IL-22 mediates mucosal host defense against Gram-negative bacterial pneumonia

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IL-22 mediates mucosal host defense against Gram-negative bacterial pneumonia is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/NM1710
P932PMC publication ID2901867
P698PubMed publication ID18264110
P5875ResearchGate publication ID5588231

P50authorYoichiro IwakuraQ56564114
P2093author name stringJames L Kreindler
Jay K Kolls
Shean J Aujla
Joseph M Pilewski
Shahid Husain
Mingquan Zheng
Todd A Reinhart
Patricia J Dubin
Derek A Pociask
Mike M Myerburg
Carol A Mason
Yvonne R Chan
Florencia McAllister
Mingjian Fei
David J Askew
Jennifer Edeal
Kristi Gaus
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The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cellsQ27860620
Transforming growth factor-beta induces development of the T(H)17 lineageQ28237370
Cutting edge: interleukin 17 signals through a heteromeric receptor complexQ28247130
IL-22 increases the innate immunity of tissuesQ28276850
Interleukin-17 family members and inflammationQ28287876
TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cellsQ28296956
Lipocalin 2-deficient mice exhibit increased sensitivity to Escherichia coli infection but not to ischemia-reperfusion injuryQ28591880
IL-23 drives a pathogenic T cell population that induces autoimmune inflammationQ29547525
Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineagesQ29547871
Development, cytokine profile and function of human interleukin 17-producing helper T cellsQ29617131
Interleukins 1beta and 6 but not transforming growth factor-beta are essential for the differentiation of interleukin 17-producing human T helper cellsQ29618163
IL-17 family cytokines and the expanding diversity of effector T cell lineagesQ29619361
Lipocalin 2 mediates an innate immune response to bacterial infection by sequestrating ironQ29619561
Surface phenotype and antigenic specificity of human interleukin 17-producing T helper memory cellsQ29622847
CD4+ T cells mediate abscess formation in intra-abdominal sepsis by an IL-17-dependent mechanismQ30885696
Requirement of interleukin 17 receptor signaling for lung CXC chemokine and granulocyte colony-stimulating factor expression, neutrophil recruitment, and host defenseQ34087551
IL-23 compensates for the absence of IL-12p70 and is essential for the IL-17 response during tuberculosis but is dispensable for protection and antigen-specific IFN-gamma responses if IL-12p70 is availableQ34432140
Divergent roles of IL-23 and IL-12 in host defense against Klebsiella pneumoniaeQ34450323
Antibody-independent, interleukin-17A-mediated, cross-serotype immunity to pneumococci in mice immunized intranasally with the cell wall polysaccharideQ34492821
Interleukin 27 limits autoimmune encephalomyelitis by suppressing the development of interleukin 17-producing T cellsQ34556912
IL-23-dependent IL-17 production is essential in neutrophil recruitment and activity in mouse lung defense against respiratory Mycoplasma pneumoniae infectionQ34596743
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Pneumonia in the solid organ transplant patientQ36085182
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Production of beta-defensins by human airway epitheliaQ36758628
Cloning and characterization of IL-10-related T cell-derived inducible factor (IL-TIF), a novel cytokine structurally related to IL-10 and inducible by IL-9.Q40902420
Improved detection of simian immunodeficiency virus RNA by in situ hybridization in fixed tissue sections: combined effects of temperatures for tissue fixation and probe hybridizationQ45734981
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IL-17 markedly up-regulates beta-defensin-2 expression in human airway epithelium via JAK and NF-kappaB signaling pathwaysQ46156771
Lung pathology of severe acute respiratory syndrome (SARS): a study of 8 autopsy cases from SingaporeQ51652773
Growth and differentiation of mouse tracheal epithelial cells: selection of a proliferative population.Q52547922
TLR4 mediates vaccine-induced protective cellular immunity to Bordetella pertussis: role of IL-17-producing T cells.Q53013441
IL-23 and IL-17 in the establishment of protective pulmonary CD4+ T cell responses after vaccination and during Mycobacterium tuberculosis challengeQ58518610
Resident Vdelta1+ gammadelta T cells control early infiltration of neutrophils after Escherichia coli infection via IL-17 productionQ79984931
Interleukin 27 negatively regulates the development of interleukin 17-producing T helper cells during chronic inflammation of the central nervous systemQ80102518
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectpneumoniaQ12192
Gram-negative bacteriaQ632006
P304page(s)275-281
P577publication date2008-02-10
P1433published inNature MedicineQ1633234
P1476titleIL-22 mediates mucosal host defense against Gram-negative bacterial pneumonia
P478volume14

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Q88683196IL22 Promotes Kras-Mutant Lung Cancer by Induction of a Protumor Immune Response and Protection of Stemness Properties
Q95660451Identification of Reference Genes in Chicken Intraepithelial Lymphocyte Natural Killer Cells Infected with Very-virulent Infectious Bursal Disease Virus
Q50041515Identification of an innate T helper type 17 response to intestinal bacterial pathogens.
