Abnormal changes in NKT cells, the IGF-1 axis, and liver pathology in an animal model of ALS.

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Abnormal changes in NKT cells, the IGF-1 axis, and liver pathology in an animal model of ALS. is …
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scholarly articleQ13442814

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P819ADS bibcode2011PLoSO...622374F
P356DOI10.1371/JOURNAL.PONE.0022374
P932PMC publication ID3149057
P698PubMed publication ID21829620
P5875ResearchGate publication ID51559933

P50authorMichal SchwartzQ21264411
Ayal RonenQ125288774
Akop SeksenyanQ125289982
Tamara BerkutzkiQ125290233
Arseny FinkelsteinQ67212289
Maya Koronyo-HamaouiQ77526984
P2093author name stringGilad Kunis
David Azoulay
P2860cites workSOD1 mutations disrupt redox-sensitive Rac regulation of NADPH oxidase in a familial ALS modelQ24307703
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Glatiramer acetate fights against Alzheimer's disease by inducing dendritic-like microglia expressing insulin-like growth factor 1Q24676445
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Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosisQ28131805
CD1d-restricted and TCR-mediated activation of valpha14 NKT cells by glycosylceramidesQ28254991
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NKG2A inhibits invariant NKT cell activation in hepatic injuryQ33739557
Immature myeloid cells induced by a high-fat diet contribute to liver inflammation.Q33781288
Glycolipid antigen induces long-term natural killer T cell anergy in miceQ33930869
Protective autoimmunity is a physiological response to CNS trauma.Q33947118
Limited effects of glatiramer acetate in the high-copy number hSOD1-G93A mouse model of ALSQ80540415
Hepatocyte proliferation during liver regeneration is impaired in mice with liver-specific IGF-1R knockoutQ82581005
Natural killer T cells regulate the homing of chemokine CXC receptor 3-positive regulatory T cells to the liver in miceQ83179770
A modified alpha-galactosyl ceramide for staining and stimulating natural killer T cellsQ83220628
Retrograde viral delivery of IGF-1 prolongs survival in a mouse ALS modelQ51659718
Selective ablation of bone marrow-derived dendritic cells increases amyloid plaques in a mouse Alzheimer's disease model.Q53287908
An adverse property of a familial ALS-linked SOD1 mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondriaQ54965159
Choroid Plexus Megalin Is Involved in Neuroprotection by Serum Insulin-Like Growth Factor IQ60693600
Functional and morphometric study of the liver in motor neuron diseaseQ70113581
Gangliosides of human spinal cord: aberrant composition of cords from patients with amyotrophic lateral sclerosisQ70679263
Sialosylglobotetraosylceramide: a marker for amyotropic lateral sclerosisQ71269642
Functional natural killer T cells in experimental mouse strains, including NK1.1- strainsQ73277872
Cell-specific localization of insulin-like growth factor binding protein mRNAs in rat liverQ73536584
Circulating V(alpha24+) Vbeta11+ NKT cell numbers are decreased in a wide variety of diseases that are characterized by autoreactive tissue damageQ74243201
Massive Mitochondrial Degeneration in Motor Neurons Triggers the Onset of Amyotrophic Lateral Sclerosis in Mice Expressing a Mutant SOD1Q74454204
NKT cells inhibit the onset of diabetes by impairing the development of pathogenic T cells specific for pancreatic beta cellsQ78651183
Therapeutic immunization with a glatiramer acetate derivative does not alter survival in G93A and G37R SOD1 mouse models of familial ALSQ79716540
Oral tolerance to nickel requires CD4+ invariant NKT cells for the infectious spread of tolerance and the induction of specific regulatory T cellsQ80304558
Mutant SOD1(G93A) microglia are more neurotoxic relative to wild-type microgliaQ80445359
Dyslipidemia is a protective factor in amyotrophic lateral sclerosisQ80503053
NKT cell stimulation with glycolipid antigen in vivo: costimulation-dependent expansion, Bim-dependent contraction, and hyporesponsiveness to further antigenic challengeQ34333607
