precise Gene Editing Preserves Hematopoietic Stem Cell Function following Transient p53-Mediated DNA Damage Response
Q64973383Staurosporine Increases Lentiviral Vector Transduction Efficiency of Human Hematopoietic Stem and Progenitor Cells.
Q89625766Successfully transfected primary peripherally mobilized human CD34+ hematopoietic stem and progenitor cells (HSPCs) demonstrate increased susceptibility to retroviral infection
Q59443482Wake-up Sleepy Gene: Reactivating Fetal Globin for β-Hemoglobinopathies

Search more.