Q35276001Immune modulatory effects of IL-22 on allergen-induced pulmonary inflammation
Q33621874Immunological Aspect of Radiation-Induced Pneumonitis, Current Treatment Strategies, and Future Prospects
Q37225474Immunological mechanisms behind the cystic fibrosis-ABPA link
Q37991394Immunomodulation for gastrointestinal infections.
Q37776837Inborn errors of mucocutaneous immunity to Candida albicans in humans: a role for IL-17 cytokines?
Q47280526Increased autophagic sequestration in adaptor protein-3 deficient dendritic cells limits inflammasome activity and impairs antibacterial immunity.
Q34634513Increased expression of IL-22 is associated with disease activity in Behcet's disease
Q37825597Inducible NO synthase and antibacterial host defence in times of Th17/Th22/T22 immunity
Q35754472Inducible innate resistance of lung epithelium to infection
Q91889502Induction of IL-22 protein and IL-22-producing cells in rainbow trout Oncorhynchus mykiss
Q33778264Induction of TGF-beta1 and TGF-beta1-dependent predominant Th17 differentiation by group A streptococcal infection
Q37688392Infection and apoptosis as a combined inflammatory trigger
Q36396866Inflammatory monocyte recruitment is regulated by interleukin-23 during systemic bacterial infection
Q47844444Influence of hypoxia-inducible factor 1α on dendritic cell differentiation and migration
Q35643199Influence of oral lactoferrin on Mycobacterium tuberculosis induced immunopathology.
Q42604162Influence of the transcription factor RORgammat on the development of NKp46+ cell populations in gut and skin
Q34764015Influenza A inhibits Th17-mediated host defense against bacterial pneumonia in mice
Q37604453Influenza A virus exacerbates Staphylococcus aureus pneumonia in mice by attenuating antimicrobial peptide production
Q35859321Influenza-induced type I interferon enhances susceptibility to gram-negative and gram-positive bacterial pneumonia in mice
Q33608575Innate IL-17-producing cells: the sentinels of the immune system
Q60954877Innate Immune Cell Suppression and the Link With Secondary Lung Bacterial Pneumonia
Q36422470Innate Immune Signaling Activated by MDR Bacteria in the Airway
Q42683314Innate Lymphoid Cells in Intestinal Inflammation
Q64255314Innate Lymphoid Cells in Mucosal Immunity
Q27002611Innate immune signaling in defense against intestinal microbes
Q36908615Innate lymphoid cells in the initiation, regulation and resolution of inflammation
Q34279451Innate lymphoid cells promote anatomical containment of lymphoid-resident commensal bacteria.
Q36645149Innate lymphoid cells: balancing immunity, inflammation, and tissue repair in the intestine.
Q42747718Innate-like function of memory Th17 cells for enhancing endotoxin-induced acute lung inflammation through IL-22
Q33956973Insights into IBD Pathogenesis
Q89787324Insulin-like Growth Factor 1 Supports a Pulmonary Niche that Promotes Type 3 Innate Lymphoid Cell Development in Newborn Lungs
Q88691581Integrative Physiology of Pneumonia
Q38051328Interaction of the pathogenic mold Aspergillus fumigatus with lung epithelial cells
Q39076009Interferon Control of the Sterol Metabolic Network: Bidirectional Molecular Circuitry-Mediating Host Protection
Q27655546Interferon-  Is Functionally an Interferon but Structurally Related to the Interleukin-10 Family
Q36108222Interferon-λ and interleukin 22 act synergistically for the induction of interferon-stimulated genes and control of rotavirus infection
Q60630406Interleukin (IL)-17A and IL-22-producing neutrophils in psoriatic skin
Q39314776Interleukin 17 is a chief orchestrator of immunity
Q37332692Interleukin 17-producing T helper cells in alloimmunity
Q33708468Interleukin 22 attenuated angiotensin II induced acute lung injury through inhibiting the apoptosis of pulmonary microvascular endothelial cells
Q35784100Interleukin 23 production by intestinal CD103(+)CD11b(+) dendritic cells in response to bacterial flagellin enhances mucosal innate immune defense.
Q40539825Interleukin 7 immunotherapy improves host immunity and survival in a two-hit model of Pseudomonas aeruginosa pneumonia
Q37680986Interleukin and interleukin receptor diversity: role of alternative splicing
Q41826464Interleukin-1 receptor-associated kinase M-deficient mice demonstrate an improved host defense during Gram-negative pneumonia
Q38034469Interleukin-10 and interleukin-10-receptor defects in inflammatory bowel disease
Q37199853Interleukin-17 Pathophysiology and Therapeutic Intervention in Cystic Fibrosis Lung Infection and Inflammation
Q37735334Interleukin-17 and its target genes: mechanisms of interleukin-17 function in disease
Q34739767Interleukin-17 contributes to generation of Th1 immunity and neutrophil recruitment during Chlamydia muridarum genital tract infection but is not required for macrophage influx or normal resolution of infection
Q37363266Interleukin-17 in host defence against bacterial, mycobacterial and fungal pathogens
Q35009321Interleukin-17 is required for T helper 1 cell immunity and host resistance to the intracellular pathogen Francisella tularensis
Q47689166Interleukin-17 regulates matrix metalloproteinase activity in human pulmonary tuberculosis.