Autoimmune T cells protect neurons from secondary degeneration after central nervous system axotomyQ34486849
Wild-type microglia extend survival in PU.1 knockout mice with familial amyotrophic lateral sclerosisQ35094527
T cell immunity to copolymer 1 confers neuroprotection on the damaged optic nerve: possible therapy for optic neuropathiesQ35160575
Natural killer T cells: natural or unnatural regulators of autoimmunity?Q35589842
Insulin-like growth factor binding protein (IGFBP) signallingQ35825099
Initiation of liver growth by tumor necrosis factor: deficient liver regeneration in mice lacking type I tumor necrosis factor receptorQ35997495
MyD88-deficient bone marrow cells accelerate onset and reduce survival in a mouse model of amyotrophic lateral sclerosisQ36274514
Liver-derived insulin-like growth factor I (IGF-I) is the principal source of IGF-I in blood but is not required for postnatal body growth in miceQ36392687
CD4+CD25+ Tregs and NKT cells: regulators regulating regulatorsQ36492658
Type I NKT cells protect (and type II NKT cells suppress) the host's innate antitumor immune response to a B-cell lymphoma.Q36713547
CD4+ T cells support glial neuroprotection, slow disease progression, and modify glial morphology in an animal model of inherited ALS.Q36899833
T lymphocytes potentiate endogenous neuroprotective inflammation in a mouse model of ALS.Q36968498
Activation of invariant NKT cells ameliorates experimental ocular autoimmunity by a mechanism involving innate IFN-gamma production and dampening of the adaptive Th1 and Th17 responsesQ37002932
Microglial dysfunction and defective beta-amyloid clearance pathways in aging Alzheimer's disease miceQ37003128
Myeloid-derived suppressor cell role in tumor-related inflammationQ37146806
Immunity to self and self-maintenance: what can tumor immunology teach us about ALS and Alzheimer's disease?Q37153110
Application of glatiramer acetate to neurodegenerative diseases beyond multiple sclerosis: the need for disease-specific approachesQ37263175
Murine CD8+ regulatory T lymphocytes: the new era.Q37279458
Evidence for defective energy homeostasis in amyotrophic lateral sclerosis: benefit of a high-energy diet in a transgenic mouse modelQ37285915
Thymic involution, a co-morbidity factor in amyotrophic lateral sclerosisQ37295387
Systemic inflammatory cells fight off neurodegenerative diseaseQ37763505
Protective autoimmunity: interferon-gamma enables microglia to remove glutamate without evoking inflammatory mediators.Q38330556
Invariant NKT cells regulate experimental autoimmune encephalomyelitis and infiltrate the central nervous system in a CD1d-independent mannerQ38476162
Cutting edge: V alpha 14-J alpha 281 NKT cells naturally regulate experimental autoimmune encephalomyelitis in nonobese diabetic mice.Q38495710
Massive hepatic apoptosis associated with TGF-beta1 activation after Fas ligand treatment of IGF binding protein-1-deficient miceQ39740877
Development of central nervous system pathology in a murine transgenic model of human amyotrophic lateral sclerosisQ42049901
Presence of dendritic cells, MCP-1, and activated microglia/macrophages in amyotrophic lateral sclerosis spinal cord tissueQ44172339
Role of Vα 14 NKT cells in the development of impaired liver regeneration in vivoQ44632301
Ablation of proliferating microglia does not affect motor neuron degeneration in amyotrophic lateral sclerosis caused by mutant superoxide dismutase.Q46325370
Ganglioside patterns in amyotrophic lateral sclerosis brain regionsQ48472144
Neuroprotection by IL-10-producing MOG CD4+ T cells following ischemic strokeQ48886218
Inflammation in amyotrophic lateral sclerosis spinal cord and brain is mediated by activated macrophages, mast cells and T cellsQ48949631
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue8
P407language of work or nameEnglishQ1860
P921main subjectamyotrophic lateral sclerosisQ206901
P304page(s)e22374
P577publication date2011-08-02
P1433published inPLOS OneQ564954
P1476titleAbnormal changes in NKT cells, the IGF-1 axis, and liver pathology in an animal model of ALS
P478volume6

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