Response and resistance to MEK inhibition in leukaemias initiated by hyperactive Ras

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Response and resistance to MEK inhibition in leukaemias initiated by hyperactive Ras is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1044687046
P356DOI10.1038/NATURE08279
P932PMC publication ID4119783
P698PubMed publication ID19727076
P5875ResearchGate publication ID26786391

P50authorNeal G. CopelandQ66818896
Nancy A. JenkinsQ66818899
Jeannette M. BonifasQ107438263
P2093author name stringQing Li
Scott C Kogan
Jeroen P Roose
Keiko Akagi
Judith Sebolt-Leopold
Kevin Shannon
Linda Wolff
Matthew Gorman
Luis Parada
Doan T Le
Doris Kim
Michael Crone
Sally Przybranowski
Ernesto Diaz-Flores
Kristen M Coakley
Mary Tran
Jennifer O Lauchle
Kegan Warner
Kimberly Krisman
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Targeting RAS signalling pathways in cancer therapyQ28201363
Blockade of the MAP kinase pathway suppresses growth of colon tumors in vivoQ28368373
Somatic inactivation of Nf1 in hematopoietic cells results in a progressive myeloproliferative disorderQ28508406
Multiple BCR-ABL kinase domain mutations confer polyclonal resistance to the tyrosine kinase inhibitor imatinib (STI571) in chronic phase and blast crisis chronic myeloid leukemiaQ29615030
Hyperactive Ras in developmental disorders and cancerQ29616397
A small molecule-kinase interaction map for clinical kinase inhibitorsQ29617451
Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosomeQ33336718
Isolation and analysis of candidate myeloid tumor suppressor genes from a commonly deleted segment of 7q22.Q34410067
A Moloney murine leukemia virus-based retrovirus with 4070A long terminal repeat sequences induces a high incidence of myeloid as well as lymphoid neoplasmsQ34858364
RTCGD: retroviral tagged cancer gene databaseQ34923778
Digital signaling and hysteresis characterize ras activation in lymphoid cellsQ34929087
Focus on myeloproliferative diseases and myelodysplastic syndromesQ35988519
Inherited predispositions and hyperactive Ras in myeloid leukemogenesisQ36302528
A common signaling cascade may underlie "addiction" to the Src, BCR-ABL, and EGF receptor oncogenesQ37169157
Genomic analysis of the clonal origins of relapsed acute lymphoblastic leukemia.Q37351577
Role of the p38 mitogen-activated protein kinase pathway in the generation of the effects of imatinib mesylate (STI571) in BCR-ABL-expressing cellsQ40571427
Regulation of Ras in lymphocytes: get a GRP.Q45345580
Homozygous inactivation of the NF1 gene in bone marrow cells from children with neurofibromatosis type 1 and malignant myeloid disordersQ46134351
Loss of the normal NF1 allele from the bone marrow of children with type 1 neurofibromatosis and malignant myeloid disordersQ46413091
Loss of NF1 results in activation of the Ras signaling pathway and leads to aberrant growth in haematopoietic cellsQ46486969
Mammalian mutagenesis using a highly mobile somatic Sleeping Beauty transposon system.Q53356315
Bethesda proposals for classification of nonlymphoid hematopoietic neoplasms in miceQ74314309
Relapse in children with acute lymphoblastic leukemia involving selection of a preexisting drug-resistant subcloneQ79984705
Pharmacodynamic and toxicokinetic evaluation of the novel MEK inhibitor, PD0325901, in the rat following oral and intravenous administrationQ80194445
P433issue7262
P407language of work or nameEnglishQ1860
P921main subjectleukemiaQ29496
P304page(s)411-414
P577publication date2009-09-02
P1433published inNatureQ180445
P1476titleResponse and resistance to MEK inhibition in leukaemias initiated by hyperactive Ras
P478volume461

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