Q42279685Interleukin-17-dependent CXCL13 mediates mucosal vaccine-induced immunity against tuberculosis
Q34309786Interleukin-17-mediated control of parasitemia in experimental Trypanosoma congolense infection in mice
Q64997334Interleukin-17D Promotes Pathogenicity During Infection by Suppressing CD8 T Cell Activity.
Q39610932Interleukin-21 induces the differentiation of human Tc22 cells via phosphorylation of signal transducers and activators of transcription
Q92881803Interleukin-22 (IL-22) Binding Protein Constrains IL-22 Activity, Host Defense, and Oxidative Phosphorylation Genes during Pneumococcal Pneumonia
Q33964145Interleukin-22 (IL-22) production by pulmonary Natural Killer cells and the potential role of IL-22 during primary influenza virus infection
Q96680272Interleukin-22 Inhibits Respiratory Syncytial Virus Production by Blocking Virus-Mediated Subversion of Cellular Autophagy
Q24658609Interleukin-22 ameliorates acute severe pancreatitis-associated lung injury in mice
Q37530484Interleukin-22 as a molecular adjuvant facilitates IL-17-producing CD8+ T cell responses against a HBV DNA vaccine in mice
Q43102028Interleukin-22 binding protein (IL-22BP) is constitutively expressed by a subset of conventional dendritic cells and is strongly induced by retinoic acid
Q52691346Interleukin-22 immunotherapy during severe influenza enhances lung tissue integrity and reduces secondary bacterial systemic invasion.
Q26752528Interleukin-22 in Graft-Versus-Host Disease after Allogeneic Stem Cell Transplantation
Q27687335Interleukin-22 in kidney injury and regeneration
Q36070332Interleukin-22 is elevated in lavage from patients with lung cancer and other pulmonary diseases
Q35780751Interleukin-22 is increased in multiple sclerosis patients and targets astrocytes
Q35841871Interleukin-22 is produced by invariant natural killer T lymphocytes during influenza A virus infection: potential role in protection against lung epithelial damages
Q40059573Interleukin-22 level is negatively correlated with neutrophil recruitment in the lungs in a Pseudomonas aeruginosa pneumonia model.
Q36478883Interleukin-22 modulates gut epithelial and immune barrier functions following acute alcohol exposure and burn injury
Q34411311Interleukin-22 predicts severity and death in advanced liver cirrhosis: a prospective cohort study
Q46118254Interleukin-22 produced by alveolar macrophages during activation of the innate immune response
Q35095074Interleukin-22 promotes T helper 1 (Th1)/Th17 immunity in chlamydial lung infection
Q84365414Interleukin-22 promotes human hepatocellular carcinoma by activation of STAT3
Q36483525Interleukin-22 promotes intestinal-stem-cell-mediated epithelial regeneration
Q40688717Interleukin-22 protects against non-typeable Haemophilus influenzae infection: alteration during chronic obstructive pulmonary disease
Q64994747Interleukin-22 receptor 1 is expressed in multinucleated giant cells: A study on intestinal tuberculosis and Crohn's disease.
Q36911822Interleukin-22 reduces lung inflammation during influenza A virus infection and protects against secondary bacterial infection.
Q36745327Interleukin-22 reduces the severity of collagen-induced arthritis in association with increased levels of interleukin-10.
Q53139446Interleukin-22 regulates antimicrobial peptide expression and keratinocyte differentiation to control Staphylococcus aureus colonization of the nasal mucosa.
Q34453038Interleukin-22 regulates the complement system to promote resistance against pathobionts after pathogen-induced intestinal damage.
Q39320252Interleukin-22-Induced Antimicrobial Phospholipase A2 Group IIA Mediates Protective Innate Immunity of Nonhematopoietic Cells against Listeria monocytogenes.
Q80830002Interleukin-22: a sheep in wolf's clothing
Q35530956Interleukin-22: immunobiology and pathology
Q36108832Interleukin-22: implications for liver ischemia-reperfusion injury
Q40444654Interleukin-23 (IL-23), independent of IL-17 and IL-22, drives neutrophil recruitment and innate inflammation during Clostridium difficile colitis in mice
Q37033085Interleukin-23 orchestrates mucosal responses to Salmonella enterica serotype Typhimurium in the intestine
Q40313360Interleukin-23-mediated inflammation in Pseudomonas aeruginosa pulmonary infection.
Q37404716Interleukin-23/Th17 pathways and inflammatory bowel disease
Q35665393Interleukin-4 (IL-4) and IL-13 suppress excessive neutrophil infiltration and hepatocyte damage during acute murine schistosomiasis japonica
Q35717842Intestinal Microbiota of Mice Influences Resistance to Staphylococcus aureus Pneumonia.
Q38971101Intestinal commensal bacteria mediate lung mucosal immunity and promote resistance of newborn mice to infection
Q37845442Intestinal microbiota, evolution of the immune system and the bad reputation of pro-inflammatory immunity
Q34031527Involvement of CCR6/CCL20/IL-17 axis in NSCLC disease progression
Q42094104Involvement of the IL-23/IL-17 axis and the Th17/Treg balance in the pathogenesis and control of autoimmune arthritis
Q38369782Ixekizumab for treatment of psoriasis.
Q93211674Klebsiella pneumoniae infection biology: living to counteract host defences
Q26745802Klebsiella pneumoniae: Going on the Offense with a Strong Defense
Q34371338L-22 enhances the invasiveness of endometrial stromal cells of adenomyosis in an autocrine manner
Q47403907Lactobacillus plantarum Enhanced IL-22 Production in Natural Killer (NK) Cells That Protect the Integrity of Intestinal Epithelial Cell Barrier Damaged by Enterotoxigenic Escherichia coli
Q36016336Leukemia inhibitory factor signaling is required for lung protection during pneumonia
Q46239692Limited Presence of IL-22 Binding Protein, a Natural IL-22 Inhibitor, Strengthens Psoriatic Skin Inflammation
Q34646648Lipocalin 2 imparts selective pressure on bacterial growth in the bladder and is elevated in women with urinary tract infection
Q37257477Lipocalin 2 is required for pulmonary host defense against Klebsiella infection
Q34490941Lipocalin 2 regulates inflammation during pulmonary mycobacterial infections.
Q37401782Lipocalin-2 resistance confers an advantage to Salmonella enterica serotype Typhimurium for growth and survival in the inflamed intestine
Q35001902Liver is the major source of elevated serum lipocalin-2 levels after bacterial infection or partial hepatectomy: a critical role for IL-6/STAT3.
Q30412824Location of CD4+ T cell priming regulates the differentiation of Th1 and Th17 cells and their contribution to arthritis
Q27316093Loss of Function of Intestinal IL-17 and IL-22 Producing Cells Contributes to Inflammation and Viral Persistence in SIV-Infected Rhesus Macaques
Q41759033Low DEFB4 copy number and high systemic hBD-2 and IL-22 levels are associated with dermatophytosis
Q40091655Lung epithelial cells: therapeutically inducible effectors of antimicrobial defense
Q37783745Lymphoid tissue inducer cells and the evolution of CD4 dependent high-affinity antibody responses.
Q37594571Lymphoid tissue inducer cells: bridges between the ancient innate and the modern adaptive immune systems
Q37977138Lymphoid tissue inducer cells: innate cells critical for CD4+ T cell memory responses?
Q42144635Lymphoid tissue inducer cells: pivotal cells in the evolution of CD4 immunity and tolerance?
Q28727683Marking and quantifying IL-17A-producing cells in vivo
Q28238414Mast cells and neutrophils release IL-17 through extracellular trap formation in psoriasis
Q90723370Mechanical Ventilation Impairs IL-17 Cytokine Family Expression in Ventilator-Associated Pneumonia
Q52448914Mechanisms and Targeted Therapies for Pseudomonas aeruginosa Lung Infection.
Q35096758Mechanisms controlling Th17 cytokine expression and host defense
Q37641941Mechanisms of Cholera Toxin in the Modulation of TH17 Responses
Q35763089Mechanisms of rapid induction of interleukin-22 in activated T cells and its modulation by cyclosporin a.
Q36650805Membrane-bound IL-22 after de novo production in tuberculosis and anti-Mycobacterium tuberculosis effector function of IL-22+ CD4+ T cells
Q28245271Memory IL-22-producing CD4+ T cells specific for Candida albicans are present in humans
Q46165208Mice genetically inactivated in interleukin-17A receptor are defective in long-term control of Mycobacterium tuberculosis infection
Q36441742Microbial translocation across the GI tract
Q37727840Microparticles released by Listeria monocytogenes-infected macrophages are required for dendritic cell-elicited protective immunity
Q37264694Modeling Klebsiella pneumoniae pathogenesis by infection of the wax moth Galleria mellonella.
Q101051175Modelling early events in Mycobacterium bovis infection using a co-culture model of the bovine alveolus
Q51770929Modulation of Th17 development and function by activation of the aryl hydrocarbon receptor--the role of endogenous ligands.
Q49710668Molecular characteristics of rhesus macaque interleukin-22: cloning, in vitro expression and biological activities.
Q37273205Molecular explanation for the contradiction between systemic Th17 defect and localized bacterial infection in hyper-IgE syndrome
Q38144077Molecular mechanisms and cell targets of Th17 cells in the gastrointestinal tract: an innate sense of adaptivity.
Q91307598Molecular signature of interleukin-22 in colon carcinoma cells and organoid models
Q51770957Mouse Th17 cells: current understanding of their generation and regulation.
Q49551961Mucocutaneous IL-17 immunity in mice and humans: host defense vs. excessive inflammation.
Q27010562Mucocutaneous candidiasis: the IL-17 pathway and implications for targeted immunotherapy
Q37415460Mucosal pre-exposure to Th17-inducing adjuvants exacerbates pathology after influenza infection
Q27334516Multifunctional double-negative T cells in sooty mangabeys mediate T-helper functions irrespective of SIV infection
Q37718355Multiple hats for natural killers
Q33425939Multiplex Analysis of Serum Cytokines in Humans with Hantavirus Pulmonary Syndrome
Q41896588Mycobacteria bypass mucosal NF-kB signalling to induce an epithelial anti-inflammatory IL-22 and IL-10 response
Q44764762NK cells exacerbate the pathology of influenza virus infection in mice
Q36455293NK cells influence both innate and adaptive immune responses after mucosal immunization with antigen and mucosal adjuvant.
Q35980771NLRC4 inflammasome-mediated production of IL-1β modulates mucosal immunity in the lung against gram-negative bacterial infection
Q41374805Nasal immunization with M cell-targeting ligand-conjugated ApxIIA toxin fragment induces protective immunity against Actinobacillus pleuropneumoniae infection in a murine model
Q37568931Natural killer (NK) and NK-like cells at mucosal epithelia: Mediators of anti-microbial defense and maintenance of tissue integrity
Q37706595Neutrophils recruited by IL-22 in peripheral tissues function as TRAIL-dependent antiviral effectors against MCMV.
Q36288405New Approaches for Studying Alcoholic Liver Disease
Q34175958New insights into T cell biology and T cell-directed therapy for autoimmunity, inflammation, and immunosuppression
Q90446129Nicotine Impairs the Response of Lung Epithelial Cells to IL-22
Q35327027Nitric oxide sustains IL-1β expression in human dendritic cells enhancing their capacity to induce IL-17-producing T-cells
Q59134894Nonclinical safety assessment of a human interleukin-22FC IG fusion protein demonstrates in vitro to in vivo and cross-species translatability
Q40094981Nongenetically modified Lactococcus lactis-adjuvanted vaccination enhanced innate immunity against Helicobacter pylori.
Q33778205Notch signaling drives IL-22 secretion in CD4+ T cells by stimulating the aryl hydrocarbon receptor.
Q92875084Novel key cytokines in allergy: IL-17, IL-22
Q38936163Novel role for IL-22 in protection during chronic Mycobacterium tuberculosis HN878 infection.
Q46089932Novel therapeutic targets along the Th17 pathway
Q37948124OX40 and CD30 signals in CD4(+) T-cell effector and memory function: a distinct role for lymphoid tissue inducer cells in maintaining CD4(+) T-cell memory but not effector function
Q91312483PAD4-dependent NETs generation are indispensable for intestinal clearance of Citrobacter rodentium
Q97423512Participation of the IL-10RB Related Cytokines, IL-22 and IFN-λ in Defense of the Airway Mucosal Barrier
Q34802944Pathogenesis of allergic bronchopulmonary aspergillosis in cystic fibrosis: current understanding and future directions.
Q37487728Pathogenesis of hyper IgE syndrome
Q24597173Pathological versus protective functions of IL-22 in airway inflammation are regulated by IL-17A
Q26771860Pathophysiology of chronic rhinosinusitis, pharmaceutical therapy options
Q36368544Patients with cystic fibrosis have inducible IL-17+IL-22+ memory cells in lung draining lymph nodes
Q37645889Perspectives on the etiology of chronic rhinosinusitis
Q38597444Phenotype and antimicrobial activity of Th17 cells induced by Propionibacterium acnes strains associated with healthy and acne skin
Q55445913Pivotal Role of IL-22 Binding Protein in the Epithelial Autoregulation of Interleukin-22 Signaling in the Control of Skin Inflammation.
Q38310232Plasticity of human CD4 T cell subsets
Q34318203Polyfunctional type-1, -2, and -17 CD8⁺ T cell responses to apoptotic self-antigens correlate with the chronic evolution of hepatitis C virus infection
Q36694323Potential role of ixekizumab in the treatment of moderate-to-severe plaque psoriasis
Q37630095Precarious balance: Th17 cells in host defense.
Q35563366Predominance of interleukin-22 over interleukin-17 at the site of disease in human tuberculosis
Q41999154Pro-Inflammatory Signaling by IL-10 and IL-22: Bad Habit Stirred Up by Interferons?
Q36948594Prostaglandin E2 synergistically with interleukin-23 favors human Th17 expansion
Q34270562Prostaglandin I2 signaling drives Th17 differentiation and exacerbates experimental autoimmune encephalomyelitis
Q37994635Proteases and the gut barrier.
Q35154329Protection against Streptococcus pneumoniae lung infection after nasopharyngeal colonization requires both humoral and cellular immune responses
Q26825858Protective and pathological properties of IL-22 in liver disease: implications for viral hepatitis
Q39704573Protective properties of inhaled IL-22 in a model of ventilator-induced lung injury.
Q40506767Protective role of IL-22 against Schistosoma mansoni soluble egg antigen-induced granuloma in Vitro.
Q38734006Protective role of Th17 cells in pulmonary infection
Q40477924Pseudomonas aeruginosa proteolytically alters the interleukin 22-dependent lung mucosal defense.
Q53691450Pulmonary Regnase-1 orchestrates the interplay of epithelium and adaptive immune systems to protect against pneumonia.
Q37018586Pulmonary Th17 Antifungal Immunity Is Regulated by the Gut Microbiome
Q34295528Quantitative RT-PCR profiling of the rabbit immune response: assessment of acute Shigella flexneri infection
Q64109976R. nukuhivensis acts by reinforcing skin barrier function, boosting skin immunity and by inhibiting IL-22 induced keratinocyte hyperproliferation
Q46167903RORγt+ innate lymphoid cells regulate intestinal homeostasis by integrating negative signals from the symbiotic microbiota
Q38972759RORγt, a multitask nuclear receptor at mucosal surfaces.
Q89305209Randomized Phase I Healthy Volunteer Study of UTTR1147A (IL-22Fc): A Potential Therapy for Epithelial Injury
Q36591501Rapamycin attenuates acute lung injury induced by LPS through inhibition of Th17 cell proliferation in mice
Q37851777Recent advances in IL-22 biology.
Q30419007Recent insights into pulmonary repair following virus-induced inflammation of the respiratory tract
Q38205440Recognition strategies of group 3 innate lymphoid cells
Q35662232Reduced IL-17A Secretion Is Associated with High Levels of Pneumococcal Nasopharyngeal Carriage in Fijian Children
Q35205539Redundant and pathogenic roles for IL-22 in mycobacterial, protozoan, and helminth infections
Q97525703Regeneration and repair in the healing lung
Q40209420Regionally compartmentalized resident memory T cells mediate naturally acquired protection against pneumococcal pneumonia.
Q37348457Regulation and function of proinflammatory TH17 cells
Q37442153Regulation of TH17 cells in the mucosal surfaces
Q37915047Regulation of Th17 cell differentiation by intestinal commensal bacteria
Q26864694Regulation of the adaptive immune system by innate lymphoid cells
Q54346247Regulation of the development of acute hepatitis by IL-23 through IL-22 and IL-17 production.
Q38190986Role of IL-23 in the pathogenesis of psoriasis: a novel potential therapeutic target?
Q63362830Role of MAIT cells in pulmonary bacterial infection
Q37622866Role of Th17 cells and IL-17 in lung transplant rejection
Q42150907Role of innate lymphocytes in infection and inflammation
Q34456769Role of interleukin-22 in inflammatory bowel disease
Q37263002Role of mucosal dendritic cells in inflammatory bowel disease
Q34127425Role of th17 cell and autoimmunity in chronic obstructive pulmonary disease
Q41863661Roles of interleukin-17 in an experimental Legionella pneumophila pneumonia model
Q35589806STAT3-Activating Cytokines: A Therapeutic Opportunity for Inflammatory Bowel Disease?
Q36888504STAT6 Signaling Attenuates Interleukin-17-Producing γδ T Cells during Acute Klebsiella pneumoniae Infection
Q64969864SU5416 attenuated lipopolysaccharide-induced acute lung injury in mice by modulating properties of vascular endothelial cells.
Q37774907Searching for novel intercellular signal-transducing molecules in the kidney and their clinical application
Q40683898Seasonal influenza A/H3N2 virus infection and IL-1Β, IL-10, IL-17, and IL-28 polymorphisms in Iranian population
Q48253677Sebocytes contribute to skin inflammation by promoting the differentiation of T helper 17 cells.
Q53637767Serum IL-17F combined with VEGF as potential diagnostic biomarkers for oral squamous cell carcinoma.
Q37040753Signaling via the IL-20 receptor inhibits cutaneous production of IL-1β and IL-17A to promote infection with methicillin-resistant Staphylococcus aureus
Q24648636Specific microbiota direct the differentiation of IL-17-producing T-helper cells in the mucosa of the small intestine
Q33921803Stat3: linking inflammation to epithelial cancer - more than a "gut" feeling?
Q33601917Stimulated innate resistance of lung epithelium protects mice broadly against bacteria and fungi
Q37747165Structure and function of interleukin-22 and other members of the interleukin-10 family
Q24656543Structure of IL-22 bound to its high-affinity IL-22R1 chain
Q39370971Synergism between interleukin (IL)-17 and Toll-like receptor 2 and 4 signals to induce IL-8 expression in cystic fibrosis airway epithelial cells.
Q58121724T Cell-Intrinsic Receptor Interacting Protein 2 Regulates Pathogenic T Helper 17 Cell Differentiation
Q28395374T cell-mediated host immune defenses in the lung
Q37669790T helper 17 cells: discovery, function, and physiological trigger
Q35108903T helper cell subsets specific for Pseudomonas aeruginosa in healthy individuals and patients with cystic fibrosis
Q38134677T helper cells plasticity in inflammation.
Q45928617T helper type 17-related cytokine expression is increased in the bronchial mucosa of stable chronic obstructive pulmonary disease patients.
Q37278356T-helper 17 lymphocytes in ocular cicatricial pemphigoid
Q39950912TGF-beta promotes Th17 cell development through inhibition of SOCS3.
Q28276449TH17 cells in development: an updated view of their molecular identity and genetic programming
Q38195597TLR Agonists as Modulators of the Innate Immune Response and Their Potential as Agents Against Infectious Disease.
Q46599011TLR2 deficiency by compromising p19 (IL-23) expression limits Th 17 cell responses to Mycobacterium tuberculosis
Q37268619TLR2 deficiency leads to increased Th17 infiltrates in experimental brain abscesses
Q34694834TLR5 signaling stimulates the innate production of IL-17 and IL-22 by CD3(neg)CD127+ immune cells in spleen and mucosa
Q35105613Tailored immune responses: novel effector helper T cell subsets in protective immunity
Q38047820Targeting IL-17 and TH17 cells in chronic inflammation
Q38633741Targeting IL-17 with ixekizumab in patients with psoriasis
Q37763951Targeting IL-23 in human diseases.
Q58562408Targeting IL22: a potential therapeutic approach for Kras mutant lung cancer?
Q38584529Targeting Th17 Effector Cytokines for the Treatment of Autoimmune Diseases
Q90617558Targeting the IL-22/IL-22BP axis enhances tight junctions and reduces inflammation during influenza infection
Q33894387Th 17 cells interplay with Foxp3+ Tregs in regulation of inflammation and autoimmunity
Q34038557Th1 and Th17 cells: adversaries and collaborators
Q36151179Th17 Cells Are More Protective Than Th1 Cells Against the Intracellular Parasite Trypanosoma cruzi
Q34432491Th17 Cells Coordinate with Th22 Cells in Maintaining Homeostasis of Intestinal Tissues and both are Depleted in SIV-Infected Macaques
Q34336840Th17 can regulate silica-induced lung inflammation through an IL-1β-dependent mechanism
Q38106558Th17 cell based vaccines in mucosal immunity
Q37106755Th17 cells and IL-17 receptor signaling are essential for mucosal host defense against oral candidiasis
Q33611067Th17 cells at the crossroads of innate and adaptive immunity against infectious diseases at the mucosa
Q34242697Th17 cells mediate clade-specific, serotype-independent mucosal immunity
Q36188911Th17 cells: critical mediators of host responses to burn injury and sepsis
Q37173921Th17 cells: from precursors to players in inflammation and infection
Q37576442Th17 cytokines and host-pathogen interactions at the mucosa: dichotomies of help and harm
Q33743570Th17 cytokines and the gut mucosal barrier
Q33792227Th17 cytokines and vaccine-induced immunity
Q33943805Th17 cytokines in mucosal immunity and inflammation
Q27335276Th17 effector cells support B cell responses outside of germinal centres
Q39426939Th17 profile in COPD exacerbations.
Q26861492Th17-mediated inflammation in asthma
Q37396933Th17-polarized immune response in a murine model of hypersensitivity pneumonitis and lung fibrosis
Q38068964Th22 and related cytokines in inflammatory and autoimmune diseases
Q42148408Th22 cells are an important source of IL-22 for host protection against enteropathogenic bacteria
Q37725429Th22 cells are associated with hepatocellular carcinoma development and progression
Q37224613Th22 cells control colon tumorigenesis through STAT3 and Polycomb Repression complex 2 signaling
Q24647357Th22 cells represent a distinct human T cell subset involved in epidermal immunity and remodeling
Q37850717Th22 in inflammatory and autoimmune disease: prospects for therapeutic intervention
Q37215886The Current STATus of lymphocyte signaling: new roles for old players.
Q37026138The Distribution and the Fibrotic Role of Elevated Inflammatory Th17 Cells in Patients With Primary Biliary Cirrhosis
Q35682867The Etiology and Pathogenesis of Chronic Rhinosinusitis: a Review of Current Hypotheses
Q35782202The Human IL-22 Receptor Is Regulated through the Action of the Novel E3 Ligase Subunit FBXW12, Which Functions as an Epithelial Growth Suppressor.
Q37697039The IL-17 family cytokines in immunity and disease.
Q28300826The IL-17 pathway as a major therapeutic target in autoimmune diseases
Q28252101The IL-20 subfamily of cytokines--from host defence to tissue homeostasis
Q37989164The IL-23/IL-17 pathway in inflammatory bowel disease
Q54216565The Immunoregulation of Th17 in Host against Intracellular Bacterial Infection.
Q55233965The Interleukin-20 Cytokine Family in Liver Disease.
Q40852964The N-glycan on Asn54 affects the atypical N-glycan composition of plant-produced interleukin-22, but does not influence its activity
Q36947949The Role of IL-22 in Viral Infections: Paradigms and Paradoxes
Q28070412The Role of Lymphocytes in Radiotherapy-Induced Adverse Late Effects in the Lung
Q34289823The Th1 immune response to Plasmodium falciparum circumsporozoite protein is boosted by adenovirus vectors 35 and 26 with a homologous insert
Q36713721The Th17 family: flexibility follows function.
Q37662888The Th17 pathway and inflammatory diseases of the intestines, lungs, and skin
Q36054539The Th17 pathway in cystic fibrosis lung disease.
Q59793706The Two-Faced Cytokine IL-6 in Host Defense and Diseases
Q38137012The aryl hydrocarbon receptor in innate T cell immunity
Q35713322The aryl hydrocarbon receptor regulates gut immunity through modulation of innate lymphoid cells
Q46470522The best defense is a good (Protease) offense: How Pseudomonas aeruginosa evades mucosal immunity in the lung
Q24614431The biological functions of T helper 17 cell effector cytokines in inflammation
Q35594963The changing face of asthma and its relation with microbes
Q35579076The current concept of T (h) 17 cells and their expanding role in systemic lupus erythematosus
Q37660167The cytokine IL-22 promotes pathogen colonization by suppressing related commensal bacteria.
Q56607716The dual nature of TH17 cells: shifting the focus to function
Q38797781The enigmatic role of IL-22 in asthma
Q47606845The expressions and roles of different forms of IL-22 in Mycobacterium tuberculosis infection.
Q24594675The interleukin-17 cytokine family: critical players in host defence and inflammatory diseases
Q38181085The multifaceted role of Th17 lymphocytes and their associated cytokines in cancer
Q35996059The multifaceted roles of neutrophil gelatinase associated lipocalin (NGAL) in inflammation and cancer
Q24321872The non-conventional MHC class I MR1 molecule controls infection by Klebsiella pneumoniae in mice
Q41948431The other T helper cells in asthma pathogenesis
Q89959893The protective efficacy of recombinant hypoxic response protein 1 of Nocardia seriolae in largemouth bass (Micropterus salmoides)
Q35484658The protective role of TLR6 in a mouse model of asthma is mediated by IL-23 and IL-17A.
Q37859621The role of IL-10 in immune regulation during M. tuberculosis infection
Q34151076The role of Th17 cytokines in primary mucosal immunity
Q38184626The role of innate and lymphoid IL-22-producing cells in the immunopathology of primary Sjögren's syndrome.
Q48146269The role of innate lymphoid cells in health and disease
Q26859112The role of nuclear hormone receptors in cutaneous wound repair
Q34126426The role of osteopontin (OPN/SPP1) haplotypes in the susceptibility to Crohn's disease
Q26750673The roles and functional mechanisms of interleukin-17 family cytokines in mucosal immunity
Q27691303The route less taken: pulmonary models of enteric Gram-negative infection
Q37830196The unexpected link between infection-induced apoptosis and a TH17 immune response.
Q41812432The β-glucan receptor dectin-1 promotes lung immunopathology during fungal allergy via IL-22.
Q36631313Therapeutic Role of Interleukin 22 in Experimental Intra-abdominal Klebsiella pneumoniae Infection in Mice.
Q38174792Therapeutic opportunities of the IL-22-IL-22R1 system
Q38407736Tissue-expressed B7-H1 critically controls intestinal inflammation
Q37733573Toll-like receptor 4-induced IL-22 accelerates kidney regeneration.
Q40050850Transcript profiling of the immunological interactions between Actinobacillus pleuropneumoniae serotype 7 and the host by dual RNA-seq.
Q46052625Transcription factor c-Maf mediates the TGF-β-dependent suppression of IL-22 production in T(H)17 cells.
Q37425866Transcriptional regulatory networks in Th17 cell differentiation
Q101038726Transcriptome analysis of chicken intraepithelial lymphocyte natural killer cells infected with very virulent infectious bursal disease virus
Q34984567Transcriptome profiling reveals Th17-like immune responses induced in zebrafish bath-vaccinated with a live attenuated Vibrio anguillarum
Q37511583Transition metal ions at the crossroads of mucosal immunity and microbial pathogenesis
Q26824855Treg cells: a potential regulator for IL-22 expression?
Q36338729Type 2 diabetes - Tuberculosis co-morbidity is associated with diminished circulating levels of IL-20 subfamily of cytokines
Q61807031Type 3 ILCs in Lung Disease
Q33619034Unexpected role for IL-17 in protective immunity against hypervirulent Mycobacterium tuberculosis HN878 infection.
Q34217243Unlike Th1, Th17 cells mediate sustained autoimmune inflammation and are highly resistant to restimulation-induced cell death
Q41273420Update in the mechanisms of allergen-specific immunotheraphy
Q36277359Vaccine-induced th17 cells are maintained long-term postvaccination as a distinct and phenotypically stable memory subset
Q39699269Variation in genes of β-glucan recognition pathway and susceptibility to opportunistic infections in HIV-positive patients
Q35557138Virus infection stages and distinct Th1 or Th17/Th22 T-cell responses in malaria/SHIV coinfection correlate with different outcomes of disease
Q92132713Vitamin D Induces Differential Effects on Inflammatory Responses During Bacterial and/or Viral Stimulation of Human Peripheral Blood Mononuclear Cells
Q35673174Vitamin D regulates cytokine patterns secreted by dendritic cells to promote differentiation of IL-22-producing T cells
Q34090830Vitamin D3 attenuates Th2 responses to Aspergillus fumigatus mounted by CD4+ T cells from cystic fibrosis patients with allergic bronchopulmonary aspergillosis
Q26767293Years in Review: Recent Progress in Cellular Allergology
Q36302839rIL-22 as an adjuvant enhances the immunogenicity of rGroEL in mice and its protective efficacy against S. Typhi and S. Typhimurium
Q40091484β-Carotene Biosynthesis in Probiotic Bacteria
Q34434443γδ T cells enhance autoimmunity by restraining regulatory T cell responses via an interleukin-23-dependent mechanism.
Q34161552γδ T cells protect against lung fibrosis via IL-22.

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